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The map label for this gene is hemC [H]

Identifier: 113478006

GI number: 113478006

Start: 7100809

End: 7101771

Strand: Reverse

Name: hemC [H]

Synonym: Tery_4621

Alternate gene names: 113478006

Gene position: 7101771-7100809 (Counterclockwise)

Preceding gene: 113478010

Following gene: 113478005

Centisome position: 91.63

GC content: 38.84

Gene sequence:

>963_bases
ATGACAATATCTGCCTCTACTCCTACCATTCGGATCGGTTCACGCAAAAGTCAACTCGCCTTAATTCAAACCTACTGGGT
CCAAGAAAAACTTGAAAAAAATTTCCCAAATATTACATTTGAAGTCCACAAAATGTCTACCCAAGGAGATAAAATTCTAG
ATGTAGCTTTAGCAAAAATAGGAGATAAAGGGCTTTTTACTAAAGAACTAGAATTAGGAATGCTGCAAAATGAAACTGAC
CTAGCAGTTCATTCCTTAAAAGACTTACCCACAAACTTACCAGAAGGTCTAATTCTCGGTTGCGTCACCGAACGGGAAAA
CCCTGCAGATGCTTTAGTCCTCCATGAAAAATTAAAAGATAAACAACTTGAGACTTTACCAGAAGGTGCTGTCATTGGTA
CCTCTTCCCTAAGACGTTTAGCACAACTGCGCTACCACTTCCCTCACTTAGAATTTAAAGATGTTCGTGGTAACCTGAAT
ACTAGACTAGCAAAATTAGATGCTGGTGAGTATGATGCTCTAATATTGGCTTTTGCTGGTTTGCATAGGTTGGGGATGAG
CGATCGCATTCATCAAATTATACCTCCAGAAATTTCTCTTCATGCCGTTGGACAAGGTGCTTTAGGAATAGAATGTCGTG
CCGGAGATAATAATATTCTCAATTTATTGAAAAGTCTGGAACATACTGCCACTGCTCAGAGATGTTATGCCGAACGTGCT
TTTCTGAGAGAATTAGAAGGAGGCTGTCAAGTTCCCATTGGTGTTAACACCCAAATAGAAGGAGAACAACTAACTTTAAC
TGGTTTAGTCGCTAGTTTAGATGGTAAGAAATTAGTTAAGGATATTGTAACTGGAGCCACTGCTGATGCAGAACAAATAG
GCATCGAATTAGCTCAAAAACTAAGAAAACAAGGCGCCCAAGAAATCTTAGATCAAATTTTAGCAGAAATTAACCGTAGT
TAA

Upstream 100 bases:

>100_bases
CATTAGCTTTTAACTTTTGACTTTTGATTTCAAATATTTAAGCCTCAATTTAAGGTAGTCTAGAAAGAACAATCAAACTT
ATTTATTTCAACATTAAGAT

Downstream 100 bases:

>100_bases
TTTTGAAGTTATCCATAAAACAATATGGTTCAGTTAAAGATTTTTTTTTGTAGTTTTGTAATTTGAAAAGCTGATCTCAT
GCTTCCACACTACAAGAGTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTISASTPTIRIGSRKSQLALIQTYWVQEKLEKNFPNITFEVHKMSTQGDKILDVALAKIGDKGLFTKELELGMLQNETD
LAVHSLKDLPTNLPEGLILGCVTERENPADALVLHEKLKDKQLETLPEGAVIGTSSLRRLAQLRYHFPHLEFKDVRGNLN
TRLAKLDAGEYDALILAFAGLHRLGMSDRIHQIIPPEISLHAVGQGALGIECRAGDNNILNLLKSLEHTATAQRCYAERA
FLRELEGGCQVPIGVNTQIEGEQLTLTGLVASLDGKKLVKDIVTGATADAEQIGIELAQKLRKQGAQEILDQILAEINRS

Sequences:

