Click here to switch to the map view.

The map label for this gene is rio1 [H]

Identifier: 113969008

GI number: 113969008

Start: 773705

End: 774562

Strand: Direct

Name: rio1 [H]

Synonym: Shewmr4_0664

Alternate gene names: 113969008

Gene position: 773705-774562 (Clockwise)

Preceding gene: 113969007

Following gene: 113969010

Centisome position: 16.44

GC content: 48.72

Gene sequence:

>858_bases
ATGAAAACTCCTAAACGAATCCAACCTCTGGTTGATGAAGGACTGGTTGACGAAGTCATTAGCCAGTTGATGAGCGGTAA
AGAGGCTACAGTGTACGTGGTACGCTGTGGTGAGGATATTCGCTGCGCTAAGGTATATAAAGAGGCGGATAAACGCAGTT
TTAAGCAGGCGGTGGTTTACCAAGAGGGCCGTAAGGTCCGTAATAGTCGCCGTGCTCGGGCAATGGAAAAAGGCTCTAAA
TTTGGCCGCGAACAAATGGAAGAAGCCTGGCAAAATTCAGAAGTGGATGCGCTGTTCCGTTTAGCCCATGCGGGAGTGAG
AGTGCCGACGCCATTTGGTTGTTTCGATGGCGTGTTATTGATGGAATTAGTGACCGACAGCGAAGGCCATGTTGCGCCCC
GTCTTAATGACGTGAGCCTCAGCGCTGAGCAGGCCATGCGTGATCACGCTTTGGTGATGATATATGTTAAACGTATGCTT
TGTGCCGGTTTGGTCCATGGCGATTTATCCGAATTTAACGTCCTAGTCGATGCCGATGGCCCAGTGATCATCGATTTACC
TCAGGCAGTCGATGCCGCGGCCAACAACCATGCGAAATGGATGCTGGAGCGTGACGTTAATAACATGACGCAATATTATG
GCCAGTACGCCCCAGAGCTGCTCAAGACACAATATGCAAAAGAAATGTGGGCGTTATTTGAAGCGGGTGAATTAAAACCT
GATACCCAATTAACAGGCAAGTTCACCGAGGTCTTAGTCGATGCCGATGTCAATTCAGTGTTAGATGAGATCCAAGCTGC
CTACGATGAAGCACAGGAACGTAAGCTGCGACTTCAAGAAGCCAATGAAGATTATTAG

Upstream 100 bases:

>100_bases
TTCACTGAATCTTTTTATCTATCATCTTTAAAAGGTTGCTTTTATATGAAGATTTGTCCGGCACATTCCATCTTACGCCT
AACTAAGGTATAAGGTCGGT

Downstream 100 bases:

>100_bases
TGAAATATTCTTCAATAAAATAGACGCCTTATGAGCGTCTTTTTTATTGGGATTAATTATTTTGGGACTGATTTTAAAGC
CTGTGGCATTGCCATCCTTG

Product: hypothetical protein

Products: NA

Alternate protein names: AfRio1 [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKTPKRIQPLVDEGLVDEVISQLMSGKEATVYVVRCGEDIRCAKVYKEADKRSFKQAVVYQEGRKVRNSRRARAMEKGSK
FGREQMEEAWQNSEVDALFRLAHAGVRVPTPFGCFDGVLLMELVTDSEGHVAPRLNDVSLSAEQAMRDHALVMIYVKRML
CAGLVHGDLSEFNVLVDADGPVIIDLPQAVDAAANNHAKWMLERDVNNMTQYYGQYAPELLKTQYAKEMWALFEAGELKP
DTQLTGKFTEVLVDADVNSVLDEIQAAYDEAQERKLRLQEANEDY

Sequences:

>Translated_285_residues
MKTPKRIQPLVDEGLVDEVISQLMSGKEATVYVVRCGEDIRCAKVYKEADKRSFKQAVVYQEGRKVRNSRRARAMEKGSK
FGREQMEEAWQNSEVDALFRLAHAGVRVPTPFGCFDGVLLMELVTDSEGHVAPRLNDVSLSAEQAMRDHALVMIYVKRML
CAGLVHGDLSEFNVLVDADGPVIIDLPQAVDAAANNHAKWMLERDVNNMTQYYGQYAPELLKTQYAKEMWALFEAGELKP
DTQLTGKFTEVLVDADVNSVLDEIQAAYDEAQERKLRLQEANEDY
>Mature_285_residues
MKTPKRIQPLVDEGLVDEVISQLMSGKEATVYVVRCGEDIRCAKVYKEADKRSFKQAVVYQEGRKVRNSRRARAMEKGSK
FGREQMEEAWQNSEVDALFRLAHAGVRVPTPFGCFDGVLLMELVTDSEGHVAPRLNDVSLSAEQAMRDHALVMIYVKRML
CAGLVHGDLSEFNVLVDADGPVIIDLPQAVDAAANNHAKWMLERDVNNMTQYYGQYAPELLKTQYAKEMWALFEAGELKP
DTQLTGKFTEVLVDADVNSVLDEIQAAYDEAQERKLRLQEANEDY

Specific function: Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis [H]

COG id: COG1718

COG function: function code TD; Serine/threonine protein kinase involved in cell cycle control

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI23510356, Length=210, Percent_Identity=29.0476190476191, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI22325377, Length=216, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115532073, Length=214, Percent_Identity=28.9719626168224, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324693, Length=237, Percent_Identity=25.7383966244726, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24662811, Length=271, Percent_Identity=28.4132841328413, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356879, Length=271, Percent_Identity=28.4132841328413, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 32151; Mature: 32151

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00109 PROTEIN_KINASE_TYR ; PS01245 RIO1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPKRIQPLVDEGLVDEVISQLMSGKEATVYVVRCGEDIRCAKVYKEADKRSFKQAVVY
CCCCHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
QEGRKVRNSRRARAMEKGSKFGREQMEEAWQNSEVDALFRLAHAGVRVPTPFGCFDGVLL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
MELVTDSEGHVAPRLNDVSLSAEQAMRDHALVMIYVKRMLCAGLVHGDLSEFNVLVDADG
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEECCC
PVIIDLPQAVDAAANNHAKWMLERDVNNMTQYYGQYAPELLKTQYAKEMWALFEAGELKP
CEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DTQLTGKFTEVLVDADVNSVLDEIQAAYDEAQERKLRLQEANEDY
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTPKRIQPLVDEGLVDEVISQLMSGKEATVYVVRCGEDIRCAKVYKEADKRSFKQAVVY
CCCCHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
QEGRKVRNSRRARAMEKGSKFGREQMEEAWQNSEVDALFRLAHAGVRVPTPFGCFDGVLL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
MELVTDSEGHVAPRLNDVSLSAEQAMRDHALVMIYVKRMLCAGLVHGDLSEFNVLVDADG
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEECCC
PVIIDLPQAVDAAANNHAKWMLERDVNNMTQYYGQYAPELLKTQYAKEMWALFEAGELKP
CEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DTQLTGKFTEVLVDADVNSVLDEIQAAYDEAQERKLRLQEANEDY
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]