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The map label for this gene is gltT [H]

Identifier: 113969108

GI number: 113969108

Start: 890252

End: 891559

Strand: Direct

Name: gltT [H]

Synonym: Shewmr4_0764

Alternate gene names: 113969108

Gene position: 890252-891559 (Clockwise)

Preceding gene: 113969107

Following gene: 113969110

Centisome position: 18.92

GC content: 50.46

Gene sequence:

>1308_bases
ATGTCAAAACATAGGTCATCAGCCCTAGGCCGGATCTGGTCTTCCTGGATGTCAGTGCCCCTGTGGCTGCAAATTTTCGT
TGGTATGGTGTTGGGGATTGCGGTGGGCGTCAGCTTAGGTGAGCAGGCTTCTTACCTGAAACCTATTGGCACCCTGTTTG
TGAATACCATCAAGATGCTGATTGTGCCTTTAGTGTTTTGTTCATTGATTGTCGGTGTGACCTCAATGGAAGACACCGCC
AAAATGGGCCGAATTGGTTTTAAATCCTTTGCGTTTTACCTTTGCACCACCGCGATTGCGATCAGTTTAGGTTTAGCCGT
GGGCTATGTGGTGCAACCCGGTGCGGGCGTGCCTTTACTGCAACACGAAGCGGTGCAAACGGCGAAAGAAGTGCCTTCGG
TGATGCAAACCCTGATTGATATTGTCCCTACTAACCCCGTTGCCGCCTTGGCGAGTGGCCAAATCCTGCAAGTCATTGTG
TTTGCCGTGGCCTTAGGGATTGCCTTGGTCTTGATTGGCGACCATGGAAAGCCTGCGATTAAGGTATTTGAAAGCCTTGC
CGAGGCCATGTACAAGCTTACCGACATGGTGATGAAGCTTGCTCCTTATGGGGTATTTGGTCTGATGGCATGGGTCGCGG
GCGAGTATGGCATCGATATGCTGTGGCCGCTGATTAAAGTGATTATTGCCGTATATATTGGCTGTATTATCCACGTGTTA
GGCTTCTACAGTATAGTGCTGCGCCTATTTGCCAAGCTGAATCCACTGCATTTTTTCAAGGGGATCAGCAATGCGATGGC
GGTGGCATTTACCACTTCAAGTTCGGCGGGTACCTTACCGGCCAGCATGAAATGTGCGAGCGAATATCTCGGGGTCAATA
AGAAGATCTCTAGCTTTGTGCTGCCCTTAGGGACCACCATCAATATGGATGGTACGGCCTTGTATCAAGGCGTGACCGCG
CTGTTTGTGGCGCAGGCCTTTGGTATCGATTTAACTTGGGTCGACTATCTAACGATTATTTTAACCGCGACCTTAGCCTC
AATCGGCACCGCGGGTGTGCCGGGCGCAGGCTTAGTGATGTTGACCTTAGTGCTTTCGACCGTGGGCTTACCCTTAGAAG
GTGTGGCCTTGATTGCGGGGATTGACCGTATTCTCGATATGGCACGTACTGTCGTAAACGTTTCTGGTGACTTAGTGGCG
ACGACTGTGATTGCTAAGTCGGAAGATGAGCTGGATGTTGAACATTACAATGCCGACATGGTACAGAGCGCTATGATTGC
CGAGCAAAACGCCGCGACGAAAAGTTAA

Upstream 100 bases:

>100_bases
TTTTATCCCTTATGTTAGACTCGGCGGCTGGCTAATTTAAGTTAGTCCCGCCAAGGATAAGGCTCAGCCCTATCATCATT
TCAAACTCAAGGTTATAAAC

Downstream 100 bases:

>100_bases
TTCATCGAATAATAAAAAACCGCCAACTAGGCGGTTTTTTATTATCGAAGCGAGCTTATTTAAGCTGGCTTAGGACGAGT
ACGGGCTTATCGTCGCTGCT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSKHRSSALGRIWSSWMSVPLWLQIFVGMVLGIAVGVSLGEQASYLKPIGTLFVNTIKMLIVPLVFCSLIVGVTSMEDTA
KMGRIGFKSFAFYLCTTAIAISLGLAVGYVVQPGAGVPLLQHEAVQTAKEVPSVMQTLIDIVPTNPVAALASGQILQVIV
FAVALGIALVLIGDHGKPAIKVFESLAEAMYKLTDMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYIGCIIHVL
GFYSIVLRLFAKLNPLHFFKGISNAMAVAFTTSSSAGTLPASMKCASEYLGVNKKISSFVLPLGTTINMDGTALYQGVTA
LFVAQAFGIDLTWVDYLTIILTATLASIGTAGVPGAGLVMLTLVLSTVGLPLEGVALIAGIDRILDMARTVVNVSGDLVA
TTVIAKSEDELDVEHYNADMVQSAMIAEQNAATKS

Sequences:

