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The map label for this gene is yfhK [H]

Identifier: 114330167

GI number: 114330167

Start: 134703

End: 136202

Strand: Direct

Name: yfhK [H]

Synonym: Neut_0136

Alternate gene names: 114330167

Gene position: 134703-136202 (Clockwise)

Preceding gene: 114330159

Following gene: 114330168

Centisome position: 5.06

GC content: 45.67

Gene sequence:

>1500_bases
ATGAAAATTTCTACAGATGTTTCATCTTCTGAGCGAATACACCGGGAAAACAGATCCAGATATAAACCGAAATCATTTCT
GGCTCTAATCCTGCTTGGATTTTCAATTGTCGGCTTGCCTCTGATCAGTGCGCTGATATACAGTGCCATACGTATTGATC
AGCTATCCGAACAAAGCCGATACAATGTTTATCAAGCCACCCAGATTACCAATGGTACCGGGGTTATTATTGGTGAAATC
ATGGCGATGGAGCGTAGTGTGCAACATGCGCTGGTGCTGGATGATGCAACTCTGCTAGAAGGCTATTTTATTGCGCACAC
CAAGTTTGAAAACATTACCAATCACCTCTCCATTATTTCCACGTATCCGGAACAACAGCTTCCACTGGAAAAGCTGCGGC
TACTGGAAACTGGAATTTTTCGGGAAATACTGGATCTGAAAGAACACCCGCAGGATTTACAGTATCTGCTTGAACGTTTC
GCTTCTTTGCTCGACCTTGCCCAGGAATTTTCAACCAACAGTTTTCGTATGATCGGGCAAAGTGTCGGTAATGTAAGTGA
GATTGCCACACAAACCCGCTCACTGGTTGAATGGGAGTTACTGATTCTGGTTCCACTGGTTATTTTTCTGGCACTGGTTT
TTTCCGTATTTATTGCTCGTCCCGTCCGCCAGATTGATGAAGCAATTGCTCAAATGGGGCGTGGTAATCTTTCCCGACCA
ATCCGTGTCAACGGGCCGCAAAACCTCACCTACATTGGGGAACGTTTGGACTGGCTGCGACAGCGCCTGCTCAAGCTGGA
GAACCAGAAAATACAGTTCTTTCGCCATATTTCCCATGAGCTGAAAACACCCCTGACAGCAATTCGGGAAGGCGCTGATC
TTTTGGCTGAGGGGGTGACGGGCAATCTCAACCGGAAACAACAGCTCATTGCCGGGATTCTTCATACCAGCAGCATACAA
TTGCAAAAACGTATAGAAGATTTGCTCAATTTCAGCGCGCTCCAGGCGGAGATCATTACGCTTGCCAAACAGAATGTTAA
TTTGGAAAAAATGATAAATTCAGTTATTCAAGCGCAAAATCTTTCCATCTTGAGCAAAAGCCTTACAATTAACCTGAATT
GCCCGGAGTTATTTCTGGAGTGTGACAAACAGAAGCTGGACATCATGCTTGATAACCTACTTTCCAATGCCGTCAAATTT
TCTTCGGCATATGGTCACATTGAAATTACTGCTTTGTGTGATGAAAACAAGGTGCAGATCGACATTATGGATTTCGGCCC
AGGTGTTGATAATGCTGATGGAGATCGGATATTTGAGCCGTTCTACCAGGGGCGCAATACGCCTGAAAATCATGCCAAGG
GCACGGGCCTCGGCCTGGCGATTGCGAAGGAATATGCCGTCGCACATGGAGGAAATATCGAACTTGTTCGGGATACCGGA
AAATGTGGCGCACATTTTCGATTAACACTGCCCACCAACAGTTCTGAATCCACATCATGA

Upstream 100 bases:

>100_bases
CGGGGAAAAATTGCTGTGCAGAGAATCAATGCGTGAAAATGGCCATAATCTTTCTACTCAGGTATTTTCGCCCAGGTCGC
ACGAAAGGTAAACCTGATAT

Downstream 100 bases:

>100_bases
AAACAATTTGTAAATTATTGGCAGGGCTGATTTTAATCACGACCCTTCCCGGGTGTATGCGTACACTAGTTCAGCCGGTA
CATCAGCCATCCGAACATAT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MKISTDVSSSERIHRENRSRYKPKSFLALILLGFSIVGLPLISALIYSAIRIDQLSEQSRYNVYQATQITNGTGVIIGEI
MAMERSVQHALVLDDATLLEGYFIAHTKFENITNHLSIISTYPEQQLPLEKLRLLETGIFREILDLKEHPQDLQYLLERF
ASLLDLAQEFSTNSFRMIGQSVGNVSEIATQTRSLVEWELLILVPLVIFLALVFSVFIARPVRQIDEAIAQMGRGNLSRP
IRVNGPQNLTYIGERLDWLRQRLLKLENQKIQFFRHISHELKTPLTAIREGADLLAEGVTGNLNRKQQLIAGILHTSSIQ
LQKRIEDLLNFSALQAEIITLAKQNVNLEKMINSVIQAQNLSILSKSLTINLNCPELFLECDKQKLDIMLDNLLSNAVKF
SSAYGHIEITALCDENKVQIDIMDFGPGVDNADGDRIFEPFYQGRNTPENHAKGTGLGLAIAKEYAVAHGGNIELVRDTG
KCGAHFRLTLPTNSSESTS

Sequences:

>Translated_499_residues
MKISTDVSSSERIHRENRSRYKPKSFLALILLGFSIVGLPLISALIYSAIRIDQLSEQSRYNVYQATQITNGTGVIIGEI
MAMERSVQHALVLDDATLLEGYFIAHTKFENITNHLSIISTYPEQQLPLEKLRLLETGIFREILDLKEHPQDLQYLLERF
ASLLDLAQEFSTNSFRMIGQSVGNVSEIATQTRSLVEWELLILVPLVIFLALVFSVFIARPVRQIDEAIAQMGRGNLSRP
IRVNGPQNLTYIGERLDWLRQRLLKLENQKIQFFRHISHELKTPLTAIREGADLLAEGVTGNLNRKQQLIAGILHTSSIQ
LQKRIEDLLNFSALQAEIITLAKQNVNLEKMINSVIQAQNLSILSKSLTINLNCPELFLECDKQKLDIMLDNLLSNAVKF
SSAYGHIEITALCDENKVQIDIMDFGPGVDNADGDRIFEPFYQGRNTPENHAKGTGLGLAIAKEYAVAHGGNIELVRDTG
KCGAHFRLTLPTNSSESTS
>Mature_499_residues
MKISTDVSSSERIHRENRSRYKPKSFLALILLGFSIVGLPLISALIYSAIRIDQLSEQSRYNVYQATQITNGTGVIIGEI
MAMERSVQHALVLDDATLLEGYFIAHTKFENITNHLSIISTYPEQQLPLEKLRLLETGIFREILDLKEHPQDLQYLLERF
ASLLDLAQEFSTNSFRMIGQSVGNVSEIATQTRSLVEWELLILVPLVIFLALVFSVFIARPVRQIDEAIAQMGRGNLSRP
IRVNGPQNLTYIGERLDWLRQRLLKLENQKIQFFRHISHELKTPLTAIREGADLLAEGVTGNLNRKQQLIAGILHTSSIQ
LQKRIEDLLNFSALQAEIITLAKQNVNLEKMINSVIQAQNLSILSKSLTINLNCPELFLECDKQKLDIMLDNLLSNAVKF
SSAYGHIEITALCDENKVQIDIMDFGPGVDNADGDRIFEPFYQGRNTPENHAKGTGLGLAIAKEYAVAHGGNIELVRDTG
KCGAHFRLTLPTNSSESTS

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=35.3535353535354, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1790346, Length=281, Percent_Identity=29.1814946619217, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=31.4159292035398, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=307, Percent_Identity=28.0130293159609, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787894, Length=302, Percent_Identity=27.4834437086093, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=29.6296296296296, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788279, Length=328, Percent_Identity=26.5243902439024, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=29.9559471365639, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=25, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=29.8642533936652, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87081816, Length=342, Percent_Identity=24.2690058479532, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=21.6666666666667, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=273, Percent_Identity=26.007326007326, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=30.9090909090909, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=30.2631578947368, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=22.7722772277228, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55976; Mature: 55976

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISTDVSSSERIHRENRSRYKPKSFLALILLGFSIVGLPLISALIYSAIRIDQLSEQSR
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YNVYQATQITNGTGVIIGEIMAMERSVQHALVLDDATLLEGYFIAHTKFENITNHLSIIS
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEECCHHHHCCEEEEHHHHHHHHHHHHHHC
TYPEQQLPLEKLRLLETGIFREILDLKEHPQDLQYLLERFASLLDLAQEFSTNSFRMIGQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SVGNVSEIATQTRSLVEWELLILVPLVIFLALVFSVFIARPVRQIDEAIAQMGRGNLSRP
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IRVNGPQNLTYIGERLDWLRQRLLKLENQKIQFFRHISHELKTPLTAIREGADLLAEGVT
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHCCC
GNLNRKQQLIAGILHTSSIQLQKRIEDLLNFSALQAEIITLAKQNVNLEKMINSVIQAQN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LSILSKSLTINLNCPELFLECDKQKLDIMLDNLLSNAVKFSSAYGHIEITALCDENKVQI
HHEEEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEE
DIMDFGPGVDNADGDRIFEPFYQGRNTPENHAKGTGLGLAIAKEYAVAHGGNIELVRDTG
EEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECC
KCGAHFRLTLPTNSSESTS
CCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKISTDVSSSERIHRENRSRYKPKSFLALILLGFSIVGLPLISALIYSAIRIDQLSEQSR
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YNVYQATQITNGTGVIIGEIMAMERSVQHALVLDDATLLEGYFIAHTKFENITNHLSIIS
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEECCHHHHCCEEEEHHHHHHHHHHHHHHC
TYPEQQLPLEKLRLLETGIFREILDLKEHPQDLQYLLERFASLLDLAQEFSTNSFRMIGQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SVGNVSEIATQTRSLVEWELLILVPLVIFLALVFSVFIARPVRQIDEAIAQMGRGNLSRP
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IRVNGPQNLTYIGERLDWLRQRLLKLENQKIQFFRHISHELKTPLTAIREGADLLAEGVT
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHCCC
GNLNRKQQLIAGILHTSSIQLQKRIEDLLNFSALQAEIITLAKQNVNLEKMINSVIQAQN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LSILSKSLTINLNCPELFLECDKQKLDIMLDNLLSNAVKFSSAYGHIEITALCDENKVQI
HHEEEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEE
DIMDFGPGVDNADGDRIFEPFYQGRNTPENHAKGTGLGLAIAKEYAVAHGGNIELVRDTG
EEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECC
KCGAHFRLTLPTNSSESTS
CCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]