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The map label for this gene is fadD [C]

Identifier: 113968423

GI number: 113968423

Start: 89713

End: 91506

Strand: Direct

Name: fadD [C]

Synonym: Shewmr4_0078

Alternate gene names: 113968423

Gene position: 89713-91506 (Clockwise)

Preceding gene: 113968422

Following gene: 113968424

Centisome position: 1.91

GC content: 51.34

Gene sequence:

>1794_bases
ATGTCTCTCGAACAATATCACGTAATTCGACTATTACAGCAGCAAAGCCAGTCATTAAAAGAGGCTATAGCGCTGGAAGG
TTTTGAAATGGCTGCGCCTTGGCATCAAGTCAGTTGGCAGGCATTCGATCAAATCAGCCATAAAATTGCACAGGTGTTGA
TTGAACTTGGCGTACAAGTGCAAGACCGTTGCGTGATCCTGTCGCAAAACTGCCCTCAATGGACCTGCGCCGACATAGGT
ACCCTGAAAAGTCGTGCCGTTGTGGTCCCCATTTACCCGACCAGTACCTTAGAGCAAGCCAGCTTTATCATTAACGATGC
GGCGGCTAAGGTGATTTTTGTCGACGACGCTAAGCAATATGCGCTGGCCTGTGAGCTGCAAAAACAGTGTCCAACCCTAG
AGCATGTGATTGTGTTTGACGCGAGTGTTGAGCTGGCGCAGGACAAGGCTCAACATCAGCATTTAGACAGTTTGCTAGCC
AAAGAATATGGCCAGAGTGCTGAGCTTGAGCAGCGCTTAAAGGATGCCAATCTCGACGACCTGTTAACCCTAATTTATAC
CTCTGGTACCACGGGCGACCCTAAGGGCGTGATGCTGGATTACCGCAATATGGCTTCGACTGTGCGTCAGCACGATCAGA
TCCTGCCGTTTACCACTGGCGATGTGTCGTTAGCTTTCCTACCGCTAAGCCATGTGTTTGAGCGTGGTTGGAGCTTCTAT
GTGCTGTGCCGTGGCGGCCACAACGTGTATCTGCAAAACACCCAAAGAGTGAAAGAGGCCATCAGCGCCGTGCGTCCGCA
TACCCTGTGCGTGGTGCCGCGTTTCCTCGAGAAGGTTTACAGCGCAGTGCAGGATAAGGTCGCTAAATCCGCCGAAGGCC
GTAAAAAACTCTTCGCCTGGGCCATGGGCGTCGGCGAACGCCAGTTTGAGGTGAGCCAAGGCCGCGCTAAGGGCGGTTTA
TGGTTATCCTTGCAATGGCGTTTAGCGCACAAGCTGGTTTACAGCAAGTTGCAAGCCGTGCTCGGTGGGCGCTTAAAGTT
TATGCCCTGCGGTGGCGCCGCCCTCGATTTAAACGTGGCGTCTTTCTTCCATGCTATTGGTATTCCGGTACTTTGTGGTT
ACGGCATGACGGAAACGAACGCCACAGTGACCTGTAATACCCTAGATAACCGAGTTGCGGGTTCGAACGGTAAAGTATTG
CCCGAAATCGAGGTGAAGCTAGGTAAGGACGATGAGATTTTAGTCCGTGGCGACACTGTGATGCGCGGTTATTACAATCG
CCCCGAAGACACTGCAGCTGCCTTCGAAGATGGCTGGTTAAAGACTGGCGATGCGGGACGACTCGATGCCAATGGCAATT
TATTTATTACCGACCGCATCAAAGAGTTAATGAAAACTTCCAACGGTAAATACATTGCTCCGCAGCGGGTTGAAGGCACA
GTGGGCCGTTGCCCCTTTATCGAACAGGTGGCTGTGATTGCCGATGCCCGTAACTATGTGACGGCGCTGATTGTGCCAGC
CTTTGAATCCCTCGAAGCCTGGGCCAAGGATAAGGGCTTGAAATACGAGTCGTCTATCGAGCTGCTGCGTCACAGCCATG
TGGTTGAACATTTCGAGCAGCGCTTAAAGCATTTGCAGCAAGAGTTGGCGGGGTTTGAGCAAATCAAAAAGTTTACCCTG
TTGCCTGAAGCCTTTTCGATGGAGGCGGGATTAATCACCCCGACGCTGAAATTGCGCCGCAAAATGATTTACCACAAGTA
CGCCCACGAAATTAATGCGATGTACAATAATTGA

Upstream 100 bases:

>100_bases
CATTTGCACAAGATTAGAGCAAAAACTCTTAGTTTTTAGCTTGCCTTCAGGTAGAATGCCGCAAAAGCGGTACACTTGTA
AGCTAAAAGGTGAGTCACTC

Downstream 100 bases:

>100_bases
TTGTTAAATCTTTGATCTTAAAAGGCCGCTTAGCGGCCTTTTTTGTGTCAGCCACTTCCTGAAGCATCTGACTTCGCTTA
AAATTCGTCCCGCTTACTGG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MSLEQYHVIRLLQQQSQSLKEAIALEGFEMAAPWHQVSWQAFDQISHKIAQVLIELGVQVQDRCVILSQNCPQWTCADIG
TLKSRAVVVPIYPTSTLEQASFIINDAAAKVIFVDDAKQYALACELQKQCPTLEHVIVFDASVELAQDKAQHQHLDSLLA
KEYGQSAELEQRLKDANLDDLLTLIYTSGTTGDPKGVMLDYRNMASTVRQHDQILPFTTGDVSLAFLPLSHVFERGWSFY
VLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSAEGRKKLFAWAMGVGERQFEVSQGRAKGGL
WLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALDLNVASFFHAIGIPVLCGYGMTETNATVTCNTLDNRVAGSNGKVL
PEIEVKLGKDDEILVRGDTVMRGYYNRPEDTAAAFEDGWLKTGDAGRLDANGNLFITDRIKELMKTSNGKYIAPQRVEGT
VGRCPFIEQVAVIADARNYVTALIVPAFESLEAWAKDKGLKYESSIELLRHSHVVEHFEQRLKHLQQELAGFEQIKKFTL
LPEAFSMEAGLITPTLKLRRKMIYHKYAHEINAMYNN

Sequences:

>Translated_597_residues
MSLEQYHVIRLLQQQSQSLKEAIALEGFEMAAPWHQVSWQAFDQISHKIAQVLIELGVQVQDRCVILSQNCPQWTCADIG
TLKSRAVVVPIYPTSTLEQASFIINDAAAKVIFVDDAKQYALACELQKQCPTLEHVIVFDASVELAQDKAQHQHLDSLLA
KEYGQSAELEQRLKDANLDDLLTLIYTSGTTGDPKGVMLDYRNMASTVRQHDQILPFTTGDVSLAFLPLSHVFERGWSFY
VLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSAEGRKKLFAWAMGVGERQFEVSQGRAKGGL
WLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALDLNVASFFHAIGIPVLCGYGMTETNATVTCNTLDNRVAGSNGKVL
PEIEVKLGKDDEILVRGDTVMRGYYNRPEDTAAAFEDGWLKTGDAGRLDANGNLFITDRIKELMKTSNGKYIAPQRVEGT
VGRCPFIEQVAVIADARNYVTALIVPAFESLEAWAKDKGLKYESSIELLRHSHVVEHFEQRLKHLQQELAGFEQIKKFTL
LPEAFSMEAGLITPTLKLRRKMIYHKYAHEINAMYNN
>Mature_596_residues
SLEQYHVIRLLQQQSQSLKEAIALEGFEMAAPWHQVSWQAFDQISHKIAQVLIELGVQVQDRCVILSQNCPQWTCADIGT
LKSRAVVVPIYPTSTLEQASFIINDAAAKVIFVDDAKQYALACELQKQCPTLEHVIVFDASVELAQDKAQHQHLDSLLAK
EYGQSAELEQRLKDANLDDLLTLIYTSGTTGDPKGVMLDYRNMASTVRQHDQILPFTTGDVSLAFLPLSHVFERGWSFYV
LCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSAEGRKKLFAWAMGVGERQFEVSQGRAKGGLW
LSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALDLNVASFFHAIGIPVLCGYGMTETNATVTCNTLDNRVAGSNGKVLP
EIEVKLGKDDEILVRGDTVMRGYYNRPEDTAAAFEDGWLKTGDAGRLDANGNLFITDRIKELMKTSNGKYIAPQRVEGTV
GRCPFIEQVAVIADARNYVTALIVPAFESLEAWAKDKGLKYESSIELLRHSHVVEHFEQRLKHLQQELAGFEQIKKFTLL
PEAFSMEAGLITPTLKLRRKMIYHKYAHEINAMYNN

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=593, Percent_Identity=30.0168634064081, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI27477105, Length=629, Percent_Identity=29.093799682035, Blast_Score=235, Evalue=1e-61,
Organism=Homo sapiens, GI57165410, Length=559, Percent_Identity=30.5903398926655, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI57165412, Length=558, Percent_Identity=30.2867383512545, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI42794756, Length=595, Percent_Identity=29.9159663865546, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI42794760, Length=595, Percent_Identity=29.9159663865546, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI42794758, Length=595, Percent_Identity=29.9159663865546, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI83745141, Length=597, Percent_Identity=26.8006700167504, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI42794754, Length=602, Percent_Identity=26.7441860465116, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI42794752, Length=602, Percent_Identity=26.7441860465116, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI4758332, Length=602, Percent_Identity=25.5813953488372, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI12669909, Length=599, Percent_Identity=25.3756260434057, Blast_Score=172, Evalue=7e-43,
Organism=Escherichia coli, GI1788107, Length=511, Percent_Identity=24.6575342465753, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788595, Length=210, Percent_Identity=29.0476190476191, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693145, Length=163, Percent_Identity=31.9018404907975, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17556552, Length=559, Percent_Identity=30.9481216457961, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17510401, Length=590, Percent_Identity=31.0169491525424, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17541856, Length=594, Percent_Identity=28.956228956229, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17564090, Length=536, Percent_Identity=29.8507462686567, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17553312, Length=610, Percent_Identity=26.0655737704918, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25147511, Length=599, Percent_Identity=26.5442404006678, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI193204819, Length=616, Percent_Identity=26.461038961039, Blast_Score=182, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI32563687, Length=482, Percent_Identity=23.8589211618257, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17558820, Length=226, Percent_Identity=30.0884955752212, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17559526, Length=134, Percent_Identity=42.5373134328358, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI133901848, Length=208, Percent_Identity=26.4423076923077, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=229, Percent_Identity=26.6375545851528, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71996755, Length=231, Percent_Identity=27.7056277056277, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560140, Length=175, Percent_Identity=29.7142857142857, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324893, Length=665, Percent_Identity=24.812030075188, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320852, Length=585, Percent_Identity=26.1538461538462, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323903, Length=614, Percent_Identity=25.5700325732899, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322182, Length=616, Percent_Identity=24.8376623376623, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24666501, Length=596, Percent_Identity=30.0335570469799, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24666497, Length=596, Percent_Identity=30.0335570469799, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281366413, Length=596, Percent_Identity=30.0335570469799, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17933690, Length=640, Percent_Identity=26.40625, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI62471679, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI62471683, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI62471685, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24586636, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI62471681, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI62471687, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24586634, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI22026970, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI62471689, Length=605, Percent_Identity=27.4380165289256, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI19921316, Length=629, Percent_Identity=26.550079491256, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI18859661, Length=507, Percent_Identity=24.0631163708087, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355181, Length=504, Percent_Identity=24.4047619047619, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130357, Length=140, Percent_Identity=34.2857142857143, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24653035, Length=192, Percent_Identity=30.2083333333333, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 66817; Mature: 66685

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEQYHVIRLLQQQSQSLKEAIALEGFEMAAPWHQVSWQAFDQISHKIAQVLIELGVQV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCE
QDRCVILSQNCPQWTCADIGTLKSRAVVVPIYPTSTLEQASFIINDAAAKVIFVDDAKQY
ECEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHEECCCEEEEEEECCHHH
ALACELQKQCPTLEHVIVFDASVELAQDKAQHQHLDSLLAKEYGQSAELEQRLKDANLDD
HHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHH
LLTLIYTSGTTGDPKGVMLDYRNMASTVRQHDQILPFTTGDVSLAFLPLSHVFERGWSFY
HHHHHEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCEECCCCEEEEEEHHHHHHCCCEEE
VLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSAEGRKKLFAW
EEEECCCEEEECCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AMGVGERQFEVSQGRAKGGLWLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALDLNVA
HHCCCCCEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEHHHH
SFFHAIGIPVLCGYGMTETNATVTCNTLDNRVAGSNGKVLPEIEVKLGKDDEILVRGDTV
HHHHHHCHHHEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEECCEE
MRGYYNRPEDTAAAFEDGWLKTGDAGRLDANGNLFITDRIKELMKTSNGKYIAPQRVEGT
EECCCCCCCHHHHHHHCCCEECCCCCEECCCCCEEEHHHHHHHHHCCCCCEECCCCCCCC
VGRCPFIEQVAVIADARNYVTALIVPAFESLEAWAKDKGLKYESSIELLRHSHVVEHFEQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RLKHLQQELAGFEQIKKFTLLPEAFSMEAGLITPTLKLRRKMIYHKYAHEINAMYNN
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLEQYHVIRLLQQQSQSLKEAIALEGFEMAAPWHQVSWQAFDQISHKIAQVLIELGVQV
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCE
QDRCVILSQNCPQWTCADIGTLKSRAVVVPIYPTSTLEQASFIINDAAAKVIFVDDAKQY
ECEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHEECCCEEEEEEECCHHH
ALACELQKQCPTLEHVIVFDASVELAQDKAQHQHLDSLLAKEYGQSAELEQRLKDANLDD
HHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHH
LLTLIYTSGTTGDPKGVMLDYRNMASTVRQHDQILPFTTGDVSLAFLPLSHVFERGWSFY
HHHHHEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCEECCCCEEEEEEHHHHHHCCCEEE
VLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSAEGRKKLFAW
EEEECCCEEEECCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AMGVGERQFEVSQGRAKGGLWLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALDLNVA
HHCCCCCEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEHHHH
SFFHAIGIPVLCGYGMTETNATVTCNTLDNRVAGSNGKVLPEIEVKLGKDDEILVRGDTV
HHHHHHCHHHEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEECCEE
MRGYYNRPEDTAAAFEDGWLKTGDAGRLDANGNLFITDRIKELMKTSNGKYIAPQRVEGT
EECCCCCCCHHHHHHHCCCEECCCCCEECCCCCEEEHHHHHHHHHCCCCCEECCCCCCCC
VGRCPFIEQVAVIADARNYVTALIVPAFESLEAWAKDKGLKYESSIELLRHSHVVEHFEQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RLKHLQQELAGFEQIKKFTLLPEAFSMEAGLITPTLKLRRKMIYHKYAHEINAMYNN
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]