Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 114330235

GI number: 114330235

Start: 211268

End: 212911

Strand: Reverse

Name: groEL

Synonym: Neut_0206

Alternate gene names: 114330235

Gene position: 212911-211268 (Counterclockwise)

Preceding gene: 114330236

Following gene: 114330234

Centisome position: 8.0

GC content: 50.12

Gene sequence:

>1644_bases
ATGGCAGCTAAAGAAGTAAGATTTGGAGATGCAGCGCGCAGCGCCGTAATCACTGGCGTAAATGTACTGGCAGATGCGGT
TAAAGTGACGTTAGGCCCTAAAGGACGCAATGTTGTACTGGAGCGTTCATACGGCGCCCCCACCATCACCAAGGATGGCG
TATCGGTTGCGAAAGAGATTGAACTGAAAGACAAGTTCGAAAACATGGGCGCACAAATGGTCAAGGAAGTCGCCAGCAAA
ACCTCGGATACAGCAGGAGATGGCACAACGACGGCAACTGTTTTAGCACAAGCCATCGTCAAGGAAGGTATGCGTTATGT
CGCAGCCGGAATGAATCCAATGGATCTGAAGCGCGGGATCGAAAAGGCAGTTAGCGCCGCTGTTGAAGAATTGAAAAAAC
TTTCCAAGCCATGTTCCACCAGCAAGGAAATCGCTCAAGTTGGCAGCATTTCTGCCAATTCCGATGCCGAAATCGGCAGA
ATCATTGCTGAAGCAATGGATAAAGTCGGCAAGGAAGGCGTCATTACGGTTGAAGATGGTTCCGGCCTGGAAAATGAGCT
GGATGTCGTGGAAGGCATGCAGTTTGACCGGGGTTATCTCTCTCCCTATTTTGTCAGCAGCGCTGAGAAACAGATTGCAG
CACTCGAAAACCCTTTCATTCTGTTGCACGACAAAAAAATATCCAATATTCGTGACCTTCTGCCAATACTCGAACAAGTA
GCCAAAGCAGGTAAACCACTGCTGATCATTGCTGAAGATGTTGATGGTGAAGCCCTGGCAACACTGGTCGTGAACAATAT
TCGCGGCATCCTCAAAACATGCGCAGTCAAGGCACCTGGTTTTGGTGATCGTCGTAAGGCTATGCTGGAAGATATCGCGA
TCCTGACGGGTGGTACGGTGATTGCCGAAGAAGTCGGTTTATCCCTGGAGAAAGCTAAACTGGAAGATCTGGGCCAGGCT
AAACGCGTTGAAGTTGGCAAGGAAAACACCACCATTATTGATGGTGCCGGAGATACCAAAGCCATTGAAGCACGCGTTAC
ACAGATTCGCAAGCAAATCGAAGAAGCAACCAGTGACTATGATCGCGAGAAGCTTCAAGAACGCGTAGCCAAACTGGCTG
GGGGTGTAGCTCTAATCAAGGTTGGCGCTGCCACGGAAATGGAGATGAAAGAGAAAAAAGCTCGCGTTGAAGATGCCTTT
CACGCAACACGCGCTGCGGTTGAAGAAGGTATTGTTCCTGGTGGTGGCGTCGCCCTGCTGCGTACAATTGATGCTGTGAG
CAAGGCCAAAGGCGACAACCATGATCAGGATTCCGGCATCAAAATTGTTTTGCGTGCACTGGAAGAGCCACTACGCCAGA
TCGTAACCAACTGCGGAGATGAAGCTTCTGTAGTCGTCAACAAAGTTAAGGAAGGTAAAGGTAACTTTGGTTACAATGCT
GCAACGGGTGAATATGGCGATCTAGTTGCTATGGGCGTGCTGGACCCTACCAAAGTAACCCGCTCGGCTCTGCAAAACGC
CTCATCAGTTGCAGGATTGATTCTGACGACGGACGCAATGGTTGCAGAGCTTCCAAAAGAAGATTCGCCTGGGGCAGGTG
CCGGCATGGGCGGTATGGGTGGCATGGGCGGTATGGACATGTAA

Upstream 100 bases:

>100_bases
TAAGGGCGAAGAGTTCCTCGTAATGCGTGAAGAAGACATCATGGGTGTGATTGAAGGTTAATTGATCGTTGAATAACCAA
CTGAAATCAGGAGTAAAGAT

Downstream 100 bases:

>100_bases
CCGACTCCAATCGGTCTATCTGTTAACAATAATGAACCACAACGGATCGGTATGCAAAAAACCGGACGTTGTGGTTTTTA
ACTTCTATCGGTCGTGCTGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKEVRFGDAARSAVITGVNVLADAVKVTLGPKGRNVVLERSYGAPTITKDGVSVAKEIELKDKFENMGAQMVKEVASK
TSDTAGDGTTTATVLAQAIVKEGMRYVAAGMNPMDLKRGIEKAVSAAVEELKKLSKPCSTSKEIAQVGSISANSDAEIGR
IIAEAMDKVGKEGVITVEDGSGLENELDVVEGMQFDRGYLSPYFVSSAEKQIAALENPFILLHDKKISNIRDLLPILEQV
AKAGKPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGTVIAEEVGLSLEKAKLEDLGQA
KRVEVGKENTTIIDGAGDTKAIEARVTQIRKQIEEATSDYDREKLQERVAKLAGGVALIKVGAATEMEMKEKKARVEDAF
HATRAAVEEGIVPGGGVALLRTIDAVSKAKGDNHDQDSGIKIVLRALEEPLRQIVTNCGDEASVVVNKVKEGKGNFGYNA
ATGEYGDLVAMGVLDPTKVTRSALQNASSVAGLILTTDAMVAELPKEDSPGAGAGMGGMGGMGGMDM

Sequences:

>Translated_547_residues
MAAKEVRFGDAARSAVITGVNVLADAVKVTLGPKGRNVVLERSYGAPTITKDGVSVAKEIELKDKFENMGAQMVKEVASK
TSDTAGDGTTTATVLAQAIVKEGMRYVAAGMNPMDLKRGIEKAVSAAVEELKKLSKPCSTSKEIAQVGSISANSDAEIGR
IIAEAMDKVGKEGVITVEDGSGLENELDVVEGMQFDRGYLSPYFVSSAEKQIAALENPFILLHDKKISNIRDLLPILEQV
AKAGKPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGTVIAEEVGLSLEKAKLEDLGQA
KRVEVGKENTTIIDGAGDTKAIEARVTQIRKQIEEATSDYDREKLQERVAKLAGGVALIKVGAATEMEMKEKKARVEDAF
HATRAAVEEGIVPGGGVALLRTIDAVSKAKGDNHDQDSGIKIVLRALEEPLRQIVTNCGDEASVVVNKVKEGKGNFGYNA
ATGEYGDLVAMGVLDPTKVTRSALQNASSVAGLILTTDAMVAELPKEDSPGAGAGMGGMGGMGGMDM
>Mature_546_residues
AAKEVRFGDAARSAVITGVNVLADAVKVTLGPKGRNVVLERSYGAPTITKDGVSVAKEIELKDKFENMGAQMVKEVASKT
SDTAGDGTTTATVLAQAIVKEGMRYVAAGMNPMDLKRGIEKAVSAAVEELKKLSKPCSTSKEIAQVGSISANSDAEIGRI
IAEAMDKVGKEGVITVEDGSGLENELDVVEGMQFDRGYLSPYFVSSAEKQIAALENPFILLHDKKISNIRDLLPILEQVA
KAGKPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGTVIAEEVGLSLEKAKLEDLGQAK
RVEVGKENTTIIDGAGDTKAIEARVTQIRKQIEEATSDYDREKLQERVAKLAGGVALIKVGAATEMEMKEKKARVEDAFH
ATRAAVEEGIVPGGGVALLRTIDAVSKAKGDNHDQDSGIKIVLRALEEPLRQIVTNCGDEASVVVNKVKEGKGNFGYNAA
TGEYGDLVAMGVLDPTKVTRSALQNASSVAGLILTTDAMVAELPKEDSPGAGAGMGGMGGMGGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=51.8026565464896, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=51.8026565464896, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI24307939, Length=373, Percent_Identity=23.0563002680965, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI38455427, Length=137, Percent_Identity=27.007299270073, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=76.3705103969754, Blast_Score=815, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=51.8867924528302, Blast_Score=547, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=50, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17532603, Length=570, Percent_Identity=22.4561403508772, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25147750, Length=137, Percent_Identity=34.3065693430657, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.6615969581749, Blast_Score=551, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322524, Length=483, Percent_Identity=23.6024844720497, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322350, Length=587, Percent_Identity=23.679727427598, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=571, Percent_Identity=22.4168126094571, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=53.7001897533207, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=53.7001897533207, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.6641366223909, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.6641366223909, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.6641366223909, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=45.1905626134301, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=37.4524714828897, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=37.4524714828897, Blast_Score=343, Evalue=2e-94,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_NITEC (Q0AJH9)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746457.1
- ProteinModelPortal:   Q0AJH9
- SMR:   Q0AJH9
- STRING:   Q0AJH9
- GeneID:   4271916
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0206
- NMPDR:   fig|335283.3.peg.1674
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   EIDTKEQ
- PhylomeDB:   Q0AJH9
- ProtClustDB:   PRK00013
- BioCyc:   NEUT335283:NEUT_0206-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57463; Mature: 57331

