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The map label for this gene is ung [H]

Identifier: 113969237

GI number: 113969237

Start: 1044926

End: 1045585

Strand: Direct

Name: ung [H]

Synonym: Shewmr4_0893

Alternate gene names: 113969237

Gene position: 1044926-1045585 (Clockwise)

Preceding gene: 113969236

Following gene: 113969239

Centisome position: 22.2

GC content: 49.55

Gene sequence:

>660_bases
TTGGCGACTTGGCAGGCATTTATTGACCATCAACGTTCTCAACCCTATTACCAGCAGTTGATAGCATTTGTGAATCAAGA
GCGTGAATTGGGTAAGGTGATCTATCCTCCTAAAGAGGATGTGTATAACGCCTTTAAAACAACCCCATTGGAGCAAGTGC
GTGTAGTGCTTATAGGTCAAGATCCCTACCATGGCCCCGACCAAGCCCACGGCCTGTGTTTCTCGGTTAAGCGAGGCATT
AAACCGCCGCCATCGCTAGCCAATATGTATAAAGAGTTAGTGAACGATATTCCCGGTTTCCAAATCCCAAATCATGGTGA
TTTAACCCAATGGGCGGAGCAGGGGATTTTGATGCTTAATACCGTGCTGACGGTGGAACAAGGGCAAGCCCACTCACATG
CCAATGCAGGCTGGGAAACCTTTACCACTGAGGCCTTAAAGCTGTTAAATGCGCAGGAACGGCCGATTATTTTCGTACTC
TGGGGCAGTCATGCTATCAAAAAAGGGGCGGTGATTACTGCGCCACAGCATCAAATTCTGTCGGGACCCCACCCGTCACC
ACTGTCGGCTTATCGCGGCTTCTTCGGTTGTGGGCATTTTTCTAAAGTGAATCAACTGCTGATGGCGCGGGGCGAAGCAC
CGATCCAATGGCAGGTTTAA

Upstream 100 bases:

>100_bases
GATACCTCAAGACTCGGGAATAAAAACCGGAGTTGGCTTGTCATGTCGTGCTATCACTTTTAAGCTAACGGCATCGTAAC
TTAAGTAAGAGAAACAGATT

Downstream 100 bases:

>100_bases
GTTCACTTGGATAAAGAACCTTAAAAACAAAAAGGCCTTGCTTAGCAAGGCCTTTTTGTTGGTTTATCGCTGCCAATTAG
TGGTTACGATCAACGGAGAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MATWQAFIDHQRSQPYYQQLIAFVNQERELGKVIYPPKEDVYNAFKTTPLEQVRVVLIGQDPYHGPDQAHGLCFSVKRGI
KPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILMLNTVLTVEQGQAHSHANAGWETFTTEALKLLNAQERPIIFVL
WGSHAIKKGAVITAPQHQILSGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEAPIQWQV

Sequences:

>Translated_219_residues
MATWQAFIDHQRSQPYYQQLIAFVNQERELGKVIYPPKEDVYNAFKTTPLEQVRVVLIGQDPYHGPDQAHGLCFSVKRGI
KPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILMLNTVLTVEQGQAHSHANAGWETFTTEALKLLNAQERPIIFVL
WGSHAIKKGAVITAPQHQILSGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEAPIQWQV
>Mature_218_residues
ATWQAFIDHQRSQPYYQQLIAFVNQERELGKVIYPPKEDVYNAFKTTPLEQVRVVLIGQDPYHGPDQAHGLCFSVKRGIK
PPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILMLNTVLTVEQGQAHSHANAGWETFTTEALKLLNAQERPIIFVLW
GSHAIKKGAVITAPQHQILSGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEAPIQWQV

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=50.462962962963, Blast_Score=237, Evalue=7e-63,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=50.462962962963, Blast_Score=236, Evalue=9e-63,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=59.0697674418605, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=45.3703703703704, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=233, Percent_Identity=43.7768240343348, Blast_Score=191, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24558; Mature: 24427

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATWQAFIDHQRSQPYYQQLIAFVNQERELGKVIYPPKEDVYNAFKTTPLEQVRVVLIGQ
CCCHHHHHHCCCCCHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHCCCHHHEEEEEECC
DPYHGPDQAHGLCFSVKRGIKPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILMLN
CCCCCCCHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCEEEEH
TVLTVEQGQAHSHANAGWETFTTEALKLLNAQERPIIFVLWGSHAIKKGAVITAPQHQIL
HEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHCCEEEECCCHHHH
SGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEAPIQWQV
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
ATWQAFIDHQRSQPYYQQLIAFVNQERELGKVIYPPKEDVYNAFKTTPLEQVRVVLIGQ
CCHHHHHHCCCCCHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHCCCHHHEEEEEECC
DPYHGPDQAHGLCFSVKRGIKPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILMLN
CCCCCCCHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCEEEEH
TVLTVEQGQAHSHANAGWETFTTEALKLLNAQERPIIFVLWGSHAIKKGAVITAPQHQIL
HEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHCCEEEECCCHHHH
SGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEAPIQWQV
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]