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The map label for this gene is cobB [H]

Identifier: 113969982

GI number: 113969982

Start: 1944697

End: 1945437

Strand: Direct

Name: cobB [H]

Synonym: Shewmr4_1642

Alternate gene names: 113969982

Gene position: 1944697-1945437 (Clockwise)

Preceding gene: 113969980

Following gene: 113969983

Centisome position: 41.32

GC content: 49.93

Gene sequence:

>741_bases
ATGTACCAGCATATTGTGGTGTTAACTGGCGCAGGTATTTCGGCCGAATCGGGATTGCGTACCTTTCGCGACCAAGATGG
TTTATGGGAGGAGCATCATATTGAAGATGTTGCAACCCCTGAAGGTTATGCCCGCGATACCGAACTGGTTGAACGTTTTT
ATAACAGCCGCTGGGAGCAATTACACAGTGGCACAGTGATGCCCAATGCGGCACATATTGCGTTGGCTAAGTTAGAGGCT
GAATTTCCTGGTCAATTATTGATTGTGACCCAAAATATTGACGACCTACACGAACGTGCGGGTTCTCGTCGTTTGTTGCA
CATGCATGGCGAATTGTCCAAAGGTCGCTGCCCACGTTCTCGTCAAACTTTCTTATTAAGGGAACCCTTCGGCCCCAATA
ACTGTTGTACTTGCTGCATTCCCGCGCAACGATTACGTCCCCATGTGGTGTGGTTTGGTGAGATGCCGCTGGGGATGGAC
AGGATCCACGATGCGCTCGATAGCTGCGATTTGTTCATTGCCATTGGCACGTCGGGCACTGTGTATCCGGCGGCAGGGTT
TGTCGATACGGCCAATCATCATGGCGCGCAAACGGTGGAAGTAAATTTAGTCACACCCGATAGACACAGCCAGTTCCAAT
ATCATTTAACCGGTAAGGCAGGGGATTTGGTGCCTAAATTGGTCGATACCATACTCGCTGGCAAAGTGATTGGCTCCGAT
ATAGCCGAGTCCGATGTTTAA

Upstream 100 bases:

>100_bases
AATTCAAGCATAGTTTTTGTAAGGTTATACCAAGGAATAATGTTCACGACGCTAAAATTTCGGGACAATAAACAGAATAA
TTACAATAAAAGGAAGCGGT

Downstream 100 bases:

>100_bases
GAATGAGCAACGAGCCCATGACGCAAAAACTGGCGATTATTATGCGGGGATTACCGGGCAGCGGTAAATCCCATTGGGTC
GAGCAGTTTGTGGCTAATCT

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MYQHIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYARDTELVERFYNSRWEQLHSGTVMPNAAHIALAKLEA
EFPGQLLIVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSRQTFLLREPFGPNNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDSCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNLVTPDRHSQFQYHLTGKAGDLVPKLVDTILAGKVIGSD
IAESDV

Sequences:

>Translated_246_residues
MYQHIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYARDTELVERFYNSRWEQLHSGTVMPNAAHIALAKLEA
EFPGQLLIVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSRQTFLLREPFGPNNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDSCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNLVTPDRHSQFQYHLTGKAGDLVPKLVDTILAGKVIGSD
IAESDV
>Mature_246_residues
MYQHIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYARDTELVERFYNSRWEQLHSGTVMPNAAHIALAKLEA
EFPGQLLIVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSRQTFLLREPFGPNNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDSCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNLVTPDRHSQFQYHLTGKAGDLVPKLVDTILAGKVIGSD
IAESDV

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=233, Percent_Identity=38.1974248927039, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI6912664, Length=254, Percent_Identity=35.0393700787402, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI13787215, Length=242, Percent_Identity=35.1239669421488, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI7657575, Length=246, Percent_Identity=28.0487804878049, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI308199517, Length=235, Percent_Identity=57.4468085106383, Blast_Score=268, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17541892, Length=197, Percent_Identity=32.48730964467, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71990482, Length=242, Percent_Identity=27.6859504132231, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17137536, Length=229, Percent_Identity=28.82096069869, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571445, Length=118, Percent_Identity=35.5932203389831, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27258; Mature: 27258

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYARDTELVERFYNSRWEQ
CCCEEEEEECCCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LHSGTVMPNAAHIALAKLEAEFPGQLLIVTQNIDDLHERAGSRRLLHMHGELSKGRCPRS
HHCCCCCCCHHHEEEEEECCCCCCEEEEEECCHHHHHHCCCCCEEEEECCCCCCCCCCCC
RQTFLLREPFGPNNCCTCCIPAQRLRPHVVWFGEMPLGMDRIHDALDSCDLFIAIGTSGT
CCEEEEECCCCCCCCEEEEECHHHCCCEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCC
VYPAAGFVDTANHHGAQTVEVNLVTPDRHSQFQYHLTGKAGDLVPKLVDTILAGKVIGSD
EEECCCCEECCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
IAESDV
HHCCCC
>Mature Secondary Structure
MYQHIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYARDTELVERFYNSRWEQ
CCCEEEEEECCCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LHSGTVMPNAAHIALAKLEAEFPGQLLIVTQNIDDLHERAGSRRLLHMHGELSKGRCPRS
HHCCCCCCCHHHEEEEEECCCCCCEEEEEECCHHHHHHCCCCCEEEEECCCCCCCCCCCC
RQTFLLREPFGPNNCCTCCIPAQRLRPHVVWFGEMPLGMDRIHDALDSCDLFIAIGTSGT
CCEEEEECCCCCCCCEEEEECHHHCCCEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCC
VYPAAGFVDTANHHGAQTVEVNLVTPDRHSQFQYHLTGKAGDLVPKLVDTILAGKVIGSD
EEECCCCEECCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
IAESDV
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]