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The map label for this gene is lepB [H]

Identifier: 113969823

GI number: 113969823

Start: 1736645

End: 1737307

Strand: Direct

Name: lepB [H]

Synonym: Shewmr4_1481

Alternate gene names: 113969823

Gene position: 1736645-1737307 (Clockwise)

Preceding gene: 113969822

Following gene: 113969827

Centisome position: 36.9

GC content: 47.21

Gene sequence:

>663_bases
ATGTTTAAAAAACATAGAACATTACTTAGAGATAATCGCTCCATTTTATTGTTTATCAGCCTAATGCTGGTATTCAGGAG
CGCGGTAGCTGATTGGAATACAGTGCCGACAGGTTCTATGTTGCCGACGATTGTCGAGGGCGACCGCATTCTGGTGAATA
AGATGGCTTACGATATCAGAGTGCCATTTACCCATATCCCACTCGTTAAACTTGCGGACCCTACACGTGGGGATATTATC
GTGTTCGACTCTAAAAAAGCCGATAAAAAGCTGATTAAACGGGTGATCGCCGTACCCGGTGATACTGTGATGATGCGGGA
TAATCGCTTGTATTTAAATGACAAACCACTCGCATATACACAGCAAACATTAAGTGCCTATGCGCCGGCGAATGTCACCG
AGTGGCAGGAGGATCTACTCGGCATAGCGCACAGTATTCGCCTCAATCCGCAGCCTTCGCAGCTGGCTAATTTTGGCCCA
GTTACGGTTCCTGATAACCAGTATTTGGCGCTAGGGGACAATCGAGATAACAGTGCCGATTCAAGAGTCATAGGTTTTGT
GCCAAGAGAGGAGATTGTTGGCCGCTCAAGCTCCGTAGTCTTCTCATTGGATTACAACGATTATTACATGCCGCGGCCTG
AGCGCATGATGCGCGCGTTCTAA

Upstream 100 bases:

>100_bases
TATTTAACGAGCAAGCGTTGCTTACGTCAGGCAATTGATAGCTTCGCATTGTCATCAAACGAGAAGATTGCTGGATTTTG
GCCTCAGGGAGATAAACAGA

Downstream 100 bases:

>100_bases
CTTGTCCTTAGATTTCACTCTTCACGAGATATAAAAATGGCGCCCTTATCGGCGCCATTTTTGTTTGATGATAAAGCGTT
GCACTCTTACATCAAAAAGC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MFKKHRTLLRDNRSILLFISLMLVFRSAVADWNTVPTGSMLPTIVEGDRILVNKMAYDIRVPFTHIPLVKLADPTRGDII
VFDSKKADKKLIKRVIAVPGDTVMMRDNRLYLNDKPLAYTQQTLSAYAPANVTEWQEDLLGIAHSIRLNPQPSQLANFGP
VTVPDNQYLALGDNRDNSADSRVIGFVPREEIVGRSSSVVFSLDYNDYYMPRPERMMRAF

Sequences:

>Translated_220_residues
MFKKHRTLLRDNRSILLFISLMLVFRSAVADWNTVPTGSMLPTIVEGDRILVNKMAYDIRVPFTHIPLVKLADPTRGDII
VFDSKKADKKLIKRVIAVPGDTVMMRDNRLYLNDKPLAYTQQTLSAYAPANVTEWQEDLLGIAHSIRLNPQPSQLANFGP
VTVPDNQYLALGDNRDNSADSRVIGFVPREEIVGRSSSVVFSLDYNDYYMPRPERMMRAF
>Mature_220_residues
MFKKHRTLLRDNRSILLFISLMLVFRSAVADWNTVPTGSMLPTIVEGDRILVNKMAYDIRVPFTHIPLVKLADPTRGDII
VFDSKKADKKLIKRVIAVPGDTVMMRDNRLYLNDKPLAYTQQTLSAYAPANVTEWQEDLLGIAHSIRLNPQPSQLANFGP
VTVPDNQYLALGDNRDNSADSRVIGFVPREEIVGRSSSVVFSLDYNDYYMPRPERMMRAF

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=263, Percent_Identity=33.0798479087452, Blast_Score=111, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25015; Mature: 25015

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKHRTLLRDNRSILLFISLMLVFRSAVADWNTVPTGSMLPTIVEGDRILVNKMAYDIR
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEEEE
VPFTHIPLVKLADPTRGDIIVFDSKKADKKLIKRVIAVPGDTVMMRDNRLYLNDKPLAYT
CCCCCCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCEEEECCCCCHHH
QQTLSAYAPANVTEWQEDLLGIAHSIRLNPQPSQLANFGPVTVPDNQYLALGDNRDNSAD
HHHHHHCCCCCHHHHHHHHHHHHHHEECCCCHHHHHCCCCEECCCCCEEEECCCCCCCCC
SRVIGFVPREEIVGRSSSVVFSLDYNDYYMPRPERMMRAF
CEEEECCCHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCC
>Mature Secondary Structure
MFKKHRTLLRDNRSILLFISLMLVFRSAVADWNTVPTGSMLPTIVEGDRILVNKMAYDIR
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEEEE
VPFTHIPLVKLADPTRGDIIVFDSKKADKKLIKRVIAVPGDTVMMRDNRLYLNDKPLAYT
CCCCCCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCEEEECCCCCHHH
QQTLSAYAPANVTEWQEDLLGIAHSIRLNPQPSQLANFGPVTVPDNQYLALGDNRDNSAD
HHHHHHCCCCCHHHHHHHHHHHHHHEECCCCHHHHHCCCCEECCCCCEEEECCCCCCCCC
SRVIGFVPREEIVGRSSSVVFSLDYNDYYMPRPERMMRAF
CEEEECCCHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]