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The map label for this gene is gmk [H]

Identifier: 114330629

GI number: 114330629

Start: 624404

End: 625009

Strand: Reverse

Name: gmk [H]

Synonym: Neut_0614

Alternate gene names: 114330629

Gene position: 625009-624404 (Counterclockwise)

Preceding gene: 114330630

Following gene: 114330628

Centisome position: 23.49

GC content: 50.17

Gene sequence:

>606_bases
ATGAGTTGTCTGTTTGTAATCAGCGCACCCTCTGGTGCCGGTAAAACCAGTGTAATCCGTACTTTGCTGCAAACGGATAT
CAATGTAACCCTCTCAGTTTCCTATACCACACGCCCCCCCAGGCGGGATGAAGAGAACGGTCGTGATTACTTTTTTGTTG
ATCACGCAACTTTCAGGGAAATGCAGGCACATGGTGAATTCCTGGAAAGCGCCGAGGTGTATGGCAATTTTTATGGCACC
TCACGCAAGTGGATAGAAGAAACCATGGTGGCGGAACAGGATGTCCTGCTGGAAATAGATTGTCAGGGGGCGCAACAGGT
GCGCGAACTCTACCCGCAGGCTGCTTCCATATTTATTCTGCCTCCATCCATGGAAACATTAAAAAACCGTCTGGAGCAAC
GCGGCCTGGATGAAAGCAAGACCATTGAACGGCGGTTGTCGGCTGCGTGCAGCGAGACCAGCCATCTCAATAGATTTGAC
TATGTCGTTGTTAATCACGAACTGGAGACAGCAGCACAGGAAATCTCCTGCATTATTCGGGCTGAACGGCTGAAAACAAT
CCGTCAGCTTGTCAGGCAGCGCGCTCTGCTTGCTGAATTTTCCTGA

Upstream 100 bases:

>100_bases
AAATTTATTGACGACTTCCATTATCAACAATAAATAATCCCGGGAGTTTCCGGGTATTTACCTGTTAAAATACGCCAGAA
TTTCAATAAAACGAAATATT

Downstream 100 bases:

>100_bases
TCAGCCTTACGTTTTTACATTTTTGTAAATTTTTACTGGAGTTATCCATCATGGCACGCATTACCGTAGAAGATTGTCTG
AAAGTGATCCCGAACCGTTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSCLFVISAPSGAGKTSVIRTLLQTDINVTLSVSYTTRPPRRDEENGRDYFFVDHATFREMQAHGEFLESAEVYGNFYGT
SRKWIEETMVAEQDVLLEIDCQGAQQVRELYPQAASIFILPPSMETLKNRLEQRGLDESKTIERRLSAACSETSHLNRFD
YVVVNHELETAAQEISCIIRAERLKTIRQLVRQRALLAEFS

Sequences:

>Translated_201_residues
MSCLFVISAPSGAGKTSVIRTLLQTDINVTLSVSYTTRPPRRDEENGRDYFFVDHATFREMQAHGEFLESAEVYGNFYGT
SRKWIEETMVAEQDVLLEIDCQGAQQVRELYPQAASIFILPPSMETLKNRLEQRGLDESKTIERRLSAACSETSHLNRFD
YVVVNHELETAAQEISCIIRAERLKTIRQLVRQRALLAEFS
>Mature_200_residues
SCLFVISAPSGAGKTSVIRTLLQTDINVTLSVSYTTRPPRRDEENGRDYFFVDHATFREMQAHGEFLESAEVYGNFYGTS
RKWIEETMVAEQDVLLEIDCQGAQQVRELYPQAASIFILPPSMETLKNRLEQRGLDESKTIERRLSAACSETSHLNRFDY
VVVNHELETAAQEISCIIRAERLKTIRQLVRQRALLAEFS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=35.2941176470588, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=35.2941176470588, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=35.2941176470588, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI14780902, Length=198, Percent_Identity=29.7979797979798, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI38570142, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI52630447, Length=198, Percent_Identity=29.2929292929293, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI21361598, Length=192, Percent_Identity=25.5208333333333, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186972120, Length=171, Percent_Identity=25.1461988304094, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700627, Length=171, Percent_Identity=25.1461988304094, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700629, Length=171, Percent_Identity=25.1461988304094, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4505237, Length=166, Percent_Identity=27.710843373494, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI262118255, Length=166, Percent_Identity=27.710843373494, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI262118263, Length=166, Percent_Identity=27.710843373494, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI262118259, Length=166, Percent_Identity=27.710843373494, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=48.7562189054726, Blast_Score=200, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI193203132, Length=195, Percent_Identity=34.8717948717949, Blast_Score=116, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17508835, Length=195, Percent_Identity=34.8717948717949, Blast_Score=116, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=28.1767955801105, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=188, Percent_Identity=39.3617021276596, Blast_Score=129, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=31.3186813186813, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22954; Mature: 22823

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCLFVISAPSGAGKTSVIRTLLQTDINVTLSVSYTTRPPRRDEENGRDYFFVDHATFRE
CCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEEEHHHHHH
MQAHGEFLESAEVYGNFYGTSRKWIEETMVAEQDVLLEIDCQGAQQVRELYPQAASIFIL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEEE
PPSMETLKNRLEQRGLDESKTIERRLSAACSETSHLNRFDYVVVNHELETAAQEISCIIR
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
AERLKTIRQLVRQRALLAEFS
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SCLFVISAPSGAGKTSVIRTLLQTDINVTLSVSYTTRPPRRDEENGRDYFFVDHATFRE
CEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEEEHHHHHH
MQAHGEFLESAEVYGNFYGTSRKWIEETMVAEQDVLLEIDCQGAQQVRELYPQAASIFIL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEEE
PPSMETLKNRLEQRGLDESKTIERRLSAACSETSHLNRFDYVVVNHELETAAQEISCIIR
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
AERLKTIRQLVRQRALLAEFS
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]