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The map label for this gene is copA [H]

Identifier: 114330056

GI number: 114330056

Start: 23288

End: 25171

Strand: Direct

Name: copA [H]

Synonym: Neut_0021

Alternate gene names: 114330056

Gene position: 23288-25171 (Clockwise)

Preceding gene: 114330055

Following gene: 114330057

Centisome position: 0.88

GC content: 58.39

Gene sequence:

>1884_bases
ATGATTGATATCTACCCTCTTTCGACTTTGGGATACGCTCACGTGAAACACTTGCTACCGCACTCGCTTGCACTGCCTAT
ACTGCCCCGTCGCCGATTCGTTCAGGGCCTTGCGGCTGGCGGCGTATTGTTGGGCTTATCGCCCTTTGCCCGAGCCGCCG
GAGTTCCGTCCGTCAATACGAGTACCGGTTCGGCCGCTGTGCTGACGGGGACCGAGTTCAACCTCGATATCGGTGAATCG
CCCGTCAATTTCACCGGCAGCCCACGCATCGCAACGACGGTGAATGGCTCGCTTCCTGCGCCTACCTTACGCTGGCGCGA
AGGCGATACGGTCACTATTCGCGTCAAGAACCGTCTGAAGGAAGCCACCTCCATCCATTGGCACGGCATCATCCTGCCCT
TCCAAATGGATGGCGTGCCAGGTATCAGTTTTACGGGCATTGCTCCAGGAGAAACATTTACCTACCGATTTAAAGTTGAA
CAAAGCGGCACGTACTGGTATCACTCCCATTCTGGCATGCAGGAGGCGACCGGCGTTTATGGGGCGATCATTATCGACCC
GGCACAAACCGACTCCATACGGGCCGATCGCGAGTACGTCGTTCAGCTTTCTGACTGGACCGACGAGGATCCGATGCGAG
TCCTGGCCAAGCTCAAAATGCAAGGCGACTACTACAACTACAACCAGCCCACCGCCATTGATTTCTTCCAGGACGTGTCA
CGAGATGGCCTGAAAGCGGCCATCGACAAGCGCAAGATGTGGAACGAAATGCGCATGAGTCCAACCGACCTGGCGGACTT
GTCGGCTAATGTGTTGACCTATTTGATGAACGGCACAACCCCGGCCGGCAACTGGACGGGATTATTCCGTCCCGGTGAGC
GGGTCCGCCTGCGTTTCATCAACGGGGCAGCCAACACTTTTTACGACGTGCGTATACCAGGTCTGAAGCTAACGGTGGTT
CAGGCCGACGGCGTCAATGTAGAGCCCGTAACGGTGGATGAATTCCGCTTTGGTCCAGGGGAAACCTACGACGTGCTGGT
CCAGCCCAAAGACGATACCTATACCGTTTTTGCGCAAGCCATGGACCGCACCGGGTATGCACGGGGCACACTGGCTACGC
GTGCCGGTCTCGACGCGCCCGTGCCCGCGCTTGACCCAGTGGAATGGCTCACCATGGCGGACATGATGGGTTCAATGGGC
GCGGGCATGGCAGGAATGAGCCATGGTGGGTCCGGCCAATCGTCCATGGGCGGTATGGATCACGGTGCTATGGCTGGGAT
GAATCATGGCAGTATGCAGGGCATGAATCACGCAGGCATGGCTGGTATGGATCATGGCGCAATGACAGCAACTGGCGCCA
GCACCCAAGTACGCCACGCCAGGACCGAGTATGGCCCCAGCATTGATATGCGGGTCGACATGCCGCGCACCAACCTGGAC
GATCCCGGCATTGGGCTGCGCAACAACGGCCGCCGAGTATTGACGCTATCGGACTTGCACACCGTGGGTGGTGCAATGGA
TCCGCGCGGCGCGGAGCGTGAAATTGAGCTCCATCTGACCGGCAACATGGAACGCTATGCCTGGTCATTCGACGGCGTGG
AATATGGAAAATCGACGCCCGTTCATTTTCGCTACGGCGAGCGGGTCAGGGTTATTTTGCACAACGACACCATGATGACG
CACCCCATGCACTTGCACGGCATGTGGAGTGAGCTAGAAGCGCCTGACGGCAGCTTCCAGGCGCGCCGCCACACGATTCC
GGTGCAGCCAGCGCAACGCATCAGCTTTCTTGTGACCGCCGATGCACTGGGTCGCTGGGCCTGGCATTGCCATCTGATGC
TGCACATGGATGCGGGGATGTTTCGCGAAGTGGTGGTGGCATGA

Upstream 100 bases:

>100_bases
CTCGCATTACAAAAATGTAATGCCAGCGTCATTGGGCCGACATGCACATTTCGTTAAAGTGCATGTCATCAATTTAATTT
GAGGCTTTGATCATCGAAGG

Downstream 100 bases:

>100_bases
GCTCAGTAAACGAGAAAAAGGGAATCTTGACCGTGAATACTCATATAAGAAAACGCATTCTTGCAACCGCTATCGCAACG
CTGGGAGCCACTCCGCTTCT

Product: copper-resistance protein, CopA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MIDIYPLSTLGYAHVKHLLPHSLALPILPRRRFVQGLAAGGVLLGLSPFARAAGVPSVNTSTGSAAVLTGTEFNLDIGES
PVNFTGSPRIATTVNGSLPAPTLRWREGDTVTIRVKNRLKEATSIHWHGIILPFQMDGVPGISFTGIAPGETFTYRFKVE
QSGTYWYHSHSGMQEATGVYGAIIIDPAQTDSIRADREYVVQLSDWTDEDPMRVLAKLKMQGDYYNYNQPTAIDFFQDVS
RDGLKAAIDKRKMWNEMRMSPTDLADLSANVLTYLMNGTTPAGNWTGLFRPGERVRLRFINGAANTFYDVRIPGLKLTVV
QADGVNVEPVTVDEFRFGPGETYDVLVQPKDDTYTVFAQAMDRTGYARGTLATRAGLDAPVPALDPVEWLTMADMMGSMG
AGMAGMSHGGSGQSSMGGMDHGAMAGMNHGSMQGMNHAGMAGMDHGAMTATGASTQVRHARTEYGPSIDMRVDMPRTNLD
DPGIGLRNNGRRVLTLSDLHTVGGAMDPRGAEREIELHLTGNMERYAWSFDGVEYGKSTPVHFRYGERVRVILHNDTMMT
HPMHLHGMWSELEAPDGSFQARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVA

Sequences:

>Translated_627_residues
MIDIYPLSTLGYAHVKHLLPHSLALPILPRRRFVQGLAAGGVLLGLSPFARAAGVPSVNTSTGSAAVLTGTEFNLDIGES
PVNFTGSPRIATTVNGSLPAPTLRWREGDTVTIRVKNRLKEATSIHWHGIILPFQMDGVPGISFTGIAPGETFTYRFKVE
QSGTYWYHSHSGMQEATGVYGAIIIDPAQTDSIRADREYVVQLSDWTDEDPMRVLAKLKMQGDYYNYNQPTAIDFFQDVS
RDGLKAAIDKRKMWNEMRMSPTDLADLSANVLTYLMNGTTPAGNWTGLFRPGERVRLRFINGAANTFYDVRIPGLKLTVV
QADGVNVEPVTVDEFRFGPGETYDVLVQPKDDTYTVFAQAMDRTGYARGTLATRAGLDAPVPALDPVEWLTMADMMGSMG
AGMAGMSHGGSGQSSMGGMDHGAMAGMNHGSMQGMNHAGMAGMDHGAMTATGASTQVRHARTEYGPSIDMRVDMPRTNLD
DPGIGLRNNGRRVLTLSDLHTVGGAMDPRGAEREIELHLTGNMERYAWSFDGVEYGKSTPVHFRYGERVRVILHNDTMMT
HPMHLHGMWSELEAPDGSFQARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVA
>Mature_627_residues
MIDIYPLSTLGYAHVKHLLPHSLALPILPRRRFVQGLAAGGVLLGLSPFARAAGVPSVNTSTGSAAVLTGTEFNLDIGES
PVNFTGSPRIATTVNGSLPAPTLRWREGDTVTIRVKNRLKEATSIHWHGIILPFQMDGVPGISFTGIAPGETFTYRFKVE
QSGTYWYHSHSGMQEATGVYGAIIIDPAQTDSIRADREYVVQLSDWTDEDPMRVLAKLKMQGDYYNYNQPTAIDFFQDVS
RDGLKAAIDKRKMWNEMRMSPTDLADLSANVLTYLMNGTTPAGNWTGLFRPGERVRLRFINGAANTFYDVRIPGLKLTVV
QADGVNVEPVTVDEFRFGPGETYDVLVQPKDDTYTVFAQAMDRTGYARGTLATRAGLDAPVPALDPVEWLTMADMMGSMG
AGMAGMSHGGSGQSSMGGMDHGAMAGMNHGSMQGMNHAGMAGMDHGAMTATGASTQVRHARTEYGPSIDMRVDMPRTNLD
DPGIGLRNNGRRVLTLSDLHTVGGAMDPRGAEREIELHLTGNMERYAWSFDGVEYGKSTPVHFRYGERVRVILHNDTMMT
HPMHLHGMWSELEAPDGSFQARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVA

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=449, Percent_Identity=27.3942093541203, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321067, Length=283, Percent_Identity=29.6819787985866, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320714, Length=306, Percent_Identity=26.797385620915, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323703, Length=287, Percent_Identity=29.9651567944251, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28574104, Length=312, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24650186, Length=301, Percent_Identity=29.2358803986711, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859919, Length=306, Percent_Identity=28.1045751633987, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585842, Length=275, Percent_Identity=28, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281360167, Length=275, Percent_Identity=28, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221329998, Length=275, Percent_Identity=28, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221330000, Length=275, Percent_Identity=28, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 68715; Mature: 68715

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIYPLSTLGYAHVKHLLPHSLALPILPRRRFVQGLAAGGVLLGLSPFARAAGVPSVNT
CEEEEECCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCEEEECCHHHHHCCCCCCCC
STGSAAVLTGTEFNLDIGESPVNFTGSPRIATTVNGSLPAPTLRWREGDTVTIRVKNRLK
CCCCEEEEECCEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCEEEEEEHHHHH
EATSIHWHGIILPFQMDGVPGISFTGIAPGETFTYRFKVEQSGTYWYHSHSGMQEATGVY
HHHEEEEEEEEEEEEECCCCCCEEECCCCCCEEEEEEEEECCCEEEEECCCCCHHHCCCE
GAIIIDPAQTDSIRADREYVVQLSDWTDEDPMRVLAKLKMQGDYYNYNQPTAIDFFQDVS
EEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHC
RDGLKAAIDKRKMWNEMRMSPTDLADLSANVLTYLMNGTTPAGNWTGLFRPGERVRLRFI
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCCCEEECCCCCEEEEEEE
NGAANTFYDVRIPGLKLTVVQADGVNVEPVTVDEFRFGPGETYDVLVQPKDDTYTVFAQA
ECCCCEEEEEEECCEEEEEEEECCCEECCEEECCEECCCCCCEEEEEECCCCCEEEEEHH
MDRTGYARGTLATRAGLDAPVPALDPVEWLTMADMMGSMGAGMAGMSHGGSGQSSMGGMD
HHCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
HGAMAGMNHGSMQGMNHAGMAGMDHGAMTATGASTQVRHARTEYGPSIDMRVDMPRTNLD
CCHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCC
DPGIGLRNNGRRVLTLSDLHTVGGAMDPRGAEREIELHLTGNMERYAWSFDGVEYGKSTP
CCCCCCCCCCCEEEEEECHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCEECCCCCC
VHFRYGERVRVILHNDTMMTHPMHLHGMWSELEAPDGSFQARRHTIPVQPAQRISFLVTA
EEEEECCEEEEEEECCEEEECCEEEECCHHHHCCCCCCCCHHCCCCCCCHHHHEEEEEEH
DALGRWAWHCHLMLHMDAGMFREVVVA
HHHCCEEEEEEEEEEECCCHHHHHHCC
>Mature Secondary Structure
MIDIYPLSTLGYAHVKHLLPHSLALPILPRRRFVQGLAAGGVLLGLSPFARAAGVPSVNT
CEEEEECCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCEEEECCHHHHHCCCCCCCC
STGSAAVLTGTEFNLDIGESPVNFTGSPRIATTVNGSLPAPTLRWREGDTVTIRVKNRLK
CCCCEEEEECCEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCEEEEEEHHHHH
EATSIHWHGIILPFQMDGVPGISFTGIAPGETFTYRFKVEQSGTYWYHSHSGMQEATGVY
HHHEEEEEEEEEEEEECCCCCCEEECCCCCCEEEEEEEEECCCEEEEECCCCCHHHCCCE
GAIIIDPAQTDSIRADREYVVQLSDWTDEDPMRVLAKLKMQGDYYNYNQPTAIDFFQDVS
EEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHC
RDGLKAAIDKRKMWNEMRMSPTDLADLSANVLTYLMNGTTPAGNWTGLFRPGERVRLRFI
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCCCEEECCCCCEEEEEEE
NGAANTFYDVRIPGLKLTVVQADGVNVEPVTVDEFRFGPGETYDVLVQPKDDTYTVFAQA
ECCCCEEEEEEECCEEEEEEEECCCEECCEEECCEECCCCCCEEEEEECCCCCEEEEEHH
MDRTGYARGTLATRAGLDAPVPALDPVEWLTMADMMGSMGAGMAGMSHGGSGQSSMGGMD
HHCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
HGAMAGMNHGSMQGMNHAGMAGMDHGAMTATGASTQVRHARTEYGPSIDMRVDMPRTNLD
CCHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCC
DPGIGLRNNGRRVLTLSDLHTVGGAMDPRGAEREIELHLTGNMERYAWSFDGVEYGKSTP
CCCCCCCCCCCEEEEEECHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCEECCCCCC
VHFRYGERVRVILHNDTMMTHPMHLHGMWSELEAPDGSFQARRHTIPVQPAQRISFLVTA
EEEEECCEEEEEEECCEEEECCEEEECCHHHHCCCCCCCCHHCCCCCCCHHHHEEEEEEH
DALGRWAWHCHLMLHMDAGMFREVVVA
HHHCCEEEEEEEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]