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The map label for this gene is czcD [H]

Identifier: 114330076

GI number: 114330076

Start: 44910

End: 45842

Strand: Reverse

Name: czcD [H]

Synonym: Neut_0043

Alternate gene names: 114330076

Gene position: 45842-44910 (Counterclockwise)

Preceding gene: 114330078

Following gene: 114330074

Centisome position: 1.72

GC content: 54.56

Gene sequence:

>933_bases
ATGATTCACACATCAGCTCATCGTTGGCAGCATTCCCACGTATTTGATCAAGGTAATCCTGTTGCTGAGCGTAGGACTCG
CTGGGCTGTATGGCTCACGGCTACCATGATGGTCGCCGAGATAGTGGGCGGTTGGTGGTACAACTCCATGGCGCTCCTGG
CTGACGGTTGGCACATGAGCTCGCACGCTTTAGCGCTTGGGCTCTCTGTCCTTGCATATGCCGCAGCCAGGCGCTACGCC
GATGATCGACGTTTCGCCTTTGGAACCTGGAAGATTGAGATCCTAGGTGGATACTCCAGCGCCATCATGTTGTTGGGTGT
GGCCGGTTTGATGCTTTTCCAGTCAGTCGAAAGACTCTTTTCTCCCACTGAAATCCACTACAACCAAGCAATTAGCATTG
CTGTCGTCGGCTTGCTGGTGAATCTGGCCTGCGCGTGGCTGTTACGAGGAGATCATGGGCACCATCACGCGCATCATGCA
GGAGAGGGCACAGCGCACCACCATCACCATGATCTGAACCTGCGTTCAGCGTACCTGCACGTCATTGCCGATGCGGCGAC
CTCTGTCCTGGCGATAATCGCTTTGCTGGGCGGAAAGCTGTGGGGCGCAGCATGGCTCGATCCTCTTATGGGGATTGTTG
GTGCAGCCCTCGTGGCGATGTGGGCAAAAGGCCTATTGCGCGAGACCGGGCGCGTCTTGTTGGACGCGGAAATGGATATC
CCGGTGGTAGAGGAAATCCGAGAAGCTTTACGTCAAACCCCGACGGTGCAGATCACCGATCTTCATGTATGGAGGGTTGG
CGCAGGAAAGTATGCGTGTATTGTGTCGCTCGCCACGTCAAGCTCGATTACGGCAGACCAGATTCGGCAGCAACTGAGCA
TTCATGATGAACTTGTCCATGTAACCGTGGAAATAAACAATCTACATACATAA

Upstream 100 bases:

>100_bases
GGAGGCGGCCCTTGCTTTTAACTGTGTGCGCCATTTGAATTTCACCGTAAATAATAGGGTACTGGGGTATAGTATACGTT
GACATAAACTAGAGGTCCTC

Downstream 100 bases:

>100_bases
GTATTAGGCGTAGCCGCTCAGCGTCGCCTAATTCATTCGCTTCTTACATGGTGAGGTGCTCATACAGAATGACCGTACCG
ACACCCATTAGCGCTAACCC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MIHTSAHRWQHSHVFDQGNPVAERRTRWAVWLTATMMVAEIVGGWWYNSMALLADGWHMSSHALALGLSVLAYAAARRYA
DDRRFAFGTWKIEILGGYSSAIMLLGVAGLMLFQSVERLFSPTEIHYNQAISIAVVGLLVNLACAWLLRGDHGHHHAHHA
GEGTAHHHHHDLNLRSAYLHVIADAATSVLAIIALLGGKLWGAAWLDPLMGIVGAALVAMWAKGLLRETGRVLLDAEMDI
PVVEEIREALRQTPTVQITDLHVWRVGAGKYACIVSLATSSSITADQIRQQLSIHDELVHVTVEINNLHT

Sequences:

