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The map label for this gene is lldD [H]

Identifier: 113476028

GI number: 113476028

Start: 3703342

End: 3704421

Strand: Direct

Name: lldD [H]

Synonym: Tery_2398

Alternate gene names: 113476028

Gene position: 3703342-3704421 (Clockwise)

Preceding gene: 113476025

Following gene: 113476029

Centisome position: 47.78

GC content: 40.0

Gene sequence:

>1080_bases
ATGAATAAACCAATTAATATTTTTGAATATGAGTCTTTAGCACCAAAATATTTATCTCAAATGGCGCTAGATTATTATGC
TAGTGGTGCATGGGATGAAGTTACTTTACGAGATAACCGTACTGCTTATGAAAAATATAAACTTCGACCTCGGATGTTAG
TAGACGTTAGCCAGCGAAATTTAAGTACAAAAATTTTGGGGCAACTTATGAAAATGCCGATTTTAATTGCCCCTATGGCT
TTTCAATGTTTGGCGCACCCAGAAGGAGAGTTAGCAACAGCAAGAGTAGCAGCAGATCATGGTATAACAATGGTATTAAG
TACCATGTCAACAAAAAGTTTAGAAGATGTGGCATTAGCGACAAATGTCCCACAAAGTCTGTGGTTTCAACTCTATGTAC
ATCGCGATCGGTTTCTGACTCGAACTTTAGTTGAAAGAGCTAAAGCAGCAGGTTATCAAGCACTATGTTTGACAGTTGAT
GCGCCAGTTTTAGGTGTTAGGGAACGAGACCGAAGAAATCAATTTACTCTACCATCTGGCCTGGAGTTAGCTAATTTAAC
ATCAATGGCAAATTTAGAGATTCCTGAGACAGAAGAGGAGTCTGGGTTATTTGCTTATGTTGCTAATCAATTTGACCCAG
CTCTTACCTGGCAAGATCTTGAGTGGTTACAGTCGTTAACGTCATTACCTGTAATAGTTAAAGGAATTTTACGGGGAGAT
GATGCTGTTCGAGCAGTTGAACATGGGGCCAAAGGAATTATTGTTTCTAATCATGGAGGTAGACAGTTGGATGGAGCGAT
CGCTACTATTGATGCTCTCCCAGAAGTAGTTGCAGCGGTAGGAAATAAAGTTGATGTGTTGATGGATGGTGGTATCCGTA
GAGGTACAGATATTCTCAAAGCTTTAGCATTGGGAGCAAAAGCAGTTTTAATTGGGCGTCCGGTTTTGTGGGCCTTAGCG
GTGAATGGAGAAACTGGGGTACATCATTTGTTGGAGCTATTACGTAATGAATTAGATGTGGCTATGGCTTTGAGTGGATG
TGCTAAGGTAGAAAATATAAATCCTAGTTTGGTACGTTAA

Upstream 100 bases:

>100_bases
GTTCTAAATTTTAAGGATAAAAGTAATTTATGATGCTGGTTGCTTTCTTCCTAACACTAAAAGTAATTTATAATTTTGGG
TCTCCAGCAACTATTTATTG

Downstream 100 bases:

>100_bases
TTCAGAAAGTAAAACTTATATAGAGATTTTTTTTGTTGATATAAGGACTAAAAAAATGAACAAATCTAAACTTGTTAATA
ATTCGAAAGTAAATGAAACT

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MNKPINIFEYESLAPKYLSQMALDYYASGAWDEVTLRDNRTAYEKYKLRPRMLVDVSQRNLSTKILGQLMKMPILIAPMA
FQCLAHPEGELATARVAADHGITMVLSTMSTKSLEDVALATNVPQSLWFQLYVHRDRFLTRTLVERAKAAGYQALCLTVD
APVLGVRERDRRNQFTLPSGLELANLTSMANLEIPETEEESGLFAYVANQFDPALTWQDLEWLQSLTSLPVIVKGILRGD
DAVRAVEHGAKGIIVSNHGGRQLDGAIATIDALPEVVAAVGNKVDVLMDGGIRRGTDILKALALGAKAVLIGRPVLWALA
VNGETGVHHLLELLRNELDVAMALSGCAKVENINPSLVR

Sequences:

>Translated_359_residues
MNKPINIFEYESLAPKYLSQMALDYYASGAWDEVTLRDNRTAYEKYKLRPRMLVDVSQRNLSTKILGQLMKMPILIAPMA
FQCLAHPEGELATARVAADHGITMVLSTMSTKSLEDVALATNVPQSLWFQLYVHRDRFLTRTLVERAKAAGYQALCLTVD
APVLGVRERDRRNQFTLPSGLELANLTSMANLEIPETEEESGLFAYVANQFDPALTWQDLEWLQSLTSLPVIVKGILRGD
DAVRAVEHGAKGIIVSNHGGRQLDGAIATIDALPEVVAAVGNKVDVLMDGGIRRGTDILKALALGAKAVLIGRPVLWALA
VNGETGVHHLLELLRNELDVAMALSGCAKVENINPSLVR
>Mature_359_residues
MNKPINIFEYESLAPKYLSQMALDYYASGAWDEVTLRDNRTAYEKYKLRPRMLVDVSQRNLSTKILGQLMKMPILIAPMA
FQCLAHPEGELATARVAADHGITMVLSTMSTKSLEDVALATNVPQSLWFQLYVHRDRFLTRTLVERAKAAGYQALCLTVD
APVLGVRERDRRNQFTLPSGLELANLTSMANLEIPETEEESGLFAYVANQFDPALTWQDLEWLQSLTSLPVIVKGILRGD
DAVRAVEHGAKGIIVSNHGGRQLDGAIATIDALPEVVAAVGNKVDVLMDGGIRRGTDILKALALGAKAVLIGRPVLWALA
VNGETGVHHLLELLRNELDVAMALSGCAKVENINPSLVR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=358, Percent_Identity=52.2346368715084, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI54234014, Length=356, Percent_Identity=45.7865168539326, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI7705393, Length=356, Percent_Identity=45.7865168539326, Blast_Score=315, Evalue=3e-86,
Organism=Escherichia coli, GI1790033, Length=370, Percent_Identity=38.6486486486486, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI193208036, Length=348, Percent_Identity=48.8505747126437, Blast_Score=328, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI32566217, Length=265, Percent_Identity=47.5471698113208, Blast_Score=241, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6323587, Length=368, Percent_Identity=39.1304347826087, Blast_Score=262, Evalue=5e-71,
Organism=Drosophila melanogaster, GI78707188, Length=352, Percent_Identity=49.1477272727273, Blast_Score=339, Evalue=1e-93,
Organism=Drosophila melanogaster, GI281363140, Length=352, Percent_Identity=49.1477272727273, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI78707190, Length=352, Percent_Identity=49.1477272727273, Blast_Score=339, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 39365; Mature: 39365

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPINIFEYESLAPKYLSQMALDYYASGAWDEVTLRDNRTAYEKYKLRPRMLVDVSQRN
CCCCCCEEECHHCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCHHEEEEHHCC
LSTKILGQLMKMPILIAPMAFQCLAHPEGELATARVAADHGITMVLSTMSTKSLEDVALA
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEHHCCCCHHHHHHH
TNVPQSLWFQLYVHRDRFLTRTLVERAKAAGYQALCLTVDAPVLGVRERDRRNQFTLPSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECCCCCCCCCCCCCCCC
LELANLTSMANLEIPETEEESGLFAYVANQFDPALTWQDLEWLQSLTSLPVIVKGILRGD
CCHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCC
DAVRAVEHGAKGIIVSNHGGRQLDGAIATIDALPEVVAAVGNKVDVLMDGGIRRGTDILK
HHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
ALALGAKAVLIGRPVLWALAVNGETGVHHLLELLRNELDVAMALSGCAKVENINPSLVR
HHHHCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MNKPINIFEYESLAPKYLSQMALDYYASGAWDEVTLRDNRTAYEKYKLRPRMLVDVSQRN
CCCCCCEEECHHCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCHHEEEEHHCC
LSTKILGQLMKMPILIAPMAFQCLAHPEGELATARVAADHGITMVLSTMSTKSLEDVALA
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEHHCCCCHHHHHHH
TNVPQSLWFQLYVHRDRFLTRTLVERAKAAGYQALCLTVDAPVLGVRERDRRNQFTLPSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECCCCCCCCCCCCCCCC
LELANLTSMANLEIPETEEESGLFAYVANQFDPALTWQDLEWLQSLTSLPVIVKGILRGD
CCHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCC
DAVRAVEHGAKGIIVSNHGGRQLDGAIATIDALPEVVAAVGNKVDVLMDGGIRRGTDILK
HHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
ALALGAKAVLIGRPVLWALAVNGETGVHHLLELLRNELDVAMALSGCAKVENINPSLVR
HHHHCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA