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The map label for this gene is hemF [H]

Identifier: 113474939

GI number: 113474939

Start: 1826159

End: 1827190

Strand: Direct

Name: hemF [H]

Synonym: Tery_1166

Alternate gene names: 113474939

Gene position: 1826159-1827190 (Clockwise)

Preceding gene: 113474927

Following gene: 113474940

Centisome position: 23.56

GC content: 39.83

Gene sequence:

>1032_bases
ATGGTAGTTTCGAGTAAGGACCAAGAAATATCTTTATCTGTACCAGCGAGTGACACAAAAGAACGAGTCAGTCAATTTAT
GCAGACTCTACAAGATGAAATTTGCCAAGGACTAGAAGAATTAGATGGAGTTAGTAAGTTCAAGGAAGACTCTTGGAAAC
GTCCAGGTGGCGGCGGAGGAAAGTCTCGTGTAATAAGAGACGGTGGAGTTTTTGAACAAGGGGGAGTTAATTTTTCAGAA
GTATGGGGAGATAAATTACCTCCAAGTGTACTGAAGCAAAGACCAGAAGCGGCAGGTAATAGTTTCTATGCCACAGGAAC
CTCTATGGTGCTGCACCCTAAAAATCCTTATGTACCAACAGTACATCTTAACTATCGTTATTTTGAAGCTGGATCTGTAT
GGTGGTTTGGTGGTGGTGTAGATTTAACACCTTACTATCCTTATGCCGAAGACGCAGCGCACTTTCATCAAACGATTAAG
GCAGCCTGTGACAAAAGCCATAAAGAGTATTATCCTATATTTAAAAGATGGTGTGATGAATATTTTTACTTAAAGCATCG
TCAAGAAACGCGGGGTGTAGGAGGTATCTTTTTTGATTATCAAGATGGTCAAGGAGAATTATACAAAGGGCCTGATAATC
AAGGACCAGCAGCAACCTATAGTAAGGATTTAGGAATTCTTGAATCTCGTAGTTGGGAATCTTTATTTACATTTGTACAA
AATTGTGGTGTATCATTTTTACCAGCATACAAGATAATAGTAGAGAGACGGCAACCCATGAAATATGGTGACCGGGAACG
CAACTTTCAGCTATACCGACGTGGCCGTTATGTTGAATTTAATTTAGTATATGATAGGGGTACAATTTTTGGTTTGCAAA
CCAATGGTCGTACAGAATCAATCTTGATGTCTTTACCACCTTTAGTTCGTTGGGAGTATGGTTACAACCCAGAACCCAAC
ACACCAGAAGCTGAACTATATGAAGTATTCTTAAAACCTCATGACTGGGCTGACTGGAAACCAAATCATTAG

Upstream 100 bases:

>100_bases
ATATAATCTGAAAATTGTAACTAGATGATTTAGGACATGGTAAGATAAAAAGTATGGAAAAGATTTAATTTTTAGCCAAC
TTCAAATATAGATTATAGTT

Downstream 100 bases:

>100_bases
TTGTTCTGAGTTAAACTACATTTAGATGGGCAACCACCACAAGTAATATCATCCTGAGGGAAGGGTCAGTGATTCAGATT
GAGCAAAAAACCCACACAAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MVVSSKDQEISLSVPASDTKERVSQFMQTLQDEICQGLEELDGVSKFKEDSWKRPGGGGGKSRVIRDGGVFEQGGVNFSE
VWGDKLPPSVLKQRPEAAGNSFYATGTSMVLHPKNPYVPTVHLNYRYFEAGSVWWFGGGVDLTPYYPYAEDAAHFHQTIK
AACDKSHKEYYPIFKRWCDEYFYLKHRQETRGVGGIFFDYQDGQGELYKGPDNQGPAATYSKDLGILESRSWESLFTFVQ
NCGVSFLPAYKIIVERRQPMKYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYGYNPEPN
TPEAELYEVFLKPHDWADWKPNH

Sequences:

>Translated_343_residues
MVVSSKDQEISLSVPASDTKERVSQFMQTLQDEICQGLEELDGVSKFKEDSWKRPGGGGGKSRVIRDGGVFEQGGVNFSE
VWGDKLPPSVLKQRPEAAGNSFYATGTSMVLHPKNPYVPTVHLNYRYFEAGSVWWFGGGVDLTPYYPYAEDAAHFHQTIK
AACDKSHKEYYPIFKRWCDEYFYLKHRQETRGVGGIFFDYQDGQGELYKGPDNQGPAATYSKDLGILESRSWESLFTFVQ
NCGVSFLPAYKIIVERRQPMKYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYGYNPEPN
TPEAELYEVFLKPHDWADWKPNH
>Mature_343_residues
MVVSSKDQEISLSVPASDTKERVSQFMQTLQDEICQGLEELDGVSKFKEDSWKRPGGGGGKSRVIRDGGVFEQGGVNFSE
VWGDKLPPSVLKQRPEAAGNSFYATGTSMVLHPKNPYVPTVHLNYRYFEAGSVWWFGGGVDLTPYYPYAEDAAHFHQTIK
AACDKSHKEYYPIFKRWCDEYFYLKHRQETRGVGGIFFDYQDGQGELYKGPDNQGPAATYSKDLGILESRSWESLFTFVQ
NCGVSFLPAYKIIVERRQPMKYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYGYNPEPN
TPEAELYEVFLKPHDWADWKPNH

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=332, Percent_Identity=44.2771084337349, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1788777, Length=321, Percent_Identity=55.1401869158878, Blast_Score=350, Evalue=9e-98,
Organism=Saccharomyces cerevisiae, GI6320249, Length=342, Percent_Identity=45.906432748538, Blast_Score=284, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17864388, Length=334, Percent_Identity=46.4071856287425, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 39440; Mature: 39440

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVSSKDQEISLSVPASDTKERVSQFMQTLQDEICQGLEELDGVSKFKEDSWKRPGGGGG
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KSRVIRDGGVFEQGGVNFSEVWGDKLPPSVLKQRPEAAGNSFYATGTSMVLHPKNPYVPT
CCCEEECCCCCCCCCCCHHHHCCCCCCHHHHHCCCHHCCCCEEECCCEEEEECCCCCCCE
VHLNYRYFEAGSVWWFGGGVDLTPYYPYAEDAAHFHQTIKAACDKSHKEYYPIFKRWCDE
EEEEEEEEECCCEEEECCCEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
YFYLKHRQETRGVGGIFFDYQDGQGELYKGPDNQGPAATYSKDLGILESRSWESLFTFVQ
HHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCCCCHHHHCCCCCCCCCHHHHHHHHH
NCGVSFLPAYKIIVERRQPMKYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTES
HCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCEEEEEEEEECCEEEEEECCCCCHH
ILMSLPPLVRWEYGYNPEPNTPEAELYEVFLKPHDWADWKPNH
HHHHCCCCEEEECCCCCCCCCCHHHHHHEEECCCCCCCCCCCC
>Mature Secondary Structure
MVVSSKDQEISLSVPASDTKERVSQFMQTLQDEICQGLEELDGVSKFKEDSWKRPGGGGG
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KSRVIRDGGVFEQGGVNFSEVWGDKLPPSVLKQRPEAAGNSFYATGTSMVLHPKNPYVPT
CCCEEECCCCCCCCCCCHHHHCCCCCCHHHHHCCCHHCCCCEEECCCEEEEECCCCCCCE
VHLNYRYFEAGSVWWFGGGVDLTPYYPYAEDAAHFHQTIKAACDKSHKEYYPIFKRWCDE
EEEEEEEEECCCEEEECCCEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
YFYLKHRQETRGVGGIFFDYQDGQGELYKGPDNQGPAATYSKDLGILESRSWESLFTFVQ
HHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCCCCHHHHCCCCCCCCCHHHHHHHHH
NCGVSFLPAYKIIVERRQPMKYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTES
HCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCEEEEEEEEECCEEEEEECCCCCHH
ILMSLPPLVRWEYGYNPEPNTPEAELYEVFLKPHDWADWKPNH
HHHHCCCCEEEECCCCCCCCCCHHHHHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]