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The map label for this gene is serA [H]

Identifier: 114330453

GI number: 114330453

Start: 447380

End: 448315

Strand: Reverse

Name: serA [H]

Synonym: Neut_0433

Alternate gene names: 114330453

Gene position: 448315-447380 (Counterclockwise)

Preceding gene: 114330454

Following gene: 114330452

Centisome position: 16.85

GC content: 53.42

Gene sequence:

>936_bases
ATGAGCAAGATCGTCGTTTCCACTTCCTCTTTCGATTTTGATCACAACCCCGCCATACAGCGACTGCAGGCACAAGGCTT
CACCGTCACCGGCAATCCTTACCGGCGCAAGCTCGCCGAAGATGAAATTATTGATTTACTCAGCACGGATACCGTCGCCC
TGCTGGCGGGAGTTGAGCCGCTGACAGAACATGTGTTGACAAGCGCCAGTGCTTTGCGTGTCATTGCACGTTGCGGCACT
GGCATGGATAGTGTTGATCTGAAAGCTGCCCAGCAAAGAAACATCAAGGTTTCCAATACCCCTGAAGCGCCCGCTCAGGC
TGTTGCAGAACTGACACTAGGGCTGATGCTTGATTGCCTGCGCCAGATCAATCACACTGATCGTTCCGTACGCAAAGGTG
AATGGCCACGCACACAGGGACGGCTGCTGGCTGCACGCACAGTGGGCATTGTTGGCCTGGGACATATTGGCCGACGGGTT
GCTAAACTATGTCAGGCATTCGAGGCAAAGGTCATCGCACATGACCCTCATCTGCAGCAAGCACCCGGCGGCATCGAACT
CGTTTCATTGAATACTTTGCTCGAACAGGCTGATATTGTGACACTCCACTTGCCCTACTCTCCGGATGTTCGCCATTTAA
TTAATGCCGAAGCCATTGCGCATATGCAACCCGGAACAATCTTTATCAACGCCGCCCGTGGCGGATTGGTCGATGAAACC
GCTTTATGCACAGCGCTCAATTCAGGGCACATTGAAGCGGCTGCACTAGACAGCTTCGAACAGGAGCCCTACCAAGGACC
TCTGCGCGAATGCAAACGGGCGATACTGACTTCTCATATCGGATCACTTGCGCGAGAAACACGGCAGCGCATGGAAATCG
AAGCGGCTGAAAATTTGTGGCGGGGAATGGTCGAGGCAGGTTTGATCAATGAGTGA

Upstream 100 bases:

>100_bases
AACGGATCAAACAGGGATTTTCATTTCTGGGATACAGCCTTGATATCCGCATGCTTGATTCCCTTTGCCGCACCCATCTG
AACATGATCAGAACATCTTC

Downstream 100 bases:

>100_bases
AGCAATACAGCCGGGGCAAATTGCAGTTGTACTGGGTGCAGGCGGCTTTCTGGGCAGCCACGTTGCCGATGCCCTGTCCA
ATGCAGGCTATCAGGTGCGT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSKIVVSTSSFDFDHNPAIQRLQAQGFTVTGNPYRRKLAEDEIIDLLSTDTVALLAGVEPLTEHVLTSASALRVIARCGT
GMDSVDLKAAQQRNIKVSNTPEAPAQAVAELTLGLMLDCLRQINHTDRSVRKGEWPRTQGRLLAARTVGIVGLGHIGRRV
AKLCQAFEAKVIAHDPHLQQAPGGIELVSLNTLLEQADIVTLHLPYSPDVRHLINAEAIAHMQPGTIFINAARGGLVDET
ALCTALNSGHIEAAALDSFEQEPYQGPLRECKRAILTSHIGSLARETRQRMEIEAAENLWRGMVEAGLINE

Sequences:

>Translated_311_residues
MSKIVVSTSSFDFDHNPAIQRLQAQGFTVTGNPYRRKLAEDEIIDLLSTDTVALLAGVEPLTEHVLTSASALRVIARCGT
GMDSVDLKAAQQRNIKVSNTPEAPAQAVAELTLGLMLDCLRQINHTDRSVRKGEWPRTQGRLLAARTVGIVGLGHIGRRV
AKLCQAFEAKVIAHDPHLQQAPGGIELVSLNTLLEQADIVTLHLPYSPDVRHLINAEAIAHMQPGTIFINAARGGLVDET
ALCTALNSGHIEAAALDSFEQEPYQGPLRECKRAILTSHIGSLARETRQRMEIEAAENLWRGMVEAGLINE
>Mature_310_residues
SKIVVSTSSFDFDHNPAIQRLQAQGFTVTGNPYRRKLAEDEIIDLLSTDTVALLAGVEPLTEHVLTSASALRVIARCGTG
MDSVDLKAAQQRNIKVSNTPEAPAQAVAELTLGLMLDCLRQINHTDRSVRKGEWPRTQGRLLAARTVGIVGLGHIGRRVA
KLCQAFEAKVIAHDPHLQQAPGGIELVSLNTLLEQADIVTLHLPYSPDVRHLINAEAIAHMQPGTIFINAARGGLVDETA
LCTALNSGHIEAAALDSFEQEPYQGPLRECKRAILTSHIGSLARETRQRMEIEAAENLWRGMVEAGLINE

