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The map label for this gene is saeS [H]

Identifier: 113968626

GI number: 113968626

Start: 301776

End: 303011

Strand: Direct

Name: saeS [H]

Synonym: Shewmr4_0282

Alternate gene names: 113968626

Gene position: 301776-303011 (Clockwise)

Preceding gene: 113968625

Following gene: 113968627

Centisome position: 6.41

GC content: 51.54

Gene sequence:

>1236_bases
TTGCTGTTTGCCCTTTATCGGCAACTGATTATCGAACAGCAGTACCAAGTGACTCAGTATCTCGAGTCAGAAACCCAACG
TTATCAGCAGCTTGCTCTTACTGTCGACCGTCGTAGTTTTGCGGCGCAAATCCGTGCCGCCGATCCGCAGACGGCGCTCA
TCGCTTGGCGTAACAGTTATGACATGGTTGGTGCCTTAAGCTTTATGCCCGAAGGCATGCCCATGCTGCCGCAAACTCGG
GATTTCCCGATTTTAACTGGCGGCCCTGATAAGCTGCATATCCTTACCGGCGGCCTAGTGATGACCCGCTATGGCCCTGT
GCTCATTGCCACCCGTACCGATAACTTAGCCACCTTGATCGATAAGTTTATCAGTGCGGCGGCCACGGCCGTGATGCTGA
CTATTGTACTCACTTTGGCACTGGGCTATTTGTTTTCTAAGGCGATTTTGCGCCGCTTAGTGCAGTACAACCGCTTGAGT
GAGCAAATTGAGCGGGGGCATTACGATACGCGTCTGCCGCTCAGTTGGCGTCAGGACGAGTTCGATATGCTGGCGCTGCA
GTTTAATAACGTGCTGGATATTCTTGAGAATAACCTGATGGCGGTGCGCGGGGTGACTGACAATATTGCCCACGATTTGC
GTACGCCCCTATCCCATATTCGCATCGGTCTTGAGGAGTTAGCGGCCAAATCCCCCGATGAAATCAGCGAAGGTTGCGCT
ATTTTGACCGAAGAGCTCGACCACTGCCTTGCGACCTTCGATGCCATGCTCTCGCTGACACGCATCGAGGAAGGGCAGCA
AACCTTAGATCTGCAGGAGCTGAGCTTGGCGCAGCTATGTACCGATCTGCTGGATATGGCCGACGCGGTCGCCGAATCGA
ATGAGCAAACTTTGAGCCTGTCGCTTCTATCTGATCATAAAGTTTATGGCGATAAATATTTGTTGTTCCAGGCTTTATAT
AATCTGGTCGACAATGCGATGAAGTACTCAGGTCAAGGCGCTCGCATCGATATTATTCAATCCGGCGCCCAAATTAAGAT
TTGCGATAACGGCCCAGGGATCCCCGATGACAGCAAAGAAAGGGTGTTTGAGCGTCTAGTGCGTCTCGACCCAAGCCGAC
ATTTGCAGGGCACGGGTTTAGGATTATCTATGGTCAAAGCGATCATGTCGCGGCACAATGCGCAAATTACTCTTTCGGAT
AATCATCCAGGCCTAGTGGTGACCATTCAGTTTTAG

Upstream 100 bases:

>100_bases
GCGGGTTATCGCTTACGCCAAAGGCATTAAGCCTTACCAAAGCAGCGCCTGGCGCATCACTATTATCTTCTCGACCTTAG
TGACTGTGATCATAGGCGCT

Downstream 100 bases:

>100_bases
GCCTATATCCGCGTGACAGTGTTGAGAACCCCATGTACCGAATCATAGCCGATGAGGCTGATTTTCTTGTTATTTCTAAA
TCGCCGAATGTGCATTTTCA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Sensor protein saeS [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGMPMLPQTR
DFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLS
EQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLSDHKVYGDKYLLFQALY
NLVDNAMKYSGQGARIDIIQSGAQIKICDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSD
NHPGLVVTIQF

Sequences:

>Translated_411_residues
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGMPMLPQTR
DFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLS
EQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLSDHKVYGDKYLLFQALY
NLVDNAMKYSGQGARIDIIQSGAQIKICDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSD
NHPGLVVTIQF
>Mature_411_residues
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGMPMLPQTR
DFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLS
EQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLSDHKVYGDKYLLFQALY
NLVDNAMKYSGQGARIDIIQSGAQIKICDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSD
NHPGLVVTIQF

Specific function: Member of the two-component regulatory system saeR/saeS. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator saeR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=331, Percent_Identity=25.3776435045317, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=28.8321167883212, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787894, Length=267, Percent_Identity=28.8389513108614, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=27.5985663082437, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=26.5217391304348, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786600, Length=209, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786912, Length=204, Percent_Identity=29.9019607843137, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=26.5017667844523, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=205, Percent_Identity=28.2926829268293, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788713, Length=213, Percent_Identity=26.7605633802817, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=202, Percent_Identity=25.7425742574257, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=207, Percent_Identity=27.0531400966184, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790436, Length=211, Percent_Identity=26.5402843601896, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46001; Mature: 46001

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DMVGALSFMPEGMPMLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLI
CHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECCEEEECCCCEEEEECCCHHHHHH
DKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLSEQIERGHYDTRLPLSWRQDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
HHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCHHHHHHCHHHHCCCCCHHHHHHHH
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SLLSDHKVYGDKYLLFQALYNLVDNAMKYSGQGARIDIIQSGAQIKICDNGPGIPDDSKE
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHH
RVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSDNHPGLVVTIQF
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEC
>Mature Secondary Structure
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DMVGALSFMPEGMPMLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLI
CHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECCEEEECCCCEEEEECCCHHHHHH
DKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLSEQIERGHYDTRLPLSWRQDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
HHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCHHHHHHCHHHHCCCCCHHHHHHHH
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SLLSDHKVYGDKYLLFQALYNLVDNAMKYSGQGARIDIIQSGAQIKICDNGPGIPDDSKE
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHH
RVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSDNHPGLVVTIQF
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA