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The map label for this gene is fmt

Identifier: 113475441

GI number: 113475441

Start: 2692226

End: 2693236

Strand: Direct

Name: fmt

Synonym: Tery_1769

Alternate gene names: 113475441

Gene position: 2692226-2693236 (Clockwise)

Preceding gene: 113475440

Following gene: 113475451

Centisome position: 34.74

GC content: 40.06

Gene sequence:

>1011_bases
ATGATGAAAATAATATTTTTTGGTACACCTCTATTTGCTGTTCCTACTTTGAAAAAATTGTTAGATAACCCAAAAATAGA
AGTTACAGCAGTTGTAACTCAACCTGATAAACGGCGTGGGCGAGGCAATAAACTGATTCCATCTCCTGTTAAGTCAGTGG
CAGTTGCCCATAATATCCCTGTCTGGCAACCACGACGAGTTAAAAAAAATCCTGAAACTCTCAATTTATTGAGAGAGGCA
CAAGCAGATGTATTTGTTGTAGTTGCTTATGGACAAATATTGTCTACAGAAATTTTGGAGATGCCAAAGTTGGGTTGTGT
GAATGTTCATGGTTCAATTTTGCCAAAATATCGTGGTGCTGCTCCTATTCAGTGGTCTATTTATCATGGGGAGGCGGAAA
CAGGTAATACTACGATGTTAATGGATGTGGGAATGGATACTGGTCCAATGCTCTTGAAGAGTATAATTCCTATTGGTTTG
TTAGATAATGCTGTATCTATAGCGGAAATTTTGGCAAAGGATGGAGCAGATTTATTGCTGGAAACTTTGTTAAGGTTGGA
GGACAAGGAAATTGAACCTATTCCTCAAGATAATTCTCTGGCAACTTATGCTCCACTGATTCAAAATTCTGATTATGAAA
TTGATTGGTCGAGGAGTGCTTTGGATATTCACAACCAAATCAGAGGATTTTTTCCTAATTGCTTTACCAGTTTTCGGGGT
CAGTCTTTGAAGGTAATGGCGACTATTCCTGTGGGGACTGAATATTGGTCAGAGTTACCTCCGGAATTACAGAAGTTGGA
GAAGGTTTGGTCTTCTGAGTCTGAGGTTGTGGGAAATATTGGGGAGGTTGTCAAAGTAATTAAGGGTTTAGGACCTGTGG
TGCAAACTGGTAGTGGTTGGTTGTTGTTGTGGCAGGTACAGTTGGCTGGGAAAAAGGTGGTTTCTGGTTGGGATTTTGCT
AATGGTACTCGTTTGTTAGTGGGGGAAGTTAGTGAAGTTTTCTCCCGTTAA

Upstream 100 bases:

>100_bases
CAATCAAGAAAGTTAACTGGGCTATCGGTTAAAAGCGTTCAGGTCGTTTCCATCTAGCTATTACAACTGGCTAGTTTCCA
ATTTACAAATACGAGTTTTT

Downstream 100 bases:

>100_bases
GTTGGAGATTAAATATTTAGAACTGAAGGCTAACCTAACCGACCCCCAATAAGGGGGGTAGGTACAGCAGCTATGAGATG
CCAGCTTAAATGAAGGCTAC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MMKIIFFGTPLFAVPTLKKLLDNPKIEVTAVVTQPDKRRGRGNKLIPSPVKSVAVAHNIPVWQPRRVKKNPETLNLLREA
QADVFVVVAYGQILSTEILEMPKLGCVNVHGSILPKYRGAAPIQWSIYHGEAETGNTTMLMDVGMDTGPMLLKSIIPIGL
LDNAVSIAEILAKDGADLLLETLLRLEDKEIEPIPQDNSLATYAPLIQNSDYEIDWSRSALDIHNQIRGFFPNCFTSFRG
QSLKVMATIPVGTEYWSELPPELQKLEKVWSSESEVVGNIGEVVKVIKGLGPVVQTGSGWLLLWQVQLAGKKVVSGWDFA
NGTRLLVGEVSEVFSR

Sequences:

>Translated_336_residues
MMKIIFFGTPLFAVPTLKKLLDNPKIEVTAVVTQPDKRRGRGNKLIPSPVKSVAVAHNIPVWQPRRVKKNPETLNLLREA
QADVFVVVAYGQILSTEILEMPKLGCVNVHGSILPKYRGAAPIQWSIYHGEAETGNTTMLMDVGMDTGPMLLKSIIPIGL
LDNAVSIAEILAKDGADLLLETLLRLEDKEIEPIPQDNSLATYAPLIQNSDYEIDWSRSALDIHNQIRGFFPNCFTSFRG
QSLKVMATIPVGTEYWSELPPELQKLEKVWSSESEVVGNIGEVVKVIKGLGPVVQTGSGWLLLWQVQLAGKKVVSGWDFA
NGTRLLVGEVSEVFSR
>Mature_336_residues
MMKIIFFGTPLFAVPTLKKLLDNPKIEVTAVVTQPDKRRGRGNKLIPSPVKSVAVAHNIPVWQPRRVKKNPETLNLLREA
QADVFVVVAYGQILSTEILEMPKLGCVNVHGSILPKYRGAAPIQWSIYHGEAETGNTTMLMDVGMDTGPMLLKSIIPIGL
LDNAVSIAEILAKDGADLLLETLLRLEDKEIEPIPQDNSLATYAPLIQNSDYEIDWSRSALDIHNQIRGFFPNCFTSFRG
QSLKVMATIPVGTEYWSELPPELQKLEKVWSSESEVVGNIGEVVKVIKGLGPVVQTGSGWLLLWQVQLAGKKVVSGWDFA
NGTRLLVGEVSEVFSR

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=263, Percent_Identity=29.277566539924, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI21614513, Length=234, Percent_Identity=28.6324786324786, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI164663775, Length=338, Percent_Identity=25.7396449704142, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789683, Length=325, Percent_Identity=43.0769230769231, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1788589, Length=250, Percent_Identity=28.8, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI133930964, Length=241, Percent_Identity=32.7800829875519, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550868, Length=325, Percent_Identity=29.2307692307692, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28571984, Length=247, Percent_Identity=31.5789473684211, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585660, Length=234, Percent_Identity=29.0598290598291, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_TRIEI (Q114P5)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721502.1
- ProteinModelPortal:   Q114P5
- SMR:   Q114P5
- STRING:   Q114P5
- GeneID:   4242234
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1769
- NMPDR:   fig|203124.1.peg.458
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   Q114P5
- ProtClustDB:   PRK00005
- BioCyc:   TERY203124:TERY_1769-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 37077; Mature: 37077

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKIIFFGTPLFAVPTLKKLLDNPKIEVTAVVTQPDKRRGRGNKLIPSPVKSVAVAHNIP
CEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCHHHCCCCCCCCCCHHHHHHHHCCCC
VWQPRRVKKNPETLNLLREAQADVFVVVAYGQILSTEILEMPKLGCVNVHGSILPKYRGA
CCCCCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
APIQWSIYHGEAETGNTTMLMDVGMDTGPMLLKSIIPIGLLDNAVSIAEILAKDGADLLL
CCEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
ETLLRLEDKEIEPIPQDNSLATYAPLIQNSDYEIDWSRSALDIHNQIRGFFPNCFTSFRG
HHHHHCCCCCCCCCCCCCCCEEEHHHHCCCCCEEECCCHHHHHHHHHHHHCCHHHHHHCC
QSLKVMATIPVGTEYWSELPPELQKLEKVWSSESEVVGNIGEVVKVIKGLGPVVQTGSGW
CCEEEEEEECCCHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCCE
LLLWQVQLAGKKVVSGWDFANGTRLLVGEVSEVFSR
EEEEEEEECCCHHCCCCCCCCCCEEEEEHHHHHHCC
>Mature Secondary Structure
MMKIIFFGTPLFAVPTLKKLLDNPKIEVTAVVTQPDKRRGRGNKLIPSPVKSVAVAHNIP
CEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCHHHCCCCCCCCCCHHHHHHHHCCCC
VWQPRRVKKNPETLNLLREAQADVFVVVAYGQILSTEILEMPKLGCVNVHGSILPKYRGA
CCCCCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
APIQWSIYHGEAETGNTTMLMDVGMDTGPMLLKSIIPIGLLDNAVSIAEILAKDGADLLL
CCEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
ETLLRLEDKEIEPIPQDNSLATYAPLIQNSDYEIDWSRSALDIHNQIRGFFPNCFTSFRG
HHHHHCCCCCCCCCCCCCCCEEEHHHHCCCCCEEECCCHHHHHHHHHHHHCCHHHHHHCC
QSLKVMATIPVGTEYWSELPPELQKLEKVWSSESEVVGNIGEVVKVIKGLGPVVQTGSGW
CCEEEEEEECCCHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCCE
LLLWQVQLAGKKVVSGWDFANGTRLLVGEVSEVFSR
EEEEEEEECCCHHCCCCCCCCCCEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA