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The map label for this gene is lldD [H]

Identifier: 114330395

GI number: 114330395

Start: 373515

End: 374612

Strand: Reverse

Name: lldD [H]

Synonym: Neut_0372

Alternate gene names: 114330395

Gene position: 374612-373515 (Counterclockwise)

Preceding gene: 114330396

Following gene: 114330387

Centisome position: 14.08

GC content: 54.19

Gene sequence:

>1098_bases
ATGAATGAGCTGTTACCTAAACTCTCAACTGTCCCGGAAGGCATACACAGCCCGTCCGATTACCTCCCTTATGCCAAAGA
ACGCCTGCCACCTGAAATCTGGCGTTATCTGGAGGAAGGCAGCGCTAATAATGTCAGCTTGCAAGCTAACCCTCATGCAT
TTGACTCCATTCACCTCATTCCACGGCCGCTGTCCGATGTACGTAGCGGTCATACGAAAATCACCCTGTTTGGGCAGACG
CTTGCCCATCCCGTCATTCTGGCACCATTAGCGTATCAACAACTCTATCACCCACATGGGGAATCGGCTAGCGCCATGGC
AGCCAGTGCGCAGGAAGGGCAGTCATGTGTCAGCAGCCTGGCGAGCCAAACGCTGGAAGATATTATCAGCGCAGCCGGAC
AACCCTTATGGTTTCAGCTGTACTGGCAGGAAAATCGTGAACGAACACTAAAATTACTGCAACGAACCATTGCAGCAGGT
TACAACGCCATCATATTTACGGTAGATGCCCCGGTTAAACAGGCAACCATCCAGCTGCCGACGACCATCCAACCGATAAA
TCTGGATCTTCCCGCTCCCTTTCCCGCGTTGCTACCGCAACAAAGCCAAGTATTCAACGGCTGGATGGCGCAAGCCCCAC
GTTGGGAGGATCTCGCCTGGTTGCGGGATCAAACCTCGCTACCACTGCTAGTCAAAGGTATCCTGCACTCGGAGGATGCC
GAAAAAGTGATCAACCTGGGATGTGACGGGCTGGTGGTTTCCAACCACGGAGGACGTGTCCTGGATGGCACACCAGCAAG
CCTTGCCTGCCTGCCGCCAATCGTCAGCGCCATTTCTGGCCGAGGGAAAGTACTGTTTGACAGCGGCATTCGTAATGGAC
GGGATATTTACAAGGCACTCGCCTTGGGCGCAGATGCAGTCATGGTTGGCCGCCCCTACATCTGGGGACTGGCCACAGCA
GGCGCCCTTGGCGTGGCGCACATCATTCGACTGCTGCGAGATGAACTGGAACTGACCATGGCACTGACCGGCACCGCCAG
CATCCAGGAAATTACACAGGAAAAAATTCAGATTAGCCGGAATCAGAATCGGAATTGA

Upstream 100 bases:

>100_bases
CGCTAACTGGATTGCTTCAATCCTGTGGATTTTCGCAACGATGGGCGAATCACCGCAACCTGATGACCGCATGATGACAA
AATAAGTCAGCACTTTTAAA

Downstream 100 bases:

>100_bases
GACGATCAACATACTGTAGTCTTAGAACCTGATCAAGATCCCGATCAAGGGATGCAATGCAAGGCAAAATTGAACAAGAA
AGCGAAGCATACTTGAAGTA

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNELLPKLSTVPEGIHSPSDYLPYAKERLPPEIWRYLEEGSANNVSLQANPHAFDSIHLIPRPLSDVRSGHTKITLFGQT
LAHPVILAPLAYQQLYHPHGESASAMAASAQEGQSCVSSLASQTLEDIISAAGQPLWFQLYWQENRERTLKLLQRTIAAG
YNAIIFTVDAPVKQATIQLPTTIQPINLDLPAPFPALLPQQSQVFNGWMAQAPRWEDLAWLRDQTSLPLLVKGILHSEDA
EKVINLGCDGLVVSNHGGRVLDGTPASLACLPPIVSAISGRGKVLFDSGIRNGRDIYKALALGADAVMVGRPYIWGLATA
GALGVAHIIRLLRDELELTMALTGTASIQEITQEKIQISRNQNRN

Sequences:

>Translated_365_residues
MNELLPKLSTVPEGIHSPSDYLPYAKERLPPEIWRYLEEGSANNVSLQANPHAFDSIHLIPRPLSDVRSGHTKITLFGQT
LAHPVILAPLAYQQLYHPHGESASAMAASAQEGQSCVSSLASQTLEDIISAAGQPLWFQLYWQENRERTLKLLQRTIAAG
YNAIIFTVDAPVKQATIQLPTTIQPINLDLPAPFPALLPQQSQVFNGWMAQAPRWEDLAWLRDQTSLPLLVKGILHSEDA
EKVINLGCDGLVVSNHGGRVLDGTPASLACLPPIVSAISGRGKVLFDSGIRNGRDIYKALALGADAVMVGRPYIWGLATA
GALGVAHIIRLLRDELELTMALTGTASIQEITQEKIQISRNQNRN
>Mature_365_residues
MNELLPKLSTVPEGIHSPSDYLPYAKERLPPEIWRYLEEGSANNVSLQANPHAFDSIHLIPRPLSDVRSGHTKITLFGQT
LAHPVILAPLAYQQLYHPHGESASAMAASAQEGQSCVSSLASQTLEDIISAAGQPLWFQLYWQENRERTLKLLQRTIAAG
YNAIIFTVDAPVKQATIQLPTTIQPINLDLPAPFPALLPQQSQVFNGWMAQAPRWEDLAWLRDQTSLPLLVKGILHSEDA
EKVINLGCDGLVVSNHGGRVLDGTPASLACLPPIVSAISGRGKVLFDSGIRNGRDIYKALALGADAVMVGRPYIWGLATA
GALGVAHIIRLLRDELELTMALTGTASIQEITQEKIQISRNQNRN

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=353, Percent_Identity=36.2606232294618, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI7705393, Length=353, Percent_Identity=36.2606232294618, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI11068137, Length=374, Percent_Identity=35.0267379679144, Blast_Score=225, Evalue=6e-59,
Organism=Escherichia coli, GI1790033, Length=374, Percent_Identity=35.5614973262032, Blast_Score=219, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI193208036, Length=362, Percent_Identity=35.3591160220994, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=275, Percent_Identity=31.6363636363636, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323587, Length=381, Percent_Identity=29.6587926509186, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI78707188, Length=352, Percent_Identity=36.9318181818182, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI281363140, Length=356, Percent_Identity=37.3595505617978, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI78707190, Length=356, Percent_Identity=37.3595505617978, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 39811; Mature: 39811

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELLPKLSTVPEGIHSPSDYLPYAKERLPPEIWRYLEEGSANNVSLQANPHAFDSIHLI
CCCHHHHHHHCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEC
PRPLSDVRSGHTKITLFGQTLAHPVILAPLAYQQLYHPHGESASAMAASAQEGQSCVSSL
CCCHHHHHCCCCEEEEECHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ASQTLEDIISAAGQPLWFQLYWQENRERTLKLLQRTIAAGYNAIIFTVDAPVKQATIQLP
HHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECC
TTIQPINLDLPAPFPALLPQQSQVFNGWMAQAPRWEDLAWLRDQTSLPLLVKGILHSEDA
CEECEEECCCCCCCHHHCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHCCHHH
EKVINLGCDGLVVSNHGGRVLDGTPASLACLPPIVSAISGRGKVLFDSGIRNGRDIYKAL
HHHHHCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHH
ALGADAVMVGRPYIWGLATAGALGVAHIIRLLRDELELTMALTGTASIQEITQEKIQISR
HHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHC
NQNRN
CCCCC
>Mature Secondary Structure
MNELLPKLSTVPEGIHSPSDYLPYAKERLPPEIWRYLEEGSANNVSLQANPHAFDSIHLI
CCCHHHHHHHCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEC
PRPLSDVRSGHTKITLFGQTLAHPVILAPLAYQQLYHPHGESASAMAASAQEGQSCVSSL
CCCHHHHHCCCCEEEEECHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ASQTLEDIISAAGQPLWFQLYWQENRERTLKLLQRTIAAGYNAIIFTVDAPVKQATIQLP
HHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECC
TTIQPINLDLPAPFPALLPQQSQVFNGWMAQAPRWEDLAWLRDQTSLPLLVKGILHSEDA
CEECEEECCCCCCCHHHCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHCCHHH
EKVINLGCDGLVVSNHGGRVLDGTPASLACLPPIVSAISGRGKVLFDSGIRNGRDIYKAL
HHHHHCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHH
ALGADAVMVGRPYIWGLATAGALGVAHIIRLLRDELELTMALTGTASIQEITQEKIQISR
HHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHC
NQNRN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA