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The map label for this gene is zraS [H]

Identifier: 113475352

GI number: 113475352

Start: 2539184

End: 2541211

Strand: Direct

Name: zraS [H]

Synonym: Tery_1669

Alternate gene names: 113475352

Gene position: 2539184-2541211 (Clockwise)

Preceding gene: 113475351

Following gene: 113475353

Centisome position: 32.76

GC content: 36.74

Gene sequence:

>2028_bases
ATGATGAGAAAACTTTTGTACTTATTAAAACAATATCAAGGGACAGGAGTAGTAGGATTAATTGGTATTACTTTTTCGAT
TACCGCTATGCTCATAGTTGATAACTGGGAACTAGCAATAGATAAAGAGCAGTTTCAACAACAATCTACTGTTTTGGTAA
ATGAGTTCCAGAGGCAATTAGATGGTTACAACCAACTAACTAGATCCGTAGGTACCTTCCTAAATATGTCTCAAGAATTG
ACGAGAGAAGAATTTGAAGAATTGACCAGCCCCCTATTACCTTACTATGATGGTTTTTTAGCATTAGGCTGGAGTCAGAA
AGTAAAGAATCAGGAACGATCGCTGTATGAGCAAAAATTACAAGCCCAAGGAATAATAAATTTTAAGATTAGCGAACGTA
ACCACAAAGGAAATCAAGTACTGGCAGGCGATCGCTCGACCTACTTCCCCACAACCTATATTGAACCCTTAGATAGATGG
CAAAACTATATTGGTTGGGATGCTGCTGCAGACAGAAAACGTTTGCTGAGTATAGAAAAAGCAGAACGTACAGGAGTAAC
TGTAAGTACACCTTTAGTGCAGTTAGAAAATGGCGAACCAGGCTTTGTGCTTTACTATCCGGTCTTTGGTTCTAAGAACT
TGAATTCTCAATCCCTTGAATCAGAAAAACTTGACAGCAATAGAGAATTGCAAGGAGTAGTATTTGGTTTTTATGAAGTT
ATGACTTGGGTTGAAAAAGCCATCAAAAATCTTAACCTTAACGGACTTAATTTCTATCTCTATAGTTTACCAGAAGATCA
ATTAGATTCTGCTTTAAACAAAACCGCTATTACTGCCACTGACTATTTCCTTGTAGCATACAAAGATGATTCCCAAAGCT
TGACAGCATCTCCTCAAGTTGCGAATTTAGCACTCATTGATAGCCCTAAAGAGCAGCGATCACATCTGTGTCGTTATAGC
GATGAGTGGCAATTTTGTATTCGTTCAATTCATGTAGGGCAACAGGAATTTTCCTTGCTAATATTACCTGCTTCTAATCG
TTCTATAACTGTTTGGTCTTCTGAAATAGTTTTGGTATTAGGATTATTAGTGACAGCCTCTTTAGTAATGTATTTCTTAA
TTTCCCATCAGGCAACTTTAAAAATTGAAACCAAAAACCGGAAGTTAGAAAAACTAGTGCAAGAAATACAGCAGACTAAA
CTACAACTGGTACAAACAGAAAAAATGTCAAGTTTAGGTCTGTTGATAGCAGGTGTTGCCCATGAAATCAAGAATCCGAT
CAGTTTTATTTCGGGAAACATTAAATATGCAAGCCATTATTTTCAAGATTTGTTGAATTTAATTCAGCTCTATCAAGTCG
AATATCCCAGTCCTACTCCAAAAATTGAAGCAGCTATTGAAGATATTGGTTTAGATTTTATTGTTCAAGATTTACCTAAG
TTATTAAATTCTATGAACGTTGGGAGTACACGTCTGCACGAAATAGTTTTATCCCTGCGTAATTTTTCCCGCTCAGATGA
GTCAAAAGTAAAGGAAGTGGATATTCACACGGGTATTGAAAGTACGTTAATGATTTTGGCACATCGCCTCAAGACCCAGC
TAGCTCACCCAGAAATTATGGTGACTAAAAACTATGGTAATTTGCCTTTGATTGAATGTTATGCAGGTAAATTAAATCAA
GTATTTATGAATATTTTGGCTAATGCTATTGATGCTCTAGAAGATTCAATTCTGGTAGGGGAGTTAAAGGAGCGATCGCC
GATAATTTCAATTAAAACAGCTCAACTTAACACCGAGTGGATTACAATCCAAATTGCTGATAACGGTCCGGGTATTGCAC
CAGATATTAAAACTCAGTTGTTTAATCCCTTTTTTACAACTAAACCAGTTGGCAAAGGAACGGGACTTGGACTGTCAATT
AGTTATGACATTATTTGTGATCAGCATCAGGGACATTTACTGTGTTCCTCTGAAGAGGGAAAGGGTACAGAGTTTATCAT
TAAGTTGCCGATCGCATTATCAACTTAA

Upstream 100 bases:

>100_bases
TAAACTCAGAAAAATATATGTATAAATAACTTTCAACAAATTCTCAAAAAAAAATGTTAAAATCACCATAATCAGATTTT
ATTAAAAATCAATTCTAATA

Downstream 100 bases:

>100_bases
TTCAAGCTAGACGTGATACTAGATTCAGTTGTATTGATTAATATCAAAGGATTACGTACGCAATCTTTTGATAAGATAAA
CCATTGTTTTAACCATAGAA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MMRKLLYLLKQYQGTGVVGLIGITFSITAMLIVDNWELAIDKEQFQQQSTVLVNEFQRQLDGYNQLTRSVGTFLNMSQEL
TREEFEELTSPLLPYYDGFLALGWSQKVKNQERSLYEQKLQAQGIINFKISERNHKGNQVLAGDRSTYFPTTYIEPLDRW
QNYIGWDAAADRKRLLSIEKAERTGVTVSTPLVQLENGEPGFVLYYPVFGSKNLNSQSLESEKLDSNRELQGVVFGFYEV
MTWVEKAIKNLNLNGLNFYLYSLPEDQLDSALNKTAITATDYFLVAYKDDSQSLTASPQVANLALIDSPKEQRSHLCRYS
DEWQFCIRSIHVGQQEFSLLILPASNRSITVWSSEIVLVLGLLVTASLVMYFLISHQATLKIETKNRKLEKLVQEIQQTK
LQLVQTEKMSSLGLLIAGVAHEIKNPISFISGNIKYASHYFQDLLNLIQLYQVEYPSPTPKIEAAIEDIGLDFIVQDLPK
LLNSMNVGSTRLHEIVLSLRNFSRSDESKVKEVDIHTGIESTLMILAHRLKTQLAHPEIMVTKNYGNLPLIECYAGKLNQ
VFMNILANAIDALEDSILVGELKERSPIISIKTAQLNTEWITIQIADNGPGIAPDIKTQLFNPFFTTKPVGKGTGLGLSI
SYDIICDQHQGHLLCSSEEGKGTEFIIKLPIALST

Sequences:

>Translated_675_residues
MMRKLLYLLKQYQGTGVVGLIGITFSITAMLIVDNWELAIDKEQFQQQSTVLVNEFQRQLDGYNQLTRSVGTFLNMSQEL
TREEFEELTSPLLPYYDGFLALGWSQKVKNQERSLYEQKLQAQGIINFKISERNHKGNQVLAGDRSTYFPTTYIEPLDRW
QNYIGWDAAADRKRLLSIEKAERTGVTVSTPLVQLENGEPGFVLYYPVFGSKNLNSQSLESEKLDSNRELQGVVFGFYEV
MTWVEKAIKNLNLNGLNFYLYSLPEDQLDSALNKTAITATDYFLVAYKDDSQSLTASPQVANLALIDSPKEQRSHLCRYS
DEWQFCIRSIHVGQQEFSLLILPASNRSITVWSSEIVLVLGLLVTASLVMYFLISHQATLKIETKNRKLEKLVQEIQQTK
LQLVQTEKMSSLGLLIAGVAHEIKNPISFISGNIKYASHYFQDLLNLIQLYQVEYPSPTPKIEAAIEDIGLDFIVQDLPK
LLNSMNVGSTRLHEIVLSLRNFSRSDESKVKEVDIHTGIESTLMILAHRLKTQLAHPEIMVTKNYGNLPLIECYAGKLNQ
VFMNILANAIDALEDSILVGELKERSPIISIKTAQLNTEWITIQIADNGPGIAPDIKTQLFNPFFTTKPVGKGTGLGLSI
SYDIICDQHQGHLLCSSEEGKGTEFIIKLPIALST
>Mature_675_residues
MMRKLLYLLKQYQGTGVVGLIGITFSITAMLIVDNWELAIDKEQFQQQSTVLVNEFQRQLDGYNQLTRSVGTFLNMSQEL
TREEFEELTSPLLPYYDGFLALGWSQKVKNQERSLYEQKLQAQGIINFKISERNHKGNQVLAGDRSTYFPTTYIEPLDRW
QNYIGWDAAADRKRLLSIEKAERTGVTVSTPLVQLENGEPGFVLYYPVFGSKNLNSQSLESEKLDSNRELQGVVFGFYEV
MTWVEKAIKNLNLNGLNFYLYSLPEDQLDSALNKTAITATDYFLVAYKDDSQSLTASPQVANLALIDSPKEQRSHLCRYS
DEWQFCIRSIHVGQQEFSLLILPASNRSITVWSSEIVLVLGLLVTASLVMYFLISHQATLKIETKNRKLEKLVQEIQQTK
LQLVQTEKMSSLGLLIAGVAHEIKNPISFISGNIKYASHYFQDLLNLIQLYQVEYPSPTPKIEAAIEDIGLDFIVQDLPK
LLNSMNVGSTRLHEIVLSLRNFSRSDESKVKEVDIHTGIESTLMILAHRLKTQLAHPEIMVTKNYGNLPLIECYAGKLNQ
VFMNILANAIDALEDSILVGELKERSPIISIKTAQLNTEWITIQIADNGPGIAPDIKTQLFNPFFTTKPVGKGTGLGLSI
SYDIICDQHQGHLLCSSEEGKGTEFIIKLPIALST

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=273, Percent_Identity=29.6703296703297, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788549, Length=276, Percent_Identity=29.7101449275362, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI145693157, Length=301, Percent_Identity=25.2491694352159, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76141; Mature: 76141

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50839 CHASE ; PS00041 HTH_ARAC_FAMILY_1 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRKLLYLLKQYQGTGVVGLIGITFSITAMLIVDNWELAIDKEQFQQQSTVLVNEFQRQL
CHHHHHHHHHHHCCCCEEEEHHHHHEEEEEEEEECCEEEECHHHHHHHHHHHHHHHHHHH
DGYNQLTRSVGTFLNMSQELTREEFEELTSPLLPYYDGFLALGWSQKVKNQERSLYEQKL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHCCCCEEECCHHHHHHHHHHHHHHHH
QAQGIINFKISERNHKGNQVLAGDRSTYFPTTYIEPLDRWQNYIGWDAAADRKRLLSIEK
HHCCEEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AERTGVTVSTPLVQLENGEPGFVLYYPVFGSKNLNSQSLESEKLDSNRELQGVVFGFYEV
HHHCCCEEECCEEEEECCCCCEEEEEEECCCCCCCCHHCCHHHCCCCCCHHHHHHHHHHH
MTWVEKAIKNLNLNGLNFYLYSLPEDQLDSALNKTAITATDYFLVAYKDDSQSLTASPQV
HHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCC
ANLALIDSPKEQRSHLCRYSDEWQFCIRSIHVGQQEFSLLILPASNRSITVWSSEIVLVL
EEEEEECCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCHHHHHH
GLLVTASLVMYFLISHQATLKIETKNRKLEKLVQEIQQTKLQLVQTEKMSSLGLLIAGVA
HHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEIKNPISFISGNIKYASHYFQDLLNLIQLYQVEYPSPTPKIEAAIEDIGLDFIVQDLPK
HHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LLNSMNVGSTRLHEIVLSLRNFSRSDESKVKEVDIHTGIESTLMILAHRLKTQLAHPEIM
HHHCCCCCHHHHHHHHHHHHHCCCCCCHHHEEEEHHCCHHHHHHHHHHHHHHHHCCCEEE
VTKNYGNLPLIECYAGKLNQVFMNILANAIDALEDSILVGELKERSPIISIKTAQLNTEW
EEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEECHHCCCCEEEEEEEEECCEE
ITIQIADNGPGIAPDIKTQLFNPFFTTKPVGKGTGLGLSISYDIICDQHQGHLLCSSEEG
EEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEECCCC
KGTEFIIKLPIALST
CCCEEEEEECEEECC
>Mature Secondary Structure
MMRKLLYLLKQYQGTGVVGLIGITFSITAMLIVDNWELAIDKEQFQQQSTVLVNEFQRQL
CHHHHHHHHHHHCCCCEEEEHHHHHEEEEEEEEECCEEEECHHHHHHHHHHHHHHHHHHH
DGYNQLTRSVGTFLNMSQELTREEFEELTSPLLPYYDGFLALGWSQKVKNQERSLYEQKL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHCCCCEEECCHHHHHHHHHHHHHHHH
QAQGIINFKISERNHKGNQVLAGDRSTYFPTTYIEPLDRWQNYIGWDAAADRKRLLSIEK
HHCCEEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AERTGVTVSTPLVQLENGEPGFVLYYPVFGSKNLNSQSLESEKLDSNRELQGVVFGFYEV
HHHCCCEEECCEEEEECCCCCEEEEEEECCCCCCCCHHCCHHHCCCCCCHHHHHHHHHHH
MTWVEKAIKNLNLNGLNFYLYSLPEDQLDSALNKTAITATDYFLVAYKDDSQSLTASPQV
HHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCC
ANLALIDSPKEQRSHLCRYSDEWQFCIRSIHVGQQEFSLLILPASNRSITVWSSEIVLVL
EEEEEECCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCHHHHHH
GLLVTASLVMYFLISHQATLKIETKNRKLEKLVQEIQQTKLQLVQTEKMSSLGLLIAGVA
HHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEIKNPISFISGNIKYASHYFQDLLNLIQLYQVEYPSPTPKIEAAIEDIGLDFIVQDLPK
HHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LLNSMNVGSTRLHEIVLSLRNFSRSDESKVKEVDIHTGIESTLMILAHRLKTQLAHPEIM
HHHCCCCCHHHHHHHHHHHHHCCCCCCHHHEEEEHHCCHHHHHHHHHHHHHHHHCCCEEE
VTKNYGNLPLIECYAGKLNQVFMNILANAIDALEDSILVGELKERSPIISIKTAQLNTEW
EEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEECHHCCCCEEEEEEEEECCEE
ITIQIADNGPGIAPDIKTQLFNPFFTTKPVGKGTGLGLSISYDIICDQHQGHLLCSSEEG
EEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEECCCC
KGTEFIIKLPIALST
CCCEEEEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]