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The map label for this gene is abcA [H]

Identifier: 114330183

GI number: 114330183

Start: 153294

End: 154607

Strand: Direct

Name: abcA [H]

Synonym: Neut_0152

Alternate gene names: 114330183

Gene position: 153294-154607 (Clockwise)

Preceding gene: 114330180

Following gene: 114330184

Centisome position: 5.76

GC content: 44.14

Gene sequence:

>1314_bases
GTGAACAAAGAACAGAACGACATCGCCATTCGCGTGGAAAACCTCAGCAAGTGTTATCAAATCTACGACACCCCGCGTGA
CCGGCTCAAGCAATTCATCCTGCCTCGCGTGCAGCGCGTTATTGGTAGACAGCCGAAGCAGTATTTTCGTGAGTTTTGGG
CGCTTAAGGACATATCGTTTGAGGTGAAGAAAGGTGAGACTATCGGTATTATCGGGCGTAACGGCAGCGGTAAATCCACC
TTGTTGCAAATGATCTGCGGCACACTCAGCCCGACTTCTGGCAGCATTACAACCCATGGTCGCATTGCAGCGCTACTGGA
GCTTGGCTCCGGATTTAACCCGGAATTTACCGGGCGTGAAAACGTCTACATGAACGCATCGGTTCTGGGTTTGAGTCAGG
AAGAAACGGATGCGCGCTTTGATGATATTGTCGCATTTGCCGATATTGGTGAGTTCATTGAACAACCGGTCAAAACTTAC
TCCAGCGGGATGATGGTGAGATTGGCTTTTAGTGTAGCCATCAATGTGGCCCCTGATATTTTGATTGTCGACGAGGCGCT
TGCAGTAGGTGATGCTGCATTCCAACGTAAATGTATGCGTAAAATCGGTGAGTTAAGTGATAGCGGAGTGACCTTGCTAT
TTGTTAGCCATGATTTAGAGACGGTGAAGAAAATTTGTAGTGAGGCACTTTATCTGATCCGAGGGGAGATGATCGAGTTT
GGCGTAGCTAAGCAAGTTTGTATCTCATATGAATGTGATTTATTTGGAGCATCTAAGAAGTCAGAAACATCTCAGATAGA
AGCTCAGGCGGATTTATCGAACTCAGATCAGGCGATCTTGGATCCAGATTTGCTTGGAACCAATGAAAAGATCTATGGGG
ATGGCCGTTCCCAGATTACGGGTGTTATGGTTACAAATAAAAATCGGCATATAACAAATGTTCTGAATGCAAATACTGAG
TTTATTGTATCTTATAGGGCAAAATTCCTAGCCGAGGTGTCTTTCCCTATTTTCGGGATGATGATTACAAACCGAGAAGG
CGTTTGTATCTTCGGTACGAACACAGAAAATCATTTAGTTTCCAAACGACATTTTGCAGAAGGTGATGAGGTTGTAGTTG
AATTTCATCTAACAAATCATCTTGGCCCAGGGATTTTTTATCTTACTTGTGGGATTTATACGACAGAAAATAGTGATAGT
CTGATATACCTTCAGCGTCGCATGGATGTCCTTATAATAAAGGTCATCGCGGATAATGATTCATGTATCGGGGGAGTTGC
GAACCTCAATTCTAAAATTGTAGTCACTGAGTAA

Upstream 100 bases:

>100_bases
GACTGGATCATGCAGCCCATGATGTTACGTCAAACGTAACACGTAAAGCGAGAAAAATTTCAGGCTATCTACCCTGCTAT
GGGCAGTCAGCGGAGGCAGC

Downstream 100 bases:

>100_bases
GATTTTTGTAATGCTGAGCGAAATTCAAGAAAAAAAAATAATGGGAGTGGTTTTTATACATTCGCTTTTTCGTTCGGGTA
GTACATACTTTTACAACGCA

Product: ABC transporter-related protein

Products: Ni2; [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNKEQNDIAIRVENLSKCYQIYDTPRDRLKQFILPRVQRVIGRQPKQYFREFWALKDISFEVKKGETIGIIGRNGSGKST
LLQMICGTLSPTSGSITTHGRIAALLELGSGFNPEFTGRENVYMNASVLGLSQEETDARFDDIVAFADIGEFIEQPVKTY
SSGMMVRLAFSVAINVAPDILIVDEALAVGDAAFQRKCMRKIGELSDSGVTLLFVSHDLETVKKICSEALYLIRGEMIEF
GVAKQVCISYECDLFGASKKSETSQIEAQADLSNSDQAILDPDLLGTNEKIYGDGRSQITGVMVTNKNRHITNVLNANTE
FIVSYRAKFLAEVSFPIFGMMITNREGVCIFGTNTENHLVSKRHFAEGDEVVVEFHLTNHLGPGIFYLTCGIYTTENSDS
LIYLQRRMDVLIIKVIADNDSCIGGVANLNSKIVVTE

Sequences:

>Translated_437_residues
MNKEQNDIAIRVENLSKCYQIYDTPRDRLKQFILPRVQRVIGRQPKQYFREFWALKDISFEVKKGETIGIIGRNGSGKST
LLQMICGTLSPTSGSITTHGRIAALLELGSGFNPEFTGRENVYMNASVLGLSQEETDARFDDIVAFADIGEFIEQPVKTY
SSGMMVRLAFSVAINVAPDILIVDEALAVGDAAFQRKCMRKIGELSDSGVTLLFVSHDLETVKKICSEALYLIRGEMIEF
GVAKQVCISYECDLFGASKKSETSQIEAQADLSNSDQAILDPDLLGTNEKIYGDGRSQITGVMVTNKNRHITNVLNANTE
FIVSYRAKFLAEVSFPIFGMMITNREGVCIFGTNTENHLVSKRHFAEGDEVVVEFHLTNHLGPGIFYLTCGIYTTENSDS
LIYLQRRMDVLIIKVIADNDSCIGGVANLNSKIVVTE
>Mature_437_residues
MNKEQNDIAIRVENLSKCYQIYDTPRDRLKQFILPRVQRVIGRQPKQYFREFWALKDISFEVKKGETIGIIGRNGSGKST
LLQMICGTLSPTSGSITTHGRIAALLELGSGFNPEFTGRENVYMNASVLGLSQEETDARFDDIVAFADIGEFIEQPVKTY
SSGMMVRLAFSVAINVAPDILIVDEALAVGDAAFQRKCMRKIGELSDSGVTLLFVSHDLETVKKICSEALYLIRGEMIEF
GVAKQVCISYECDLFGASKKSETSQIEAQADLSNSDQAILDPDLLGTNEKIYGDGRSQITGVMVTNKNRHITNVLNANTE
FIVSYRAKFLAEVSFPIFGMMITNREGVCIFGTNTENHLVSKRHFAEGDEVVVEFHLTNHLGPGIFYLTCGIYTTENSDS
LIYLQRRMDVLIIKVIADNDSCIGGVANLNSKIVVTE

Specific function: Influences the expression of the surface array protein gene (vapA). May have both regulatory and transport activities [H]

COG id: COG1134

COG function: function code GM; ABC-type polysaccharide/polyol phosphate transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=229, Percent_Identity=26.6375545851528, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI31657092, Length=221, Percent_Identity=25.7918552036199, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI6005701, Length=223, Percent_Identity=25.5605381165919, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI27477115, Length=223, Percent_Identity=26.457399103139, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI27436953, Length=221, Percent_Identity=26.6968325791855, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI116734710, Length=206, Percent_Identity=26.2135922330097, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI27881501, Length=205, Percent_Identity=23.4146341463415, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI30795238, Length=205, Percent_Identity=23.4146341463415, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI27262624, Length=252, Percent_Identity=25.7936507936508, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI27262626, Length=252, Percent_Identity=25.7936507936508, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI105990541, Length=185, Percent_Identity=25.9459459459459, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI45446740, Length=247, Percent_Identity=24.6963562753036, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI47078218, Length=247, Percent_Identity=24.6963562753036, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI157502201, Length=214, Percent_Identity=28.0373831775701, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI157502203, Length=214, Percent_Identity=28.0373831775701, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI150417984, Length=193, Percent_Identity=22.7979274611399, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789891, Length=208, Percent_Identity=28.8461538461538, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787758, Length=201, Percent_Identity=25.8706467661692, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081709, Length=198, Percent_Identity=26.2626262626263, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87081791, Length=233, Percent_Identity=24.0343347639485, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786319, Length=213, Percent_Identity=26.2910798122066, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787029, Length=210, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786398, Length=221, Percent_Identity=25.7918552036199, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081782, Length=213, Percent_Identity=28.6384976525822, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786703, Length=214, Percent_Identity=28.9719626168224, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788225, Length=212, Percent_Identity=26.8867924528302, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788761, Length=217, Percent_Identity=25.3456221198157, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081834, Length=191, Percent_Identity=29.8429319371728, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789032, Length=213, Percent_Identity=23.4741784037559, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI48995001, Length=208, Percent_Identity=25.4807692307692, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790467, Length=213, Percent_Identity=24.4131455399061, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788506, Length=243, Percent_Identity=26.3374485596708, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI48994883, Length=220, Percent_Identity=28.6363636363636, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789593, Length=207, Percent_Identity=26.5700483091787, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI48994943, Length=242, Percent_Identity=22.3140495867769, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994997, Length=212, Percent_Identity=26.4150943396226, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789751, Length=235, Percent_Identity=25.9574468085106, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788210, Length=198, Percent_Identity=29.2929292929293, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788897, Length=213, Percent_Identity=26.2910798122066, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789873, Length=210, Percent_Identity=26.6666666666667, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787712, Length=176, Percent_Identity=26.1363636363636, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790739, Length=210, Percent_Identity=25.7142857142857, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1788450, Length=205, Percent_Identity=25.8536585365854, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=215, Percent_Identity=26.5116279069767, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI115533608, Length=206, Percent_Identity=26.6990291262136, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17510237, Length=212, Percent_Identity=27.3584905660377, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71983523, Length=211, Percent_Identity=26.5402843601896, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983510, Length=210, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=210, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569081, Length=209, Percent_Identity=25.8373205741627, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648314, Length=224, Percent_Identity=27.2321428571429, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643674, Length=364, Percent_Identity=23.0769230769231, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666092, Length=212, Percent_Identity=26.4150943396226, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221512771, Length=202, Percent_Identity=25.2475247524752, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573571, Length=295, Percent_Identity=20.3389830508475, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573573, Length=295, Percent_Identity=20.3389830508475, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221500365, Length=240, Percent_Identity=22.5, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007184, Length=240, Percent_Identity=22.5, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 48457; Mature: 48457

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEQNDIAIRVENLSKCYQIYDTPRDRLKQFILPRVQRVIGRQPKQYFREFWALKDISF
CCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEE
EVKKGETIGIIGRNGSGKSTLLQMICGTLSPTSGSITTHGRIAALLELGSGFNPEFTGRE
EEECCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCHHHEEHHHCCCCCCCCCCCC
NVYMNASVLGLSQEETDARFDDIVAFADIGEFIEQPVKTYSSGMMVRLAFSVAINVAPDI
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCE
LIVDEALAVGDAAFQRKCMRKIGELSDSGVTLLFVSHDLETVKKICSEALYLIRGEMIEF
EEEECHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
GVAKQVCISYECDLFGASKKSETSQIEAQADLSNSDQAILDPDLLGTNEKIYGDGRSQIT
CCHHHEEEEEECCEECCCCCCCCHHEEEEECCCCCCCEEECCCCCCCCCEEECCCCCEEE
GVMVTNKNRHITNVLNANTEFIVSYRAKFLAEVSFPIFGMMITNREGVCIFGTNTENHLV
EEEEECCCCEEEHHHCCCCEEEEHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCHHH
SKRHFAEGDEVVVEFHLTNHLGPGIFYLTCGIYTTENSDSLIYLQRRMDVLIIKVIADND
HHHHCCCCCEEEEEEEECCCCCCCEEEEEEEEEEECCCCCEEEEEECCCEEEEEEEECCC
SCIGGVANLNSKIVVTE
CCCCHHCCCCCEEEEEC
>Mature Secondary Structure
MNKEQNDIAIRVENLSKCYQIYDTPRDRLKQFILPRVQRVIGRQPKQYFREFWALKDISF
CCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEE
EVKKGETIGIIGRNGSGKSTLLQMICGTLSPTSGSITTHGRIAALLELGSGFNPEFTGRE
EEECCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCHHHEEHHHCCCCCCCCCCCC
NVYMNASVLGLSQEETDARFDDIVAFADIGEFIEQPVKTYSSGMMVRLAFSVAINVAPDI
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCE
LIVDEALAVGDAAFQRKCMRKIGELSDSGVTLLFVSHDLETVKKICSEALYLIRGEMIEF
EEEECHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
GVAKQVCISYECDLFGASKKSETSQIEAQADLSNSDQAILDPDLLGTNEKIYGDGRSQIT
CCHHHEEEEEECCEECCCCCCCCHHEEEEECCCCCCCEEECCCCCCCCCEEECCCCCEEE
GVMVTNKNRHITNVLNANTEFIVSYRAKFLAEVSFPIFGMMITNREGVCIFGTNTENHLV
EEEEECCCCEEEHHHCCCCEEEEHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCHHH
SKRHFAEGDEVVVEFHLTNHLGPGIFYLTCGIYTTENSDSLIYLQRRMDVLIIKVIADND
HHHHCCCCCEEEEEEEECCCCCCCEEEEEEEEEEECCCCCEEEEEECCCEEEEEEEECCC
SCIGGVANLNSKIVVTE
CCCCHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; ATP; H2O [C]

Specific reaction: Ni2+ [Periplasm] + ATP + H2O = Ni2+ [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491726 [H]