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The map label for this gene is selA [H]

Identifier: 113968451

GI number: 113968451

Start: 118635

End: 120065

Strand: Direct

Name: selA [H]

Synonym: Shewmr4_0106

Alternate gene names: 113968451

Gene position: 118635-120065 (Clockwise)

Preceding gene: 113968450

Following gene: 113968452

Centisome position: 2.52

GC content: 55.84

Gene sequence:

>1431_bases
ATGATACAAATGATGACCCAAGTACCCGATACACCCCAAGCCCTGTACCGAGCGCTGCCGTCGATGGACAGTCTGCTCGC
CGATGCGATATTGGCGCCTCTGCTGCAAAGCTATGGTAAAGCGGCGGTAAAAGCGGCGCTGGATAGCCAGTTACGCACGG
CGCGTGAGCTGATTGCCCAGGAGCGACGTTTACCCGCTTGGTGTGCTAACCCGTCATTATTGAACGGATATTTGGTTGAT
CAATTGTCTAAGGACTATAGCCATAGTCTAAAACCCGTGTGGAACCTCACGGGAACTATCCTGCATACCAATCTTGGTCG
CGCCCAGCAGTCTGAGGCGGCCATTCGGGCGGTGACCTCTGTGATGCGTTATCCGACGCCGCTGGAATTTGAGTTGGCAG
CGGGTGAGCGCGGCCATCGGGATAATGCTATTAGTGGGTTAATCCAACGCTTAACAGGGGCAGAGGCCTGCTGCGTGGTG
AATAACAACGCCGCCGCTGTGTTGCTGATGTTGTCGGCGGTGGCCGCGGGTAAAGAAGTGATCGTCTCCCGCGGCGAGCT
GGTGGAAATCGGCGGTGCCTTTCGCATTCCTGACATTATGCGCCAAGCGGGTTGTACCTTAGTGGAAGTCGGCAGCACTA
ATCGTACTCACCTCAAGGACTATGAGCAGGCGATCACCGAAAATACCGCCGCCATTATGAAGGTGCACACCAGCAACTAC
CATATCAGTGGCTTTACCGCTTCGGTGGATGAGGCCAGATTAGGCCAACTCTGCCGCGAGCGTGGGGTCGCGCTGATCTC
GGATCTTGGCAGTGGTTCACTCACCGACTTACGCCGTTTTGGCCTTAAACAAGAGCCGACGCCCCAAGCCATGTTGGCGG
ATGGGGTCGATCTGGTCAGCTTCTCCGGCGATAAACTCCTCGGCGGCCCGCAATCGGGTTTGATTGTCGGCAAACAGGCG
CTAATTAATAAGCTTCAAAGCCATCCGCTCAAGCGTGCATTGCGTTGCGACAAGCTGATTCTCGCGGCGCTTGAGGCGAC
GCTGATCCACTATCTCAACCCAGAATCCTTGGATCGGGAACTGCCGATTATGGCCAAATTTGCCCGCAGTCAAGCAGAGT
TACGCCAAATTGGTGAGCGCCTGCAGCGCGCCTTAGCGCCACTGTTTGCCCCGAGTTATGGCATCGAGCTAGTGGAGTGC
CAAACTCAAGTCGGTAGCGGCTCGCAGCCCGATACCTTTTTGCCCTCAATCGCCCTGTGCTTTAACGCGCAAGAGGGTGG
CAGTCTAACGCTGCTCGAGCAGCATTTTAAGCAGGCGCAGCGGCCTGTGATTGGCCGTATGACCCAAGATCAACTTCGTC
TCGATTTGCGCGGTATCGATGATGAGGCCGAATTGTTAGCCGAACTCAGCACCTTAGGTGTGCAGCTATGA

Upstream 100 bases:

>100_bases
TGGAGCGACCACGGTCAATCCATTGCTACTGGCCCACGAAACTGAGCAATAACCAAAGTCGGGAAGGGCTCACCGAGTCC
TTCCCCTTATATTTATCAAG

Downstream 100 bases:

>100_bases
TTATGGTCACCGCGGGCCACGTCGACCACGGCAAGAGCACGCTGATCCGAGCCTTGACGGGGATGAACACCGACAGGCTC
CCCGAAGAAAAACGCCGTGG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MIQMMTQVPDTPQALYRALPSMDSLLADAILAPLLQSYGKAAVKAALDSQLRTARELIAQERRLPAWCANPSLLNGYLVD
QLSKDYSHSLKPVWNLTGTILHTNLGRAQQSEAAIRAVTSVMRYPTPLEFELAAGERGHRDNAISGLIQRLTGAEACCVV
NNNAAAVLLMLSAVAAGKEVIVSRGELVEIGGAFRIPDIMRQAGCTLVEVGSTNRTHLKDYEQAITENTAAIMKVHTSNY
HISGFTASVDEARLGQLCRERGVALISDLGSGSLTDLRRFGLKQEPTPQAMLADGVDLVSFSGDKLLGGPQSGLIVGKQA
LINKLQSHPLKRALRCDKLILAALEATLIHYLNPESLDRELPIMAKFARSQAELRQIGERLQRALAPLFAPSYGIELVEC
QTQVGSGSQPDTFLPSIALCFNAQEGGSLTLLEQHFKQAQRPVIGRMTQDQLRLDLRGIDDEAELLAELSTLGVQL

Sequences:

>Translated_476_residues
MIQMMTQVPDTPQALYRALPSMDSLLADAILAPLLQSYGKAAVKAALDSQLRTARELIAQERRLPAWCANPSLLNGYLVD
QLSKDYSHSLKPVWNLTGTILHTNLGRAQQSEAAIRAVTSVMRYPTPLEFELAAGERGHRDNAISGLIQRLTGAEACCVV
NNNAAAVLLMLSAVAAGKEVIVSRGELVEIGGAFRIPDIMRQAGCTLVEVGSTNRTHLKDYEQAITENTAAIMKVHTSNY
HISGFTASVDEARLGQLCRERGVALISDLGSGSLTDLRRFGLKQEPTPQAMLADGVDLVSFSGDKLLGGPQSGLIVGKQA
LINKLQSHPLKRALRCDKLILAALEATLIHYLNPESLDRELPIMAKFARSQAELRQIGERLQRALAPLFAPSYGIELVEC
QTQVGSGSQPDTFLPSIALCFNAQEGGSLTLLEQHFKQAQRPVIGRMTQDQLRLDLRGIDDEAELLAELSTLGVQL
>Mature_476_residues
MIQMMTQVPDTPQALYRALPSMDSLLADAILAPLLQSYGKAAVKAALDSQLRTARELIAQERRLPAWCANPSLLNGYLVD
QLSKDYSHSLKPVWNLTGTILHTNLGRAQQSEAAIRAVTSVMRYPTPLEFELAAGERGHRDNAISGLIQRLTGAEACCVV
NNNAAAVLLMLSAVAAGKEVIVSRGELVEIGGAFRIPDIMRQAGCTLVEVGSTNRTHLKDYEQAITENTAAIMKVHTSNY
HISGFTASVDEARLGQLCRERGVALISDLGSGSLTDLRRFGLKQEPTPQAMLADGVDLVSFSGDKLLGGPQSGLIVGKQA
LINKLQSHPLKRALRCDKLILAALEATLIHYLNPESLDRELPIMAKFARSQAELRQIGERLQRALAPLFAPSYGIELVEC
QTQVGSGSQPDTFLPSIALCFNAQEGGSLTLLEQHFKQAQRPVIGRMTQDQLRLDLRGIDDEAELLAELSTLGVQL

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis [H]

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family [H]

Homologues:

Organism=Escherichia coli, GI2367248, Length=461, Percent_Identity=55.531453362256, Blast_Score=443, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534 [H]

Pfam domain/function: PF03841 SelA [H]

EC number: =2.9.1.1 [H]

Molecular weight: Translated: 51631; Mature: 51631

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQMMTQVPDTPQALYRALPSMDSLLADAILAPLLQSYGKAAVKAALDSQLRTARELIAQ
CCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERRLPAWCANPSLLNGYLVDQLSKDYSHSLKPVWNLTGTILHTNLGRAQQSEAAIRAVTS
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHEECCCCCCHHHHHHHHHHHH
VMRYPTPLEFELAAGERGHRDNAISGLIQRLTGAEACCVVNNNAAAVLLMLSAVAAGKEV
HHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCHHH
IVSRGELVEIGGAFRIPDIMRQAGCTLVEVGSTNRTHLKDYEQAITENTAAIMKVHTSNY
HHCCCCEEEECCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCE
HISGFTASVDEARLGQLCRERGVALISDLGSGSLTDLRRFGLKQEPTPQAMLADGVDLVS
EEECEECCHHHHHHHHHHHHCCCEEEHHCCCCCHHHHHHCCCCCCCCCHHHHHCCCCEEE
FSGDKLLGGPQSGLIVGKQALINKLQSHPLKRALRCDKLILAALEATLIHYLNPESLDRE
CCCCCCCCCCCCCCEECHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
LPIMAKFARSQAELRQIGERLQRALAPLFAPSYGIELVECQTQVGSGSQPDTFLPSIALC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCHHHCHHHHE
FNAQEGGSLTLLEQHFKQAQRPVIGRMTQDQLRLDLRGIDDEAELLAELSTLGVQL
EECCCCCCCHHHHHHHHHHCCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIQMMTQVPDTPQALYRALPSMDSLLADAILAPLLQSYGKAAVKAALDSQLRTARELIAQ
CCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERRLPAWCANPSLLNGYLVDQLSKDYSHSLKPVWNLTGTILHTNLGRAQQSEAAIRAVTS
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHEECCCCCCHHHHHHHHHHHH
VMRYPTPLEFELAAGERGHRDNAISGLIQRLTGAEACCVVNNNAAAVLLMLSAVAAGKEV
HHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCHHH
IVSRGELVEIGGAFRIPDIMRQAGCTLVEVGSTNRTHLKDYEQAITENTAAIMKVHTSNY
HHCCCCEEEECCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCE
HISGFTASVDEARLGQLCRERGVALISDLGSGSLTDLRRFGLKQEPTPQAMLADGVDLVS
EEECEECCHHHHHHHHHHHHCCCEEEHHCCCCCHHHHHHCCCCCCCCCHHHHHCCCCEEE
FSGDKLLGGPQSGLIVGKQALINKLQSHPLKRALRCDKLILAALEATLIHYLNPESLDRE
CCCCCCCCCCCCCCEECHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
LPIMAKFARSQAELRQIGERLQRALAPLFAPSYGIELVECQTQVGSGSQPDTFLPSIALC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCHHHCHHHHE
FNAQEGGSLTLLEQHFKQAQRPVIGRMTQDQLRLDLRGIDDEAELLAELSTLGVQL
EECCCCCCCHHHHHHHHHHCCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]