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The map label for this gene is yqjI [H]

Identifier: 113969949

GI number: 113969949

Start: 1904570

End: 1906096

Strand: Direct

Name: yqjI [H]

Synonym: Shewmr4_1609

Alternate gene names: 113969949

Gene position: 1904570-1906096 (Clockwise)

Preceding gene: 113969948

Following gene: 113969950

Centisome position: 40.47

GC content: 51.28

Gene sequence:

>1527_bases
ATGCAAAACCACAGCAATCTTAATGACATTGGCGTGATTGGCCTTGGCGTGATGGGCAAAAACCTCGCGCTAAACATTGC
CGACAATCAATATCGCGTCAGTGCCTTCGACCTCGATCCTGTTAAAGTCAACGGTGTTTTACAGCAAGAAAAACAAGAAC
GTGTAGGACAGGATCTGCGAATTACAGGCTGTGCTAATCTTTCAGAAATGTTAGCAAGCCTCGCTCAACCCCGTATTCTC
GTGCTCTCAGTCCCTGCGGGGGCGCCTGTGGATGGGGTATGTCATGCCTTGATTTCTGCCGGTATCGAAGCGGACGACAT
CGTTATCGATACGGGCAACAGTCTTTGGACGGACACCGTTGAACGCGAAAAGCGTTACCAAGGGAAATTTATCTTCTTCA
GCTCGGCGGTTTCGGGCGGGGAAGTGGGTGCTCGTTTTGGCCCTTCATTAATGCCAAGTGGCGATCTTGGAGCTTGGCAG
CATGTGGCGCCGATTTGGAAGGCCATTGCTGCTAAGGTTGATCCTCAAACTGGGCTGCCGATTGAGCGTTTTGAGCCGGG
TAATCCCGTGACCGAAGGTGAGCCTTGCACGACCTATATTGGTCCTGCTGGCGCCGGACATTATGTGAAAATGGTGCATA
ACGGGATTGAATACGCCGATATGCAGCTGATTTGCGAAGCCTATCAGTTAATGCACGATGGCTTAGGCATGAGTGCAGCT
CAAGTGGGTGAGGTGTTTGAACGCTGGAATAAGGGCAGTTTAAACAGCTATCTGATGGGGATCAGCGCCGAGGTGCTCAA
ACAGGCGGATCCGCTAACCGGTCTGCCATTAGTTGAGATGATCCTCGATAAAGCTGGTCAAAAGGGCACTGGCCTTTGGA
CTGCGGTGAGCAGTTTGCAAATTGGTTGTCCGGCTCCCACTATTGCCGAAGCGGTTTATGCGCGCGCGGTGAGCACCCAA
AAATCCCTCCGTGTTGAGCTTAGTAAAAAGCTCGCAGGTCCTGTCTCTGTGGCGATGGATGATGCTCAAAAAGCCGTCTT
AATCGATGCCTTAGAGAGTGCGCTCTATTGCGCTAAAGTGTGTTGCTACGCGCAGGGCTTCCAATTGATGGCGATGACGG
CGCAGGAGCAAAAATGGCAGCTCGATTTTGCTGAAATCGCGAAGATTTGGCGTGCGGGTTGTATTATTCGTGCCACCTTC
TTGCAATCTATCACTCAAGCTTATCAAGCGGATGCGGACTTAAGCTGTTTATTGATGGCCGACACCTTTGCAACTACCTT
GTCGGAAAAACAAACCGAGTGGCGCAGTGCTGTGGCGGCGGCTGTGATGCAAGGGATCCCCGTGCCTTGCATTAGTTCGG
CATTGGCCTATTACGACAGTTATCGCAGCGAGACCCTGCCAGCAAACTTGCTTCAAGGTCAAAGGGACTTTTTCGGTGCC
CACACCTTTGAGCGCTCAGATAAGCCCGCTGGCGAGAAATATCATTTAGATTGGAGTGCCCCAAACAGGGTATTAATCAA
ACTCTAA

Upstream 100 bases:

>100_bases
TGCATCGTCTATTGTCTCTGGTAATTAAGTTACAAAGCCCGATATAATTACACCTCCAAATTGGTTATTTCTAACCTCTG
TGACCCGTGGGAATTATATA

Downstream 100 bases:

>100_bases
ATAAATCGTACAAAGGCCCCTAAATAGGGGCTTTTTTATCGGGTTAATTTATTATGACAACCAATAATTGTATGAACATT
GTTAACTAAATAATGGGTTA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MQNHSNLNDIGVIGLGVMGKNLALNIADNQYRVSAFDLDPVKVNGVLQQEKQERVGQDLRITGCANLSEMLASLAQPRIL
VLSVPAGAPVDGVCHALISAGIEADDIVIDTGNSLWTDTVEREKRYQGKFIFFSSAVSGGEVGARFGPSLMPSGDLGAWQ
HVAPIWKAIAAKVDPQTGLPIERFEPGNPVTEGEPCTTYIGPAGAGHYVKMVHNGIEYADMQLICEAYQLMHDGLGMSAA
QVGEVFERWNKGSLNSYLMGISAEVLKQADPLTGLPLVEMILDKAGQKGTGLWTAVSSLQIGCPAPTIAEAVYARAVSTQ
KSLRVELSKKLAGPVSVAMDDAQKAVLIDALESALYCAKVCCYAQGFQLMAMTAQEQKWQLDFAEIAKIWRAGCIIRATF
LQSITQAYQADADLSCLLMADTFATTLSEKQTEWRSAVAAAVMQGIPVPCISSALAYYDSYRSETLPANLLQGQRDFFGA
HTFERSDKPAGEKYHLDWSAPNRVLIKL

Sequences:

>Translated_508_residues
MQNHSNLNDIGVIGLGVMGKNLALNIADNQYRVSAFDLDPVKVNGVLQQEKQERVGQDLRITGCANLSEMLASLAQPRIL
VLSVPAGAPVDGVCHALISAGIEADDIVIDTGNSLWTDTVEREKRYQGKFIFFSSAVSGGEVGARFGPSLMPSGDLGAWQ
HVAPIWKAIAAKVDPQTGLPIERFEPGNPVTEGEPCTTYIGPAGAGHYVKMVHNGIEYADMQLICEAYQLMHDGLGMSAA
QVGEVFERWNKGSLNSYLMGISAEVLKQADPLTGLPLVEMILDKAGQKGTGLWTAVSSLQIGCPAPTIAEAVYARAVSTQ
KSLRVELSKKLAGPVSVAMDDAQKAVLIDALESALYCAKVCCYAQGFQLMAMTAQEQKWQLDFAEIAKIWRAGCIIRATF
LQSITQAYQADADLSCLLMADTFATTLSEKQTEWRSAVAAAVMQGIPVPCISSALAYYDSYRSETLPANLLQGQRDFFGA
HTFERSDKPAGEKYHLDWSAPNRVLIKL
>Mature_508_residues
MQNHSNLNDIGVIGLGVMGKNLALNIADNQYRVSAFDLDPVKVNGVLQQEKQERVGQDLRITGCANLSEMLASLAQPRIL
VLSVPAGAPVDGVCHALISAGIEADDIVIDTGNSLWTDTVEREKRYQGKFIFFSSAVSGGEVGARFGPSLMPSGDLGAWQ
HVAPIWKAIAAKVDPQTGLPIERFEPGNPVTEGEPCTTYIGPAGAGHYVKMVHNGIEYADMQLICEAYQLMHDGLGMSAA
QVGEVFERWNKGSLNSYLMGISAEVLKQADPLTGLPLVEMILDKAGQKGTGLWTAVSSLQIGCPAPTIAEAVYARAVSTQ
KSLRVELSKKLAGPVSVAMDDAQKAVLIDALESALYCAKVCCYAQGFQLMAMTAQEQKWQLDFAEIAKIWRAGCIIRATF
LQSITQAYQADADLSCLLMADTFATTLSEKQTEWRSAVAAAVMQGIPVPCISSALAYYDSYRSETLPANLLQGQRDFFGA
HTFERSDKPAGEKYHLDWSAPNRVLIKL

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=493, Percent_Identity=44.421906693712, Blast_Score=414, Evalue=1e-115,
Organism=Escherichia coli, GI1788341, Length=490, Percent_Identity=44.2857142857143, Blast_Score=404, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17542558, Length=493, Percent_Identity=46.0446247464503, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321695, Length=502, Percent_Identity=45.2191235059761, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321977, Length=498, Percent_Identity=43.574297188755, Blast_Score=412, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24639279, Length=492, Percent_Identity=44.9186991869919, Blast_Score=395, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 54840; Mature: 54840

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNHSNLNDIGVIGLGVMGKNLALNIADNQYRVSAFDLDPVKVNGVLQQEKQERVGQDLR
CCCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCCCEEECHHHHHHHHHHCCCCEE
ITGCANLSEMLASLAQPRILVLSVPAGAPVDGVCHALISAGIEADDIVIDTGNSLWTDTV
EECCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
EREKRYQGKFIFFSSAVSGGEVGARFGPSLMPSGDLGAWQHVAPIWKAIAAKVDPQTGLP
HHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
IERFEPGNPVTEGEPCTTYIGPAGAGHYVKMVHNGIEYADMQLICEAYQLMHDGLGMSAA
HHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHH
QVGEVFERWNKGSLNSYLMGISAEVLKQADPLTGLPLVEMILDKAGQKGTGLWTAVSSLQ
HHHHHHHHCCCCCHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCC
IGCPAPTIAEAVYARAVSTQKSLRVELSKKLAGPVSVAMDDAQKAVLIDALESALYCAKV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHH
CCYAQGFQLMAMTAQEQKWQLDFAEIAKIWRAGCIIRATFLQSITQAYQADADLSCLLMA
HHHHCCCEEEEEEHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEH
DTFATTLSEKQTEWRSAVAAAVMQGIPVPCISSALAYYDSYRSETLPANLLQGQRDFFGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHCC
HTFERSDKPAGEKYHLDWSAPNRVLIKL
CCCCCCCCCCCCEEEEECCCCCEEEEEC
>Mature Secondary Structure
MQNHSNLNDIGVIGLGVMGKNLALNIADNQYRVSAFDLDPVKVNGVLQQEKQERVGQDLR
CCCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCCCEEECHHHHHHHHHHCCCCEE
ITGCANLSEMLASLAQPRILVLSVPAGAPVDGVCHALISAGIEADDIVIDTGNSLWTDTV
EECCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
EREKRYQGKFIFFSSAVSGGEVGARFGPSLMPSGDLGAWQHVAPIWKAIAAKVDPQTGLP
HHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
IERFEPGNPVTEGEPCTTYIGPAGAGHYVKMVHNGIEYADMQLICEAYQLMHDGLGMSAA
HHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHH
QVGEVFERWNKGSLNSYLMGISAEVLKQADPLTGLPLVEMILDKAGQKGTGLWTAVSSLQ
HHHHHHHHCCCCCHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCC
IGCPAPTIAEAVYARAVSTQKSLRVELSKKLAGPVSVAMDDAQKAVLIDALESALYCAKV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHH
CCYAQGFQLMAMTAQEQKWQLDFAEIAKIWRAGCIIRATFLQSITQAYQADADLSCLLMA
HHHHCCCEEEEEEHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEH
DTFATTLSEKQTEWRSAVAAAVMQGIPVPCISSALAYYDSYRSETLPANLLQGQRDFFGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHCC
HTFERSDKPAGEKYHLDWSAPNRVLIKL
CCCCCCCCCCCCEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]