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The map label for this gene is clpP

Identifier: 114330232

GI number: 114330232

Start: 208124

End: 208768

Strand: Reverse

Name: clpP

Synonym: Neut_0203

Alternate gene names: 114330232

Gene position: 208768-208124 (Counterclockwise)

Preceding gene: 114330233

Following gene: 114330231

Centisome position: 7.85

GC content: 44.5

Gene sequence:

>645_bases
ATGCAGCCAATACTTGATTGGGAGAAAAACGAATTGAATACTACAGGACTGGGTTTGATTCCCATGGTAATCGAGTCCAG
TGGTCGCGGAGAGCGCGCCTACGATATTTATTCAAGGCTGCTCAGAGAAAGAATCATTTTTTTAGTGGGCCCGGTTACAG
AAACATCTGCCAACTTGGTAATTGCGCAGCTCTTGTTTCTAGAATCCGAAAATTCAGAGAAAGATATTTCCTTATATATC
AATTCGCCCGGCGGACTTGTCACGGCAGGACTAGCTGTGTATGACACCATGCAATTCATTAAACCGGATGTCAGCACACT
TTGCATAGGACAAGCTGCCAGCATGGGTGCCTTGCTGCTTACTGCGGGCGCCAAAGGCAAGCGTTATTGCCTACCCAATT
CACGCGTAATGATCCATCAGCCACTGGGCGGATTTCAGGGACAAGCATCCGACATAGAAATACACGCTAAGGAAATTTTG
GCACTGAAAGGTCGTTTAAATGAAATTTTGGCTAAACATACCAGTCAAACAATTAGAACTATTGAGAAAGATACTGATCG
TGACAATTTTCTCGGCGCAGAAGCAGCCGTAAAGTATAGTTTAGTGGATGCAGTATTAACGAGCCGGAAAGTAAAACACG
AGTAA

Upstream 100 bases:

>100_bases
GAACCGCTTGTTCTGGAGGATAACGCCGTATCATGGATACTGGACAGAGCCAATATCGTTGATCAGAATGTCACTTTCGA
TGAACTAATGGGATATTCAC

Downstream 100 bases:

>100_bases
AATCAAATTGCTCCTGCTGAACAAGAGCAATATTCGTTTGATGATTGTGGGGTGGAATAATGTCTGAAAAAACAAATGAC
GAAAAACTTTTGTATTGTTC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MQPILDWEKNELNTTGLGLIPMVIESSGRGERAYDIYSRLLRERIIFLVGPVTETSANLVIAQLLFLESENSEKDISLYI
NSPGGLVTAGLAVYDTMQFIKPDVSTLCIGQAASMGALLLTAGAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEIL
ALKGRLNEILAKHTSQTIRTIEKDTDRDNFLGAEAAVKYSLVDAVLTSRKVKHE

Sequences:

>Translated_214_residues
MQPILDWEKNELNTTGLGLIPMVIESSGRGERAYDIYSRLLRERIIFLVGPVTETSANLVIAQLLFLESENSEKDISLYI
NSPGGLVTAGLAVYDTMQFIKPDVSTLCIGQAASMGALLLTAGAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEIL
ALKGRLNEILAKHTSQTIRTIEKDTDRDNFLGAEAAVKYSLVDAVLTSRKVKHE
>Mature_214_residues
MQPILDWEKNELNTTGLGLIPMVIESSGRGERAYDIYSRLLRERIIFLVGPVTETSANLVIAQLLFLESENSEKDISLYI
NSPGGLVTAGLAVYDTMQFIKPDVSTLCIGQAASMGALLLTAGAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEIL
ALKGRLNEILAKHTSQTIRTIEKDTDRDNFLGAEAAVKYSLVDAVLTSRKVKHE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=193, Percent_Identity=59.0673575129534, Blast_Score=244, Evalue=6e-65,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=70.6185567010309, Blast_Score=309, Evalue=9e-86,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=60.1063829787234, Blast_Score=226, Evalue=5e-60,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=58.9473684210526, Blast_Score=240, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_NITEC (Q0AJI2)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746454.1
- ProteinModelPortal:   Q0AJI2
- SMR:   Q0AJI2
- STRING:   Q0AJI2
- MEROPS:   S14.001
- GeneID:   4272444
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0203
- NMPDR:   fig|335283.3.peg.1677
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- PhylomeDB:   Q0AJI2
- ProtClustDB:   PRK00277
- BioCyc:   NEUT335283:NEUT_0203-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23443; Mature: 23443

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 114-114 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPILDWEKNELNTTGLGLIPMVIESSGRGERAYDIYSRLLRERIIFLVGPVTETSANLV
CCCCCCCCCCCCCCCCCCCEEHEEECCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHH
IAQLLFLESENSEKDISLYINSPGGLVTAGLAVYDTMQFIKPDVSTLCIGQAASMGALLL
HHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCEEEE
TAGAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEILALKGRLNEILAKHTSQTIRT
ECCCCCCEEECCCCCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IEKDTDRDNFLGAEAAVKYSLVDAVLTSRKVKHE
HHCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQPILDWEKNELNTTGLGLIPMVIESSGRGERAYDIYSRLLRERIIFLVGPVTETSANLV
CCCCCCCCCCCCCCCCCCCEEHEEECCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHH
IAQLLFLESENSEKDISLYINSPGGLVTAGLAVYDTMQFIKPDVSTLCIGQAASMGALLL
HHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCEEEE
TAGAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEILALKGRLNEILAKHTSQTIRT
ECCCCCCEEECCCCCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IEKDTDRDNFLGAEAAVKYSLVDAVLTSRKVKHE
HHCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA