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The map label for this gene is cobA [H]

Identifier: 113474946

GI number: 113474946

Start: 1837408

End: 1838166

Strand: Direct

Name: cobA [H]

Synonym: Tery_1175

Alternate gene names: 113474946

Gene position: 1837408-1838166 (Clockwise)

Preceding gene: 113474945

Following gene: 113474947

Centisome position: 23.71

GC content: 38.87

Gene sequence:

>759_bases
ATGAATCAGCTAAAATTTGTAGGTAAGGTGTATTTAGTAGGAGCAGGACCGGGAGATCCTGGATTAATTACACTAAAAGG
TAAAGTGCTATTAAAACAAGCTGATGTTGTTATCTATGATGCTCTTGTCAGCGCTTCTATCTTAGAAATGATTAACCCAA
ATGCTGAAAAATTTAATGCAGGTAAACGTCGAGATCGCCATTCTCTAGAGCAAACACAAACAACTCAACTACTAATTGAA
AAAGCAAAAACTCATGCAGTTGTGGTACGTCTAAAAGGAGGTGACCCTTTTGTATTTGGTCGTGGTGGAGAGGAGATGGA
AGATTTAATGCAAGTAGGAATAGCTGTGGAAGTTATTCCGGGGGTTACTTCCGGTATCGCTGCACCTGCTTATGCTGGTA
TTCCTTTAACTCACAGAAACTATAGTTCCTCGGTTACTTTTGTCACAGGTCACGAAGCAGCAGGCAAATATCGACCAGAG
GTTAATTGGGAGGCGGTCGCCCAGGGTGCAGAAACGATAGTAATTTACATGGGGGTTCATAACTTACAAAATATTATCAA
AAAACTAATCGCTGCTGGACGTGACCCAGAAACACCAATTGCTTTAATTCAGTGGGGAACTTATCCAAAACAAAAAGAAT
TAATTGGAACTCTTAATAATATTGTGGGACAAATTGAGTCAACTGGTTTTGAAGCACCAGCTATTACTGTTATTGGTAAT
GTAGTTAATTTACATCAAATATTAGGAAATAGGGAGTAA

Upstream 100 bases:

>100_bases
TTTTTTGAACCCCAAAAGGCTAAGTGCCAATATTACTCAATATTTTGATAGTTAATTATCCAGCCCTAATTATATTAGAG
AGTTATCTAAAATAATAAAT

Downstream 100 bases:

>100_bases
TACTATTTATTAAAAGTAATGGTATTTTTTACATCTTATCAAAATAACTAGAGAAATAACATAGTTTAGTAAACAATGAA
ATTACGCTAATAAATAGTAT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MNQLKFVGKVYLVGAGPGDPGLITLKGKVLLKQADVVIYDALVSASILEMINPNAEKFNAGKRRDRHSLEQTQTTQLLIE
KAKTHAVVVRLKGGDPFVFGRGGEEMEDLMQVGIAVEVIPGVTSGIAAPAYAGIPLTHRNYSSSVTFVTGHEAAGKYRPE
VNWEAVAQGAETIVIYMGVHNLQNIIKKLIAAGRDPETPIALIQWGTYPKQKELIGTLNNIVGQIESTGFEAPAITVIGN
VVNLHQILGNRE

Sequences:

>Translated_252_residues
MNQLKFVGKVYLVGAGPGDPGLITLKGKVLLKQADVVIYDALVSASILEMINPNAEKFNAGKRRDRHSLEQTQTTQLLIE
KAKTHAVVVRLKGGDPFVFGRGGEEMEDLMQVGIAVEVIPGVTSGIAAPAYAGIPLTHRNYSSSVTFVTGHEAAGKYRPE
VNWEAVAQGAETIVIYMGVHNLQNIIKKLIAAGRDPETPIALIQWGTYPKQKELIGTLNNIVGQIESTGFEAPAITVIGN
VVNLHQILGNRE
>Mature_252_residues
MNQLKFVGKVYLVGAGPGDPGLITLKGKVLLKQADVVIYDALVSASILEMINPNAEKFNAGKRRDRHSLEQTQTTQLLIE
KAKTHAVVVRLKGGDPFVFGRGGEEMEDLMQVGIAVEVIPGVTSGIAAPAYAGIPLTHRNYSSSVTFVTGHEAAGKYRPE
VNWEAVAQGAETIVIYMGVHNLQNIIKKLIAAGRDPETPIALIQWGTYPKQKELIGTLNNIVGQIESTGFEAPAITVIGN
VVNLHQILGNRE

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=245, Percent_Identity=44.4897959183673, Blast_Score=209, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322922, Length=241, Percent_Identity=32.7800829875519, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27143; Mature: 27143

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLKFVGKVYLVGAGPGDPGLITLKGKVLLKQADVVIYDALVSASILEMINPNAEKFNA
CCCCEEEEEEEEEECCCCCCCEEEEECEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHCC
GKRRDRHSLEQTQTTQLLIEKAKTHAVVVRLKGGDPFVFGRGGEEMEDLMQVGIAVEVIP
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCCHHHHHHHHHCCCEEECC
GVTSGIAAPAYAGIPLTHRNYSSSVTFVTGHEAAGKYRPEVNWEAVAQGAETIVIYMGVH
CCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEEEEECHH
NLQNIIKKLIAAGRDPETPIALIQWGTYPKQKELIGTLNNIVGQIESTGFEAPAITVIGN
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEHHH
VVNLHQILGNRE
HHHHHHHHCCCC
>Mature Secondary Structure
MNQLKFVGKVYLVGAGPGDPGLITLKGKVLLKQADVVIYDALVSASILEMINPNAEKFNA
CCCCEEEEEEEEEECCCCCCCEEEEECEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHCC
GKRRDRHSLEQTQTTQLLIEKAKTHAVVVRLKGGDPFVFGRGGEEMEDLMQVGIAVEVIP
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCCHHHHHHHHHCCCEEECC
GVTSGIAAPAYAGIPLTHRNYSSSVTFVTGHEAAGKYRPEVNWEAVAQGAETIVIYMGVH
CCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEEEEECHH
NLQNIIKKLIAAGRDPETPIALIQWGTYPKQKELIGTLNNIVGQIESTGFEAPAITVIGN
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEHHH
VVNLHQILGNRE
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]