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The map label for this gene is pan [H]

Identifier: 113475933

GI number: 113475933

Start: 3566510

End: 3567196

Strand: Direct

Name: pan [H]

Synonym: Tery_2297

Alternate gene names: 113475933

Gene position: 3566510-3567196 (Clockwise)

Preceding gene: 113475932

Following gene: 113475936

Centisome position: 46.02

GC content: 34.35

Gene sequence:

>687_bases
ATGCCTACAGGATGGGAAAGACAAAAAAGTACAAATACAAAAACAGAGGAAATAAAAACTACAAATATTAACAAACCTCC
TCAACAAACTCCCACCAATAATTCCTCTGATAAAACAACTGAAATAAACAGAATGGAAATGTTTATCCCAGAAGAACCTC
AGAGAAGTTTAGACGATCTAATAGTTCCCTCAACCGTCAAAAATAGAATTGATACAGCACTGAATAGAATTAAATATCAC
GATATTTTATATTACCAATGGAACTTAAAAAGTATTGACCCCAGAGGTAAACGTACCGCAATTAATTTATTTGGGTTACC
AGGTACAGGTAAAACTTTTTGTGCAGAAGCGATCGCTCACATTTTAAAGAAAAAAATCATCAAAGTTAACTACGCAGAAA
TTGAGTCTAAATATGTAGGTGAAACCCCAAAAAACATTACCGCAGCTTTTAAAAAAGCCCAAGAAACTGACTCAGTTTTA
TTCTTTGATGAAGCTGACTCTATCTTAGGAAAAAGATTAACTAATGTCACCCAAAGTTCCGATCATGGAGTTAATGTTAG
TCGTTCCGTAATGTTACTTCAACTAGACAAATTTGATGGAGTCGTAATTTTTGCCACGAACCTCGCCAAAAACTATGATG
GAGCATTTGTCCGTCGCATTTTAGCACACATTGAATTTGAATTATAG

Upstream 100 bases:

>100_bases
AAATTAATCTGTAGCCAGGAAAAAAATTTAATAGTCTAAACTTTTAACTAACTACTTAATTTTTCAATATTTAGCAAATT
ATTATAAGGAGAATTAATTT

Downstream 100 bases:

>100_bases
CAATCGAAGCAAAGGTTAGGACGTTAACTTAACAGCATAATCAACTCTCAATGCGAAAATTTTCTATTGTTCCTTCTGAC
TTTCTGACTCGATTTTTAAT

Product: AAA ATPase

Products: NA

Alternate protein names: PAN; Proteasomal ATPase; Proteasome regulatory ATPase; Proteasome regulatory particle [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MPTGWERQKSTNTKTEEIKTTNINKPPQQTPTNNSSDKTTEINRMEMFIPEEPQRSLDDLIVPSTVKNRIDTALNRIKYH
DILYYQWNLKSIDPRGKRTAINLFGLPGTGKTFCAEAIAHILKKKIIKVNYAEIESKYVGETPKNITAAFKKAQETDSVL
FFDEADSILGKRLTNVTQSSDHGVNVSRSVMLLQLDKFDGVVIFATNLAKNYDGAFVRRILAHIEFEL

Sequences:

>Translated_228_residues
MPTGWERQKSTNTKTEEIKTTNINKPPQQTPTNNSSDKTTEINRMEMFIPEEPQRSLDDLIVPSTVKNRIDTALNRIKYH
DILYYQWNLKSIDPRGKRTAINLFGLPGTGKTFCAEAIAHILKKKIIKVNYAEIESKYVGETPKNITAAFKKAQETDSVL
FFDEADSILGKRLTNVTQSSDHGVNVSRSVMLLQLDKFDGVVIFATNLAKNYDGAFVRRILAHIEFEL
>Mature_227_residues
PTGWERQKSTNTKTEEIKTTNINKPPQQTPTNNSSDKTTEINRMEMFIPEEPQRSLDDLIVPSTVKNRIDTALNRIKYHD
ILYYQWNLKSIDPRGKRTAINLFGLPGTGKTFCAEAIAHILKKKIIKVNYAEIESKYVGETPKNITAAFKKAQETDSVLF
FDEADSILGKRLTNVTQSSDHGVNVSRSVMLLQLDKFDGVVIFATNLAKNYDGAFVRRILAHIEFEL

Specific function: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereb

COG id: COG0464

COG function: function code O; ATPases of the AAA+ class

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI24430155, Length=156, Percent_Identity=36.5384615384615, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI5729991, Length=156, Percent_Identity=36.5384615384615, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI89064750, Length=156, Percent_Identity=36.5384615384615, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4506209, Length=148, Percent_Identity=37.1621621621622, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI24430151, Length=172, Percent_Identity=33.7209302325581, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI24497435, Length=140, Percent_Identity=37.1428571428571, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI195539395, Length=121, Percent_Identity=36.3636363636364, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4505725, Length=130, Percent_Identity=36.9230769230769, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI11875211, Length=230, Percent_Identity=30, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40806170, Length=230, Percent_Identity=30, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17563248, Length=148, Percent_Identity=35.8108108108108, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71987364, Length=121, Percent_Identity=38.8429752066116, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71987372, Length=121, Percent_Identity=38.8429752066116, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17554786, Length=142, Percent_Identity=38.7323943661972, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25144278, Length=140, Percent_Identity=36.4285714285714, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144281, Length=140, Percent_Identity=36.4285714285714, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563250, Length=158, Percent_Identity=32.9113924050633, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554784, Length=192, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146157, Length=139, Percent_Identity=35.2517985611511, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562804, Length=105, Percent_Identity=39.0476190476191, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532375, Length=147, Percent_Identity=36.0544217687075, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320602, Length=151, Percent_Identity=39.7350993377483, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322704, Length=145, Percent_Identity=36.551724137931, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321390, Length=143, Percent_Identity=37.0629370629371, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322651, Length=130, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324833, Length=124, Percent_Identity=34.6774193548387, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322994, Length=124, Percent_Identity=35.4838709677419, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320197, Length=155, Percent_Identity=34.1935483870968, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324000, Length=130, Percent_Identity=39.2307692307692, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281361487, Length=192, Percent_Identity=35.4166666666667, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI18860063, Length=192, Percent_Identity=34.375, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137738, Length=148, Percent_Identity=36.4864864864865, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24651451, Length=142, Percent_Identity=38.0281690140845, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24649446, Length=175, Percent_Identity=33.7142857142857, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24663015, Length=121, Percent_Identity=36.3636363636364, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640100, Length=133, Percent_Identity=36.0902255639098, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19920408, Length=140, Percent_Identity=36.4285714285714, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21355121, Length=130, Percent_Identity=34.6153846153846, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581396, Length=138, Percent_Identity=36.231884057971, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005937
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 25880; Mature: 25749

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTGWERQKSTNTKTEEIKTTNINKPPQQTPTNNSSDKTTEINRMEMFIPEEPQRSLDDL
CCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCCCEECCEEEEECCCCHHHHHHHC
IVPSTVKNRIDTALNRIKYHDILYYQWNLKSIDPRGKRTAINLFGLPGTGKTFCAEAIAH
CCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
ILKKKIIKVNYAEIESKYVGETPKNITAAFKKAQETDSVLFFDEADSILGKRLTNVTQSS
HHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCC
DHGVNVSRSVMLLQLDKFDGVVIFATNLAKNYDGAFVRRILAHIEFEL
CCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTGWERQKSTNTKTEEIKTTNINKPPQQTPTNNSSDKTTEINRMEMFIPEEPQRSLDDL
CCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCCCEECCEEEEECCCCHHHHHHHC
IVPSTVKNRIDTALNRIKYHDILYYQWNLKSIDPRGKRTAINLFGLPGTGKTFCAEAIAH
CCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
ILKKKIIKVNYAEIESKYVGETPKNITAAFKKAQETDSVLFFDEADSILGKRLTNVTQSS
HHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCC
DHGVNVSRSVMLLQLDKFDGVVIFATNLAKNYDGAFVRRILAHIEFEL
CCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]