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The map label for this gene is mrpD [H]

Identifier: 113475306

GI number: 113475306

Start: 2470555

End: 2472012

Strand: Direct

Name: mrpD [H]

Synonym: Tery_1615

Alternate gene names: 113475306

Gene position: 2470555-2472012 (Clockwise)

Preceding gene: 113475305

Following gene: 113475307

Centisome position: 31.88

GC content: 35.53

Gene sequence:

>1458_bases
ATGGCTAATTTGACAGTTGCCTGGATGGCATTACAATTTTGTGTTGGTTTCATTATCTATTTACTACCCAAATGTTCTCG
CTTTCTGGCACTGGGAGTAGCATTGCTTTCTGTTAACTATGCTTTGATAATATTTGCAGACCCATCGTTTCTTTTAGAAA
TAAAGTTACTTGATAATTTTGGTGTAACTTTAACTATTGACCAAATAGGTGGCTTTTTTATTATCACTAATGCTCTAGTA
ACAACAGCAGTAATATTTTACTGTTGGGATAGCAATAAAACAGCTTTTTTCTATATGCAATTAACGATTTTGCATGCTAG
TGTTAATGCTACTTTTATTTGTACAGATTTTATTAGTTTGTATGTAGCTTTGGAAGTAATTACTATTGCTTCATTTCTAC
TGATAACTTATAGTCGTACCGATAGGTCTATTTGGGTAGGGTTACGCTATTTGTTTGTGGGTAATACAGGAATGCTGTTT
TATCTTTTAGGGGCAGTTTTAGTATATCAAGCACATCATTCCTTTGGTTTTGAAGGTCTGCGGGGTGCGCCTCCAGAAGC
TATTGCGGTGATATTTTTGGGATTATTGATAAAAGGTGGTATATTTGTATCTGGGTTATGGTTGCCCTTAACTCATTCTG
AGTCAGAGAGTCCGGTATCGGCAATATTGTCAGGAGTGGTAGTCAAGGCAGGAGTTTTTCCATTAGTGCGTTGTGCGCTA
ATTGTAGAAGAAATAGAGCCGATAGTTAGACTTTTTGGAATAGGTACGGCCCTTTTAGGAGTTAGTTTTGCCATATTGGA
AAAAGATACTAAGCGTATGCTGGCATTTCACACTATTTCTCAGTTGGGTTTTATACTTGCTGCCCCAGTAGTAGGAGGTT
TCTATGCTTTGAGTCACGGTTTGGTTAAATCTGCTTTGTTTTTAATTTCAGGAGTTTTGCCTAGTCGTAATTTTAAGGAA
TTACAGAATCATCCTATTGATAATAGAATTTGGGTAATTTTAGCGATCGCTAGTTTTTCTATTTCTGGTTGTCCATTACT
TGCTGGTTTTGAAGCCAAGGTATTAACCTCGAAAAATTTATTATCCTGGGAGGTTATTGCTATCAATATTGCAGCAGTAG
GAACGGCAATTTCTTTTGCTAAATTCATTTTTCTGCCTCACCAGAAAAATGAGGAACCAATCAAAGTTAATTTGAGTTTT
TGGTTTGCGATAGTACCATTGATCGGTGGTTTGATAGTGGCAAATGGTTTTTATTCTGAAGCTTACAACATTGAAAATAT
TACTAAAGCATTGATAACTATAACTATTGGTTGGGTAATATATATATGTATTTTTCAGAAATTGGCGATTAAGTTACCAA
GGTCGATGGAAGAATTTGACCATCTGATTGGGTTTATGAGCCTAATGTTAATTTTACTATTCTGGATGATATGGACGCAA
CTGCCCTTTTTAACATAA

Upstream 100 bases:

>100_bases
AAAAACTATACTCAGTAGACTCTGAAAGGATTGGCTGAAATCTATCTTTTTTTTCTTAATGTATGACTTTTAAATGCATT
ATTTTTGACTTTTATGTTTT

Downstream 100 bases:

>100_bases
TATTACGACTGGCAATTTGGTTTTTACTCACCACCGACTTAAGTTGGGAAAATACGATTATTGGTGTTAGTGTTGCTTGT
TTATTGCCCCATAAAAAAAC

Product: putative monovalent cation/H+ antiporter subunit D

Products: NAD+; ubiquinol

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MANLTVAWMALQFCVGFIIYLLPKCSRFLALGVALLSVNYALIIFADPSFLLEIKLLDNFGVTLTIDQIGGFFIITNALV
TTAVIFYCWDSNKTAFFYMQLTILHASVNATFICTDFISLYVALEVITIASFLLITYSRTDRSIWVGLRYLFVGNTGMLF
YLLGAVLVYQAHHSFGFEGLRGAPPEAIAVIFLGLLIKGGIFVSGLWLPLTHSESESPVSAILSGVVVKAGVFPLVRCAL
IVEEIEPIVRLFGIGTALLGVSFAILEKDTKRMLAFHTISQLGFILAAPVVGGFYALSHGLVKSALFLISGVLPSRNFKE
LQNHPIDNRIWVILAIASFSISGCPLLAGFEAKVLTSKNLLSWEVIAINIAAVGTAISFAKFIFLPHQKNEEPIKVNLSF
WFAIVPLIGGLIVANGFYSEAYNIENITKALITITIGWVIYICIFQKLAIKLPRSMEEFDHLIGFMSLMLILLFWMIWTQ
LPFLT

Sequences:

