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The map label for this gene is pdhA [H]

Identifier: 113478382

GI number: 113478382

Start: 7727163

End: 7728194

Strand: Reverse

Name: pdhA [H]

Synonym: Tery_5066

Alternate gene names: 113478382

Gene position: 7728194-7727163 (Counterclockwise)

Preceding gene: 113478384

Following gene: 113478380

Centisome position: 99.72

GC content: 38.66

Gene sequence:

>1032_bases
ATGATCCAAGAACGCACCGTACCTAAATTTGATACTAATAGTGTAAAAATCACTAAGGAAAAAGCATTAATTCTATATGA
AGATATGGTTTTAGGGCGCTTATTTGAAGATAAGTGTGCTGAAATGTATTACCGAGGCAAAATGTTTGGCTTTGTCCATC
TTTATAATGGACAAGAAGCAGTTTCTTCCGGTGTAATTAAAGCTATGCGTCAAGATGAAGATTTTGTTAGTAGCACCTAT
AGAGACCACGTTCATGCTCTAAGTGCTGGTGTACCTGCACGAGAAGTAATGGCTGAATTATTTGGCAAAGCTACAGGTTG
TTCTAAAGGTCGTGGTGGTTCGATGCATATGTTCTCAGCTACGCATAATCTATTAGGGGGTTATGCTTTTGTTGCTGAAG
GTATTCCTGTCGCGACTGGGGCAGCTTTTCAGAGTAAATATCGTCGGGAAACTATGGGAAATCAAGCGGCTGACCAAGTA
ACGGCTTGTTTCTTTGGAGATGGAGCTTGTAATAATGGTCAGTTTTTTGAATGCCTAAATATGGCTGCACTGTGGAAACT
ACCAATTATTTATGTAGTAGAAAATAACAAATGGGCAATTGGTATGGCTCACGAACGCGCTACTTCTGAACCGGAAATTT
ATAAAAAAGCTCATGCTTTTGGCATGGTAGGTGTAGAAGTTGATGGTATGGATATATTAGCAGTACATTCTGCTGCTCAA
GAGGCTGTTGCTCGGGCTCGTGCTGGCGAAGGACCAACTTTAATTGAAGCTTTGACTTATCGTTTTCGAGGACATTCTTT
GGCAGACCCTGATGAATTAAGAGATCAAGAAGAAAAGCAATATTGGTTTTCTCGTGACCCCATTAAAAAATTTACAACTT
ACTTAACAGAAAATAATTTGGTAGATGTTGCAGAATTAGTGGCAATTGATAAAAAGATTGAGAATTTAATTACTGAAGCT
GTTGATTTTGCTACAAATAGTCCAGAACCAGGTTCAGATGAACTATATCGGTATATTTTTGCAGAGGATTAG

Upstream 100 bases:

>100_bases
CACCATTCCCATATAAGCTAATAATTATAAGGTCATTTTAGACTTTTGCAAAACATTACACAAAATTTATCGCTTATTAT
ACTACCTTAGGATGTATAAA

Downstream 100 bases:

>100_bases
TTAGTCGGATTATTGATTTAATTTTCATTAAGCTTGATGTCAAAATCAAGCAATTTTATTTCTTATTAAAATAGGACTAA
AAATCTTTTCGGAAGCTAAA

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MIQERTVPKFDTNSVKITKEKALILYEDMVLGRLFEDKCAEMYYRGKMFGFVHLYNGQEAVSSGVIKAMRQDEDFVSSTY
RDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSATHNLLGGYAFVAEGIPVATGAAFQSKYRRETMGNQAADQV
TACFFGDGACNNGQFFECLNMAALWKLPIIYVVENNKWAIGMAHERATSEPEIYKKAHAFGMVGVEVDGMDILAVHSAAQ
EAVARARAGEGPTLIEALTYRFRGHSLADPDELRDQEEKQYWFSRDPIKKFTTYLTENNLVDVAELVAIDKKIENLITEA
VDFATNSPEPGSDELYRYIFAED

Sequences:

>Translated_343_residues
MIQERTVPKFDTNSVKITKEKALILYEDMVLGRLFEDKCAEMYYRGKMFGFVHLYNGQEAVSSGVIKAMRQDEDFVSSTY
RDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSATHNLLGGYAFVAEGIPVATGAAFQSKYRRETMGNQAADQV
TACFFGDGACNNGQFFECLNMAALWKLPIIYVVENNKWAIGMAHERATSEPEIYKKAHAFGMVGVEVDGMDILAVHSAAQ
EAVARARAGEGPTLIEALTYRFRGHSLADPDELRDQEEKQYWFSRDPIKKFTTYLTENNLVDVAELVAIDKKIENLITEA
VDFATNSPEPGSDELYRYIFAED
>Mature_343_residues
MIQERTVPKFDTNSVKITKEKALILYEDMVLGRLFEDKCAEMYYRGKMFGFVHLYNGQEAVSSGVIKAMRQDEDFVSSTY
RDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSATHNLLGGYAFVAEGIPVATGAAFQSKYRRETMGNQAADQV
TACFFGDGACNNGQFFECLNMAALWKLPIIYVVENNKWAIGMAHERATSEPEIYKKAHAFGMVGVEVDGMDILAVHSAAQ
EAVARARAGEGPTLIEALTYRFRGHSLADPDELRDQEEKQYWFSRDPIKKFTTYLTENNLVDVAELVAIDKKIENLITEA
VDFATNSPEPGSDELYRYIFAED

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=39.209726443769, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI291084742, Length=329, Percent_Identity=40.1215805471125, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI4505685, Length=329, Percent_Identity=40.1215805471125, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=39.2857142857143, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=37.0820668693009, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI11386135, Length=328, Percent_Identity=29.2682926829268, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI258645172, Length=333, Percent_Identity=29.4294294294294, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17536047, Length=330, Percent_Identity=38.4848484848485, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32564172, Length=330, Percent_Identity=38.7878787878788, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI86563355, Length=299, Percent_Identity=28.4280936454849, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI86563357, Length=299, Percent_Identity=28.4280936454849, Blast_Score=117, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6321026, Length=319, Percent_Identity=36.3636363636364, Blast_Score=208, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24639740, Length=331, Percent_Identity=39.2749244712991, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24639744, Length=331, Percent_Identity=39.2749244712991, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI28571106, Length=331, Percent_Identity=39.2749244712991, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24639748, Length=334, Percent_Identity=39.8203592814371, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24639746, Length=313, Percent_Identity=38.9776357827476, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI21355903, Length=335, Percent_Identity=24.4776119402985, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38175; Mature: 38175

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQERTVPKFDTNSVKITKEKALILYEDMVLGRLFEDKCAEMYYRGKMFGFVHLYNGQEA
CCCCCCCCCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHH
VSSGVIKAMRQDEDFVSSTYRDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEHHH
THNLLGGYAFVAEGIPVATGAAFQSKYRRETMGNQAADQVTACFFGDGACNNGQFFECLN
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHEEEEECCCCCCCCHHHHHHH
MAALWKLPIIYVVENNKWAIGMAHERATSEPEIYKKAHAFGMVGVEVDGMDILAVHSAAQ
HHHHHHCCEEEEEECCEEEEEECHHCCCCCHHHHHHHHHHEEEEEEECCEEEEHHHHHHH
EAVARARAGEGPTLIEALTYRFRGHSLADPDELRDQEEKQYWFSRDPIKKFTTYLTENNL
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHHHCCCCCHHHHHHHHHCCCCC
VDVAELVAIDKKIENLITEAVDFATNSPEPGSDELYRYIFAED
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEECC
>Mature Secondary Structure
MIQERTVPKFDTNSVKITKEKALILYEDMVLGRLFEDKCAEMYYRGKMFGFVHLYNGQEA
CCCCCCCCCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHH
VSSGVIKAMRQDEDFVSSTYRDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEHHH
THNLLGGYAFVAEGIPVATGAAFQSKYRRETMGNQAADQVTACFFGDGACNNGQFFECLN
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHEEEEECCCCCCCCHHHHHHH
MAALWKLPIIYVVENNKWAIGMAHERATSEPEIYKKAHAFGMVGVEVDGMDILAVHSAAQ
HHHHHHCCEEEEEECCEEEEEECHHCCCCCHHHHHHHHHHEEEEEEECCEEEEHHHHHHH
EAVARARAGEGPTLIEALTYRFRGHSLADPDELRDQEEKQYWFSRDPIKKFTTYLTENNL
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHHHCCCCCHHHHHHHHHCCCCC
VDVAELVAIDKKIENLITEAVDFATNSPEPGSDELYRYIFAED
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA