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The map label for this gene is deoA [H]

Identifier: 113969382

GI number: 113969382

Start: 1211341

End: 1212672

Strand: Direct

Name: deoA [H]

Synonym: Shewmr4_1038

Alternate gene names: 113969382

Gene position: 1211341-1212672 (Clockwise)

Preceding gene: 113969381

Following gene: 113969383

Centisome position: 25.74

GC content: 50.0

Gene sequence:

>1332_bases
ATGTTTCTAGCTCAGGAAATTATACGTAAGAAACGCAATGGGTTAGCCTTAAGCGCCGAAGAGATCCAGTTCTTCGTTAA
GGGTATAACCACTAATGCAGTGTCGGAAGGTCAGATCGCCGCATTAGGCATGGCTGTGTATTTTAATGACATGAATATGG
ATGAAAGAATCGCTTTGACCACGGCAATGCGCGATTCTGGCACTGTACTCAATTGGCAATCACTTGGTCTTAATGGCCCA
GTCATCGATAAACACAGTACTGGTGGTGTCGGTGATGTGATTAGTCTCATGCTCGGCCCCATGGCTGCGGCTTGCGGTGG
TTATGTGCCGATGATTTCGGGTCGCGGACTCGGACACACAGGCGGTACGCTCGATAAGTTCGACGCTATTCCCGGTTATC
AAACCGAACCTTCGAGTGAATTGTTCCGCAAAGTAGTTAAAGACGTTGGTGTGGCGATTATCGGCCAAACTGGCGATCTG
GTTCCCGCCGATAAACGTTTTTATTCCATCCGTGACAACACTGCGACCGTTGAATCCATCTCCCTCATTACCGCCTCTAT
TCTCTCTAAGAAATTAGCTTGTAGTCTCGATGCATTGGCGATGGACGTCAAAGTCGGTAGCGGCGCATTTATGCCAACCT
ACGAAGCCTCTGAAGAGCTTGCACGCAGTATTGCGGCGGTAGCTAATGGCGCAGGCACTAAAACGACGGCCTTACTCACC
GACATGAACCAAGTATTGGCCTCATGTGCGGGTAATGCGGTTGAAGTGAAAGAAGCCATCGACTTCCTAACTGGTGCTTA
TCGTAATCCTCGTCTGTACGCTGTGACTATGGGGCTTTGTGCCGAGATGTTACTCCTAGGCGGCCTCGCCACCGATGAAG
CGGATGCCCGTGCCAAGTTAAATCGAGTATTAGATAACGGCCGCGCTGCCGAGATCTTTGGCAAGATGGTTTCAGGCCTC
GGTGGCCCAGTCGATTTTGTTGAAAATTACAGTAAGTACTTACCGCAATCGCAAATTATTCGCCCTGTCTTTGCGGATAC
CCAAGGTTATGCCCACAGCATGGACACCCGTGAACTCGGTTTAGCCGTGGTTACCTTAGGTGGTGGTCGTCGCAAGCCTG
GTGATGCACTCGACTACAGTGTTGGTCTGACGCAAGTCTGTGCCCTTGGCGATAAGATTGATGCTTCAACGCCGATTGCC
GTGATCCACGCGCAATCTGAAGATGCCTTTGCTCAGGCGGAAGAAGCCGTGAAAAAAGCGATTCGTATTGATGAAGTCGC
TCCAGAAAAAACACCTGAGATCTATGCTTATATCCGAGCAGCGGATCTTTAA

Upstream 100 bases:

>100_bases
TTCGATAGCATGTAATTGTAATATTGCTACAGTTTTGATGTTTCATTGCAAAGCTAAATAACGGATATGTTGTATTAGTA
TTTAGCTTGGAGGCAGTATC

Downstream 100 bases:

>100_bases
GGAAGAATTATGAAACGTACAGTTATAATGATGTTGGATTCCTTTGGCGTGGGCGCCGCTGGCGATGCCGCCAAGTTTGG
GGATCTAGGTTCTGATACTT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MFLAQEIIRKKRNGLALSAEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLATDEADARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADTQGYAHSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIA
VIHAQSEDAFAQAEEAVKKAIRIDEVAPEKTPEIYAYIRAADL

Sequences:

>Translated_443_residues
MFLAQEIIRKKRNGLALSAEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLATDEADARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADTQGYAHSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIA
VIHAQSEDAFAQAEEAVKKAIRIDEVAPEKTPEIYAYIRAADL
>Mature_443_residues
MFLAQEIIRKKRNGLALSAEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLATDEADARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADTQGYAHSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIA
VIHAQSEDAFAQAEEAVKKAIRIDEVAPEKTPEIYAYIRAADL

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=443, Percent_Identity=37.2460496613996, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI4503445, Length=443, Percent_Identity=37.2460496613996, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI166158922, Length=443, Percent_Identity=37.2460496613996, Blast_Score=261, Evalue=1e-69,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=67.8082191780822, Blast_Score=614, Evalue=1e-177,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 46834; Mature: 46834

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRNGLALSAEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALT
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLATDEADARAKL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHH
NRVLDNGRAAEIFGKMVSGLGGPVDFVENYSKYLPQSQIIRPVFADTQGYAHSMDTRELG
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHC
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIAVIHAQSEDAFAQAEEAVKKA
EEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
IRIDEVAPEKTPEIYAYIRAADL
HHHHHCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MFLAQEIIRKKRNGLALSAEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALT
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLATDEADARAKL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHH
NRVLDNGRAAEIFGKMVSGLGGPVDFVENYSKYLPQSQIIRPVFADTQGYAHSMDTRELG
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHC
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIAVIHAQSEDAFAQAEEAVKKA
EEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
IRIDEVAPEKTPEIYAYIRAADL
HHHHHCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA