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The map label for this gene is guaB [H]

Identifier: 113969578

GI number: 113969578

Start: 1435422

End: 1436888

Strand: Direct

Name: guaB [H]

Synonym: Shewmr4_1234

Alternate gene names: 113969578

Gene position: 1435422-1436888 (Clockwise)

Preceding gene: 113969576

Following gene: 113969579

Centisome position: 30.5

GC content: 49.9

Gene sequence:

>1467_bases
ATGCTACGTTTAATTAAAGAAGCGCTAACCTTTGACGATGTGTTACTTGTTCCTGCGCATTCGACTGTACTCCCAAACAC
CGCCATCCTTAAAACTCGCCTGACTAACACCATTGAACTGAATATTCCGCTTGTGTCTGCCGCTATGGACACTGTGACCG
AAGCGCGTCTTGCTATTGCCATGGCACAGGAAGGTGGCTTAGGTTTTATTCATAAAAACATGAGCATAGAAAAGCAGGCC
GAAGAAGTTCGTAAAGTAAAAATTTACGAAGCGGGTGTGGTGCAACAACCTGTAACGGTAACGCCTTCAACTACGCTGGC
GGATCTTAAAGTACTGACCGCGAAGAATGGTTTTGCGGGTTACCCTGTGGTAAACGAAGCCAATGAATTGGTCGGTATCA
TCACTGGCCGTGACGTTCGTTTCGTGACTGACTGGAGCAAAACCGTAGAAGAAGTGATGACGCCAAAAGCGCGTTTAGTC
ACTGTTGCGGAAGGCACTAAGTTAGATGAAGTGCAAAAATTAATGCACTCAAACCGTATCGAAAAAGTGTTAGTTGTCGA
CGATAACTTCAAGCTGAAAGGCTTAATCACTGTAAAAGACTTCGAAAAAGCTGAGCGTAAACCTAATGCTTGTAAAGACG
AATTAGGTCGTTTACGTGTGGGCGCCGCCGTAGGTGCCGGTGCGGGTAACGAAGAGCGTGTCGATGCGCTGGTGAAAGCC
GGTGTTGACGTGCTGCTGATCGATTCTTCCCACGGCCACTCTGAAGGCGTGTTGCAACGTATCCGTGAAACCCGCGCTAA
ATACCCAGATTTACAAATCATCGGTGGTAACGTGGCAACAGCTGAAGGCGCATTAGCCCTAGTTGAAGCCGGCGTTAACG
CGGTTAAAGTGGGTATTGGCCCTGGTTCTATTTGTACCACACGTATCGTGACGGGTGTGGGCGTGCCACAAATTACCGCG
GTGTCTGACGCTGCCGAAGCTGTAAAAGGTTTAGGGATCCCAGTTATCGCCGACGGCGGTGTACGTTTCTCCGGTGACTT
AGCCAAAGCCTTAGCCGCAGGTGCATCATGCATCATGGCGGGTTCAATGTTCGCGGGTACCGACGAAGCGCCGGGCGAAA
CCGAACTCTACCAAGGCCGTGCCTATAAGTCATACCGCGGTATGGGTTCTTTAGGCGCCATGTCTCAAGGTTCTTCTGAC
CGTTATTTCCAATCTGACAATGCTGCCGACAAGCTAGTGCCGGAAGGCATCGAAGGTCGTGTACCTTACAAAGGCAAGCT
TAAGGAAATCATTCATCAACATATGGGCGGTCTGCGCTCATGCATGGGTTTAACAGGCTGTGCCACGATCCAAGAACTGA
ACGAAAAAGCGCAGTTTGTGAAAGTGACGTCTGCGGGCATGGGCGAGTCCCACGTTCACGATGTGACCATCACTAAAGAA
GCGCCAAACTACCGTTCAGGTGCGTAA

Upstream 100 bases:

>100_bases
TTTTTTCACTATTTTCCATTTACCGCTCCCCAGATGCAAGGTATAATCCCGCCGCAATATTTCACCTCTAAAATCCTACT
CAACTGGGGAGATGTTGCCT

Downstream 100 bases:

>100_bases
ACGTTTGTGATAATGGGGCGGCGATAAGCCGCCCCGTTATTAAGATTTGTATGCCCTCAAGATTGAACCTCGTAGTCTTG
AGCTAAGTTAAAACAATAGA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTAKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLV
TVAEGTKLDEVQKLMHSNRIEKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATIQELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGA

Sequences:

>Translated_488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTAKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLV
TVAEGTKLDEVQKLMHSNRIEKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATIQELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGA
>Mature_488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTAKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLV
TVAEGTKLDEVQKLMHSNRIEKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATIQELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGA

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.2489626556017, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=41.3716814159292, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=41.3716814159292, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=41.3716814159292, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=41.3716814159292, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=41.4798206278027, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=40.2654867256637, Blast_Score=316, Evalue=4e-86,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=37.8318584070796, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=38.2113821138211, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=36.8421052631579, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=36.8421052631579, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=36.8421052631579, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=36.8421052631579, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=80.327868852459, Blast_Score=745, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=36.1990950226244, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=36.4210526315789, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=38.6255924170616, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=36.9747899159664, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=40.1656314699793, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=39.5061728395062, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=482, Percent_Identity=40.2489626556017, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=41.2280701754386, Blast_Score=256, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=39.344262295082, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.1304347826087, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.1304347826087, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.6825396825397, Blast_Score=288, Evalue=5e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51672; Mature: 51672

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIA
CHHHHHHHCCCCCEEEEECCCCCCCCHHEEHEECCCEEEEECCHHHHHHHHHHHHHHEEE
MAQEGGLGFIHKNMSIEKQAEEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTAKNGFAG
EECCCCEEEEECCCCHHHHHHHHHHEEEEECCCCCCCEEECCCCCHHHEEEEEECCCCCC
YPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLVTVAEGTKLDEVQKLMHSNRI
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCC
EKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
CEEEEECCCEEEEEEEEECCHHHHHCCCCHHHHHHCCEEECEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
CCEECCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
VPYKGKLKEIIHQHMGGLRSCMGLTGCATIQELNEKAQFVKVTSAGMGESHVHDVTITKE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEEEC
APNYRSGA
CCCCCCCC
>Mature Secondary Structure
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIA
CHHHHHHHCCCCCEEEEECCCCCCCCHHEEHEECCCEEEEECCHHHHHHHHHHHHHHEEE
MAQEGGLGFIHKNMSIEKQAEEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTAKNGFAG
EECCCCEEEEECCCCHHHHHHHHHHEEEEECCCCCCCEEECCCCCHHHEEEEEECCCCCC
YPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLVTVAEGTKLDEVQKLMHSNRI
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCC
EKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
CEEEEECCCEEEEEEEEECCHHHHHCCCCHHHHHHCCEEECEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
CCEECCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
VPYKGKLKEIIHQHMGGLRSCMGLTGCATIQELNEKAQFVKVTSAGMGESHVHDVTITKE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEEEC
APNYRSGA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]