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The map label for this gene is pepA [H]

Identifier: 113969293

GI number: 113969293

Start: 1107989

End: 1109527

Strand: Direct

Name: pepA [H]

Synonym: Shewmr4_0949

Alternate gene names: 113969293

Gene position: 1107989-1109527 (Clockwise)

Preceding gene: 113969291

Following gene: 113969294

Centisome position: 23.54

GC content: 51.53

Gene sequence:

>1539_bases
ATGTTTCAAGTTAACTTTGTTGATGTACAAGCAGAAAATGCCATTTTTGATGGTGAAGGTTGGGATGCGGTTGTGGTCGT
CACACCGGATCTTGGTGCAATTGGAATTGATGAGATCAGTTTATTGGCTGAGCATGGCGCTAAGGTCGATAAGCGTGTCG
GTAAGAGCCCGACGTTGCTGTTTGCCCCCGGTTTAGCCGGTGGCCGTTTAATCATAGCGCCGGTTACTCAAGTGACTGAT
GATTATGCCGATGTGCGTGTATTTGGCGATGCGGCAAGAGCTGCTATTGCTATTGCTAAAGACGCGGGCGCTAAGCGTCC
CCTGCTTTATGTGGTGCCTTCTACCATGCCCAAGTTTGGTTTTGCGACTGAAGTTGCGGCGCTCGCCTGCGGCCAAGAAT
TATGGCAAACCTTAGAATTACGTGAGGCAACGGGCTTAACGCCAGCCTTTGAAGCCATAGGATTGCTGTCTCTATCATCT
AAAAAGAGTCAATTGCTCAACGCATTAGAAGCTGGTCGTGTGTTGGCAAGGGATTTATGTGGCACTGAACCTGAGCGTAT
GTCGGCAAAGGCCTTTGCCGAATATTGTTTGCAAGCGTTTAAAGGCAGTGTGATTAAAACGGCAGTGGTGGAAGATAGGG
ATATTCTCGAGCGTGATTATCCGCTGTTAAGTGCGGTGGCGCGTTCTTCCTTTGCCGTTGGGCGGCATCAACCGCGGGTG
GTGAAACTCGAATATCTGCCCGAAGGTGAGGTTACTCGTACCTTCTTATTTGCAGGTAAAGGTGTGGTCTACGATACGGG
CGGCGCCGATCTGAAAGTGGGCGGCGCAATGGCGGGCATGAGCCGCGATAAAGGCGGCGCTTCTGCCGTGGCGGGGTTAT
TTAAAACCTTATCTATGCTTAAGCCTAAAGGGATCCGGGTGATCGCCGAACTGGGCTTAGTGCGTAATAGCATTGGCAGC
GAAGCCTTTGTTACCGATGAAATTATCACTAGCCATGCGGGCGTGCGGGTGCGAATTGGTAATACGGATGCGGAAGGGCG
CTTAGTATTGGCTGACCTGTTAAGTCATTTGCGTATTAAAGCGGTTTCGGCGGTGCAACCAGAGTTGTTCTCGGTCGCGA
CTCTCACGGGCCATGTAGTACGTTGTTATGGGGCGTATCCAGCAGCGGTTGAAAATGCGGTCGCCAGTGGCGCCACGTGT
GCGCAGACACTCGCGTTACAGGCAAGCCAATGGGGCGAACCCTTTGAGGTTTCTACTTTGCGCCGCGAGGACTTTGCCAA
GATCCGCGAAGTCTCAGGGGCGGCTGATATTTTATCTTCTAACAATGCGCCATCTTCGGTAACGGCCCGTGGGCATCAAT
ATCCTGCGGCGTTTCTGCTTAAGGCTTCGGGATTGTTTGAACATGGCGTAAATGCCGCAATTCCTTTAGCTTACACACAC
TTAGATATCGCGGGCAGTGCAACGGAGGGCGATCCGCTCTATGGTAAACCCACAGCAAGTCCCTTGGTCGGTCTGTATCA
ATATCTGATCAATCGTTAA

Upstream 100 bases:

>100_bases
CCACCCTCAGTCTTTTCGATGGGGACAAAGGGATTTTTTGATTGGTAATTAAGCGTTATAGCGGGAATAATGCAGGCACA
ATAATGAAAAAGGATGGGTC

Downstream 100 bases:

>100_bases
CGAAATAACGTAACAAATAGAAATAATTCTGTAATATCTTACTTATTATAAGGTTACAGGATTATTTCTGTTTTTATGTG
ATACAGGTCGCCAAGATTCC

Product: peptidase M17, leucyl aminopeptidase domain-containing protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MFQVNFVDVQAENAIFDGEGWDAVVVVTPDLGAIGIDEISLLAEHGAKVDKRVGKSPTLLFAPGLAGGRLIIAPVTQVTD
DYADVRVFGDAARAAIAIAKDAGAKRPLLYVVPSTMPKFGFATEVAALACGQELWQTLELREATGLTPAFEAIGLLSLSS
KKSQLLNALEAGRVLARDLCGTEPERMSAKAFAEYCLQAFKGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
VKLEYLPEGEVTRTFLFAGKGVVYDTGGADLKVGGAMAGMSRDKGGASAVAGLFKTLSMLKPKGIRVIAELGLVRNSIGS
EAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIKAVSAVQPELFSVATLTGHVVRCYGAYPAAVENAVASGATC
AQTLALQASQWGEPFEVSTLRREDFAKIREVSGAADILSSNNAPSSVTARGHQYPAAFLLKASGLFEHGVNAAIPLAYTH
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR

Sequences:

>Translated_512_residues
MFQVNFVDVQAENAIFDGEGWDAVVVVTPDLGAIGIDEISLLAEHGAKVDKRVGKSPTLLFAPGLAGGRLIIAPVTQVTD
DYADVRVFGDAARAAIAIAKDAGAKRPLLYVVPSTMPKFGFATEVAALACGQELWQTLELREATGLTPAFEAIGLLSLSS
KKSQLLNALEAGRVLARDLCGTEPERMSAKAFAEYCLQAFKGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
VKLEYLPEGEVTRTFLFAGKGVVYDTGGADLKVGGAMAGMSRDKGGASAVAGLFKTLSMLKPKGIRVIAELGLVRNSIGS
EAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIKAVSAVQPELFSVATLTGHVVRCYGAYPAAVENAVASGATC
AQTLALQASQWGEPFEVSTLRREDFAKIREVSGAADILSSNNAPSSVTARGHQYPAAFLLKASGLFEHGVNAAIPLAYTH
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR
>Mature_512_residues
MFQVNFVDVQAENAIFDGEGWDAVVVVTPDLGAIGIDEISLLAEHGAKVDKRVGKSPTLLFAPGLAGGRLIIAPVTQVTD
DYADVRVFGDAARAAIAIAKDAGAKRPLLYVVPSTMPKFGFATEVAALACGQELWQTLELREATGLTPAFEAIGLLSLSS
KKSQLLNALEAGRVLARDLCGTEPERMSAKAFAEYCLQAFKGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
VKLEYLPEGEVTRTFLFAGKGVVYDTGGADLKVGGAMAGMSRDKGGASAVAGLFKTLSMLKPKGIRVIAELGLVRNSIGS
EAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIKAVSAVQPELFSVATLTGHVVRCYGAYPAAVENAVASGATC
AQTLALQASQWGEPFEVSTLRREDFAKIREVSGAADILSSNNAPSSVTARGHQYPAAFLLKASGLFEHGVNAAIPLAYTH
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI47155554, Length=365, Percent_Identity=30.1369863013699, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI41393561, Length=360, Percent_Identity=26.9444444444444, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790710, Length=264, Percent_Identity=31.0606060606061, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082123, Length=291, Percent_Identity=30.2405498281787, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17565172, Length=449, Percent_Identity=42.7616926503341, Blast_Score=338, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17556903, Length=369, Percent_Identity=28.9972899728997, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646701, Length=508, Percent_Identity=39.9606299212598, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24646703, Length=508, Percent_Identity=39.9606299212598, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI21358201, Length=508, Percent_Identity=39.9606299212598, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI221379063, Length=189, Percent_Identity=34.9206349206349, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221379062, Length=189, Percent_Identity=34.9206349206349, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357381, Length=189, Percent_Identity=34.9206349206349, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54057; Mature: 54057

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQVNFVDVQAENAIFDGEGWDAVVVVTPDLGAIGIDEISLLAEHGAKVDKRVGKSPTLL
CEEEEEEEEEECCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCEE
FAPGLAGGRLIIAPVTQVTDDYADVRVFGDAARAAIAIAKDAGAKRPLLYVVPSTMPKFG
EECCCCCCEEEEEEHHHHCCCCHHEEEECCHHHHEEEEECCCCCCCCEEEEECCCCCCCC
FATEVAALACGQELWQTLELREATGLTPAFEAIGLLSLSSKKSQLLNALEAGRVLARDLC
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
GTEPERMSAKAFAEYCLQAFKGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
CCCHHHHHHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHCCHHHHHHHHHHHHCCCCCCEE
VKLEYLPEGEVTRTFLFAGKGVVYDTGGADLKVGGAMAGMSRDKGGASAVAGLFKTLSML
EEEEECCCCCCEEEEEEECCCEEEECCCCCEEECCHHCCCCCCCCCHHHHHHHHHHHHHH
KPKGIRVIAELGLVRNSIGSEAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIK
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHH
AVSAVQPELFSVATLTGHVVRCYGAYPAAVENAVASGATCAQTLALQASQWGEPFEVSTL
HHHHCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHH
RREDFAKIREVSGAADILSSNNAPSSVTARGHQYPAAFLLKASGLFEHGVNAAIPLAYTH
HHHHHHHHHHHCCHHHHHCCCCCCCCEECCCCCCCCEEEEECCCHHHCCCCCEEEEEEEE
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFQVNFVDVQAENAIFDGEGWDAVVVVTPDLGAIGIDEISLLAEHGAKVDKRVGKSPTLL
CEEEEEEEEEECCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCEE
FAPGLAGGRLIIAPVTQVTDDYADVRVFGDAARAAIAIAKDAGAKRPLLYVVPSTMPKFG
EECCCCCCEEEEEEHHHHCCCCHHEEEECCHHHHEEEEECCCCCCCCEEEEECCCCCCCC
FATEVAALACGQELWQTLELREATGLTPAFEAIGLLSLSSKKSQLLNALEAGRVLARDLC
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
GTEPERMSAKAFAEYCLQAFKGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
CCCHHHHHHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHCCHHHHHHHHHHHHCCCCCCEE
VKLEYLPEGEVTRTFLFAGKGVVYDTGGADLKVGGAMAGMSRDKGGASAVAGLFKTLSML
EEEEECCCCCCEEEEEEECCCEEEECCCCCEEECCHHCCCCCCCCCHHHHHHHHHHHHHH
KPKGIRVIAELGLVRNSIGSEAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIK
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHH
AVSAVQPELFSVATLTGHVVRCYGAYPAAVENAVASGATCAQTLALQASQWGEPFEVSTL
HHHHCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHH
RREDFAKIREVSGAADILSSNNAPSSVTARGHQYPAAFLLKASGLFEHGVNAAIPLAYTH
HHHHHHHHHHHCCHHHHHCCCCCCCCEECCCCCCCCEEEEECCCHHHCCCCCEEEEEEEE
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]