>Translated_310_residues
MIHTSAHRWQHSHVFDQGNPVAERRTRWAVWLTATMMVAEIVGGWWYNSMALLADGWHMSSHALALGLSVLAYAAARRYA
DDRRFAFGTWKIEILGGYSSAIMLLGVAGLMLFQSVERLFSPTEIHYNQAISIAVVGLLVNLACAWLLRGDHGHHHAHHA
GEGTAHHHHHDLNLRSAYLHVIADAATSVLAIIALLGGKLWGAAWLDPLMGIVGAALVAMWAKGLLRETGRVLLDAEMDI
PVVEEIREALRQTPTVQITDLHVWRVGAGKYACIVSLATSSSITADQIRQQLSIHDELVHVTVEINNLHT
>Mature_310_residues
MIHTSAHRWQHSHVFDQGNPVAERRTRWAVWLTATMMVAEIVGGWWYNSMALLADGWHMSSHALALGLSVLAYAAARRYA
DDRRFAFGTWKIEILGGYSSAIMLLGVAGLMLFQSVERLFSPTEIHYNQAISIAVVGLLVNLACAWLLRGDHGHHHAHHA
GEGTAHHHHHDLNLRSAYLHVIADAATSVLAIIALLGGKLWGAAWLDPLMGIVGAALVAMWAKGLLRETGRVLLDAEMDI
PVVEEIREALRQTPTVQITDLHVWRVGAGKYACIVSLATSSSITADQIRQQLSIHDELVHVTVEINNLHT

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=302, Percent_Identity=26.8211920529801, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI222080086, Length=323, Percent_Identity=21.671826625387, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI40255009, Length=323, Percent_Identity=21.671826625387, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI21359890, Length=280, Percent_Identity=27.1428571428571, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI52352805, Length=313, Percent_Identity=24.9201277955272, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786966, Length=288, Percent_Identity=32.2916666666667, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32564488, Length=284, Percent_Identity=29.5774647887324, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17555794, Length=284, Percent_Identity=28.8732394366197, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17555796, Length=266, Percent_Identity=29.3233082706767, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193210990, Length=323, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=159, Percent_Identity=27.0440251572327, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24645863, Length=297, Percent_Identity=22.8956228956229, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34165; Mature: 34165

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHTSAHRWQHSHVFDQGNPVAERRTRWAVWLTATMMVAEIVGGWWYNSMALLADGWHMS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHEECCCCCC
SHALALGLSVLAYAAARRYADDRRFAFGTWKIEILGGYSSAIMLLGVAGLMLFQSVERLF
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
SPTEIHYNQAISIAVVGLLVNLACAWLLRGDHGHHHAHHAGEGTAHHHHHDLNLRSAYLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VIADAATSVLAIIALLGGKLWGAAWLDPLMGIVGAALVAMWAKGLLRETGRVLLDAEMDI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PVVEEIREALRQTPTVQITDLHVWRVGAGKYACIVSLATSSSITADQIRQQLSIHDELVH
HHHHHHHHHHHCCCCEEEEEEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHEEEE
VTVEINNLHT
EEEEECCCCC
>Mature Secondary Structure
MIHTSAHRWQHSHVFDQGNPVAERRTRWAVWLTATMMVAEIVGGWWYNSMALLADGWHMS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHEECCCCCC
SHALALGLSVLAYAAARRYADDRRFAFGTWKIEILGGYSSAIMLLGVAGLMLFQSVERLF
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
SPTEIHYNQAISIAVVGLLVNLACAWLLRGDHGHHHAHHAGEGTAHHHHHDLNLRSAYLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VIADAATSVLAIIALLGGKLWGAAWLDPLMGIVGAALVAMWAKGLLRETGRVLLDAEMDI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PVVEEIREALRQTPTVQITDLHVWRVGAGKYACIVSLATSSSITADQIRQQLSIHDELVH
HHHHHHHHHHHCCCCEEEEEEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHEEEE
VTVEINNLHT
EEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]