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The map label for this gene is trpA

Identifier: 113477891

GI number: 113477891

Start: 6932847

End: 6933644

Strand: Reverse

Name: trpA

Synonym: Tery_4493

Alternate gene names: 113477891

Gene position: 6933644-6932847 (Counterclockwise)

Preceding gene: 113477892

Following gene: 113477884

Centisome position: 89.47

GC content: 42.98

Gene sequence:

>798_bases
ATGATTTCAGTCTCCGATTGTTTTGAATCTCTACGCAATAATAGTAGTCAGTGTGCTCTAATTCCCTTCATTACCGCAGG
GGACCCAGACTTAGAAACGACAGCCAAAGCTCTAGAGGTATTGGATAGAAGTGGGGCCAACATGATTGAGTTGGGAGTCC
CTTATTCTGACCCTTTAGCTGATGGTCCAGTAATTCAAGCCGCTGCCACCCGTTCCTTAAACCGAGGGACTACTTTAGAG
TCAGTATTAGAGGTAGTCCAGACCGTTAGTCCGAAATTGCGATCGCCAATTATCCTATTTACTTATTACAACCCAATTTT
GTACAGAGGAGTCGAGAACTTCCTAAAAAAAATTTATGATGTAGGAGCTAGAGGTTTAGTAGTACCAGACCTGCCATTAG
AAGAAGCCGATATTTTATTAGAACCAGCAAAAGATATTGGCATAGAGCTAACCTTATTAGTAGCACCCACAAGTCCAAAA
GAGAGAATAAAGGCGATCGCTCATCAGTCCCAAGGATTTATATATTTAGTAAGTGTAACCGGAGTAACAGGAATGCGTGC
TCAAATGCAGACCAGAGTAGAAGACTTGCTAGCACAAATGCGGGAAGTTACAGATAAACCCATAGGCGTCGGCTTTGGTA
TTTCTCAACCGGAACAAGCCTTACAGGTCAAAAAGTGGGGAAGCGATGCAGTCATTGTTGGTAGTGCAGTAGTAAAGCGG
TTAGCAGAGGGAAGTCCCGATGAAGGTTTAAAAGCGATCGGCGAGTTTTGTCAAAATTTGAAAGCAGCTATTAACTGA

Upstream 100 bases:

>100_bases
CTTGTTCAATTCCACCAAAACAACCTTTGTATATTACAAACCTAAATACTCCCCTATCCTAATTCTGAATTATTTACTAT
CTAATATTGAAAATTAAAAA

Downstream 100 bases:

>100_bases
TAGCCAAAAACTGAAGGGAAAGAATAGAAACAGCTTAGACAAAAACTAATAAATCTTTTGCTTCTAAAGCACCCTCAAGA
GAAAGAATAGACCAGGAAAT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MISVSDCFESLRNNSSQCALIPFITAGDPDLETTAKALEVLDRSGANMIELGVPYSDPLADGPVIQAAATRSLNRGTTLE
SVLEVVQTVSPKLRSPIILFTYYNPILYRGVENFLKKIYDVGARGLVVPDLPLEEADILLEPAKDIGIELTLLVAPTSPK
ERIKAIAHQSQGFIYLVSVTGVTGMRAQMQTRVEDLLAQMREVTDKPIGVGFGISQPEQALQVKKWGSDAVIVGSAVVKR
LAEGSPDEGLKAIGEFCQNLKAAIN

Sequences:

>Translated_265_residues
MISVSDCFESLRNNSSQCALIPFITAGDPDLETTAKALEVLDRSGANMIELGVPYSDPLADGPVIQAAATRSLNRGTTLE
SVLEVVQTVSPKLRSPIILFTYYNPILYRGVENFLKKIYDVGARGLVVPDLPLEEADILLEPAKDIGIELTLLVAPTSPK
ERIKAIAHQSQGFIYLVSVTGVTGMRAQMQTRVEDLLAQMREVTDKPIGVGFGISQPEQALQVKKWGSDAVIVGSAVVKR
LAEGSPDEGLKAIGEFCQNLKAAIN
>Mature_265_residues
MISVSDCFESLRNNSSQCALIPFITAGDPDLETTAKALEVLDRSGANMIELGVPYSDPLADGPVIQAAATRSLNRGTTLE
SVLEVVQTVSPKLRSPIILFTYYNPILYRGVENFLKKIYDVGARGLVVPDLPLEEADILLEPAKDIGIELTLLVAPTSPK
ERIKAIAHQSQGFIYLVSVTGVTGMRAQMQTRVEDLLAQMREVTDKPIGVGFGISQPEQALQVKKWGSDAVIVGSAVVKR
LAEGSPDEGLKAIGEFCQNLKAAIN

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=248, Percent_Identity=33.8709677419355, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321412, Length=247, Percent_Identity=36.8421052631579, Blast_Score=162, Evalue=4e-41,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_TRIEI (Q10W95)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_723952.1
- ProteinModelPortal:   Q10W95
- SMR:   Q10W95
- STRING:   Q10W95
- GeneID:   4246146
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_4493
- NMPDR:   fig|203124.1.peg.3239
- eggNOG:   COG0159
- HOGENOM:   HBG391690
- OMA:   NPIYIYG
- PhylomeDB:   Q10W95
- ProtClustDB:   PRK13111
- BioCyc:   TERY203124:TERY_4493-MONOMER
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28550; Mature: 28550

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 50-50 ACT_SITE 61-61

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVSDCFESLRNNSSQCALIPFITAGDPDLETTAKALEVLDRSGANMIELGVPYSDPLA
CCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
DGPVIQAAATRSLNRGTTLESVLEVVQTVSPKLRSPIILFTYYNPILYRGVENFLKKIYD
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHCHHHCCCEEEEEEHHHHHHHHHHHHHHHHHH
VGARGLVVPDLPLEEADILLEPAKDIGIELTLLVAPTSPKERIKAIAHQSQGFIYLVSVT
CCCCCEECCCCCCCCCHHEECCHHHCCEEEEEEEECCCHHHHHHHHHHCCCCEEEEEEEC
GVTGMRAQMQTRVEDLLAQMREVTDKPIGVGFGISQPEQALQVKKWGSDAVIVGSAVVKR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHH
LAEGSPDEGLKAIGEFCQNLKAAIN
HHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISVSDCFESLRNNSSQCALIPFITAGDPDLETTAKALEVLDRSGANMIELGVPYSDPLA
CCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
DGPVIQAAATRSLNRGTTLESVLEVVQTVSPKLRSPIILFTYYNPILYRGVENFLKKIYD
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHCHHHCCCEEEEEEHHHHHHHHHHHHHHHHHH
VGARGLVVPDLPLEEADILLEPAKDIGIELTLLVAPTSPKERIKAIAHQSQGFIYLVSVT
CCCCCEECCCCCCCCCHHEECCHHHCCEEEEEEEECCCHHHHHHHHHHCCCCEEEEEEEC
GVTGMRAQMQTRVEDLLAQMREVTDKPIGVGFGISQPEQALQVKKWGSDAVIVGSAVVKR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHH
LAEGSPDEGLKAIGEFCQNLKAAIN
HHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA