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The map label for this gene is ribD [H]

Identifier: 113969440

GI number: 113969440

Start: 1287676

End: 1288821

Strand: Direct

Name: ribD [H]

Synonym: Shewmr4_1096

Alternate gene names: 113969440

Gene position: 1287676-1288821 (Clockwise)

Preceding gene: 113969439

Following gene: 113969441

Centisome position: 27.36

GC content: 52.01

Gene sequence:

>1146_bases
ATGAATTGGTCAGAACTCGATAACCAGATGATGAGCCGAGCCATACAACTGGCTCGCAAAGGATTTTATACCACTCGCCC
CAATCCCAGTGTGGGCTGCGTTATCGTAAAAGATAATCAGATTGTCGGTGAGGGTTATCATCAAAAAGCTGGCGAGCCAC
ATGCTGAGGTGCATGCACTGCGGATGGCTGGCGAGCTTGCCCGTGGCGCGACCGCCTATGTCACCTTAGAACCTTGCAGC
CATTATGGCCGCACACCGCCGTGTGCCTTGGCACTGATTAATATTGGTGTAAAACGAGTCGTGGTGGCGGTTGAAGATCC
CAATCCGCAGGTCGGTGGTCGCGGTATTCAAATGCTGCGCGATGCGGGCATTCAAGTGGATGTCGGTTTGCACCGCGACG
AAGCTTACGCTTTAAATCTTGGTTTTATGAAGCGCATGGAATCAGGCCTACCTTGGGTGACGGTAAAGCTTGCCGCGAGC
CTAGATGGTAAAACCGCGTTATCAAACGGTGTGTCCAAATGGATCACAGGCCCCGAAGCTCGCCGCGATGTGCAGCGCTT
ACGTTTACGCGCCTGCGCGCTAGTGACGGGGATTGACACTGTGCTGGCCGATGACCCTTCGCTTAATGTGCGTTACTCAG
AGCTTGGCAGTCTTAGCTCACAATTGAGTGAAGCGCAGATTTTACAACCGCTGCGGGTGATATTAGACAGTCGTTGCCGG
ATGCCGATTACGGCAGCCTTGCTTGCGATTGAATCGCCGATGTTATTAGTCTCAACTGAGCCTTACTCGCCAGCCTTTAT
GGCGCAGTTGCCCGCCCATGTGACTTGTCTTCAATTACCGGCGATTGATGGTCGAATCTCGCTGCCTGCACTCTTAAGCT
ATTTAGGCAAAAGCTGTAATCAGGTGCTTATCGAAGCGGGCGCGACCTTAGCCGGCGCCTTTATCGGTGACGGATTAGCC
GATGAATTAGTGTTGTATCAAGCGATGAAAATCCTTGGCGCACAGGGACGTAATCTACTCGAATTACCCGATTATCAAAT
GATGGCCGATATTCCGACCCTCAAACTGGTCGATGAGCGTAAAGTGGGCGCGGATACGCGTTTCACCTTGAGGCTTACAT
CCAATCCATCTTTAGCGAATAAGTGA

Upstream 100 bases:

>100_bases
ACTGCAAAAGTAATGTGGGTTATCTTAAGTTAGTGCTTAGGTTAGCGCCTCGTTATGCGCCGCATTCGGGCACGCTTCCT
CAAGATTTCATAGGGTTTAT

Downstream 100 bases:

>100_bases
GTTAACCATGTTTACTGGGATTATTGAGGCCGTTGGCACGCTGCGAAAGCTTGAACGTAAAGGCGATGATATTCGTTTGA
CGGTCGCCAGTGGCAAACTG

Product: diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHALRMAGELARGATAYVTLEPCS
HYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLRDAGIQVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAAS
LDGKTALSNGVSKWITGPEARRDVQRLRLRACALVTGIDTVLADDPSLNVRYSELGSLSSQLSEAQILQPLRVILDSRCR
MPITAALLAIESPMLLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCNQVLIEAGATLAGAFIGDGLA
DELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDERKVGADTRFTLRLTSNPSLANK

Sequences:

>Translated_381_residues
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHALRMAGELARGATAYVTLEPCS
HYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLRDAGIQVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAAS
LDGKTALSNGVSKWITGPEARRDVQRLRLRACALVTGIDTVLADDPSLNVRYSELGSLSSQLSEAQILQPLRVILDSRCR
MPITAALLAIESPMLLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCNQVLIEAGATLAGAFIGDGLA
DELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDERKVGADTRFTLRLTSNPSLANK
>Mature_381_residues
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHALRMAGELARGATAYVTLEPCS
HYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLRDAGIQVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAAS
LDGKTALSNGVSKWITGPEARRDVQRLRLRACALVTGIDTVLADDPSLNVRYSELGSLSSQLSEAQILQPLRVILDSRCR
MPITAALLAIESPMLLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCNQVLIEAGATLAGAFIGDGLA
DELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDERKVGADTRFTLRLTSNPSLANK

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=361, Percent_Identity=52.3545706371191, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI145693172, Length=152, Percent_Identity=33.5526315789474, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 41220; Mature: 41220

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHAL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEECCCCHHCCCCCHHHHHHH
RMAGELARGATAYVTLEPCSHYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLR
HHHHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHH
DAGIQVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAASLDGKTALSNGVSKWITGPEA
HCCCEEEEECCCCCEEEECHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCHHHHCCCHHH
RRDVQRLRLRACALVTGIDTVLADDPSLNVRYSELGSLSSQLSEAQILQPLRVILDSRCR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
MPITAALLAIESPMLLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCN
CCHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
QVLIEAGATLAGAFIGDGLADELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDER
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEECCC
KVGADTRFTLRLTSNPSLANK
CCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHAL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEECCCCHHCCCCCHHHHHHH
RMAGELARGATAYVTLEPCSHYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLR
HHHHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHH
DAGIQVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAASLDGKTALSNGVSKWITGPEA
HCCCEEEEECCCCCEEEECHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCHHHHCCCHHH
RRDVQRLRLRACALVTGIDTVLADDPSLNVRYSELGSLSSQLSEAQILQPLRVILDSRCR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
MPITAALLAIESPMLLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCN
CCHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
QVLIEAGATLAGAFIGDGLADELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDER
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEECCC
KVGADTRFTLRLTSNPSLANK
CCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]