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=285, Percent_Identity=34.7368421052632, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI145580578, Length=262, Percent_Identity=37.4045801526718, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4557499, Length=262, Percent_Identity=37.4045801526718, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=267, Percent_Identity=35.9550561797753, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4557497, Length=267, Percent_Identity=35.9550561797753, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI145580575, Length=265, Percent_Identity=37.3584905660377, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI6912396, Length=259, Percent_Identity=32.8185328185328, Blast_Score=115, Evalue=4e-26,
Organism=Escherichia coli, GI1789279, Length=296, Percent_Identity=32.4324324324324, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI87082289, Length=271, Percent_Identity=34.6863468634686, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787645, Length=241, Percent_Identity=30.2904564315353, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788660, Length=236, Percent_Identity=31.7796610169492, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87081824, Length=144, Percent_Identity=29.8611111111111, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=287, Percent_Identity=36.9337979094077, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=277, Percent_Identity=26.3537906137184, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=253, Percent_Identity=33.9920948616601, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=306, Percent_Identity=31.6993464052288, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=306, Percent_Identity=31.3725490196078, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=226, Percent_Identity=26.5486725663717, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19921140, Length=291, Percent_Identity=31.6151202749141, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646446, Length=263, Percent_Identity=37.6425855513308, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646448, Length=263, Percent_Identity=37.6425855513308, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646452, Length=263, Percent_Identity=37.6425855513308, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646450, Length=263, Percent_Identity=37.6425855513308, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI62472511, Length=263, Percent_Identity=37.6425855513308, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24585516, Length=272, Percent_Identity=30.5147058823529, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24585514, Length=263, Percent_Identity=28.5171102661597, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28574282, Length=263, Percent_Identity=28.5171102661597, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28574284, Length=263, Percent_Identity=28.5171102661597, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI45551003, Length=263, Percent_Identity=28.5171102661597, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552429, Length=263, Percent_Identity=28.5171102661597, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574286, Length=276, Percent_Identity=26.8115942028986, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28571528, Length=280, Percent_Identity=30, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33789; Mature: 33658

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIVVSTSSFDFDHNPAIQRLQAQGFTVTGNPYRRKLAEDEIIDLLSTDTVALLAGVEP
CCEEEEECCCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCHHHHHHCCHH
LTEHVLTSASALRVIARCGTGMDSVDLKAAQQRNIKVSNTPEAPAQAVAELTLGLMLDCL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHH
RQINHTDRSVRKGEWPRTQGRLLAARTVGIVGLGHIGRRVAKLCQAFEAKVIAHDPHLQQ
HHHCCCHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCHHEECCCCCCC
APGGIELVSLNTLLEQADIVTLHLPYSPDVRHLINAEAIAHMQPGTIFINAARGGLVDET
CCCCEEEEEHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHH
ALCTALNSGHIEAAALDSFEQEPYQGPLRECKRAILTSHIGSLARETRQRMEIEAAENLW
HHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGMVEAGLINE
HHHHHHCCCCC
>Mature Secondary Structure 
SKIVVSTSSFDFDHNPAIQRLQAQGFTVTGNPYRRKLAEDEIIDLLSTDTVALLAGVEP
CEEEEECCCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCHHHHHHCCHH
LTEHVLTSASALRVIARCGTGMDSVDLKAAQQRNIKVSNTPEAPAQAVAELTLGLMLDCL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHH
RQINHTDRSVRKGEWPRTQGRLLAARTVGIVGLGHIGRRVAKLCQAFEAKVIAHDPHLQQ
HHHCCCHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCHHEECCCCCCC
APGGIELVSLNTLLEQADIVTLHLPYSPDVRHLINAEAIAHMQPGTIFINAARGGLVDET
CCCCEEEEEHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHH
ALCTALNSGHIEAAALDSFEQEPYQGPLRECKRAILTSHIGSLARETRQRMEIEAAENLW
HHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGMVEAGLINE
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]