>Translated_320_residues
MTISASTPTIRIGSRKSQLALIQTYWVQEKLEKNFPNITFEVHKMSTQGDKILDVALAKIGDKGLFTKELELGMLQNETD
LAVHSLKDLPTNLPEGLILGCVTERENPADALVLHEKLKDKQLETLPEGAVIGTSSLRRLAQLRYHFPHLEFKDVRGNLN
TRLAKLDAGEYDALILAFAGLHRLGMSDRIHQIIPPEISLHAVGQGALGIECRAGDNNILNLLKSLEHTATAQRCYAERA
FLRELEGGCQVPIGVNTQIEGEQLTLTGLVASLDGKKLVKDIVTGATADAEQIGIELAQKLRKQGAQEILDQILAEINRS
>Mature_319_residues
TISASTPTIRIGSRKSQLALIQTYWVQEKLEKNFPNITFEVHKMSTQGDKILDVALAKIGDKGLFTKELELGMLQNETDL
AVHSLKDLPTNLPEGLILGCVTERENPADALVLHEKLKDKQLETLPEGAVIGTSSLRRLAQLRYHFPHLEFKDVRGNLNT
RLAKLDAGEYDALILAFAGLHRLGMSDRIHQIIPPEISLHAVGQGALGIECRAGDNNILNLLKSLEHTATAQRCYAERAF
LRELEGGCQVPIGVNTQIEGEQLTLTGLVASLDGKKLVKDIVTGATADAEQIGIELAQKLRKQGAQEILDQILAEINRS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=332, Percent_Identity=52.1084337349398, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=51.9519519519519, Blast_Score=319, Evalue=3e-87,
Organism=Escherichia coli, GI48994974, Length=305, Percent_Identity=50.1639344262295, Blast_Score=295, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6319996, Length=317, Percent_Identity=42.9022082018927, Blast_Score=242, Evalue=6e-65,
Organism=Drosophila melanogaster, GI20130425, Length=329, Percent_Identity=49.2401215805471, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35130; Mature: 34999

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISASTPTIRIGSRKSQLALIQTYWVQEKLEKNFPNITFEVHKMSTQGDKILDVALAKI
CEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHH
GDKGLFTKELELGMLQNETDLAVHSLKDLPTNLPEGLILGCVTERENPADALVLHEKLKD
CCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
KQLETLPEGAVIGTSSLRRLAQLRYHFPHLEFKDVRGNLNTRLAKLDAGEYDALILAFAG
HHHHHCCCCCEECHHHHHHHHHHHHHCCCCCHHHCCCCCHHEEEECCCCCHHHHHHHHHH
LHRLGMSDRIHQIIPPEISLHAVGQGALGIECRAGDNNILNLLKSLEHTATAQRCYAERA
HHHCCCCHHHHHHCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
FLRELEGGCQVPIGVNTQIEGEQLTLTGLVASLDGKKLVKDIVTGATADAEQIGIELAQK
HHHHHCCCCCCCCCCCCEECCCEEEEEHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHH
LRKQGAQEILDQILAEINRS
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TISASTPTIRIGSRKSQLALIQTYWVQEKLEKNFPNITFEVHKMSTQGDKILDVALAKI
EECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHH
GDKGLFTKELELGMLQNETDLAVHSLKDLPTNLPEGLILGCVTERENPADALVLHEKLKD
CCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
KQLETLPEGAVIGTSSLRRLAQLRYHFPHLEFKDVRGNLNTRLAKLDAGEYDALILAFAG
HHHHHCCCCCEECHHHHHHHHHHHHHCCCCCHHHCCCCCHHEEEECCCCCHHHHHHHHHH
LHRLGMSDRIHQIIPPEISLHAVGQGALGIECRAGDNNILNLLKSLEHTATAQRCYAERA
HHHCCCCHHHHHHCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
FLRELEGGCQVPIGVNTQIEGEQLTLTGLVASLDGKKLVKDIVTGATADAEQIGIELAQK
HHHHHCCCCCCCCCCCCEECCCEEEEEHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHH
LRKQGAQEILDQILAEINRS
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]