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The map label for this gene is iscS [H]

Identifier: 113475540

GI number: 113475540

Start: 2864018

End: 2865220

Strand: Direct

Name: iscS [H]

Synonym: Tery_1872

Alternate gene names: 113475540

Gene position: 2864018-2865220 (Clockwise)

Preceding gene: 113475539

Following gene: 113475541

Centisome position: 36.95

GC content: 40.32

Gene sequence:

>1203_bases
ATGATGCAAATTTATCTGGACTATAGTGCGACAACACCAACAAGACCAGAGGCAATCACTACTATGCAGCAAGTTTTGAC
TCAACAATGGGGTAATCCATCTAGCCTACATATGTGGGGCCAAAGATCGGCAACATTAGTGGAAAAGGCCAGAATTCAAG
TAGCAGATCTTATTAATACAGTGCCAGAATCAATTATTTTTACTTCTGGGGGAACTGAAGCTGATAATATGGCGATAATG
GGAGTAGCACTTTGCTATGGAAAACCTCAACATATAATTATTTCTAGTGTGGAACATTTTGCTATTTCAGAACCAGCAAG
GGTATTAGAAAACTGGGGTTGGCAAGTGACCAGATTACCTGTGGATAGACAAGGAAGGTTAGATCCTCAAGAACTACAAG
CTGCATTACAACCAAATACAGTTTTAGTTTCAATAATTTATGGCCAAAGTGAAGTTGGGACTCTCCAACCTATTGCAGAA
TTGGGCAATATTTGTCGTGATCGTGGGGTTTTGTTTCATACTGATGCAGTTCAGGTGGTGGGACGTTTACCAATAGATTT
ACAAAAACTGCCAGTAGATTTGTTGTCTTTGTCTAGCCATAAAATTTATGGCCCTCAAGGTGTAGGGGCGCTTTATGTAC
GACAGGGTGTAAAGTTAGTCCCTTTATTGAGTGGTGGAGGTCAAGAGATGAAGTTACGTTCTGGTACTCAGGCAGTAGCA
GCGATCGCTGGTTTTGGTGTGGCAGCAGAATTAGCTAATGAAGAGATAGCTACAGAAACGTCAAGGTTGAGTAGGTTACG
CGATCGCTTCTTTGCGCATATGGTAGATAATCCTTATGTAATTTTTACTGGTGATCGATTGTACAGGTTACCTCATCATG
TTAGTTTTTGTATAGTCCCTCCTGAGGTTGAAATGCCTAAGGGGAATAATCAGGTTACTGGTAAAACTCTCGTACGACAA
TTGAACTTAGCTGGAATTGGTATTAGTACGGGTTCAGCTTGTCATAGTGGAAAAATAGCTCCGAGTCCGATATTACTAGC
AATGGGGTATACAAAAGAGCATGCTATTAGGGGTGTCCGTTTCACATTAGGAAGAGAAACAACGGAAGCTGATATTGATT
GGACGGCTATAGTACTCAAGCAAATCTTGACAAGATTGATGCCTAATGTTAATTCTCAAAAATTTTATTGTATATCTTTG
TGA

Upstream 100 bases:

>100_bases
TTACTAAGGGTTTCATAAATTGTACAGAAAGCTAGCATTAATGCATGCTACTCCCTAAAACCTAAGTCACTAAAACTTAA
AAGAAAACAAAAGGAGAAAG

Downstream 100 bases:

>100_bases
TAAGGGACATTAAATACTTTTTGATAATTGCTAAATCTTGATGAACTTTAATTTTCTGTACTTAAAGAGAATGTAAAAAA
TTGGATATCATAAGGTCAGA

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MMQIYLDYSATTPTRPEAITTMQQVLTQQWGNPSSLHMWGQRSATLVEKARIQVADLINTVPESIIFTSGGTEADNMAIM
GVALCYGKPQHIIISSVEHFAISEPARVLENWGWQVTRLPVDRQGRLDPQELQAALQPNTVLVSIIYGQSEVGTLQPIAE
LGNICRDRGVLFHTDAVQVVGRLPIDLQKLPVDLLSLSSHKIYGPQGVGALYVRQGVKLVPLLSGGGQEMKLRSGTQAVA
AIAGFGVAAELANEEIATETSRLSRLRDRFFAHMVDNPYVIFTGDRLYRLPHHVSFCIVPPEVEMPKGNNQVTGKTLVRQ
LNLAGIGISTGSACHSGKIAPSPILLAMGYTKEHAIRGVRFTLGRETTEADIDWTAIVLKQILTRLMPNVNSQKFYCISL

Sequences:

>Translated_400_residues
MMQIYLDYSATTPTRPEAITTMQQVLTQQWGNPSSLHMWGQRSATLVEKARIQVADLINTVPESIIFTSGGTEADNMAIM
GVALCYGKPQHIIISSVEHFAISEPARVLENWGWQVTRLPVDRQGRLDPQELQAALQPNTVLVSIIYGQSEVGTLQPIAE
LGNICRDRGVLFHTDAVQVVGRLPIDLQKLPVDLLSLSSHKIYGPQGVGALYVRQGVKLVPLLSGGGQEMKLRSGTQAVA
AIAGFGVAAELANEEIATETSRLSRLRDRFFAHMVDNPYVIFTGDRLYRLPHHVSFCIVPPEVEMPKGNNQVTGKTLVRQ
LNLAGIGISTGSACHSGKIAPSPILLAMGYTKEHAIRGVRFTLGRETTEADIDWTAIVLKQILTRLMPNVNSQKFYCISL
>Mature_400_residues
MMQIYLDYSATTPTRPEAITTMQQVLTQQWGNPSSLHMWGQRSATLVEKARIQVADLINTVPESIIFTSGGTEADNMAIM
GVALCYGKPQHIIISSVEHFAISEPARVLENWGWQVTRLPVDRQGRLDPQELQAALQPNTVLVSIIYGQSEVGTLQPIAE
LGNICRDRGVLFHTDAVQVVGRLPIDLQKLPVDLLSLSSHKIYGPQGVGALYVRQGVKLVPLLSGGGQEMKLRSGTQAVA
AIAGFGVAAELANEEIATETSRLSRLRDRFFAHMVDNPYVIFTGDRLYRLPHHVSFCIVPPEVEMPKGNNQVTGKTLVRQ
LNLAGIGISTGSACHSGKIAPSPILLAMGYTKEHAIRGVRFTLGRETTEADIDWTAIVLKQILTRLMPNVNSQKFYCISL

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=388, Percent_Identity=40.979381443299, Blast_Score=295, Evalue=7e-80,
Organism=Homo sapiens, GI156713448, Length=427, Percent_Identity=32.7868852459016, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI48994898, Length=391, Percent_Identity=44.2455242966752, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1789175, Length=279, Percent_Identity=31.1827956989247, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787970, Length=271, Percent_Identity=26.5682656826568, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=378, Percent_Identity=40.4761904761905, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17533177, Length=343, Percent_Identity=32.0699708454811, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319831, Length=389, Percent_Identity=42.6735218508997, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI20129463, Length=380, Percent_Identity=42.3684210526316, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43829; Mature: 43829

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQIYLDYSATTPTRPEAITTMQQVLTQQWGNPSSLHMWGQRSATLVEKARIQVADLINT
CEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
VPESIIFTSGGTEADNMAIMGVALCYGKPQHIIISSVEHFAISEPARVLENWGWQVTRLP
CCHHEEEECCCCCCCCEEEEEEEECCCCCCEEEEECHHHHHCCCHHHHHHHCCCEEEECC
VDRQGRLDPQELQAALQPNTVLVSIIYGQSEVGTLQPIAELGNICRDRGVLFHTDAVQVV
CCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEECHHHHHH
GRLPIDLQKLPVDLLSLSSHKIYGPQGVGALYVRQGVKLVPLLSGGGQEMKLRSGTQAVA
HCCCCCHHHCCHHHHHCCCCEEECCCCCCHHHHHCCCEEEEEECCCCCEEEECCCHHHHH
AIAGFGVAAELANEEIATETSRLSRLRDRFFAHMVDNPYVIFTGDRLYRLPHHVSFCIVP
HHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCCEEEEEEC
PEVEMPKGNNQVTGKTLVRQLNLAGIGISTGSACHSGKIAPSPILLAMGYTKEHAIRGVR
CCCCCCCCCCCCCHHHHHHHHHHCEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHCCEE
FTLGRETTEADIDWTAIVLKQILTRLMPNVNSQKFYCISL
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MMQIYLDYSATTPTRPEAITTMQQVLTQQWGNPSSLHMWGQRSATLVEKARIQVADLINT
CEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
VPESIIFTSGGTEADNMAIMGVALCYGKPQHIIISSVEHFAISEPARVLENWGWQVTRLP
CCHHEEEECCCCCCCCEEEEEEEECCCCCCEEEEECHHHHHCCCHHHHHHHCCCEEEECC
VDRQGRLDPQELQAALQPNTVLVSIIYGQSEVGTLQPIAELGNICRDRGVLFHTDAVQVV
CCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEECHHHHHH
GRLPIDLQKLPVDLLSLSSHKIYGPQGVGALYVRQGVKLVPLLSGGGQEMKLRSGTQAVA
HCCCCCHHHCCHHHHHCCCCEEECCCCCCHHHHHCCCEEEEEECCCCCEEEECCCHHHHH
AIAGFGVAAELANEEIATETSRLSRLRDRFFAHMVDNPYVIFTGDRLYRLPHHVSFCIVP
HHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCCEEEEEEC
PEVEMPKGNNQVTGKTLVRQLNLAGIGISTGSACHSGKIAPSPILLAMGYTKEHAIRGVR
CCCCCCCCCCCCCHHHHHHHHHHCEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHCCEE
FTLGRETTEADIDWTAIVLKQILTRLMPNVNSQKFYCISL
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA