Click here to switch to the map view.

The map label for this gene is bdhA [H]

Identifier: 113968654

GI number: 113968654

Start: 334919

End: 335995

Strand: Direct

Name: bdhA [H]

Synonym: Shewmr4_0310

Alternate gene names: 113968654

Gene position: 334919-335995 (Clockwise)

Preceding gene: 113968653

Following gene: 113968655

Centisome position: 7.12

GC content: 52.37

Gene sequence:

>1077_bases
ATGAGCTTGATGACTATGCCAACGATGAATGCCATCGTTATGCAGGATGGTGAAGTCAGCCTGCAACAGGTCGATTTACC
CAAGCCACAGGCGGGCCAAGTGTTGGTGCGTAGCCTTGCTTGTGGTATTTGTGGCTCGGATATTCATATCACGCGACACT
ACAACGAAGTATTTGATTTTTATCGTCAGCTTGGGGTGATGCCCGAAGGCGTCGATAAGCATGCCGCTGTGATGCTCGGC
CATGAGTTTTGTGCCGAAATCGTCGAGTTTGGCCCACAAACTCAGCAAGCCTTGGCGCTAGGAACACGGGTGACCTCAGT
TCCGATTCTGATGAGCCAAAATGGTGCTGGGGTGGGCGTTACCCCTGGCGTGAATGGTGCTTATTCTGAGTACTTTATTC
TCGATGAGGCCTTATTAATGCCTGTACCTGAGCATTTGCCATCGGAGGCCGTGGCGCTCACCGAACCATTAGCCGTAGGA
TTACATGCGGTGAATCGGGGTGATGTGCAGGCCGAAGATGTTGCGCTGGTGGTTGGTTGCGGTCCCATTGGTCTTGCGGT
GATCTCCGCTCTGCACTTGCGCGGCGTAGCTAAGATTGTGGCTGCGGATTTACAGAGTGATAAGTTGCAATTAGCCCGAG
AATTTGGTGCCACCCATACGGTGAATCCTAGCGAGCAGGATGAAGTCGCCTTCGCCGCCAAGCTTGCTGCGGGTCAGCGC
TTGGTGATTTTCGAATGTGTGGGTATCCATAAGCTTATCGAAGGCTTTGTGCAGCGAGCTCCCGCCAAAGCGACCATAGT
GGTCACGGGCATCCACACCGCAAACTCCAATATTAATTATGCCTATGCCACGGTCAAAGAATTGGATATGTGCTTCTCCT
ACTACTATCAGCCGGCGGAATTTGCGGCCTGTTTAGAGGAGCTGGCGCAGGGGACGATTCCTTGGCGTAAGCTGCTCACG
GGTAAGGTGGGGATGGATGGTGTATCGGGTGCGTTCAAGCAATTGATGAAACCGAACCCACATATCAAAGTCGTTATCGA
ACCTTGGCGTAATGGTGAGCTAGAGATGCTCGACTAA

Upstream 100 bases:

>100_bases
CAGGCACTCTTAGCGGCTGCAAAAGCACAGGGGATTAAGCCTCGTTATATCAAGCCTGGTGCGTTAGCACGTATGAGTGA
TGCGGAATAGGAACCTTGCT

Downstream 100 bases:

>100_bases
TCGCCTCAAAATGTCCGTCCAGTTAAGCCGCCTGTTAGCAGTGCGGCTTTTTTATTACAGCTTGCCGTTTTGGCTATTCT
CATCTGGCAAATTTTTAATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSLMTMPTMNAIVMQDGEVSLQQVDLPKPQAGQVLVRSLACGICGSDIHITRHYNEVFDFYRQLGVMPEGVDKHAAVMLG
HEFCAEIVEFGPQTQQALALGTRVTSVPILMSQNGAGVGVTPGVNGAYSEYFILDEALLMPVPEHLPSEAVALTEPLAVG
LHAVNRGDVQAEDVALVVGCGPIGLAVISALHLRGVAKIVAADLQSDKLQLAREFGATHTVNPSEQDEVAFAAKLAAGQR
LVIFECVGIHKLIEGFVQRAPAKATIVVTGIHTANSNINYAYATVKELDMCFSYYYQPAEFAACLEELAQGTIPWRKLLT
GKVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELEMLD

Sequences:

>Translated_358_residues
MSLMTMPTMNAIVMQDGEVSLQQVDLPKPQAGQVLVRSLACGICGSDIHITRHYNEVFDFYRQLGVMPEGVDKHAAVMLG
HEFCAEIVEFGPQTQQALALGTRVTSVPILMSQNGAGVGVTPGVNGAYSEYFILDEALLMPVPEHLPSEAVALTEPLAVG
LHAVNRGDVQAEDVALVVGCGPIGLAVISALHLRGVAKIVAADLQSDKLQLAREFGATHTVNPSEQDEVAFAAKLAAGQR
LVIFECVGIHKLIEGFVQRAPAKATIVVTGIHTANSNINYAYATVKELDMCFSYYYQPAEFAACLEELAQGTIPWRKLLT
GKVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELEMLD
>Mature_357_residues
SLMTMPTMNAIVMQDGEVSLQQVDLPKPQAGQVLVRSLACGICGSDIHITRHYNEVFDFYRQLGVMPEGVDKHAAVMLGH
EFCAEIVEFGPQTQQALALGTRVTSVPILMSQNGAGVGVTPGVNGAYSEYFILDEALLMPVPEHLPSEAVALTEPLAVGL
HAVNRGDVQAEDVALVVGCGPIGLAVISALHLRGVAKIVAADLQSDKLQLAREFGATHTVNPSEQDEVAFAAKLAAGQRL
VIFECVGIHKLIEGFVQRAPAKATIVVTGIHTANSNINYAYATVKELDMCFSYYYQPAEFAACLEELAQGTIPWRKLLTG
KVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELEMLD

Specific function: Not Known; Probable Catabolic Enzyme. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=346, Percent_Identity=24.2774566473988, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1787863, Length=347, Percent_Identity=25.9365994236311, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=27.1641791044776, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788073, Length=347, Percent_Identity=23.0547550432277, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=23.546511627907, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790718, Length=338, Percent_Identity=26.6272189349112, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082125, Length=268, Percent_Identity=27.2388059701493, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788407, Length=322, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788075, Length=361, Percent_Identity=22.1606648199446, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786552, Length=391, Percent_Identity=24.0409207161125, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=361, Percent_Identity=28.2548476454294, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=348, Percent_Identity=27.8735632183908, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319955, Length=353, Percent_Identity=26.628895184136, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322619, Length=353, Percent_Identity=26.628895184136, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323099, Length=366, Percent_Identity=26.2295081967213, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=353, Percent_Identity=25.7790368271955, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=374, Percent_Identity=24.5989304812834, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=137, Percent_Identity=32.1167883211679, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137530, Length=351, Percent_Identity=25.0712250712251, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737897, Length=349, Percent_Identity=24.6418338108883, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 38517; Mature: 38386

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMTMPTMNAIVMQDGEVSLQQVDLPKPQAGQVLVRSLACGICGSDIHITRHYNEVFDF
CCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
YRQLGVMPEGVDKHAAVMLGHEFCAEIVEFGPQTQQALALGTRVTSVPILMSQNGAGVGV
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEECCCCCCCC
TPGVNGAYSEYFILDEALLMPVPEHLPSEAVALTEPLAVGLHAVNRGDVQAEDVALVVGC
CCCCCCCCCHHEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
GPIGLAVISALHLRGVAKIVAADLQSDKLQLAREFGATHTVNPSEQDEVAFAAKLAAGQR
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCE
LVIFECVGIHKLIEGFVQRAPAKATIVVTGIHTANSNINYAYATVKELDMCFSYYYQPAE
EEEEEHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCHHH
FAACLEELAQGTIPWRKLLTGKVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELEMLD
HHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEECC
>Mature Secondary Structure 
SLMTMPTMNAIVMQDGEVSLQQVDLPKPQAGQVLVRSLACGICGSDIHITRHYNEVFDF
CCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
YRQLGVMPEGVDKHAAVMLGHEFCAEIVEFGPQTQQALALGTRVTSVPILMSQNGAGVGV
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEECCCCCCCC
TPGVNGAYSEYFILDEALLMPVPEHLPSEAVALTEPLAVGLHAVNRGDVQAEDVALVVGC
CCCCCCCCCHHEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
GPIGLAVISALHLRGVAKIVAADLQSDKLQLAREFGATHTVNPSEQDEVAFAAKLAAGQR
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCE
LVIFECVGIHKLIEGFVQRAPAKATIVVTGIHTANSNINYAYATVKELDMCFSYYYQPAE
EEEEEHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCHHH
FAACLEELAQGTIPWRKLLTGKVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELEMLD
HHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]