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The map label for this gene is gcp

Identifier: 114330323

GI number: 114330323

Start: 303384

End: 304400

Strand: Reverse

Name: gcp

Synonym: Neut_0296

Alternate gene names: 114330323

Gene position: 304400-303384 (Counterclockwise)

Preceding gene: 114330328

Following gene: 114330321

Centisome position: 11.44

GC content: 46.8

Gene sequence:

>1017_bases
ATGCTCGTATTAGGTATTGAAACTTCATGTGATGAAACAGGCGTGGCACTCTATGACACCCGTCGAAAATTGCTTGGCCA
CGCTCTGTACTCTCAAGTTGACATGCATCGTGATTATGGTGGTGTTGTGCCGGAACTCGCATCACGTGATCATATCCGTC
GGGTATTACCCCTTGTCACACAGGTATTAGAACAAACGAATACTTCTCTGGAAACTATTGATGCAATTGCCTATACCCAG
GGTCCGGGACTTGCGGGAGCGTTATTGACAGGTGCGAGCATTAGCAATGCACTAGCTTTTGCACGCAACATCCCTGTATT
GAACATCCATCATCTTGAAGGCCATCTTCTTTCCCCACTTTTATCTGATCCGGCGCCTGATTTTCCGTTTGTGGCGCTGC
TTGTATCCGGAGGACACACTCAATTAATGCACGTAAAAGGCATCGGGCAATACAAGCTATTAGGTGAAACGGTGGATGAT
GCCGCAGGAGAAGCATTTGATAAAACTGCAAAACTATTGGGCTTGGATTATCCGGGTGGAAAATTGCTCGCAGACCTGGC
AACCCAGGGCCAACCAGGAAGATTTAAACTCCCACGCCCCATGCTTAACAGTGACGATCTGAATTTCAGTTTTAGTGGAT
TAAAAACAGCCGCAGCTTTACTCATTAATAAACAAAAAGCAAATACTCAAACCCGTGCCGACATCGCGCTTGCTTTTGAA
GATGCGGTTACTGACGTACTGGTAAAAAAATCTATCGCTGCTTTAAAAATTACCAGACTGCAACAACTGGTCGTAGCCGG
CGGTGTAGGCGCAAATAGCCGTTTACGCCAAAAACTGCGACATCATCTGGTAGGAACGGGTATTGCCGTCTTCTTTCCTG
AGCTAGAATTTTGTACTGATAACGGTGCAATGATCGCCTTAGCCGGCGCATTACGCTTGCAGCAGCTCAACGAAAAACCA
CCTGGATCAGATGGCAGCTTTACCATCAAGGCTCGCTGGAACCTGGAAGATTTATGA

Upstream 100 bases:

>100_bases
CAACCAGCCTCGAAAAATCCCGCTAGTTTAACATCAATCATTTTTTTTCCAAAAGAAAGTTTGATCACTACAAAAAATAT
TTCCCACCAAAAATCCCAAA

Downstream 100 bases:

>100_bases
GAATATGCAGCTTGAAATTAGCTACTTTTGCCTATCCTTGTTTCCTTGCCGGCGATCAAGTTAGCAATATTCGATTGATG
CTTTAATATCAATAGTATGG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLVLGIETSCDETGVALYDTRRKLLGHALYSQVDMHRDYGGVVPELASRDHIRRVLPLVTQVLEQTNTSLETIDAIAYTQ
GPGLAGALLTGASISNALAFARNIPVLNIHHLEGHLLSPLLSDPAPDFPFVALLVSGGHTQLMHVKGIGQYKLLGETVDD
AAGEAFDKTAKLLGLDYPGGKLLADLATQGQPGRFKLPRPMLNSDDLNFSFSGLKTAAALLINKQKANTQTRADIALAFE
DAVTDVLVKKSIAALKITRLQQLVVAGGVGANSRLRQKLRHHLVGTGIAVFFPELEFCTDNGAMIALAGALRLQQLNEKP
PGSDGSFTIKARWNLEDL

Sequences:

>Translated_338_residues
MLVLGIETSCDETGVALYDTRRKLLGHALYSQVDMHRDYGGVVPELASRDHIRRVLPLVTQVLEQTNTSLETIDAIAYTQ
GPGLAGALLTGASISNALAFARNIPVLNIHHLEGHLLSPLLSDPAPDFPFVALLVSGGHTQLMHVKGIGQYKLLGETVDD
AAGEAFDKTAKLLGLDYPGGKLLADLATQGQPGRFKLPRPMLNSDDLNFSFSGLKTAAALLINKQKANTQTRADIALAFE
DAVTDVLVKKSIAALKITRLQQLVVAGGVGANSRLRQKLRHHLVGTGIAVFFPELEFCTDNGAMIALAGALRLQQLNEKP
PGSDGSFTIKARWNLEDL
>Mature_338_residues
MLVLGIETSCDETGVALYDTRRKLLGHALYSQVDMHRDYGGVVPELASRDHIRRVLPLVTQVLEQTNTSLETIDAIAYTQ
GPGLAGALLTGASISNALAFARNIPVLNIHHLEGHLLSPLLSDPAPDFPFVALLVSGGHTQLMHVKGIGQYKLLGETVDD
AAGEAFDKTAKLLGLDYPGGKLLADLATQGQPGRFKLPRPMLNSDDLNFSFSGLKTAAALLINKQKANTQTRADIALAFE
DAVTDVLVKKSIAALKITRLQQLVVAGGVGANSRLRQKLRHHLVGTGIAVFFPELEFCTDNGAMIALAGALRLQQLNEKP
PGSDGSFTIKARWNLEDL

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=336, Percent_Identity=34.8214285714286, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI8923380, Length=338, Percent_Identity=28.9940828402367, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789445, Length=338, Percent_Identity=58.2840236686391, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17557464, Length=334, Percent_Identity=32.0359281437126, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71995670, Length=325, Percent_Identity=31.0769230769231, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320099, Length=369, Percent_Identity=32.7913279132791, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6322891, Length=347, Percent_Identity=24.4956772334294, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI20129063, Length=343, Percent_Identity=32.9446064139942, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI21357207, Length=330, Percent_Identity=30, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_NITEC (Q0AJ91)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746545.1
- ProteinModelPortal:   Q0AJ91
- SMR:   Q0AJ91
- STRING:   Q0AJ91
- MEROPS:   M22.001
- GeneID:   4272069
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0296
- NMPDR:   fig|335283.3.peg.2251
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q0AJ91
- ProtClustDB:   PRK09604
- BioCyc:   NEUT335283:NEUT_0296-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36268; Mature: 36268

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLGIETSCDETGVALYDTRRKLLGHALYSQVDMHRDYGGVVPELASRDHIRRVLPLVT
CEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
QVLEQTNTSLETIDAIAYTQGPGLAGALLTGASISNALAFARNIPVLNIHHLEGHLLSPL
HHHHHCCCCHHHHHHHEEECCCCCHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHH
LSDPAPDFPFVALLVSGGHTQLMHVKGIGQYKLLGETVDDAAGEAFDKTAKLLGLDYPGG
HCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEECCHHHHHCCHHHHHHHHHHCCCCCCC
KLLADLATQGQPGRFKLPRPMLNSDDLNFSFSGLKTAAALLINKQKANTQTRADIALAFE
HHHHHHHCCCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHCCHHCCCCHHHHEEEEHH
DAVTDVLVKKSIAALKITRLQQLVVAGGVGANSRLRQKLRHHLVGTGIAVFFPELEFCTD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEECC
NGAMIALAGALRLQQLNEKPPGSDGSFTIKARWNLEDL
CCCEEEEHHHHHHHHHCCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MLVLGIETSCDETGVALYDTRRKLLGHALYSQVDMHRDYGGVVPELASRDHIRRVLPLVT
CEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
QVLEQTNTSLETIDAIAYTQGPGLAGALLTGASISNALAFARNIPVLNIHHLEGHLLSPL
HHHHHCCCCHHHHHHHEEECCCCCHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHH
LSDPAPDFPFVALLVSGGHTQLMHVKGIGQYKLLGETVDDAAGEAFDKTAKLLGLDYPGG
HCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEECCHHHHHCCHHHHHHHHHHCCCCCCC
KLLADLATQGQPGRFKLPRPMLNSDDLNFSFSGLKTAAALLINKQKANTQTRADIALAFE
HHHHHHHCCCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHCCHHCCCCHHHHEEEEHH
DAVTDVLVKKSIAALKITRLQQLVVAGGVGANSRLRQKLRHHLVGTGIAVFFPELEFCTD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEECC
NGAMIALAGALRLQQLNEKPPGSDGSFTIKARWNLEDL
CCCEEEEHHHHHHHHHCCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA