Click here to switch to the map view.

The map label for this gene is hemH2 [H]

Identifier: 113969541

GI number: 113969541

Start: 1399974

End: 1400957

Strand: Direct

Name: hemH2 [H]

Synonym: Shewmr4_1197

Alternate gene names: 113969541

Gene position: 1399974-1400957 (Clockwise)

Preceding gene: 113969540

Following gene: 113969546

Centisome position: 29.75

GC content: 49.19

Gene sequence:

>984_bases
ATGGGTCACGCAAAGCGTGGCAAAGTGGGTGTGTTGTTACTTAACCTTGGCACACCCGATGCGCCAACAGCATCGGCGGT
GAGGCGTTACCTTTCCGAGTTTTTATCCGATCCTCGGGTGGTCGAAATTCCAAAACTCCTGTGGATGCTGATTTTACATG
GCATAGTGCTGCGCGTTCGCCCTGCCAAGTCTGCGGCGCTCTATCAGAAGGTCTGGACTGAAGCGGGTTCACCACTGATG
GATATCAGCTTGCGCCAAACCGCTAAGTTATCAGAAAAATTAACGGCCGATGGGCATCAAGTATCAGTACATTTAGCCAT
GCGTTATGGCAATCCTTCTGTGGCGAGCACCTTACAAACGATGCATCAACAGGGGATTGATAAGCTGGTGGTGTTACCGC
TCTATCCGCAATATGCAGCGCCGACAACCGGCTCGGCCTTCGATGCTATTGCAAGGGAATTAACCCAGTGGCGCTATCTA
CCATCGCTGCATTTTATTCACACGTATCATGATAACCCCGACTTTATTACCGCATTGGTGAACTCAATTCGTGCCGACTT
TGAGCAACAGGGTAAGCCGCAAAAGTTAGTGCTTTCTTACCATGGTATGCCGGAGCGTAATCTGCACTTAGGCGATCCTT
ATTATTGCTTTTGCATGAAGACCACCCGTCTGGTGGCCGAGCAATTAGGGCTTACAGCGGATGAGTTTGTGATGACTTTC
CAATCTCGCTTTGGTAAGGCTAAATGGTTACAACCTTATACGGATGCAACCATGCAGGCGTTACCAAGCGAAGGTGTACG
TGACGTGGCGATTGTGTGCCCAGCGTTTAGTGCAGATTGCTTAGAGACCTTAGAAGAGATCGTGGGTGAGAATGGCCATA
TCTTTGCTAATGCTGGCGGGGAGAAGTTCCGTTACATTCCGGCACTGAACGATAATGATGACCATATCAGCATGATGGCT
AACTTGGTTAAACCTTACCTGTAA

Upstream 100 bases:

>100_bases
GCTTAAGCAGGCAATAGAATCAGTGCTTTAATGCCCAATTTATTCATTTTACTCATGTTAAGAGGCTACTTTGGCTAGGT
TTTCAGGATTATCAAAAGAG

Downstream 100 bases:

>100_bases
GGTTTATAAGTGCAGAAATAAAAAAGGATAGCTTAGGCTATCCTTTTGTTTTTATGATTTATTATTCACCGAAATGATTT
TCAAAATAGCTTTCGACAAT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MGHAKRGKVGVLLLNLGTPDAPTASAVRRYLSEFLSDPRVVEIPKLLWMLILHGIVLRVRPAKSAALYQKVWTEAGSPLM
DISLRQTAKLSEKLTADGHQVSVHLAMRYGNPSVASTLQTMHQQGIDKLVVLPLYPQYAAPTTGSAFDAIARELTQWRYL
PSLHFIHTYHDNPDFITALVNSIRADFEQQGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVAEQLGLTADEFVMTF
QSRFGKAKWLQPYTDATMQALPSEGVRDVAIVCPAFSADCLETLEEIVGENGHIFANAGGEKFRYIPALNDNDDHISMMA
NLVKPYL

Sequences:

>Translated_327_residues
MGHAKRGKVGVLLLNLGTPDAPTASAVRRYLSEFLSDPRVVEIPKLLWMLILHGIVLRVRPAKSAALYQKVWTEAGSPLM
DISLRQTAKLSEKLTADGHQVSVHLAMRYGNPSVASTLQTMHQQGIDKLVVLPLYPQYAAPTTGSAFDAIARELTQWRYL
PSLHFIHTYHDNPDFITALVNSIRADFEQQGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVAEQLGLTADEFVMTF
QSRFGKAKWLQPYTDATMQALPSEGVRDVAIVCPAFSADCLETLEEIVGENGHIFANAGGEKFRYIPALNDNDDHISMMA
NLVKPYL
>Mature_326_residues
GHAKRGKVGVLLLNLGTPDAPTASAVRRYLSEFLSDPRVVEIPKLLWMLILHGIVLRVRPAKSAALYQKVWTEAGSPLMD
ISLRQTAKLSEKLTADGHQVSVHLAMRYGNPSVASTLQTMHQQGIDKLVVLPLYPQYAAPTTGSAFDAIARELTQWRYLP
SLHFIHTYHDNPDFITALVNSIRADFEQQGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVAEQLGLTADEFVMTFQ
SRFGKAKWLQPYTDATMQALPSEGVRDVAIVCPAFSADCLETLEEIVGENGHIFANAGGEKFRYIPALNDNDDHISMMAN
LVKPYL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=335, Percent_Identity=25.6716417910448, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI60499025, Length=333, Percent_Identity=25.8258258258258, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=49.0683229813665, Blast_Score=319, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324750, Length=332, Percent_Identity=25, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17864156, Length=342, Percent_Identity=25.7309941520468, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24651774, Length=273, Percent_Identity=25.2747252747253, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36484; Mature: 36352

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHAKRGKVGVLLLNLGTPDAPTASAVRRYLSEFLSDPRVVEIPKLLWMLILHGIVLRVR
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHEEEC
PAKSAALYQKVWTEAGSPLMDISLRQTAKLSEKLTADGHQVSVHLAMRYGNPSVASTLQT
CCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHH
MHQQGIDKLVVLPLYPQYAAPTTGSAFDAIARELTQWRYLPSLHFIHTYHDNPDFITALV
HHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
NSIRADFEQQGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVAEQLGLTADEFVMTF
HHHHHHHHHCCCCCEEEEEECCCCCCCEECCCCEEEEEHHHHHHHHHHHCCCHHHHHHHH
QSRFGKAKWLQPYTDATMQALPSEGVRDVAIVCPAFSADCLETLEEIVGENGHIFANAGG
HHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCC
EKFRYIPALNDNDDHISMMANLVKPYL
CEEEEECCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
GHAKRGKVGVLLLNLGTPDAPTASAVRRYLSEFLSDPRVVEIPKLLWMLILHGIVLRVR
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHEEEC
PAKSAALYQKVWTEAGSPLMDISLRQTAKLSEKLTADGHQVSVHLAMRYGNPSVASTLQT
CCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHH
MHQQGIDKLVVLPLYPQYAAPTTGSAFDAIARELTQWRYLPSLHFIHTYHDNPDFITALV
HHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
NSIRADFEQQGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVAEQLGLTADEFVMTF
HHHHHHHHHCCCCCEEEEEECCCCCCCEECCCCEEEEEHHHHHHHHHHHCCCHHHHHHHH
QSRFGKAKWLQPYTDATMQALPSEGVRDVAIVCPAFSADCLETLEEIVGENGHIFANAGG
HHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCC
EKFRYIPALNDNDDHISMMANLVKPYL
CEEEEECCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]