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The map label for this gene is folC [H]

Identifier: 113475294

GI number: 113475294

Start: 2450017

End: 2451279

Strand: Direct

Name: folC [H]

Synonym: Tery_1603

Alternate gene names: 113475294

Gene position: 2450017-2451279 (Clockwise)

Preceding gene: 113475293

Following gene: 113475296

Centisome position: 31.61

GC content: 39.59

Gene sequence:

>1263_bases
GTGAATTCTATAGACTCTTTCTTAAAACGCTTTGAACATTTCGGCGTTGAGCTTAGTCTCGAACGCATCTATCAACTTCT
AGATAATTTAGGCAAGCCTCATCTCCAAGTACCCATAATTCATGTCGCCGGAACAAATGGCAAAGGTTCTGTCTGTGCTT
ACCTATCATCCATCCTCAAAGCAGCAGGATATAAAGTCGGACGTTACACTTCACCCCACCTGGTTGACTGGACAGAACGT
ATTTGCCTCAACGAAGAAAAAATTCCCTCAAGTATATTAGAACAATTATTGGTAGAAGTAGAAACAGCTATTCAACCAGA
ACAACCTTCACCTACTCAGTTTGAGGTTATTACTGCCGCAGCTTGGTTATATTTTGCTCAACAACAAGTAGATGTGGCAG
TTGTAGAAGTAGGTTTGGGGGGCAGACTAGATGCTACTAATGTTTGTCACCAACCAATGGTAACTGTCATTACTTCTATT
AGTTGGGAACATTGGCAAAAATTAGGTCCGACTTTGAGTCATATTGCTGGGGAAAAGGCGGGTATTCTTAAACCAAGATG
TCCTGCTATAGTTGGAGTATTACCCCCAGAAGCAAAAAAAGTAGTAGAAAAACGTATTACTGATCTAGAGTGTCCTGTTG
TTTGGGCAGAGCCTGCTAAATTATTGGCAGAAAGTCAGGAATATAACTCATTGCCAGTAGCTACTTATCAAGGTATTGAA
TATAAGGTGCCATTATTTGGAGATGTACAGTTGATAAATTCAGCGATCGCTATTGCTACAGTTCAAGTGCTAGAAACACA
AGGTTGGGAGATTCCGATCACAGCAATTAAACAAGGAATAGCTGAAACTAAATGGCTTGGACGTTTGCAATGGACTACAT
GGCAAAATCGCCAATTATTAATTGATGGGGCCCATAATGCTGCTGCAGCCCAAGTATTGGGACGGTATGTCCGGACACTA
AATTATCCATCTATAAGTTGGGTTATGGGTATGCTGTCTACGAAGGAACATTCGGAAATTTTTCGGGCACTTCTTAGACC
AGGCGATCGCTTGTATTTAGTTCCTGTTCCTGACCATAGTTCGGCTGATTTGAATCAACTTAGTACCATAGCTCAGGATA
TATGCACAAAATTAGATTTTTGTCAAGTTTATCCCCATTTAACACCGGCTTTAGAAGAGGCTATTACTGATAGTAAAAAT
TTAATTGTTTTATGTGGTTCTCTATATTTATTGGGTCATTTTATCAAAATGAAAAGTAACTAA

Upstream 100 bases:

>100_bases
GTCTCCCCTGAAGCTCAGTTTTCAAGCAGAGAGACTGAATACTTTTGACTTTTGACTTTTGACTTCCAAGAGCTAGATAG
CTAATTGCTATAAAAAAACT

Downstream 100 bases:

>100_bases
ATTGTTATTGTTGGGAATTGTTCTTGAGCGTTGTTTGTGTTGGTAGTAGTGGGGTTTAATTTATCTGTTTTTATGGCTGG
TATTCTAACTCTCGACTGCC

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNSIDSFLKRFEHFGVELSLERIYQLLDNLGKPHLQVPIIHVAGTNGKGSVCAYLSSILKAAGYKVGRYTSPHLVDWTER
ICLNEEKIPSSILEQLLVEVETAIQPEQPSPTQFEVITAAAWLYFAQQQVDVAVVEVGLGGRLDATNVCHQPMVTVITSI
SWEHWQKLGPTLSHIAGEKAGILKPRCPAIVGVLPPEAKKVVEKRITDLECPVVWAEPAKLLAESQEYNSLPVATYQGIE
YKVPLFGDVQLINSAIAIATVQVLETQGWEIPITAIKQGIAETKWLGRLQWTTWQNRQLLIDGAHNAAAAQVLGRYVRTL
NYPSISWVMGMLSTKEHSEIFRALLRPGDRLYLVPVPDHSSADLNQLSTIAQDICTKLDFCQVYPHLTPALEEAITDSKN
LIVLCGSLYLLGHFIKMKSN

Sequences:

>Translated_420_residues
MNSIDSFLKRFEHFGVELSLERIYQLLDNLGKPHLQVPIIHVAGTNGKGSVCAYLSSILKAAGYKVGRYTSPHLVDWTER
ICLNEEKIPSSILEQLLVEVETAIQPEQPSPTQFEVITAAAWLYFAQQQVDVAVVEVGLGGRLDATNVCHQPMVTVITSI
SWEHWQKLGPTLSHIAGEKAGILKPRCPAIVGVLPPEAKKVVEKRITDLECPVVWAEPAKLLAESQEYNSLPVATYQGIE
YKVPLFGDVQLINSAIAIATVQVLETQGWEIPITAIKQGIAETKWLGRLQWTTWQNRQLLIDGAHNAAAAQVLGRYVRTL
NYPSISWVMGMLSTKEHSEIFRALLRPGDRLYLVPVPDHSSADLNQLSTIAQDICTKLDFCQVYPHLTPALEEAITDSKN
LIVLCGSLYLLGHFIKMKSN
>Mature_420_residues
MNSIDSFLKRFEHFGVELSLERIYQLLDNLGKPHLQVPIIHVAGTNGKGSVCAYLSSILKAAGYKVGRYTSPHLVDWTER
ICLNEEKIPSSILEQLLVEVETAIQPEQPSPTQFEVITAAAWLYFAQQQVDVAVVEVGLGGRLDATNVCHQPMVTVITSI
SWEHWQKLGPTLSHIAGEKAGILKPRCPAIVGVLPPEAKKVVEKRITDLECPVVWAEPAKLLAESQEYNSLPVATYQGIE
YKVPLFGDVQLINSAIAIATVQVLETQGWEIPITAIKQGIAETKWLGRLQWTTWQNRQLLIDGAHNAAAAQVLGRYVRTL
NYPSISWVMGMLSTKEHSEIFRALLRPGDRLYLVPVPDHSSADLNQLSTIAQDICTKLDFCQVYPHLTPALEEAITDSKN
LIVLCGSLYLLGHFIKMKSN

Specific function: Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=331, Percent_Identity=30.2114803625378, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI66932984, Length=331, Percent_Identity=30.2114803625378, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1788654, Length=421, Percent_Identity=32.7790973871734, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17553148, Length=286, Percent_Identity=32.1678321678322, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71984923, Length=286, Percent_Identity=32.1678321678322, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17553150, Length=286, Percent_Identity=32.1678321678322, Blast_Score=137, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323760, Length=435, Percent_Identity=32.8735632183908, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324815, Length=437, Percent_Identity=27.2311212814645, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322718, Length=435, Percent_Identity=26.4367816091954, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24641571, Length=423, Percent_Identity=27.8959810874704, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24581568, Length=187, Percent_Identity=35.2941176470588, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 46616; Mature: 46616

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01011 FOLYLPOLYGLU_SYNT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIDSFLKRFEHFGVELSLERIYQLLDNLGKPHLQVPIIHVAGTNGKGSVCAYLSSILK
CCHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHH
AAGYKVGRYTSPHLVDWTERICLNEEKIPSSILEQLLVEVETAIQPEQPSPTQFEVITAA
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AWLYFAQQQVDVAVVEVGLGGRLDATNVCHQPMVTVITSISWEHWQKLGPTLSHIAGEKA
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCHHHHHHHCCHHHHHHHCCHHHHHCCCCC
GILKPRCPAIVGVLPPEAKKVVEKRITDLECPVVWAEPAKLLAESQEYNSLPVATYQGIE
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCCCCCEEECCCE
YKVPLFGDVQLINSAIAIATVQVLETQGWEIPITAIKQGIAETKWLGRLQWTTWQNRQLL
EECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCEEEEEECCCEEE
IDGAHNAAAAQVLGRYVRTLNYPSISWVMGMLSTKEHSEIFRALLRPGDRLYLVPVPDHS
EECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
SADLNQLSTIAQDICTKLDFCQVYPHLTPALEEAITDSKNLIVLCGSLYLLGHFIKMKSN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSIDSFLKRFEHFGVELSLERIYQLLDNLGKPHLQVPIIHVAGTNGKGSVCAYLSSILK
CCHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHH
AAGYKVGRYTSPHLVDWTERICLNEEKIPSSILEQLLVEVETAIQPEQPSPTQFEVITAA
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AWLYFAQQQVDVAVVEVGLGGRLDATNVCHQPMVTVITSISWEHWQKLGPTLSHIAGEKA
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCHHHHHHHCCHHHHHHHCCHHHHHCCCCC
GILKPRCPAIVGVLPPEAKKVVEKRITDLECPVVWAEPAKLLAESQEYNSLPVATYQGIE
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCCCCCEEECCCE
YKVPLFGDVQLINSAIAIATVQVLETQGWEIPITAIKQGIAETKWLGRLQWTTWQNRQLL
EECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCEEEEEECCCEEE
IDGAHNAAAAQVLGRYVRTLNYPSISWVMGMLSTKEHSEIFRALLRPGDRLYLVPVPDHS
EECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
SADLNQLSTIAQDICTKLDFCQVYPHLTPALEEAITDSKNLIVLCGSLYLLGHFIKMKSN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8419299; 9384377; 2553669 [H]