Click here to switch to the map view.

The map label for this gene is hmrR [H]

Identifier: 114330116

GI number: 114330116

Start: 83808

End: 84227

Strand: Direct

Name: hmrR [H]

Synonym: Neut_0085

Alternate gene names: 114330116

Gene position: 83808-84227 (Clockwise)

Preceding gene: 114330103

Following gene: 114330126

Centisome position: 3.15

GC content: 55.95

Gene sequence:

>420_bases
ATGAACCAACGCACACTGACCATCGGTGTTCTGGCTCGGGCAACCGGAACCAATATCGAAACCATCCGCTACTACGAGCG
GGAAGGATTACTTCCTAAGCCCGAGCGAACCAAGGGTAACTATCGCGCTTATGAAGCCAGCCACCAGCAACGACTGGGAT
TTATCAGGAAGGCCCGAGACCTGGGATTCTCCTTGGCTCAGGTGCGTACCTTGTTGTCGCTCTCCGACGACAAGTCGCGA
TCTTGCTCGGCGATTGACGAGATCGCCATGGAGCATCGGAAGGCTGTCGAGCAGAAGATCCTAGACCTTCGCGCCTTGAA
GGCTGAACTCGACAATTTGATCGATCAGTGTAGTTGTGGCACGGTGGCGGAATGCCGCATCATCGAGTCACTTTCGCCGT
CAGCCGGCCTGGCGCGATAA

Upstream 100 bases:

>100_bases
CGATGCGTAGCTTTAGGGCTTTGGCGCTGGACATGGTGGACTCGACAAAAAATTGATAATGGCAGTATGATAAACCCCGT
AGTAACTACAGGGTCAACCT

Downstream 100 bases:

>100_bases
ACCCAACAGTCCAGCCCCTATCTGCATTGAGCAGAGCGGGAGGGAAAGACGTCGGCTGCTCATCACCAATACGAAATGAC
TGCAAAGGGTTGTCTTCTGC

Product: transcriptional regulator, MerR family protein

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MNQRTLTIGVLARATGTNIETIRYYEREGLLPKPERTKGNYRAYEASHQQRLGFIRKARDLGFSLAQVRTLLSLSDDKSR
SCSAIDEIAMEHRKAVEQKILDLRALKAELDNLIDQCSCGTVAECRIIESLSPSAGLAR

Sequences:

>Translated_139_residues
MNQRTLTIGVLARATGTNIETIRYYEREGLLPKPERTKGNYRAYEASHQQRLGFIRKARDLGFSLAQVRTLLSLSDDKSR
SCSAIDEIAMEHRKAVEQKILDLRALKAELDNLIDQCSCGTVAECRIIESLSPSAGLAR
>Mature_139_residues
MNQRTLTIGVLARATGTNIETIRYYEREGLLPKPERTKGNYRAYEASHQQRLGFIRKARDLGFSLAQVRTLLSLSDDKSR
SCSAIDEIAMEHRKAVEQKILDLRALKAELDNLIDQCSCGTVAECRIIESLSPSAGLAR

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=132, Percent_Identity=40.1515151515151, Blast_Score=89, Evalue=1e-19,
Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=32.2834645669291, Blast_Score=80, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15567; Mature: 15567

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQRTLTIGVLARATGTNIETIRYYEREGLLPKPERTKGNYRAYEASHQQRLGFIRKARD
CCCCEEEEEEEECCCCCCCHHHEEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LGFSLAQVRTLLSLSDDKSRSCSAIDEIAMEHRKAVEQKILDLRALKAELDNLIDQCSCG
HCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TVAECRIIESLSPSAGLAR
CHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNQRTLTIGVLARATGTNIETIRYYEREGLLPKPERTKGNYRAYEASHQQRLGFIRKARD
CCCCEEEEEEEECCCCCCCHHHEEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LGFSLAQVRTLLSLSDDKSRSCSAIDEIAMEHRKAVEQKILDLRALKAELDNLIDQCSCG
HCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TVAECRIIESLSPSAGLAR
CHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]