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The map label for this gene is ald [H]

Identifier: 114330241

GI number: 114330241

Start: 217510

End: 218622

Strand: Direct

Name: ald [H]

Synonym: Neut_0212

Alternate gene names: 114330241

Gene position: 217510-218622 (Clockwise)

Preceding gene: 114330240

Following gene: 114330246

Centisome position: 8.17

GC content: 53.37

Gene sequence:

>1113_bases
ATGATTATCGGATTACCCAAAGAGACGAAAGAGGATGAATACCGGGTCGGACTTACTCCGGGCAGCGTACATACACTGAC
TGAGCGAGGGCACCGGGTGCTGGTTGAAACCGGAGCAGGTGCGGGCAGTATTATTTCCGATCAGGATTACCGGGAAGCCG
GTGCAGAAATTGTGATGCGCGCCGCAGATGCCTGGGCAGCTGAATTGGTCGTCAAGGTAAAAGAGCCAACCGAAGTGGAA
TATCAGTATTTGCGAAAGGATTTACTGCTGTTTGCTTATCTACATCTGGCTTCAAATAGAGCCCTAGCAGAAAAACTGCT
CGCCAGCGGCGTCAGTGCAATTGCCTATGAAACAGTGCAGACGGCATTCGGCGCATTACCGTTATTGACACCCATGAGCG
AGGTAGCGGGGCGCATGGCGGTGCAGATTGGCGCAACCTATCTGTTAAAAACTCAAGGGGGGCGGGGAGTGCTGATGGGT
GGGGTGCCAGGCGTTGCCCCAGCCAATGTAGTCATTCTGGGCGCAGGGGTAGTGGGCACCAATGCTGCGGTAGTAGCAAC
CGGAATGGGGGCGATGGTGACAGTGCTGGATATCAATCATGATCGTTTGAAAGCGCTGGATGACCGTTTTTCCGGACGGC
TGCAAACTCGATATTGTGATGCGGTCAATGTGCGTCAGGCAGTTTACGAGGCAGATCTTGTCATCGGTGCCGTATTGATC
CCCGGTGGGCGCTCACCTTGGCTAGTAACTCGGGAAATGTTGCCGCAAATGCGTGTGGGTTCAGTGATTGTTGATGTGGC
AGTTGATCAGGGAGGGTGTGTGGAAACAACCCGACCGACCACACACAGCCATCCTGTTTTTGAAGTGGATGGTGTGCTGC
ATTACTGTGTGACGAACATGCCGGGCGCAGTTCCGCGTACCAGCACCTTTGCGTTGAACAACCAGACTGCCAGCTATGTT
GCCTGTCTGGCAGATGAAGGGCTGTCAGCCTTGCAGAGCAATCAGGCGTTGATGAATGGCCTTAATATCTATCGTGGACA
AGTCATGCATCCGGCAGTAGCTGAGGCTTTCGGTTTGCCGTATACATCACCGCTGGAAATACTGGTTGCTTAA

Upstream 100 bases:

>100_bases
AGGAAACTGGAACGGCCGTCAGATCATGCACCGGTTTGGGTGGAGCTGGCGTAAGCAGCAAGAAATCTGAATTTTATGTG
TGAAAAGCTTGAGGGCGTGA

Downstream 100 bases:

>100_bases
AGATGGTCTGTATAACTTTCATATCGTCCTGCGGTATTGAAAACAGGCTCAAAGTACTCTTTATCGTATGTAAACTGCGT
TTTTTCACCTATTTTCATCT

Product: alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIIGLPKETKEDEYRVGLTPGSVHTLTERGHRVLVETGAGAGSIISDQDYREAGAEIVMRAADAWAAELVVKVKEPTEVE
YQYLRKDLLLFAYLHLASNRALAEKLLASGVSAIAYETVQTAFGALPLLTPMSEVAGRMAVQIGATYLLKTQGGRGVLMG
GVPGVAPANVVILGAGVVGTNAAVVATGMGAMVTVLDINHDRLKALDDRFSGRLQTRYCDAVNVRQAVYEADLVIGAVLI
PGGRSPWLVTREMLPQMRVGSVIVDVAVDQGGCVETTRPTTHSHPVFEVDGVLHYCVTNMPGAVPRTSTFALNNQTASYV
ACLADEGLSALQSNQALMNGLNIYRGQVMHPAVAEAFGLPYTSPLEILVA

Sequences:

>Translated_370_residues
MIIGLPKETKEDEYRVGLTPGSVHTLTERGHRVLVETGAGAGSIISDQDYREAGAEIVMRAADAWAAELVVKVKEPTEVE
YQYLRKDLLLFAYLHLASNRALAEKLLASGVSAIAYETVQTAFGALPLLTPMSEVAGRMAVQIGATYLLKTQGGRGVLMG
GVPGVAPANVVILGAGVVGTNAAVVATGMGAMVTVLDINHDRLKALDDRFSGRLQTRYCDAVNVRQAVYEADLVIGAVLI
PGGRSPWLVTREMLPQMRVGSVIVDVAVDQGGCVETTRPTTHSHPVFEVDGVLHYCVTNMPGAVPRTSTFALNNQTASYV
ACLADEGLSALQSNQALMNGLNIYRGQVMHPAVAEAFGLPYTSPLEILVA
>Mature_370_residues
MIIGLPKETKEDEYRVGLTPGSVHTLTERGHRVLVETGAGAGSIISDQDYREAGAEIVMRAADAWAAELVVKVKEPTEVE
YQYLRKDLLLFAYLHLASNRALAEKLLASGVSAIAYETVQTAFGALPLLTPMSEVAGRMAVQIGATYLLKTQGGRGVLMG
GVPGVAPANVVILGAGVVGTNAAVVATGMGAMVTVLDINHDRLKALDDRFSGRLQTRYCDAVNVRQAVYEADLVIGAVLI
PGGRSPWLVTREMLPQMRVGSVIVDVAVDQGGCVETTRPTTHSHPVFEVDGVLHYCVTNMPGAVPRTSTFALNNQTASYV
ACLADEGLSALQSNQALMNGLNIYRGQVMHPAVAEAFGLPYTSPLEILVA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=355, Percent_Identity=32.112676056338, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI122939153, Length=355, Percent_Identity=32.112676056338, Blast_Score=145, Evalue=7e-35,
Organism=Escherichia coli, GI1787887, Length=378, Percent_Identity=29.3650793650794, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17550456, Length=346, Percent_Identity=29.1907514450867, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39270; Mature: 39270

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGLPKETKEDEYRVGLTPGSVHTLTERGHRVLVETGAGAGSIISDQDYREAGAEIVMR
CEECCCCCCCCCCEEEECCCCCHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
AADAWAAELVVKVKEPTEVEYQYLRKDLLLFAYLHLASNRALAEKLLASGVSAIAYETVQ
HHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHH
TAFGALPLLTPMSEVAGRMAVQIGATYLLKTQGGRGVLMGGVPGVAPANVVILGAGVVGT
HHHCCCHHCCCHHHHHHHHEEEECCEEEEEECCCCEEEECCCCCCCCCCEEEEECCEECC
NAAVVATGMGAMVTVLDINHDRLKALDDRFSGRLQTRYCDAVNVRQAVYEADLVIGAVLI
CCEEEEECCCEEEEEEECCHHHHHHHHHHHCCCEEEHHCCHHHHHHHHHHHHHEEEEEEE
PGGRSPWLVTREMLPQMRVGSVIVDVAVDQGGCVETTRPTTHSHPVFEVDGVLHYCVTNM
CCCCCCEEEEHHHCCCHHHCEEEEEEEECCCCCEECCCCCCCCCCCEEHHHHHHHHHHCC
PGAVPRTSTFALNNQTASYVACLADEGLSALQSNQALMNGLNIYRGQVMHPAVAEAFGLP
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
YTSPLEILVA
CCCCCEEEEC
>Mature Secondary Structure
MIIGLPKETKEDEYRVGLTPGSVHTLTERGHRVLVETGAGAGSIISDQDYREAGAEIVMR
CEECCCCCCCCCCEEEECCCCCHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
AADAWAAELVVKVKEPTEVEYQYLRKDLLLFAYLHLASNRALAEKLLASGVSAIAYETVQ
HHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHH
TAFGALPLLTPMSEVAGRMAVQIGATYLLKTQGGRGVLMGGVPGVAPANVVILGAGVVGT
HHHCCCHHCCCHHHHHHHHEEEECCEEEEEECCCCEEEECCCCCCCCCCEEEEECCEECC
NAAVVATGMGAMVTVLDINHDRLKALDDRFSGRLQTRYCDAVNVRQAVYEADLVIGAVLI
CCEEEEECCCEEEEEEECCHHHHHHHHHHHCCCEEEHHCCHHHHHHHHHHHHHEEEEEEE
PGGRSPWLVTREMLPQMRVGSVIVDVAVDQGGCVETTRPTTHSHPVFEVDGVLHYCVTNM
CCCCCCEEEEHHHCCCHHHCEEEEEEEECCCCCEECCCCCCCCCCCEEHHHHHHHHHHCC
PGAVPRTSTFALNNQTASYVACLADEGLSALQSNQALMNGLNIYRGQVMHPAVAEAFGLP
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
YTSPLEILVA
CCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]