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The map label for this gene is zraR [H]

Identifier: 113968871

GI number: 113968871

Start: 606618

End: 607982

Strand: Direct

Name: zraR [H]

Synonym: Shewmr4_0527

Alternate gene names: 113968871

Gene position: 606618-607982 (Clockwise)

Preceding gene: 113968870

Following gene: 113968872

Centisome position: 12.89

GC content: 46.52

Gene sequence:

>1365_bases
ATGGATGAAATCGCGAAGCCTACTCCCGTAGAAAATCTTTGGAAAAGGTGGTTGCTGGTACTCGATCCTGAGCAATCTCT
ACCTGAGTGTAGTGAAGAACTTAAACAAGCTGCTTGGAACTGTTTAAAAGCAGTGTCGGCAGCTGAAGCTCTAGTATTGC
TGCAAAAATATGATTTACGTGTCGCTATTGCCTTTATCAATGATACTAATCAAGTCTTACTCGCTAACGAAATTGCGATT
ATTCAAACCGAATATCCCTCGCTTCATTGGATTGCTGTCACCGATAGCACCTTGGAGCAGCACTGCAGTTGGTTAAGTGC
CGCTAACTTTATTGATTATTATCACCGTCCATTCGATTGGGGGCGTTTTGCCGATACCCTTGGGCATGCATGGGGGATGG
CGCAGTTGACTGTCGCTAAAAAGGGCAAGTCAGCGCCAACAGAAGCTTTGACCACCATTAAAGGGGATCATCCGTTGTTG
CAACAGCTGCGTCAGCGGTTACACAAATTTAGTTTGTCGGATGACACGGTTTTACTCAGTGGTGAAACGGGCTCAGGCAA
AGGTCTCTGTGCAAAAACGCTCCATAGTTTATCTAAACGTCGAGATGGCCCATTTATCACAGTTAATTGCGGTGCACTTC
CTATTGGACTGATCCACTCTGCACTCTTTGGTCACGAAAAAGGGGCCTTTACCGATGCAGATAAACGTTATATCGGCCAT
TTAGAGCAGGCCAATGGCGGCACGCTCTTTTTAGATGAAATTGCCGACTTACCTTTAGACTTACAGGTCAATCTACTGCA
TGTTCTCGATGATAAACAGATCATGCGGATCGGCGGTAATGTGCCCATTAAGGTGGACTGTCGTTTGTTGTTTGCTTCTC
ACCAAGACCTCGAAGTCGCGATTGATGAAGGCCGTTTCCGTGAAGACTTATATCACCGCATTAATGTGTTGCGGCTGCAT
GTCCCCAGCCTGAGGCAATATAGTGATGAAGTGATGTTACTCGCTGAAGACTTTTTACAAGAGAATACAGACAGTAATGT
CCAGTTTCATTTTAGCGACGATGCTCGCTGTGCCATGAAGCACTACAATTGGCCCGGTAATGTACGTGAACTCCGCAACC
GTATTCGCCGAGCTATGGTGTTGAGTGATGACAGCAAGATCACAGCGCAGTTGCTAGGGTTGGATCAATTGCCAAGCCGA
GCTGGTCAAGATTTGGCTCGCTGTCGTGTTGAGCATGAGGCGGAAGTACTACTAAAAGCGATCAGCGATCATAAGCACAA
TATCTCCGCCGCCGCCCGCTCATTAAATATCTCCAGAGCAACGTTTTACCGCTTATTGAAAAAGTGTCAGATCAAGATGC
CCTAG

Upstream 100 bases:

>100_bases
TGAATTATTTTAGTTCACATCGAATCAATCTGATCAGGTTTGTCGGGAGGTCATTGTCCTTCTAGACTAGATTAGTAATA
GGTTCATTTGCCCCCTTATT

Downstream 100 bases:

>100_bases
CGGGCCTGTCTCTGCTGCTACAGCTTGCTTCACTCCTGTGACACATCTTACTCATCAAATGTGAATAAATTCTTGTTTAT
CAATTGTTTAATTTTTGGCC

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MDEIAKPTPVENLWKRWLLVLDPEQSLPECSEELKQAAWNCLKAVSAAEALVLLQKYDLRVAIAFINDTNQVLLANEIAI
IQTEYPSLHWIAVTDSTLEQHCSWLSAANFIDYYHRPFDWGRFADTLGHAWGMAQLTVAKKGKSAPTEALTTIKGDHPLL
QQLRQRLHKFSLSDDTVLLSGETGSGKGLCAKTLHSLSKRRDGPFITVNCGALPIGLIHSALFGHEKGAFTDADKRYIGH
LEQANGGTLFLDEIADLPLDLQVNLLHVLDDKQIMRIGGNVPIKVDCRLLFASHQDLEVAIDEGRFREDLYHRINVLRLH
VPSLRQYSDEVMLLAEDFLQENTDSNVQFHFSDDARCAMKHYNWPGNVRELRNRIRRAMVLSDDSKITAQLLGLDQLPSR
AGQDLARCRVEHEAEVLLKAISDHKHNISAAARSLNISRATFYRLLKKCQIKMP

Sequences:

>Translated_454_residues
MDEIAKPTPVENLWKRWLLVLDPEQSLPECSEELKQAAWNCLKAVSAAEALVLLQKYDLRVAIAFINDTNQVLLANEIAI
IQTEYPSLHWIAVTDSTLEQHCSWLSAANFIDYYHRPFDWGRFADTLGHAWGMAQLTVAKKGKSAPTEALTTIKGDHPLL
QQLRQRLHKFSLSDDTVLLSGETGSGKGLCAKTLHSLSKRRDGPFITVNCGALPIGLIHSALFGHEKGAFTDADKRYIGH
LEQANGGTLFLDEIADLPLDLQVNLLHVLDDKQIMRIGGNVPIKVDCRLLFASHQDLEVAIDEGRFREDLYHRINVLRLH
VPSLRQYSDEVMLLAEDFLQENTDSNVQFHFSDDARCAMKHYNWPGNVRELRNRIRRAMVLSDDSKITAQLLGLDQLPSR
AGQDLARCRVEHEAEVLLKAISDHKHNISAAARSLNISRATFYRLLKKCQIKMP
>Mature_454_residues
MDEIAKPTPVENLWKRWLLVLDPEQSLPECSEELKQAAWNCLKAVSAAEALVLLQKYDLRVAIAFINDTNQVLLANEIAI
IQTEYPSLHWIAVTDSTLEQHCSWLSAANFIDYYHRPFDWGRFADTLGHAWGMAQLTVAKKGKSAPTEALTTIKGDHPLL
QQLRQRLHKFSLSDDTVLLSGETGSGKGLCAKTLHSLSKRRDGPFITVNCGALPIGLIHSALFGHEKGAFTDADKRYIGH
LEQANGGTLFLDEIADLPLDLQVNLLHVLDDKQIMRIGGNVPIKVDCRLLFASHQDLEVAIDEGRFREDLYHRINVLRLH
VPSLRQYSDEVMLLAEDFLQENTDSNVQFHFSDDARCAMKHYNWPGNVRELRNRIRRAMVLSDDSKITAQLLGLDQLPSR
AGQDLARCRVEHEAEVLLKAISDHKHNISAAARSLNISRATFYRLLKKCQIKMP

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=419, Percent_Identity=36.9928400954654, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1790299, Length=315, Percent_Identity=40.9523809523809, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1788550, Length=354, Percent_Identity=38.135593220339, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1786524, Length=315, Percent_Identity=39.6825396825397, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1788905, Length=425, Percent_Identity=33.4117647058824, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI87082152, Length=330, Percent_Identity=39.0909090909091, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87082117, Length=235, Percent_Identity=42.9787234042553, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI87081872, Length=312, Percent_Identity=37.8205128205128, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789087, Length=311, Percent_Identity=34.7266881028939, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789233, Length=329, Percent_Identity=34.9544072948328, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1787583, Length=244, Percent_Identity=34.0163934426229, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1789828, Length=257, Percent_Identity=33.4630350194552, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI87081858, Length=324, Percent_Identity=28.0864197530864, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51218; Mature: 51218

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEIAKPTPVENLWKRWLLVLDPEQSLPECSEELKQAAWNCLKAVSAAEALVLLQKYDLR
CCCCCCCCCHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VAIAFINDTNQVLLANEIAIIQTEYPSLHWIAVTDSTLEQHCSWLSAANFIDYYHRPFDW
EEEEEECCCCCEEEECCEEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCH
GRFADTLGHAWGMAQLTVAKKGKSAPTEALTTIKGDHPLLQQLRQRLHKFSLSDDTVLLS
HHHHHHHHHHCCHHEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEE
GETGSGKGLCAKTLHSLSKRRDGPFITVNCGALPIGLIHSALFGHEKGAFTDADKRYIGH
CCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHCC
LEQANGGTLFLDEIADLPLDLQVNLLHVLDDKQIMRIGGNVPIKVDCRLLFASHQDLEVA
CCCCCCCEEEEHHHHCCCCCCEEEEEEEECCCHHEEECCCCCEEEEEEEEEECCCCEEEE
IDEGRFREDLYHRINVLRLHVPSLRQYSDEVMLLAEDFLQENTDSNVQFHFSDDARCAMK
ECCCHHHHHHHHHHHEEEEECCHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHH
HYNWPGNVRELRNRIRRAMVLSDDSKITAQLLGLDQLPSRAGQDLARCRVEHEAEVLLKA
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHH
ISDHKHNISAAARSLNISRATFYRLLKKCQIKMP
HHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDEIAKPTPVENLWKRWLLVLDPEQSLPECSEELKQAAWNCLKAVSAAEALVLLQKYDLR
CCCCCCCCCHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VAIAFINDTNQVLLANEIAIIQTEYPSLHWIAVTDSTLEQHCSWLSAANFIDYYHRPFDW
EEEEEECCCCCEEEECCEEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCH
GRFADTLGHAWGMAQLTVAKKGKSAPTEALTTIKGDHPLLQQLRQRLHKFSLSDDTVLLS
HHHHHHHHHHCCHHEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEE
GETGSGKGLCAKTLHSLSKRRDGPFITVNCGALPIGLIHSALFGHEKGAFTDADKRYIGH
CCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHCC
LEQANGGTLFLDEIADLPLDLQVNLLHVLDDKQIMRIGGNVPIKVDCRLLFASHQDLEVA
CCCCCCCEEEEHHHHCCCCCCEEEEEEEECCCHHEEECCCCCEEEEEEEEEECCCCEEEE
IDEGRFREDLYHRINVLRLHVPSLRQYSDEVMLLAEDFLQENTDSNVQFHFSDDARCAMK
ECCCHHHHHHHHHHHEEEEECCHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHH
HYNWPGNVRELRNRIRRAMVLSDDSKITAQLLGLDQLPSRAGQDLARCRVEHEAEVLLKA
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHH
ISDHKHNISAAARSLNISRATFYRLLKKCQIKMP
HHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]