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The map label for this gene is hemB [H]

Identifier: 113477994

GI number: 113477994

Start: 7085314

End: 7086315

Strand: Reverse

Name: hemB [H]

Synonym: Tery_4608

Alternate gene names: 113477994

Gene position: 7086315-7085314 (Counterclockwise)

Preceding gene: 113477995

Following gene: 113477993

Centisome position: 91.44

GC content: 42.91

Gene sequence:

>1002_bases
ATGACAGAAGTAAATTTGTCCACAGAATCTCCCGTCGTACGTCCCCGTCGTCTTCGTCGCACTCCTGCTTTGCGACGCAT
GGTTGAAGAAACCCAGTTGACAGTCAACGATCTAATTTATCCATTGTTTGTAATGGAAGGAGAAGGGCAAAAAGTCGAGG
TTGTTTCCATGCCAGGCAGTTATCGCTATACTCTAGACCTACTGCTCAAAGAAATAGAGGATGCTTATAATTTAGGAATT
AATGCGATCGCTTTATTCCCCCTAGTTGCGGAAGCTAAAAAAGACAATTTTGGCACCGAAAGCTACAACTCAGAGGGTTT
AATACAAAGAACTGTAAGGGCGATCAAACAAACAATACCAGATATTGTTGTCATTACTGATGTAGCCCTTGACCCCTATT
CCAGCAAAGGTCATGACGGTATTGTAGGGAAAAATGGAGTCATTCTCAACGACCCTACTGTAGAAGTTTTGGTTAAACAA
GCACTATCTCAGGCCGAAGCAGGTGCCGATATCGTCGCTCCCTCAGATATGATGGATGGGCGTATTGGAGCAATTCGCAA
AGCTCTGGATGCTGCTGAATACTTTGATGTGGGAATACTTGCCTACTCTGCTAAATATGCCTCAGCTTATTATGGCCCGT
TTCGGGATGCTTTGGACTCTGCACCGAAATTTGGGGACAAAAAGACTTATCAAATGGACTCTGCTAATGCTAGGGAAGCC
CTCAAAGAGGTGGCTTTGGATATTGCCGAAGGTGCAGATATGGTAATGGTCAAGCCTGCCCTCGCTTATTTAGATATTAT
TTGTGAGGTAAAAAAGACAACAAATCTACCTGTAGCTGCTTATAACGTTAGTGGGGAATATGCCATGATTAAGGCTGCTG
GTGAGAAGGGTTGGATAGATGAAAAAAAGGTGATGTTGGAAACTTTAACCAGTATGAAACGGGCTGGTGCGGATTTGATT
TTGACTTATTTTGCTAAGGAAGTTGCATTAATTTTGAAATAG

Upstream 100 bases:

>100_bases
TTTGAGATCGGATGGAGATTATCCCTTATCTCTATTGACTAGATGTGAATTTTTGATTATGATTAATCACTATCAAAATT
ATTAGGCAAGTAATCTACCC

Downstream 100 bases:

>100_bases
GAAGAAATTCTAATGACCAAAAAAGAAATAGGAGAATTCCTTCAAGAGGGAATACCTGTTAGTATTATTATTGGTTTTCT
TGGTAGTGGGAAAACAATAT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTEVNLSTESPVVRPRRLRRTPALRRMVEETQLTVNDLIYPLFVMEGEGQKVEVVSMPGSYRYTLDLLLKEIEDAYNLGI
NAIALFPLVAEAKKDNFGTESYNSEGLIQRTVRAIKQTIPDIVVITDVALDPYSSKGHDGIVGKNGVILNDPTVEVLVKQ
ALSQAEAGADIVAPSDMMDGRIGAIRKALDAAEYFDVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDSANAREA
LKEVALDIAEGADMVMVKPALAYLDIICEVKKTTNLPVAAYNVSGEYAMIKAAGEKGWIDEKKVMLETLTSMKRAGADLI
LTYFAKEVALILK

Sequences:

>Translated_333_residues
MTEVNLSTESPVVRPRRLRRTPALRRMVEETQLTVNDLIYPLFVMEGEGQKVEVVSMPGSYRYTLDLLLKEIEDAYNLGI
NAIALFPLVAEAKKDNFGTESYNSEGLIQRTVRAIKQTIPDIVVITDVALDPYSSKGHDGIVGKNGVILNDPTVEVLVKQ
ALSQAEAGADIVAPSDMMDGRIGAIRKALDAAEYFDVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDSANAREA
LKEVALDIAEGADMVMVKPALAYLDIICEVKKTTNLPVAAYNVSGEYAMIKAAGEKGWIDEKKVMLETLTSMKRAGADLI
LTYFAKEVALILK
>Mature_332_residues
TEVNLSTESPVVRPRRLRRTPALRRMVEETQLTVNDLIYPLFVMEGEGQKVEVVSMPGSYRYTLDLLLKEIEDAYNLGIN
AIALFPLVAEAKKDNFGTESYNSEGLIQRTVRAIKQTIPDIVVITDVALDPYSSKGHDGIVGKNGVILNDPTVEVLVKQA
LSQAEAGADIVAPSDMMDGRIGAIRKALDAAEYFDVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDSANAREAL
KEVALDIAEGADMVMVKPALAYLDIICEVKKTTNLPVAAYNVSGEYAMIKAAGEKGWIDEKKVMLETLTSMKRAGADLIL
TYFAKEVALILK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=305, Percent_Identity=40.327868852459, Blast_Score=241, Evalue=6e-64,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=50.9433962264151, Blast_Score=303, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6321398, Length=310, Percent_Identity=39.6774193548387, Blast_Score=216, Evalue=3e-57,
Organism=Drosophila melanogaster, GI21358291, Length=303, Percent_Identity=38.9438943894389, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36475; Mature: 36344

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVNLSTESPVVRPRRLRRTPALRRMVEETQLTVNDLIYPLFVMEGEGQKVEVVSMPGS
CCEECCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEECCCC
YRYTLDLLLKEIEDAYNLGINAIALFPLVAEAKKDNFGTESYNSEGLIQRTVRAIKQTIP
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
DIVVITDVALDPYSSKGHDGIVGKNGVILNDPTVEVLVKQALSQAEAGADIVAPSDMMDG
CEEEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEECCCHHHCC
RIGAIRKALDAAEYFDVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDSANAREA
HHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECCCHHHHH
LKEVALDIAEGADMVMVKPALAYLDIICEVKKTTNLPVAAYNVSGEYAMIKAAGEKGWID
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCH
EKKVMLETLTSMKRAGADLILTYFAKEVALILK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEVNLSTESPVVRPRRLRRTPALRRMVEETQLTVNDLIYPLFVMEGEGQKVEVVSMPGS
CEECCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEECCCC
YRYTLDLLLKEIEDAYNLGINAIALFPLVAEAKKDNFGTESYNSEGLIQRTVRAIKQTIP
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
DIVVITDVALDPYSSKGHDGIVGKNGVILNDPTVEVLVKQALSQAEAGADIVAPSDMMDG
CEEEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEECCCHHHCC
RIGAIRKALDAAEYFDVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDSANAREA
HHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECCCHHHHH
LKEVALDIAEGADMVMVKPALAYLDIICEVKKTTNLPVAAYNVSGEYAMIKAAGEKGWID
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCH
EKKVMLETLTSMKRAGADLILTYFAKEVALILK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]