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The map label for this gene is purD [H]

Identifier: 113475173

GI number: 113475173

Start: 2231265

End: 2232536

Strand: Reverse

Name: purD [H]

Synonym: Tery_1471

Alternate gene names: 113475173

Gene position: 2232536-2231265 (Counterclockwise)

Preceding gene: 113475174

Following gene: 113475172

Centisome position: 28.81

GC content: 42.85

Gene sequence:

>1272_bases
GTGAAAATATTAATAGTAGGTAACGGTGGTAGAGAACACGCGATCGCCTGGAAACTATCCCACTCTTCCCAAGTTCAACA
AATATTCTGTACCCCTGGCAACGGCGGCACAGCTACCCAGGCAAAATGTCAAAACATAGTCATCCCAGTGACAGACTTTC
CAGCTCTCAGACAACTCATCGCTGACGAAAACATTTCTCTAGTGGTTGTTGGCCCTGAAGTTCCTTTAGCCCTCGGCATT
ACCGACTACCTACAAAAATCCCATCTCAAAATATTCGGCCCCACTAAAGCAGGGGCTATTCTTGAAGCGAGCAAATCTTG
GGCTAAACAATTCATGGCCGAAGCAAATATTCCCACTGCTAAGTCAGCCACCTTTACCAGGGCTGAAGCTGCTAAAGAAT
ACATCACAGAAATTCCCATAGTCATTAAAGCAGATGGTCTAGCGGCTGGAAAAGGAGTTACGGTAGCCACTACAATTGAA
ATGGCTCACAATGCTATAGATAGGATCTTTCAAGGAGAATTTGACAAAAAAAACCAATCTGTAGTTATCGAAGAGTTCCT
CACAGGTCAAGAAATATCAGTATTAGCCCTAACCGATGGACTAACCATTCGTCCCCTATTACCAGCCCAAGACCATAAAG
CAGTAGGAGAAGGAGACACAGGACCTAACACTGGAGGTATGGGTGCTTATGCCCCTACTCCTATTGTTACCCCCGAACTC
ATGACCCACATTCAACAACAAGTCCTAGAACCAACTTTGACTAATTTACAAAAACGTGGTATAGATTATCGAGGTGTGAT
TTATGCTGGATTAATAATAAGTCCCACAGGAGAGGCAAAAGTATTGGAATTTAACTGTAGGTTTGGCGACCCAGAAACTC
AACCTATTCTGTCATTGCTGGAAACTCCATTGGAGGAATTATTATTAGCTTGTTGTGAACAACGTTTGGGTCAGCTGCCC
CCTATTAATTGGAAATCAGGAGTAGCAGTATGTGTAGTTTTAGCTTCTGGGGGTTATCCAGGAACTTATCAGAAAGGAAA
AATCATATGTGGAGTAGAAAAGGCTGAAGCCACTGGAGTAAAAATATTTCACGCAGGAACAAAATTCCAGGCACAAAATT
TAATCACTGAGGGTGGTCGTGTCTTGGGAGTAACAGCAGTGGGGGCTAATTTTACTGAAGCCAAGGCAAAAGCTTATGCT
GCTGTAGATTGTATTCAATTTGAAAGAATGTACTATCGCAGAGATATAGGTCGTCAGGTTTTTAGCAATTAG

Upstream 100 bases:

>100_bases
TGTTATTGAGAACTAAATATTTCTTGCTGATTCAATAAAATTATCAACAGTGAGATAATAAAAAACTCAGTAAAAAAATA
ATTCAAAAAGCAAAAAAAAC

Downstream 100 bases:

>100_bases
AAATTAGAGTAGAGCCATTCCCTATCCAAATAGATGGAAACCTCAGATTTATTAGTCAAGTAGGGGGAATATTTATAAAG
GTGAAAGTGCTTATCATCGC

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKILIVGNGGREHAIAWKLSHSSQVQQIFCTPGNGGTATQAKCQNIVIPVTDFPALRQLIADENISLVVVGPEVPLALGI
TDYLQKSHLKIFGPTKAGAILEASKSWAKQFMAEANIPTAKSATFTRAEAAKEYITEIPIVIKADGLAAGKGVTVATTIE
MAHNAIDRIFQGEFDKKNQSVVIEEFLTGQEISVLALTDGLTIRPLLPAQDHKAVGEGDTGPNTGGMGAYAPTPIVTPEL
MTHIQQQVLEPTLTNLQKRGIDYRGVIYAGLIISPTGEAKVLEFNCRFGDPETQPILSLLETPLEELLLACCEQRLGQLP
PINWKSGVAVCVVLASGGYPGTYQKGKIICGVEKAEATGVKIFHAGTKFQAQNLITEGGRVLGVTAVGANFTEAKAKAYA
AVDCIQFERMYYRRDIGRQVFSN

Sequences:

>Translated_423_residues
MKILIVGNGGREHAIAWKLSHSSQVQQIFCTPGNGGTATQAKCQNIVIPVTDFPALRQLIADENISLVVVGPEVPLALGI
TDYLQKSHLKIFGPTKAGAILEASKSWAKQFMAEANIPTAKSATFTRAEAAKEYITEIPIVIKADGLAAGKGVTVATTIE
MAHNAIDRIFQGEFDKKNQSVVIEEFLTGQEISVLALTDGLTIRPLLPAQDHKAVGEGDTGPNTGGMGAYAPTPIVTPEL
MTHIQQQVLEPTLTNLQKRGIDYRGVIYAGLIISPTGEAKVLEFNCRFGDPETQPILSLLETPLEELLLACCEQRLGQLP
PINWKSGVAVCVVLASGGYPGTYQKGKIICGVEKAEATGVKIFHAGTKFQAQNLITEGGRVLGVTAVGANFTEAKAKAYA
AVDCIQFERMYYRRDIGRQVFSN
>Mature_423_residues
MKILIVGNGGREHAIAWKLSHSSQVQQIFCTPGNGGTATQAKCQNIVIPVTDFPALRQLIADENISLVVVGPEVPLALGI
TDYLQKSHLKIFGPTKAGAILEASKSWAKQFMAEANIPTAKSATFTRAEAAKEYITEIPIVIKADGLAAGKGVTVATTIE
MAHNAIDRIFQGEFDKKNQSVVIEEFLTGQEISVLALTDGLTIRPLLPAQDHKAVGEGDTGPNTGGMGAYAPTPIVTPEL
MTHIQQQVLEPTLTNLQKRGIDYRGVIYAGLIISPTGEAKVLEFNCRFGDPETQPILSLLETPLEELLLACCEQRLGQLP
PINWKSGVAVCVVLASGGYPGTYQKGKIICGVEKAEATGVKIFHAGTKFQAQNLITEGGRVLGVTAVGANFTEAKAKAYA
AVDCIQFERMYYRRDIGRQVFSN

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=420, Percent_Identity=46.4285714285714, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI209869995, Length=420, Percent_Identity=46.4285714285714, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI209869993, Length=420, Percent_Identity=46.4285714285714, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI28416899, Length=420, Percent_Identity=46.4285714285714, Blast_Score=372, Evalue=1e-103,
Organism=Escherichia coli, GI1790438, Length=421, Percent_Identity=47.9809976247031, Blast_Score=400, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567511, Length=427, Percent_Identity=40.7494145199063, Blast_Score=301, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6321203, Length=441, Percent_Identity=42.4036281179138, Blast_Score=332, Evalue=8e-92,
Organism=Drosophila melanogaster, GI62471619, Length=431, Percent_Identity=47.3317865429234, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI24582400, Length=431, Percent_Identity=47.3317865429234, Blast_Score=355, Evalue=5e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 45388; Mature: 45388

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVGNGGREHAIAWKLSHSSQVQQIFCTPGNGGTATQAKCQNIVIPVTDFPALRQLI
CEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHH
ADENISLVVVGPEVPLALGITDYLQKSHLKIFGPTKAGAILEASKSWAKQFMAEANIPTA
CCCCCEEEEECCCCCEEECHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
KSATFTRAEAAKEYITEIPIVIKADGLAAGKGVTVATTIEMAHNAIDRIFQGEFDKKNQS
CCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCC
VVIEEFLTGQEISVLALTDGLTIRPLLPAQDHKAVGEGDTGPNTGGMGAYAPTPIVTPEL
EEEEHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
MTHIQQQVLEPTLTNLQKRGIDYRGVIYAGLIISPTGEAKVLEFNCRFGDPETQPILSLL
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
ETPLEELLLACCEQRLGQLPPINWKSGVAVCVVLASGGYPGTYQKGKIICGVEKAEATGV
HCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCE
KIFHAGTKFQAQNLITEGGRVLGVTAVGANFTEAKAKAYAAVDCIQFERMYYRRDIGRQV
EEEECCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSN
HCC
>Mature Secondary Structure
MKILIVGNGGREHAIAWKLSHSSQVQQIFCTPGNGGTATQAKCQNIVIPVTDFPALRQLI
CEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHH
ADENISLVVVGPEVPLALGITDYLQKSHLKIFGPTKAGAILEASKSWAKQFMAEANIPTA
CCCCCEEEEECCCCCEEECHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
KSATFTRAEAAKEYITEIPIVIKADGLAAGKGVTVATTIEMAHNAIDRIFQGEFDKKNQS
CCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCC
VVIEEFLTGQEISVLALTDGLTIRPLLPAQDHKAVGEGDTGPNTGGMGAYAPTPIVTPEL
EEEEHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
MTHIQQQVLEPTLTNLQKRGIDYRGVIYAGLIISPTGEAKVLEFNCRFGDPETQPILSLL
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
ETPLEELLLACCEQRLGQLPPINWKSGVAVCVVLASGGYPGTYQKGKIICGVEKAEATGV
HCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCE
KIFHAGTKFQAQNLITEGGRVLGVTAVGANFTEAKAKAYAAVDCIQFERMYYRRDIGRQV
EEEECCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSN
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]