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The map label for this gene is pgi [H]

Identifier: 114330624

GI number: 114330624

Start: 619203

End: 620837

Strand: Reverse

Name: pgi [H]

Synonym: Neut_0609

Alternate gene names: 114330624

Gene position: 620837-619203 (Counterclockwise)

Preceding gene: 114330625

Following gene: 114330623

Centisome position: 23.33

GC content: 50.21

Gene sequence:

>1635_bases
ATGTCCACACTGACCCGATCCCCTGCTTGGCAAGCATTGAGCACGCATCAGCCGGATATGGCAAACCGCCCGCTACGCAC
CCTGTTTAGCGAAGACCCACATCGGTTCGACAAATTCTCGCTGCAATTTAAGGATATTTTGCTTGACTACAGCAAACAGC
CGGTTGATGAAACGACAATTCGTTTATTGCTGGCACTGGCCAGACAGCAAAATCTGGCCGACTGGATGGCTCGCATGGCC
AACGGCGACAAGATCAACTCTACTGAAAACCGGGCAGCATTGCACATCGCCTTGCGTGCCAATACACCTGTTTTTACAGA
TGGCGTGGATGTCACACAGGAGGTTAAACGCGTTTTACAGCAGATCGAACGGTTTACCGGAAAAATTCACAACAGCACGC
ACCGGGGCTATTCCGGCCTGCCAATTACCGATGTGGTCAATATCGGTATCGGCGGCTCCGATCTCGGTCCGGTGATGGCA
ACCGAAGCACTTAAGCCTTATCATGTGCCGCAACTGCAGGTTCATTGCGTTTCCAACCTTGACGGCGCGCATCTTTCCAG
CATATTGCAGCCCCTTAATCCTGCCACAACCCTGTTCATCATCGCCTCCAAAACCTTCACCACCCAGGAAACACTCACCA
ACGCCCATTCCGCGCGGGAATGGTTTTTGGCCAGCGGAGGCAGTGAACAGGATATTGCAGCACATTTCGTCGCCGTTTCC
ACTAACCGCGCAGCTGTCAGCCAGTTTGGTATCGATCCGGACAATATGTTTGAATTCTGGGATTGGGTCGGCGGGCGTTA
TTCATTATGGTCAGCCATCGGCCTGCCAATTGCATTGGCAGTAGGAATGGACAATTTCCGTTTACTGCTAGCCGGAGCGC
AGAAAATGGATGAACACTTCCTGACCACGCCTTTTGAGAAAAACTTGCCGGTTATGCTGGGATTGATTGCAGTCTGGCAA
ATCAATTTTTTTCATGTAACCAATCAGGCAATCCTGCCCTACGATCAATCCATGCACCGTTTTCCAGCTTATTTACAGCA
ACTGGAAATGGAAAGCTGTGGCAAACGTGTCACTCGTACCGGGGAAGCAGTTGACTACAGCACTGGTGCGGTGATCTGGG
GCGAACCCGGTACCAACGGCCAGCATGCTTTTTATCAATTGCTGCATCAGGGCACGCAGAAATTTACAGCTGATTTTCTG
GCACCGTGCCAATGCCAGCATTCGCTGCCCGAGCATCACCCTATGTTACTGGCGAATTTCTTTGCTCAAACCGAAGCACT
GATGCGCGGAAAAAATGAACAGGAAGTCAGAGCCGAACTGATAAATCAAAATCTGTCTGTCGAAGCGATAGAACGCTTGC
TTCCTCATCGCGTGTTTCCAGGCAATCGAGCTACCACCTCGATTTTGTTCAAAAAACTCGATCCAGCAACCCTTGGCATG
TTGATCGCACTCTATGAGCACAAAGTATTCGTGCAAAGTGTGATCTGGGAAATCAATCCATTCGATCAGTGGGGAGTAGA
ACTCGGCAAGCAACTGGCGGGAAAAATCCTGGCTGAATTGGCTGCAGATAAACCGGTAACCGGGCACGATGCATCAACCA
ACAACCTGATCGATTTTTATAGAACACAACAATAA

Upstream 100 bases:

>100_bases
GGCCGCCATGCACTGGTTACCCTGTGCATCGGTGGTGGACAGGGAATCGCTGCAATTTTTGAAAAATACTGATCCGGCTG
CCTATCTTATGGAGAAAGAT

Downstream 100 bases:

>100_bases
ATCAGAACATATATCAAGCCATGCCTTCCTCTTCCCCTCGCAAAAATATACGGGTGTTATTTGTCACCCCGGAAGTTTTT
CCATTATGCAAAACTGGCGG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSTLTRSPAWQALSTHQPDMANRPLRTLFSEDPHRFDKFSLQFKDILLDYSKQPVDETTIRLLLALARQQNLADWMARMA
NGDKINSTENRAALHIALRANTPVFTDGVDVTQEVKRVLQQIERFTGKIHNSTHRGYSGLPITDVVNIGIGGSDLGPVMA
TEALKPYHVPQLQVHCVSNLDGAHLSSILQPLNPATTLFIIASKTFTTQETLTNAHSAREWFLASGGSEQDIAAHFVAVS
TNRAAVSQFGIDPDNMFEFWDWVGGRYSLWSAIGLPIALAVGMDNFRLLLAGAQKMDEHFLTTPFEKNLPVMLGLIAVWQ
INFFHVTNQAILPYDQSMHRFPAYLQQLEMESCGKRVTRTGEAVDYSTGAVIWGEPGTNGQHAFYQLLHQGTQKFTADFL
APCQCQHSLPEHHPMLLANFFAQTEALMRGKNEQEVRAELINQNLSVEAIERLLPHRVFPGNRATTSILFKKLDPATLGM
LIALYEHKVFVQSVIWEINPFDQWGVELGKQLAGKILAELAADKPVTGHDASTNNLIDFYRTQQ

Sequences:

>Translated_544_residues
MSTLTRSPAWQALSTHQPDMANRPLRTLFSEDPHRFDKFSLQFKDILLDYSKQPVDETTIRLLLALARQQNLADWMARMA
NGDKINSTENRAALHIALRANTPVFTDGVDVTQEVKRVLQQIERFTGKIHNSTHRGYSGLPITDVVNIGIGGSDLGPVMA
TEALKPYHVPQLQVHCVSNLDGAHLSSILQPLNPATTLFIIASKTFTTQETLTNAHSAREWFLASGGSEQDIAAHFVAVS
TNRAAVSQFGIDPDNMFEFWDWVGGRYSLWSAIGLPIALAVGMDNFRLLLAGAQKMDEHFLTTPFEKNLPVMLGLIAVWQ
INFFHVTNQAILPYDQSMHRFPAYLQQLEMESCGKRVTRTGEAVDYSTGAVIWGEPGTNGQHAFYQLLHQGTQKFTADFL
APCQCQHSLPEHHPMLLANFFAQTEALMRGKNEQEVRAELINQNLSVEAIERLLPHRVFPGNRATTSILFKKLDPATLGM
LIALYEHKVFVQSVIWEINPFDQWGVELGKQLAGKILAELAADKPVTGHDASTNNLIDFYRTQQ
>Mature_543_residues
STLTRSPAWQALSTHQPDMANRPLRTLFSEDPHRFDKFSLQFKDILLDYSKQPVDETTIRLLLALARQQNLADWMARMAN
GDKINSTENRAALHIALRANTPVFTDGVDVTQEVKRVLQQIERFTGKIHNSTHRGYSGLPITDVVNIGIGGSDLGPVMAT
EALKPYHVPQLQVHCVSNLDGAHLSSILQPLNPATTLFIIASKTFTTQETLTNAHSAREWFLASGGSEQDIAAHFVAVST
NRAAVSQFGIDPDNMFEFWDWVGGRYSLWSAIGLPIALAVGMDNFRLLLAGAQKMDEHFLTTPFEKNLPVMLGLIAVWQI
NFFHVTNQAILPYDQSMHRFPAYLQQLEMESCGKRVTRTGEAVDYSTGAVIWGEPGTNGQHAFYQLLHQGTQKFTADFLA
PCQCQHSLPEHHPMLLANFFAQTEALMRGKNEQEVRAELINQNLSVEAIERLLPHRVFPGNRATTSILFKKLDPATLGML
IALYEHKVFVQSVIWEINPFDQWGVELGKQLAGKILAELAADKPVTGHDASTNNLIDFYRTQQ

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=553, Percent_Identity=56.9620253164557, Blast_Score=637, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=553, Percent_Identity=54.0687160940326, Blast_Score=586, Evalue=1e-167,
Organism=Escherichia coli, GI1790457, Length=540, Percent_Identity=57.2222222222222, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=548, Percent_Identity=54.1970802919708, Blast_Score=595, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71996703, Length=548, Percent_Identity=54.1970802919708, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319673, Length=548, Percent_Identity=50.5474452554745, Blast_Score=548, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24651916, Length=526, Percent_Identity=55.5133079847909, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24651914, Length=526, Percent_Identity=55.5133079847909, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI17737445, Length=526, Percent_Identity=55.5133079847909, Blast_Score=581, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 60823; Mature: 60692

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLTRSPAWQALSTHQPDMANRPLRTLFSEDPHRFDKFSLQFKDILLDYSKQPVDETTI
CCCCCCCCCHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
RLLLALARQQNLADWMARMANGDKINSTENRAALHIALRANTPVFTDGVDVTQEVKRVLQ
HHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCEEECCCCHHHHHHHHHH
QIERFTGKIHNSTHRGYSGLPITDVVNIGIGGSDLGPVMATEALKPYHVPQLQVHCVSNL
HHHHHHHHHCCCCCCCCCCCCHHHHEECCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCC
DGAHLSSILQPLNPATTLFIIASKTFTTQETLTNAHSAREWFLASGGSEQDIAAHFVAVS
CHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEEE
TNRAAVSQFGIDPDNMFEFWDWVGGRYSLWSAIGLPIALAVGMDNFRLLLAGAQKMDEHF
CCHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCHHEEEECCCCCEEEEHHHHHHHHHH
LTTPFEKNLPVMLGLIAVWQINFFHVTNQAILPYDQSMHRFPAYLQQLEMESCGKRVTRT
CCCCCCCCCHHHHHHHHHHHEEEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GEAVDYSTGAVIWGEPGTNGQHAFYQLLHQGTQKFTADFLAPCQCQHSLPEHHPMLLANF
CCCEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHH
FAQTEALMRGKNEQEVRAELINQNLSVEAIERLLPHRVFPGNRATTSILFKKLDPATLGM
HHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHH
LIALYEHKVFVQSVIWEINPFDQWGVELGKQLAGKILAELAADKPVTGHDASTNNLIDFY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
RTQQ
CCCC
>Mature Secondary Structure 
STLTRSPAWQALSTHQPDMANRPLRTLFSEDPHRFDKFSLQFKDILLDYSKQPVDETTI
CCCCCCCCHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
RLLLALARQQNLADWMARMANGDKINSTENRAALHIALRANTPVFTDGVDVTQEVKRVLQ
HHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCEEECCCCHHHHHHHHHH
QIERFTGKIHNSTHRGYSGLPITDVVNIGIGGSDLGPVMATEALKPYHVPQLQVHCVSNL
HHHHHHHHHCCCCCCCCCCCCHHHHEECCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCC
DGAHLSSILQPLNPATTLFIIASKTFTTQETLTNAHSAREWFLASGGSEQDIAAHFVAVS
CHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEEE
TNRAAVSQFGIDPDNMFEFWDWVGGRYSLWSAIGLPIALAVGMDNFRLLLAGAQKMDEHF
CCHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCHHEEEECCCCCEEEEHHHHHHHHHH
LTTPFEKNLPVMLGLIAVWQINFFHVTNQAILPYDQSMHRFPAYLQQLEMESCGKRVTRT
CCCCCCCCCHHHHHHHHHHHEEEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GEAVDYSTGAVIWGEPGTNGQHAFYQLLHQGTQKFTADFLAPCQCQHSLPEHHPMLLANF
CCCEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHH
FAQTEALMRGKNEQEVRAELINQNLSVEAIERLLPHRVFPGNRATTSILFKKLDPATLGM
HHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHH
LIALYEHKVFVQSVIWEINPFDQWGVELGKQLAGKILAELAADKPVTGHDASTNNLIDFY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
RTQQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]