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The map label for this gene is leuD [H]

Identifier: 113474825

GI number: 113474825

Start: 1631177

End: 1631728

Strand: Reverse

Name: leuD [H]

Synonym: Tery_1041

Alternate gene names: 113474825

Gene position: 1631728-1631177 (Counterclockwise)

Preceding gene: 113474830

Following gene: 113474820

Centisome position: 21.05

GC content: 37.5

Gene sequence:

>552_bases
ATGACCAAATCCCTAACTGGTAAAATTTTTGTCTTAGATGACAATATAGATACTGACCAAATTATACCTGCTGAGTATCT
AACATTGGTTCCTTCAAAGCCAGATGAATATGATAAACTAGGAACTTATGCTTTGTGTGGTTTGCCTGATCGCTATGGTA
GATTTATGGAGCCAGAAGCAATGAAAACAAAGTATCCCATTATCGTAGCTGGAGAAAATTTTGGTTGTGGCTCTTCAAGG
GAACATGCACCTATTGCATTGGGCGCTTCTGGTGTCCAAGCAGTAGTTGCTCAATCTTATGCTCGTATATTCTTCCGTAA
TTGTTCCGCCACTGGAGAATTATATCCTTGGGAGTCTAGCGATCGCCTGTGTGAGTTATTTAAAACTGGTCAAAAAGTTA
CTATTGATTTTGAAAAAAATCAAATAGTTAATCATACTCTTGATCAAACTTATCAGTTAAAGTCTTTGGGAGAAGTAAGA
CCTGTAATTGATGCTGGAGGTCTTTTTGCTTATGCTCGTCAAACAGGTATGATTTCCCAAAAAGAAGTTTGA

Upstream 100 bases:

>100_bases
TAATATATTTTACAAATAGTCTTTAACAAATATTATGCTAGAATATAAAATTAAAAATTGAAAATTGTAACAATATTAGA
GGGAAAACAAAAAATTAACT

Downstream 100 bases:

>100_bases
ATATTTCTTTTCAGTTGGAAGGCAATTTATCTCCCCTTTTCAGAGATATGAGCATTTTCCCCTGGACAAAGTTATTTATT
AGTGAAAATTTCTATAAAGA

Product: 3-isopropylmalate dehydratase, small subunit

Products: NA

Alternate protein names: Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTKSLTGKIFVLDDNIDTDQIIPAEYLTLVPSKPDEYDKLGTYALCGLPDRYGRFMEPEAMKTKYPIIVAGENFGCGSSR
EHAPIALGASGVQAVVAQSYARIFFRNCSATGELYPWESSDRLCELFKTGQKVTIDFEKNQIVNHTLDQTYQLKSLGEVR
PVIDAGGLFAYARQTGMISQKEV

Sequences:

>Translated_183_residues
MTKSLTGKIFVLDDNIDTDQIIPAEYLTLVPSKPDEYDKLGTYALCGLPDRYGRFMEPEAMKTKYPIIVAGENFGCGSSR
EHAPIALGASGVQAVVAQSYARIFFRNCSATGELYPWESSDRLCELFKTGQKVTIDFEKNQIVNHTLDQTYQLKSLGEVR
PVIDAGGLFAYARQTGMISQKEV
>Mature_182_residues
TKSLTGKIFVLDDNIDTDQIIPAEYLTLVPSKPDEYDKLGTYALCGLPDRYGRFMEPEAMKTKYPIIVAGENFGCGSSRE
HAPIALGASGVQAVVAQSYARIFFRNCSATGELYPWESSDRLCELFKTGQKVTIDFEKNQIVNHTLDQTYQLKSLGEVRP
VIDAGGLFAYARQTGMISQKEV

Specific function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate [H]

COG id: COG0066

COG function: function code E; 3-isopropylmalate dehydratase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the leuD family. LeuD type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786258, Length=150, Percent_Identity=35.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321429, Length=141, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012305
- InterPro:   IPR015937
- InterPro:   IPR015928
- InterPro:   IPR000573
- InterPro:   IPR011824
- InterPro:   IPR011827 [H]

Pfam domain/function: PF00694 Aconitase_C [H]

EC number: =4.2.1.33 [H]

Molecular weight: Translated: 20302; Mature: 20171

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSLTGKIFVLDDNIDTDQIIPAEYLTLVPSKPDEYDKLGTYALCGLPDRYGRFMEPEA
CCCCCCCEEEEEECCCCCCCCCCHHHEEECCCCCCCHHHCCCEEEECCCHHHCCCCCCHH
MKTKYPIIVAGENFGCGSSREHAPIALGASGVQAVVAQSYARIFFRNCSATGELYPWESS
HCCCCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DRLCELFKTGQKVTIDFEKNQIVNHTLDQTYQLKSLGEVRPVIDAGGLFAYARQTGMISQ
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHCCCCCC
KEV
CCC
>Mature Secondary Structure 
TKSLTGKIFVLDDNIDTDQIIPAEYLTLVPSKPDEYDKLGTYALCGLPDRYGRFMEPEA
CCCCCCEEEEEECCCCCCCCCCHHHEEECCCCCCCHHHCCCEEEECCCHHHCCCCCCHH
MKTKYPIIVAGENFGCGSSREHAPIALGASGVQAVVAQSYARIFFRNCSATGELYPWESS
HCCCCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DRLCELFKTGQKVTIDFEKNQIVNHTLDQTYQLKSLGEVRPVIDAGGLFAYARQTGMISQ
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHCCCCCC
KEV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA