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The map label for this gene is clpA [H]

Identifier: 113969988

GI number: 113969988

Start: 1948486

End: 1950753

Strand: Direct

Name: clpA [H]

Synonym: Shewmr4_1648

Alternate gene names: 113969988

Gene position: 1948486-1950753 (Clockwise)

Preceding gene: 113969987

Following gene: 113969992

Centisome position: 41.4

GC content: 48.68

Gene sequence:

>2268_bases
ATGCTGAACAAAGATCTGGAAGTCACCTTAAATCTGGCGTTTCAGCAAGCCAGAGAGGCACGTCACGAGTATATGACGGT
TGAACATCTGTTATTGGCTCTGATCGACAATCCTGCGGCTCAAGAAGCGCTAATCGCCTGTGGAGCGAATTTAGATAAAC
TCAGAGATGAAGTAGCAAGCTTTATCCAACAAACCACCCCAATCATTGCGGATATGGATGATGATAAAGAAACCCAGCCG
ACGCTTGGGTTTCAACGGGTGCTGCAACGCGCCGTTTTCCATGTGCAGTCTTCGGGTCGCAATGAAGTCACTGGTGCCAA
TGTGCTGGTGGCCATTTTTAGTGAGCAGGAATCCCAAGCTGTGTATCTGCTGCGTCGCAGCGACATCAGCCGTTTAGATG
TGGTGAACTATATTTCCCATGGTTTTTCAAAAAATGAGGACAGCGACGCCCATCAAGATCACGAACGCATCGAAGATCAA
ACCGAAGCGGGTGAAGAGCGCAGTATGCTGTCGCAGTTTGCGAGCAATTTAAACCAGCTTGCAAAACAAGGGATTATCGA
CCCACTCATCGGCCGCGATCAAGAAATTGAACGGGCAATTCAAACCCTCTGCCGTCGCCGTAAGAATAACCCGTTGTTAG
TGGGTGAGGCTGGCGTGGGTAAAACCGCGATTGCCGAAGGTTTAGCCTATCGAATCGTCAACAATCAAGTGCCAGAGGTG
ATGTCGCAGGCGACTGTGTATTCCCTCGACTTAGGCTCCTTACTCGCAGGCACTAAATATCGTGGCGATTTTGAAAAACG
TCTCAAGAGTCTGCTTAAGGAACTCAGCGCCGATAAACACGCCATTTTATTTATCGATGAAATTCATACCATTATTGGTG
CGGGCGCTGCATCGGGCGGGGTGATGGATGCCTCTAATCTGCTAAAACCGTTACTATCGAGCGGTAATTTGCGTTGCATG
GGTTCGACTACCTTCCAAGAATATCAAAGCATTTTTGAGAAAGATCGTGCACTGGCGCGCCGTTTCCAGAAGGTCGATAT
CAATGAGCCTTCAGTGGCTGAAACCACAAAAATTCTTATGGGGCTTAAGGCTAAGTACGAAGAGTACCATGGAGTGCGTT
ATACCCAAGCGGCGATTAATAGCGCGGCTGAGCTGTCGGCAAAACACATTAATGACCGGCATTTACCCGATAAAGCCATC
GATGTGATCGATGAGGCGGGTGCGCGTATGGCGATGTTGCCACAGAGCAAACGTAAGAAAACCATCGGTCAAGCCGAGAT
CGAAACCATAGTGGCGAAGATTGCCCGTATTCCTGAAAAGTCAGTCTCAGCGAGCGACAAGGATTTGCTGCGTAATCTTG
AGCGCAACCTCAAGATGGTGGTCTTTGGTCAAGATAAGGCGATTGAATCCTTAAGCTCGGCGATTCGATTATCACGTAGT
GGGTTAGGTACGGATAAAAAGCCTGTGGGTAGCTTCTTGTTTGCAGGCCCAACTGGGGTTGGTAAGACAGAAGTGACCAA
TCAGTTAGCCAGTTGTCTAGGGATGAAGCTGGTACGGTTTGATATGTCTGAGTACATGGAAAGTCATACGGTATCTCGTT
TGATTGGTGCTCCTCCTGGATACGTAGGATACGACCAAGGTGGCTTACTCACGGATGCAGTGATTAAGAATCCCCATTGC
GTGGTGCTGCTCGATGAAATCGAAAAGGCTCACCCCGATGTCTATAACCTGTTGCTACAGGTCATGGATCACGGCACCTT
GACCGATAATAACGGTCGCAAGGCGGACTTTAGGCATGTCACTCTGGTGATGACAACAAACGCAGGGGTTCAGGAAACGA
TCCGTAAGTCCATTGGGTTTACTCAGCAGGATCATACCCAAGATGCCTTATCGGAAATCAATCGGGTATTCTCTCCTGAG
TTTCGCAACCGCTTAGATTCCATCATTTGGTTCAACCATTTAGATATGACCATCATAGCCAAGGTGGTCGATAAATTCTT
GGTGGAATTGCAGGCGCAGTTGGATGCGAAACATGTGGTGCTGGAAGTCAGCGATGAAGCCAGAACCTTACTCGCCGAGA
AAGGCTATGATAAGAGCATGGGCGCACGGCCAATGGCACGCGTAGTGACTGAGCTGATTAAACGCCCATTAGCCGATGCG
ATTCTCTTTGGCGAACTGGAGCATGGCGGTATTGCCCATGTTGATGCCAAAGATGGTGAAATTGTTATCCACACCGAACG
CCATGAGAAGAGTACCACTAAGGCTTAA

Upstream 100 bases:

>100_bases
AAATCAATTTGCAAGACAAAACCAACATCCGTTACTGTGTTCGTTAGAGAAGGCTTAATAGCGCTTACTCTGTTGTCAGT
TGTTAATTTTGGGGGTGCTT

Downstream 100 bases:

>100_bases
TCTCTAGCTAAACCCAATAAAAATGGCTGCAATTGCAGCCATTTTTCTGATCTTACGCCAACAAAAAAACCCGGCCTCGC
CGGGTTTTTCAACTAAAGGG

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADMDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQ
TEAGEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
MSQATVYSLDLGSLLAGTKYRGDFEKRLKSLLKELSADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILMGLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAI
DVIDEAGARMAMLPQSKRKKTIGQAEIETIVAKIARIPEKSVSASDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADA
ILFGELEHGGIAHVDAKDGEIVIHTERHEKSTTKA

Sequences:

>Translated_755_residues
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADMDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQ
TEAGEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
MSQATVYSLDLGSLLAGTKYRGDFEKRLKSLLKELSADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILMGLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAI
DVIDEAGARMAMLPQSKRKKTIGQAEIETIVAKIARIPEKSVSASDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADA
ILFGELEHGGIAHVDAKDGEIVIHTERHEKSTTKA
>Mature_755_residues
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADMDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQ
TEAGEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
MSQATVYSLDLGSLLAGTKYRGDFEKRLKSLLKELSADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILMGLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAI
DVIDEAGARMAMLPQSKRKKTIGQAEIETIVAKIARIPEKSVSASDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADA
ILFGELEHGGIAHVDAKDGEIVIHTERHEKSTTKA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=300, Percent_Identity=30.6666666666667, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1787109, Length=730, Percent_Identity=70.2739726027397, Blast_Score=1082, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=413, Percent_Identity=41.6464891041162, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=320, Percent_Identity=48.75, Blast_Score=280, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=420, Percent_Identity=37.6190476190476, Blast_Score=252, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83592; Mature: 83592

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADMDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQA
HHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQTEAGEERSMLSQFASNLNQL
EEEEHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
HHHCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHH
MSQATVYSLDLGSLLAGTKYRGDFEKRLKSLLKELSADKHAILFIDEIHTIIGAGAASGG
HHHHHHEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAIDVIDEAGARMAMLPQSKRKK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCHHHHH
TIGQAEIETIVAKIARIPEKSVSASDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHC
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADA
HHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
ILFGELEHGGIAHVDAKDGEIVIHTERHEKSTTKA
HHHCCCCCCCEEEEECCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADMDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQA
HHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQTEAGEERSMLSQFASNLNQL
EEEEHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
HHHCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHH
MSQATVYSLDLGSLLAGTKYRGDFEKRLKSLLKELSADKHAILFIDEIHTIIGAGAASGG
HHHHHHEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAIDVIDEAGARMAMLPQSKRKK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCHHHHH
TIGQAEIETIVAKIARIPEKSVSASDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHC
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADA
HHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
ILFGELEHGGIAHVDAKDGEIVIHTERHEKSTTKA
HHHCCCCCCCEEEEECCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]