>Translated_485_residues
MANLTVAWMALQFCVGFIIYLLPKCSRFLALGVALLSVNYALIIFADPSFLLEIKLLDNFGVTLTIDQIGGFFIITNALV
TTAVIFYCWDSNKTAFFYMQLTILHASVNATFICTDFISLYVALEVITIASFLLITYSRTDRSIWVGLRYLFVGNTGMLF
YLLGAVLVYQAHHSFGFEGLRGAPPEAIAVIFLGLLIKGGIFVSGLWLPLTHSESESPVSAILSGVVVKAGVFPLVRCAL
IVEEIEPIVRLFGIGTALLGVSFAILEKDTKRMLAFHTISQLGFILAAPVVGGFYALSHGLVKSALFLISGVLPSRNFKE
LQNHPIDNRIWVILAIASFSISGCPLLAGFEAKVLTSKNLLSWEVIAINIAAVGTAISFAKFIFLPHQKNEEPIKVNLSF
WFAIVPLIGGLIVANGFYSEAYNIENITKALITITIGWVIYICIFQKLAIKLPRSMEEFDHLIGFMSLMLILLFWMIWTQ
LPFLT
>Mature_484_residues
ANLTVAWMALQFCVGFIIYLLPKCSRFLALGVALLSVNYALIIFADPSFLLEIKLLDNFGVTLTIDQIGGFFIITNALVT
TAVIFYCWDSNKTAFFYMQLTILHASVNATFICTDFISLYVALEVITIASFLLITYSRTDRSIWVGLRYLFVGNTGMLFY
LLGAVLVYQAHHSFGFEGLRGAPPEAIAVIFLGLLIKGGIFVSGLWLPLTHSESESPVSAILSGVVVKAGVFPLVRCALI
VEEIEPIVRLFGIGTALLGVSFAILEKDTKRMLAFHTISQLGFILAAPVVGGFYALSHGLVKSALFLISGVLPSRNFKEL
QNHPIDNRIWVILAIASFSISGCPLLAGFEAKVLTSKNLLSWEVIAINIAAVGTAISFAKFIFLPHQKNEEPIKVNLSFW
FAIVPLIGGLIVANGFYSEAYNIENITKALITITIGWVIYICIFQKLAIKLPRSMEEFDHLIGFMSLMLILLFWMIWTQL
PFLT

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=405, Percent_Identity=24.6913580246914, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788827, Length=319, Percent_Identity=30.0940438871473, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788831, Length=300, Percent_Identity=25.6666666666667, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788829, Length=347, Percent_Identity=24.207492795389, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788613, Length=298, Percent_Identity=21.4765100671141, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 53540; Mature: 53408

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLTVAWMALQFCVGFIIYLLPKCSRFLALGVALLSVNYALIIFADPSFLLEIKLLDNF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEEEECCC
GVTLTIDQIGGFFIITNALVTTAVIFYCWDSNKTAFFYMQLTILHASVNATFICTDFISL
CCEEEEHHCCCEEEHHHHHHHHEEEEEEECCCCEEEEEEEEEEEEEECCCEEEHHHHHHH
YVALEVITIASFLLITYSRTDRSIWVGLRYLFVGNTGMLFYLLGAVLVYQAHHSFGFEGL
HHHHHHHHHHHHHHHEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC
RGAPPEAIAVIFLGLLIKGGIFVSGLWLPLTHSESESPVSAILSGVVVKAGVFPLVRCAL
CCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IVEEIEPIVRLFGIGTALLGVSFAILEKDTKRMLAFHTISQLGFILAAPVVGGFYALSHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVKSALFLISGVLPSRNFKELQNHPIDNRIWVILAIASFSISGCPLLAGFEAKVLTSKNL
HHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEEEEECCCCCCCCEEECCCEEEEECCCC
LSWEVIAINIAAVGTAISFAKFIFLPHQKNEEPIKVNLSFWFAIVPLIGGLIVANGFYSE
CEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHH
AYNIENITKALITITIGWVIYICIFQKLAIKLPRSMEEFDHLIGFMSLMLILLFWMIWTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LPFLT
CCCCC
>Mature Secondary Structure 
ANLTVAWMALQFCVGFIIYLLPKCSRFLALGVALLSVNYALIIFADPSFLLEIKLLDNF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEEEECCC
GVTLTIDQIGGFFIITNALVTTAVIFYCWDSNKTAFFYMQLTILHASVNATFICTDFISL
CCEEEEHHCCCEEEHHHHHHHHEEEEEEECCCCEEEEEEEEEEEEEECCCEEEHHHHHHH
YVALEVITIASFLLITYSRTDRSIWVGLRYLFVGNTGMLFYLLGAVLVYQAHHSFGFEGL
HHHHHHHHHHHHHHHEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC
RGAPPEAIAVIFLGLLIKGGIFVSGLWLPLTHSESESPVSAILSGVVVKAGVFPLVRCAL
CCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IVEEIEPIVRLFGIGTALLGVSFAILEKDTKRMLAFHTISQLGFILAAPVVGGFYALSHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVKSALFLISGVLPSRNFKELQNHPIDNRIWVILAIASFSISGCPLLAGFEAKVLTSKNL
HHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEEEEECCCCCCCCEEECCCEEEEECCCC
LSWEVIAINIAAVGTAISFAKFIFLPHQKNEEPIKVNLSFWFAIVPLIGGLIVANGFYSE
CEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHH
AYNIENITKALITITIGWVIYICIFQKLAIKLPRSMEEFDHLIGFMSLMLILLFWMIWTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LPFLT
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]