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The map label for this gene is hemB [H]

Identifier: 114330262

GI number: 114330262

Start: 247893

End: 248900

Strand: Direct

Name: hemB [H]

Synonym: Neut_0235

Alternate gene names: 114330262

Gene position: 247893-248900 (Clockwise)

Preceding gene: 114330261

Following gene: 114330266

Centisome position: 9.32

GC content: 49.9

Gene sequence:

>1008_bases
ATGACATTTTTCAGCCAGTTTCCACAAAAAAGAATGCGCCGTAACCGCCGAGATGATTTTTCCCGTCGCCTGGTTCGGGA
AAATCACTTGCAGGTGGATGATCTGATCTACCCGGTATTTGTACTAGATGGCAGTAAGCGTGAAGAGCAAGTAGCATCAA
TGCCCGGTATTGTCCGACAGAGTGTTGATCTGCTTTTGTTTCAGGCGGAGAAATGTCTGCGTTTGGGAATCCCTGCACTG
GCAATTTTTCCGGTTATTGATGCTTCCCTGAAAAGCTTGACCGCTGATGAGGCTTATAATCCTGAGGGCCTGGTGCCCCG
CACCGTAAAGGAGTTGAAAAAACGTTTTCCGGAATTGGGTGTAATTACCGATGTGGCACTTGATCCGTATACTAGTCATG
GTCAGGATGGTCTGATTGATGCAAATGGTTATGTGTTAAATGATGAAACTGTCAGTGTGCTGGAGCGGCAGGCGTTAATG
CACGCCGAAGCCGGGGCGGATGTCGTAGCCCCTTCTGACATGATGGATGGCCGGATCGCTGCGATCCGGTCGATACTGGA
TCGTGACCGTCTCATTCATACGCGGATACTGGCTTACTCGGCCAAATATGCCTCCAGTTTTTACGGCCCCTTCCGGGATG
CAGTTGGTTCAGCTGCTATGCTGGGGACGGGTAATAAATATACCTACCAGATGGATCCGGCCAATTCGGATGAAGCATTA
TGGGAAGCAGAGTTGGATATCCAGGAAGGCGCGGATATGATCATGGTCAAACCCGGTATGCCTTATCTCGATATCGTACG
CAGAGTGAAGGACAAACTGGGTGTACCCACTTTTGTTTATCAGGTGAGTGGTGAATATGCCATGCTGAAAGCAGCGGGGA
TGAACGGATGGCTGGATGAAAGAGCCTGTGTTACCGAGGCATTGCTGGCGTGCAAACGTGCAGGTGCCGATGCGATCTTG
ACTTATTTTGCTCCGGTAGTTGCCAGCTGGTTACAGGAGAATACTTGA

Upstream 100 bases:

>100_bases
GGAAGGCGAGAGGCAGTTATTAACAACCACCTATTCATAAGAGAGAACTAATTGGAGTTAGTTCCGTGATGCATTAATTT
TTTTATTTCCAGATATAAAC

Downstream 100 bases:

>100_bases
AGCCGGATTGTCGAGGTTGCGGTAGCATCCGTATCAGCTGATTCAGCCTTTGTGAATTGTTCCAGAAAGCCGATAAAACT
TCAAAGAAATGTCACGAACA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTFFSQFPQKRMRRNRRDDFSRRLVRENHLQVDDLIYPVFVLDGSKREEQVASMPGIVRQSVDLLLFQAEKCLRLGIPAL
AIFPVIDASLKSLTADEAYNPEGLVPRTVKELKKRFPELGVITDVALDPYTSHGQDGLIDANGYVLNDETVSVLERQALM
HAEAGADVVAPSDMMDGRIAAIRSILDRDRLIHTRILAYSAKYASSFYGPFRDAVGSAAMLGTGNKYTYQMDPANSDEAL
WEAELDIQEGADMIMVKPGMPYLDIVRRVKDKLGVPTFVYQVSGEYAMLKAAGMNGWLDERACVTEALLACKRAGADAIL
TYFAPVVASWLQENT

Sequences:

>Translated_335_residues
MTFFSQFPQKRMRRNRRDDFSRRLVRENHLQVDDLIYPVFVLDGSKREEQVASMPGIVRQSVDLLLFQAEKCLRLGIPAL
AIFPVIDASLKSLTADEAYNPEGLVPRTVKELKKRFPELGVITDVALDPYTSHGQDGLIDANGYVLNDETVSVLERQALM
HAEAGADVVAPSDMMDGRIAAIRSILDRDRLIHTRILAYSAKYASSFYGPFRDAVGSAAMLGTGNKYTYQMDPANSDEAL
WEAELDIQEGADMIMVKPGMPYLDIVRRVKDKLGVPTFVYQVSGEYAMLKAAGMNGWLDERACVTEALLACKRAGADAIL
TYFAPVVASWLQENT
>Mature_334_residues
TFFSQFPQKRMRRNRRDDFSRRLVRENHLQVDDLIYPVFVLDGSKREEQVASMPGIVRQSVDLLLFQAEKCLRLGIPALA
IFPVIDASLKSLTADEAYNPEGLVPRTVKELKKRFPELGVITDVALDPYTSHGQDGLIDANGYVLNDETVSVLERQALMH
AEAGADVVAPSDMMDGRIAAIRSILDRDRLIHTRILAYSAKYASSFYGPFRDAVGSAAMLGTGNKYTYQMDPANSDEALW
EAELDIQEGADMIMVKPGMPYLDIVRRVKDKLGVPTFVYQVSGEYAMLKAAGMNGWLDERACVTEALLACKRAGADAILT
YFAPVVASWLQENT

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=307, Percent_Identity=43.9739413680782, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI87081728, Length=315, Percent_Identity=42.2222222222222, Blast_Score=224, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6321398, Length=318, Percent_Identity=38.6792452830189, Blast_Score=192, Evalue=9e-50,
Organism=Drosophila melanogaster, GI21358291, Length=308, Percent_Identity=39.6103896103896, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37294; Mature: 37163

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFFSQFPQKRMRRNRRDDFSRRLVRENHLQVDDLIYPVFVLDGSKREEQVASMPGIVRQ
CCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHHCCHHHHH
SVDLLLFQAEKCLRLGIPALAIFPVIDASLKSLTADEAYNPEGLVPRTVKELKKRFPELG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCC
VITDVALDPYTSHGQDGLIDANGYVLNDETVSVLERQALMHAEAGADVVAPSDMMDGRIA
CEECCCCCCCCCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHCHHHH
AIRSILDRDRLIHTRILAYSAKYASSFYGPFRDAVGSAAMLGTGNKYTYQMDPANSDEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEECCCCEEEEEECCCCCCCHH
WEAELDIQEGADMIMVKPGMPYLDIVRRVKDKLGVPTFVYQVSGEYAMLKAAGMNGWLDE
EEECCCHHCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCHH
RACVTEALLACKRAGADAILTYFAPVVASWLQENT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFFSQFPQKRMRRNRRDDFSRRLVRENHLQVDDLIYPVFVLDGSKREEQVASMPGIVRQ
CCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHHCCHHHHH
SVDLLLFQAEKCLRLGIPALAIFPVIDASLKSLTADEAYNPEGLVPRTVKELKKRFPELG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCC
VITDVALDPYTSHGQDGLIDANGYVLNDETVSVLERQALMHAEAGADVVAPSDMMDGRIA
CEECCCCCCCCCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHCHHHH
AIRSILDRDRLIHTRILAYSAKYASSFYGPFRDAVGSAAMLGTGNKYTYQMDPANSDEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEECCCCEEEEEECCCCCCCHH
WEAELDIQEGADMIMVKPGMPYLDIVRRVKDKLGVPTFVYQVSGEYAMLKAAGMNGWLDE
EEECCCHHCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCHH
RACVTEALLACKRAGADAILTYFAPVVASWLQENT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]