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVRFGDAARSAVITGVNVLADAVKVTLGPKGRNVVLERSYGAPTITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKFENMGAQMVKEVASKTSDTAGDGTTTATVLAQAIVKEGMRYVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EKAVSAAVEELKKLSKPCSTSKEIAQVGSISANSDAEIGRIIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
SGLENELDVVEGMQFDRGYLSPYFVSSAEKQIAALENPFILLHDKKISNIRDLLPILEQV
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLSLEKAKLEDLGQAKRVEVGKENTTIIDGAGDTKAIEARVTQIRKQIEEATSDY
HHHHHCCCHHHHHHHHCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVALIKVGAATEMEMKEKKARVEDAFHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RTIDAVSKAKGDNHDQDSGIKIVLRALEEPLRQIVTNCGDEASVVVNKVKEGKGNFGYNA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
ATGEYGDLVAMGVLDPTKVTRSALQNASSVAGLILTTDAMVAELPKEDSPGAGAGMGGMG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHEEHHHHHHHCCCCCCCCCCCCCCCCC
GMGGMDM
CCCCCCC
>Mature Secondary Structure 
AAKEVRFGDAARSAVITGVNVLADAVKVTLGPKGRNVVLERSYGAPTITKDGVSVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKFENMGAQMVKEVASKTSDTAGDGTTTATVLAQAIVKEGMRYVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EKAVSAAVEELKKLSKPCSTSKEIAQVGSISANSDAEIGRIIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
SGLENELDVVEGMQFDRGYLSPYFVSSAEKQIAALENPFILLHDKKISNIRDLLPILEQV
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLSLEKAKLEDLGQAKRVEVGKENTTIIDGAGDTKAIEARVTQIRKQIEEATSDY
HHHHHCCCHHHHHHHHCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVALIKVGAATEMEMKEKKARVEDAFHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RTIDAVSKAKGDNHDQDSGIKIVLRALEEPLRQIVTNCGDEASVVVNKVKEGKGNFGYNA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
ATGEYGDLVAMGVLDPTKVTRSALQNASSVAGLILTTDAMVAELPKEDSPGAGAGMGGMG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHEEHHHHHHHCCCCCCCCCCCCCCCCC
GMGGMDM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA