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The map label for this gene is cofH [H]

Identifier: 113475763

GI number: 113475763

Start: 3305146

End: 3306342

Strand: Direct

Name: cofH [H]

Synonym: Tery_2116

Alternate gene names: 113475763

Gene position: 3305146-3306342 (Clockwise)

Preceding gene: 113475762

Following gene: 113475764

Centisome position: 42.65

GC content: 38.85

Gene sequence:

>1197_bases
ATGACTACTTTCAATTTGACAAACCAAAACCTAGAAACAAACCTGGAGACAATTTTAAACCGTGCTCTCCAAGGTTATGA
TCTATCTCCAGCAGAGACACTTTTATTGTTATCCCCAACTACGAAACCTAATTTGGGAAAACTTGCCTTAACTGAACTTC
CAGCAGAAATAACCGCTATCCAGAAAACAGCAGACCAACTCCGACAACAACAAGTAGGTGATACGGTAACTTACGTGATC
AACCGTAATATAAATTTCACCAATATCTGTGAACAACATTGTAGTTTTTGTGCATTTCGCCGAGACGACGGGAAAACAGG
TGCATTTTGGTTAGACATCAATCAAATTTTAGCAAAAGCTAACGATGCGGTGCAACGTGGAGCCACAGAAATTTGTATGC
AGGGAGGATTAAATCTTCAAGCTAAAGTTGCAGGAAAATCTTTACCTTATTATTTGCAACTGGTAAGAGAGATTAAAAAT
GAGTTTTCCCATTTGCACTTACATGCTTTTTCTCCCCAGGAAGTTCAGTTTATTGCTAGGGAGGATGGGGTGAGTTATGA
ATATGTAATTGCTGCTTTACGGGATGCAGGGGTACATTCAATGCCCGGTACTGCTGCAGAAGTTTTGGATGATGCAGTCA
GACGAATTATTTGCCCGGAAAAAATTGATACAGGAACTTGGTTAGAAATAGTGGGTACAGCCCACCGGTTGGGAATGCCA
ACCACAAGTACTATGTTATGCGGTCATATTGAAACCCCTAAACAGCAGATTTTACATTTAGAGAGATTGCGATCGCTACA
ACAAACTGCTATTGAAAAAGATTATCCAGCAAGAATAACAGAATTTATTTTATTACCATTTGTGGGACAAGAAGCACCTG
CACCTTTACGTCGGAGGGTAGGGCACGACCAACCTATTTTGTTAGATGTTTTATTGTTAACAGCGGTGTCGAGAATATTC
TTAGGAAATTGGATTATTAATCATCAACCCAGTTGGGTGAAAATTGGTTTAGATGGAGCAAAAGAGGCATTAAAGTGGGG
TTGTAATGATATTGGTGGGACTTTAATGGAAGAACATATTACTACAATGGCTGGTGCTATTGGAGGTACTTTTATGGAAG
TCAAAAATTTACAGGAAGCTATTACAAGTTTGGGGAGAAACTATCAACAAAGAGATACTCTTTATAAATATTTGTAG

Upstream 100 bases:

>100_bases
TTGATGTGGTTCATTGGCAGAAAAATACTGTATAAAAAACTAGGTTTATAGGATACAGATGTTAGTATAGTAGAGCATTT
AATATAAAATTGATATCAAC

Downstream 100 bases:

>100_bases
GTTTGGTTGAGGTACCGAAACCCAACAAAAAAAGTAAAAGTTATATACAGATTTTTTGTTGGGTTGCTCTGTCATTGATA
GCCTACAACTATATTTTGAT

Product: FO synthase subunit 2

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTTFNLTNQNLETNLETILNRALQGYDLSPAETLLLLSPTTKPNLGKLALTELPAEITAIQKTADQLRQQQVGDTVTYVI
NRNINFTNICEQHCSFCAFRRDDGKTGAFWLDINQILAKANDAVQRGATEICMQGGLNLQAKVAGKSLPYYLQLVREIKN
EFSHLHLHAFSPQEVQFIAREDGVSYEYVIAALRDAGVHSMPGTAAEVLDDAVRRIICPEKIDTGTWLEIVGTAHRLGMP
TTSTMLCGHIETPKQQILHLERLRSLQQTAIEKDYPARITEFILLPFVGQEAPAPLRRRVGHDQPILLDVLLLTAVSRIF
LGNWIINHQPSWVKIGLDGAKEALKWGCNDIGGTLMEEHITTMAGAIGGTFMEVKNLQEAITSLGRNYQQRDTLYKYL

Sequences:

>Translated_398_residues
MTTFNLTNQNLETNLETILNRALQGYDLSPAETLLLLSPTTKPNLGKLALTELPAEITAIQKTADQLRQQQVGDTVTYVI
NRNINFTNICEQHCSFCAFRRDDGKTGAFWLDINQILAKANDAVQRGATEICMQGGLNLQAKVAGKSLPYYLQLVREIKN
EFSHLHLHAFSPQEVQFIAREDGVSYEYVIAALRDAGVHSMPGTAAEVLDDAVRRIICPEKIDTGTWLEIVGTAHRLGMP
TTSTMLCGHIETPKQQILHLERLRSLQQTAIEKDYPARITEFILLPFVGQEAPAPLRRRVGHDQPILLDVLLLTAVSRIF
LGNWIINHQPSWVKIGLDGAKEALKWGCNDIGGTLMEEHITTMAGAIGGTFMEVKNLQEAITSLGRNYQQRDTLYKYL
>Mature_397_residues
TTFNLTNQNLETNLETILNRALQGYDLSPAETLLLLSPTTKPNLGKLALTELPAEITAIQKTADQLRQQQVGDTVTYVIN
RNINFTNICEQHCSFCAFRRDDGKTGAFWLDINQILAKANDAVQRGATEICMQGGLNLQAKVAGKSLPYYLQLVREIKNE
FSHLHLHAFSPQEVQFIAREDGVSYEYVIAALRDAGVHSMPGTAAEVLDDAVRRIICPEKIDTGTWLEIVGTAHRLGMPT
TSTMLCGHIETPKQQILHLERLRSLQQTAIEKDYPARITEFILLPFVGQEAPAPLRRRVGHDQPILLDVLLLTAVSRIFL
GNWIINHQPSWVKIGLDGAKEALKWGCNDIGGTLMEEHITTMAGAIGGTFMEVKNLQEAITSLGRNYQQRDTLYKYL

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 44418; Mature: 44286

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFNLTNQNLETNLETILNRALQGYDLSPAETLLLLSPTTKPNLGKLALTELPAEITAI
CCEECCCCCCHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCCCHHHHHCCHHHHHH
QKTADQLRQQQVGDTVTYVINRNINFTNICEQHCSFCAFRRDDGKTGAFWLDINQILAKA
HHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHEEEECCCCCCCEEEEEHHHHHHHH
NDAVQRGATEICMQGGLNLQAKVAGKSLPYYLQLVREIKNEFSHLHLHAFSPQEVQFIAR
HHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHH
EDGVSYEYVIAALRDAGVHSMPGTAAEVLDDAVRRIICPEKIDTGTWLEIVGTAHRLGMP
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
TTSTMLCGHIETPKQQILHLERLRSLQQTAIEKDYPARITEFILLPFVGQEAPAPLRRRV
CCHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHC
GHDQPILLDVLLLTAVSRIFLGNWIINHQPSWVKIGLDGAKEALKWGCNDIGGTLMEEHI
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHH
TTMAGAIGGTFMEVKNLQEAITSLGRNYQQRDTLYKYL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
TTFNLTNQNLETNLETILNRALQGYDLSPAETLLLLSPTTKPNLGKLALTELPAEITAI
CEECCCCCCHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCCCHHHHHCCHHHHHH
QKTADQLRQQQVGDTVTYVINRNINFTNICEQHCSFCAFRRDDGKTGAFWLDINQILAKA
HHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHEEEECCCCCCCEEEEEHHHHHHHH
NDAVQRGATEICMQGGLNLQAKVAGKSLPYYLQLVREIKNEFSHLHLHAFSPQEVQFIAR
HHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHH
EDGVSYEYVIAALRDAGVHSMPGTAAEVLDDAVRRIICPEKIDTGTWLEIVGTAHRLGMP
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
TTSTMLCGHIETPKQQILHLERLRSLQQTAIEKDYPARITEFILLPFVGQEAPAPLRRRV
CCHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHC
GHDQPILLDVLLLTAVSRIFLGNWIINHQPSWVKIGLDGAKEALKWGCNDIGGTLMEEHI
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHH
TTMAGAIGGTFMEVKNLQEAITSLGRNYQQRDTLYKYL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA