Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 113969210

GI number: 113969210

Start: 1018412

End: 1019866

Strand: Direct

Name: atoC [H]

Synonym: Shewmr4_0866

Alternate gene names: 113969210

Gene position: 1018412-1019866 (Clockwise)

Preceding gene: 113969209

Following gene: 113969211

Centisome position: 21.64

GC content: 52.44

Gene sequence:

>1455_bases
ATGGACACTATTCTGATTGTCGACGATAACCATGCCATCTGTCAGGCCTTAGGCTTAATGCTGGAGATCAATGGTTATCA
GGTGTTGACTTGTCATACGCCCGAAGATGCCCTTAGCCTAATGGCAACCCAAGATGTTGATTTGGTTATCCAAGATATGA
ACTTCACCCGCGATACTACCTCGGGTGAAGAAGGGCGGCAGCTGTTTTATGCCCTGCGTGAGCGTCAGCAAGATCTGCCG
ATCGTCCTGATGACTGCATGGACCCAGCTCGAAACTGCGGTCGAGTTAGTTAAGGCGGGCGCCGCCGACTATATGGGTAA
ACCGTGGGATGATGCTAAGTTACTCAACAGCATCACTAATTTAATTGCGTTACATAAACTTGCCCGTGCAAACCAGCAGC
TTGAGCGAGTGAATTCCCAGCGTCAGGTGGCGATCGCCGATGCGGATCTCTGCGGAATCGTGTTTGGCAGTGGTGCCATG
CAGCGCTGTATCGACTTAGCCTTGCAACTGGCGCGCTCCGATGTGTCTGTGTTGATCACCGGCCCCAATGGTGCGGGTAA
AGACAAGCTTGCCGATATTATTCACGCCAATTCCCCCTTAAAAAACAAACCTTTTATCAAGGTGAATGTGGGCGCCTTGC
CGATGGAGTTGCTCGAAGCCGAACTCTTTGGTGCCGAGGCGGGAGCATTTACCGGTGCCAATAAGGCGCGTATTGGTCGC
TTCGAAGCGGCCGATGGCGGCACGCTGTTTTTGGACGAAATTGGCAATTTACCGCTCTCGGGCCAAGTGAAATTGCTGCG
GGTATTACAAACCGGAGAGTTTGAGCGCTTAGGCAGCCATAAAACCTTAAAGGTGAAGGTGAGGGTGATCAGTGCGACTA
ACGCCGATCTGGCCCAAGATATTGCCGAGGGGCGTTTCCGTGAGGACTTATTCTATCGTTTGAATGTGATTGAATTGGCC
TTACCGCCGCTGAATCAACGAATTGACGATATCTTGCCCTTAGTGAAGCATTTTGTCGGCGAGGGTTTTAGCCTGAGTAA
ACCAGCGCAGCAAGCCCTGTTGCAGCACCGCTGGCCGGGCAATGTGCGCGAGCTAGAAAACGCCTGCAAACGTGCAGCGC
TGTTGGCTAAAAGCCGAGTGTTAACCGAAGTCGATTTTGGTTTACCGCCCGCGCATGCCCACCATCAAACTAGCCACCAA
ACGAGTCATCATGCTAGCCATATGAGCGTCGCGCCCCTTGGGCAGACTCGCCCCATAGTCTCGCCACTTGAGATGCAATC
CATGGCGAATCCGCCGATTGAGCAAGAGAGCAATGAGGCGACGGATGTGAGCCGTGAGCAGATTGAAATGGCCTTAAGGC
AACACAAGGGAGTGATTGCGCGCGTGGCGAAATCCTTAGGGTTGAGTCGCCAAGCTTTGTATCGCCGCATGGACAAATTT
GGCTTAGAGAAGTAA

Upstream 100 bases:

>100_bases
TTAAATAGGATGAAGGGCATTAAGTGCAATAACATTAGGATGTTATTGCACTTTTTGTTACTTTAAGGTTAATAGTTTTA
CTCTGGACGCACATGCTCAC

Downstream 100 bases:

>100_bases
CGATTGGCAGCATAATGGGTGGCGATTAGGCGGGAATTAACGTGCTACTGCGAACAAAATTAATCATTTATTCAACAGTT
TGTTGTGCTTTGGGTGTGTT

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MDTILIVDDNHAICQALGLMLEINGYQVLTCHTPEDALSLMATQDVDLVIQDMNFTRDTTSGEEGRQLFYALRERQQDLP
IVLMTAWTQLETAVELVKAGAADYMGKPWDDAKLLNSITNLIALHKLARANQQLERVNSQRQVAIADADLCGIVFGSGAM
QRCIDLALQLARSDVSVLITGPNGAGKDKLADIIHANSPLKNKPFIKVNVGALPMELLEAELFGAEAGAFTGANKARIGR
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTLKVKVRVISATNADLAQDIAEGRFREDLFYRLNVIELA
LPPLNQRIDDILPLVKHFVGEGFSLSKPAQQALLQHRWPGNVRELENACKRAALLAKSRVLTEVDFGLPPAHAHHQTSHQ
TSHHASHMSVAPLGQTRPIVSPLEMQSMANPPIEQESNEATDVSREQIEMALRQHKGVIARVAKSLGLSRQALYRRMDKF
GLEK

Sequences:

>Translated_484_residues
MDTILIVDDNHAICQALGLMLEINGYQVLTCHTPEDALSLMATQDVDLVIQDMNFTRDTTSGEEGRQLFYALRERQQDLP
IVLMTAWTQLETAVELVKAGAADYMGKPWDDAKLLNSITNLIALHKLARANQQLERVNSQRQVAIADADLCGIVFGSGAM
QRCIDLALQLARSDVSVLITGPNGAGKDKLADIIHANSPLKNKPFIKVNVGALPMELLEAELFGAEAGAFTGANKARIGR
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTLKVKVRVISATNADLAQDIAEGRFREDLFYRLNVIELA
LPPLNQRIDDILPLVKHFVGEGFSLSKPAQQALLQHRWPGNVRELENACKRAALLAKSRVLTEVDFGLPPAHAHHQTSHQ
TSHHASHMSVAPLGQTRPIVSPLEMQSMANPPIEQESNEATDVSREQIEMALRQHKGVIARVAKSLGLSRQALYRRMDKF
GLEK
>Mature_484_residues
MDTILIVDDNHAICQALGLMLEINGYQVLTCHTPEDALSLMATQDVDLVIQDMNFTRDTTSGEEGRQLFYALRERQQDLP
IVLMTAWTQLETAVELVKAGAADYMGKPWDDAKLLNSITNLIALHKLARANQQLERVNSQRQVAIADADLCGIVFGSGAM
QRCIDLALQLARSDVSVLITGPNGAGKDKLADIIHANSPLKNKPFIKVNVGALPMELLEAELFGAEAGAFTGANKARIGR
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTLKVKVRVISATNADLAQDIAEGRFREDLFYRLNVIELA
LPPLNQRIDDILPLVKHFVGEGFSLSKPAQQALLQHRWPGNVRELENACKRAALLAKSRVLTEVDFGLPPAHAHHQTSHQ
TSHHASHMSVAPLGQTRPIVSPLEMQSMANPPIEQESNEATDVSREQIEMALRQHKGVIARVAKSLGLSRQALYRRMDKF
GLEK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=493, Percent_Identity=37.9310344827586, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1790299, Length=492, Percent_Identity=36.1788617886179, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1790437, Length=486, Percent_Identity=36.0082304526749, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788905, Length=388, Percent_Identity=40.2061855670103, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87082117, Length=378, Percent_Identity=38.8888888888889, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1789087, Length=382, Percent_Identity=38.4816753926702, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87082152, Length=349, Percent_Identity=38.3954154727794, Blast_Score=208, Evalue=8e-55,
Organism=Escherichia coli, GI1786524, Length=342, Percent_Identity=38.8888888888889, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789233, Length=336, Percent_Identity=38.9880952380952, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87081872, Length=215, Percent_Identity=46.9767441860465, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1787583, Length=277, Percent_Identity=38.2671480144404, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1789828, Length=273, Percent_Identity=34.7985347985348, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87081858, Length=331, Percent_Identity=29.3051359516616, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53217; Mature: 53217

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTILIVDDNHAICQALGLMLEINGYQVLTCHTPEDALSLMATQDVDLVIQDMNFTRDTT
CCEEEEEECCHHHHHHHCCEEEECCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCC
SGEEGRQLFYALRERQQDLPIVLMTAWTQLETAVELVKAGAADYMGKPWDDAKLLNSITN
CCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
LIALHKLARANQQLERVNSQRQVAIADADLCGIVFGSGAMQRCIDLALQLARSDVSVLIT
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHEECCHHHHHHHHHHHHHHCCCCEEEEE
GPNGAGKDKLADIIHANSPLKNKPFIKVNVGALPMELLEAELFGAEAGAFTGANKARIGR
CCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHCCC
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTLKVKVRVISATNADLAQD
EECCCCCEEEHHHHCCCCCCCCHHHHHHHHCCCHHHHCCCCEEEEEEEEEECCCHHHHHH
IAEGRFREDLFYRLNVIELALPPLNQRIDDILPLVKHFVGEGFSLSKPAQQALLQHRWPG
HHHCHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
NVRELENACKRAALLAKSRVLTEVDFGLPPAHAHHQTSHQTSHHASHMSVAPLGQTRPIV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCEECCCCCCCCCC
SPLEMQSMANPPIEQESNEATDVSREQIEMALRQHKGVIARVAKSLGLSRQALYRRMDKF
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHH
GLEK
CCCC
>Mature Secondary Structure
MDTILIVDDNHAICQALGLMLEINGYQVLTCHTPEDALSLMATQDVDLVIQDMNFTRDTT
CCEEEEEECCHHHHHHHCCEEEECCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCC
SGEEGRQLFYALRERQQDLPIVLMTAWTQLETAVELVKAGAADYMGKPWDDAKLLNSITN
CCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
LIALHKLARANQQLERVNSQRQVAIADADLCGIVFGSGAMQRCIDLALQLARSDVSVLIT
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHEECCHHHHHHHHHHHHHHCCCCEEEEE
GPNGAGKDKLADIIHANSPLKNKPFIKVNVGALPMELLEAELFGAEAGAFTGANKARIGR
CCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHCCC
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTLKVKVRVISATNADLAQD
EECCCCCEEEHHHHCCCCCCCCHHHHHHHHCCCHHHHCCCCEEEEEEEEEECCCHHHHHH
IAEGRFREDLFYRLNVIELALPPLNQRIDDILPLVKHFVGEGFSLSKPAQQALLQHRWPG
HHHCHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
NVRELENACKRAALLAKSRVLTEVDFGLPPAHAHHQTSHQTSHHASHMSVAPLGQTRPIV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCEECCCCCCCCCC
SPLEMQSMANPPIEQESNEATDVSREQIEMALRQHKGVIARVAKSLGLSRQALYRRMDKF
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHH
GLEK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]