>Translated_435_residues
MSKHRSSALGRIWSSWMSVPLWLQIFVGMVLGIAVGVSLGEQASYLKPIGTLFVNTIKMLIVPLVFCSLIVGVTSMEDTA
KMGRIGFKSFAFYLCTTAIAISLGLAVGYVVQPGAGVPLLQHEAVQTAKEVPSVMQTLIDIVPTNPVAALASGQILQVIV
FAVALGIALVLIGDHGKPAIKVFESLAEAMYKLTDMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYIGCIIHVL
GFYSIVLRLFAKLNPLHFFKGISNAMAVAFTTSSSAGTLPASMKCASEYLGVNKKISSFVLPLGTTINMDGTALYQGVTA
LFVAQAFGIDLTWVDYLTIILTATLASIGTAGVPGAGLVMLTLVLSTVGLPLEGVALIAGIDRILDMARTVVNVSGDLVA
TTVIAKSEDELDVEHYNADMVQSAMIAEQNAATKS
>Mature_434_residues
SKHRSSALGRIWSSWMSVPLWLQIFVGMVLGIAVGVSLGEQASYLKPIGTLFVNTIKMLIVPLVFCSLIVGVTSMEDTAK
MGRIGFKSFAFYLCTTAIAISLGLAVGYVVQPGAGVPLLQHEAVQTAKEVPSVMQTLIDIVPTNPVAALASGQILQVIVF
AVALGIALVLIGDHGKPAIKVFESLAEAMYKLTDMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYIGCIIHVLG
FYSIVLRLFAKLNPLHFFKGISNAMAVAFTTSSSAGTLPASMKCASEYLGVNKKISSFVLPLGTTINMDGTALYQGVTAL
FVAQAFGIDLTWVDYLTIILTATLASIGTAGVPGAGLVMLTLVLSTVGLPLEGVALIAGIDRILDMARTVVNVSGDLVAT
TVIAKSEDELDVEHYNADMVQSAMIAEQNAATKS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=447, Percent_Identity=32.4384787472036, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI40254478, Length=491, Percent_Identity=32.7902240325866, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI5032093, Length=396, Percent_Identity=35.1010101010101, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI66773030, Length=480, Percent_Identity=31.25, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI169790839, Length=461, Percent_Identity=31.236442516269, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI223468566, Length=280, Percent_Identity=37.8571428571429, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI223468564, Length=271, Percent_Identity=38.0073800738007, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4827012, Length=293, Percent_Identity=36.8600682593857, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI194239697, Length=297, Percent_Identity=36.026936026936, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI301601644, Length=191, Percent_Identity=36.1256544502618, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI262359914, Length=356, Percent_Identity=28.3707865168539, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1790514, Length=410, Percent_Identity=39.7560975609756, Blast_Score=281, Evalue=9e-77,
Organism=Escherichia coli, GI1789947, Length=413, Percent_Identity=37.2881355932203, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1788024, Length=410, Percent_Identity=29.7560975609756, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1789473, Length=287, Percent_Identity=27.8745644599303, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71996953, Length=460, Percent_Identity=35.4347826086957, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71983106, Length=477, Percent_Identity=34.1719077568134, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI71983099, Length=481, Percent_Identity=34.0956340956341, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI193206505, Length=462, Percent_Identity=31.8181818181818, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17537407, Length=465, Percent_Identity=29.8924731182796, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI193206654, Length=418, Percent_Identity=30.3827751196172, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17541374, Length=418, Percent_Identity=30.622009569378, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24583025, Length=438, Percent_Identity=30.8219178082192, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17137668, Length=438, Percent_Identity=30.8219178082192, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24583023, Length=438, Percent_Identity=30.8219178082192, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI281360481, Length=471, Percent_Identity=29.9363057324841, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281360483, Length=471, Percent_Identity=29.9363057324841, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17137666, Length=471, Percent_Identity=29.9363057324841, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45999; Mature: 45868

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHRSSALGRIWSSWMSVPLWLQIFVGMVLGIAVGVSLGEQASYLKPIGTLFVNTIKML
CCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IVPLVFCSLIVGVTSMEDTAKMGRIGFKSFAFYLCTTAIAISLGLAVGYVVQPGAGVPLL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
QHEAVQTAKEVPSVMQTLIDIVPTNPVAALASGQILQVIVFAVALGIALVLIGDHGKPAI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
KVFESLAEAMYKLTDMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYIGCIIHVL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
GFYSIVLRLFAKLNPLHFFKGISNAMAVAFTTSSSAGTLPASMKCASEYLGVNKKISSFV
HHHHHHHHHHHHCCHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHH
LPLGTTINMDGTALYQGVTALFVAQAFGIDLTWVDYLTIILTATLASIGTAGVPGAGLVM
HCCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LTLVLSTVGLPLEGVALIAGIDRILDMARTVVNVSGDLVATTVIAKSEDELDVEHYNADM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHCCHHH
VQSAMIAEQNAATKS
HHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKHRSSALGRIWSSWMSVPLWLQIFVGMVLGIAVGVSLGEQASYLKPIGTLFVNTIKML
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH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HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]