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The map label for this gene is thrB

Identifier: 113474806

GI number: 113474806

Start: 1585964

End: 1586881

Strand: Direct

Name: thrB

Synonym: Tery_1018

Alternate gene names: 113474806

Gene position: 1585964-1586881 (Clockwise)

Preceding gene: 113474805

Following gene: 113474810

Centisome position: 20.46

GC content: 40.96

Gene sequence:

>918_bases
ATGACCACACTTTCCTCTATTACAGTTAGCGTTCCTGCAACTACTGCTAATTTAGGCCCCGGTTTTGACTGCCTCGGTGC
TGCTATTTCCTTATATAACCGCTTCAAGTTCTCTATTGCGGATAGCGCAATAGAAGTAAAAATCACTGTTACAGGCAAAG
AAGCTCCAAAAGTCAGCACAGATAGAAACAATCTTGCCTATCAAGCATTTGTAAAGTTATATGAATATATCAATCAAACT
CCCCCATGTGTACTAGTAGAAATTGATTTGGGTGTACCATTGGCCAGAGGATTAGGAAGTTCGGCTACCGCAATAGTCGG
AGGTTTGCTAGGGGCAAATCAACTAGCAGGTAGTCCTTTAAGTCAAACTGAAGTGATGAATCTAGCGATCGCTATTGAAG
GACACCCAGATAATGTTGTACCTGCCTTACTTGGTGGCTGTCGTTTAACTGCCTCTACCTCCAAAGGTTGGGTTGTATGC
GACATTCCCTGGCATCCTGATATTGTGCCAGTAGTAGCAATTCCAGATTTTGAGCTTTCAACAACAGAAGCGCGACGAGT
TATACCAACAGAATACATTCGTTCTGATGCTATATTTAATTGTGCTCATCTGGGAATTTTGTTAAGAGGCTTAGAAACTG
GTTATGGAGAATGGTTACAAGCGGGAATGCAAGATAAAATTCACCAACCATACCGTAAATCTCTAATTAAAGGATATGAA
TATGTGCGTTCTGCTGCTTTAAATGCTGGTGCCTATGAAATGGTCATTAGTGGTGCAGGTCCGACTTTATTAGCGTTAAC
AAACTCACTCACAAGTTCAAAAGTAATAGCAGCAATGACTGGTGCTTGGGAAAACCAAGGAGTAGTTACACAAGTACAAG
CTTTAGAAATTAATACTAGAGGTGCAGTTTTTAGTTAG

Upstream 100 bases:

>100_bases
TCGCCATACCTTACTCTATTGCGCATAGCCAAAATAATATTGTCAACTGTAAAAATTCCTACTCTTCTAAGCAAACCAAA
CTACTCTAACTATTTATACT

Downstream 100 bases:

>100_bases
GATAATTCTTAAATCTAATATAGCTAAAATTTTGACAATAGGGAATTAGAAGAGAGGTAAACTTAATTCCTTATATATGT
TTTCGCTTACTTTCTAATTT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTTLSSITVSVPATTANLGPGFDCLGAAISLYNRFKFSIADSAIEVKITVTGKEAPKVSTDRNNLAYQAFVKLYEYINQT
PPCVLVEIDLGVPLARGLGSSATAIVGGLLGANQLAGSPLSQTEVMNLAIAIEGHPDNVVPALLGGCRLTASTSKGWVVC
DIPWHPDIVPVVAIPDFELSTTEARRVIPTEYIRSDAIFNCAHLGILLRGLETGYGEWLQAGMQDKIHQPYRKSLIKGYE
YVRSAALNAGAYEMVISGAGPTLLALTNSLTSSKVIAAMTGAWENQGVVTQVQALEINTRGAVFS

Sequences:

>Translated_305_residues
MTTLSSITVSVPATTANLGPGFDCLGAAISLYNRFKFSIADSAIEVKITVTGKEAPKVSTDRNNLAYQAFVKLYEYINQT
PPCVLVEIDLGVPLARGLGSSATAIVGGLLGANQLAGSPLSQTEVMNLAIAIEGHPDNVVPALLGGCRLTASTSKGWVVC
DIPWHPDIVPVVAIPDFELSTTEARRVIPTEYIRSDAIFNCAHLGILLRGLETGYGEWLQAGMQDKIHQPYRKSLIKGYE
YVRSAALNAGAYEMVISGAGPTLLALTNSLTSSKVIAAMTGAWENQGVVTQVQALEINTRGAVFS
>Mature_304_residues
TTLSSITVSVPATTANLGPGFDCLGAAISLYNRFKFSIADSAIEVKITVTGKEAPKVSTDRNNLAYQAFVKLYEYINQTP
PCVLVEIDLGVPLARGLGSSATAIVGGLLGANQLAGSPLSQTEVMNLAIAIEGHPDNVVPALLGGCRLTASTSKGWVVCD
IPWHPDIVPVVAIPDFELSTTEARRVIPTEYIRSDAIFNCAHLGILLRGLETGYGEWLQAGMQDKIHQPYRKSLIKGYEY
VRSAALNAGAYEMVISGAGPTLLALTNSLTSSKVIAAMTGAWENQGVVTQVQALEINTRGAVFS

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=306, Percent_Identity=30.3921568627451, Blast_Score=139, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321814, Length=327, Percent_Identity=28.7461773700306, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_TRIEI (Q117D0)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720867.1
- ProteinModelPortal:   Q117D0
- SMR:   Q117D0
- STRING:   Q117D0
- GeneID:   4243097
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1018
- NMPDR:   fig|203124.1.peg.6167
- eggNOG:   COG0083
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- PhylomeDB:   Q117D0
- ProtClustDB:   PRK01212
- BioCyc:   TERY203124:TERY_1018-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 32324; Mature: 32193

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLSSITVSVPATTANLGPGFDCLGAAISLYNRFKFSIADSAIEVKITVTGKEAPKVST
CCCCCEEEEECCCEECCCCCCHHHHHHHHHHHHHHEEEEECCEEEEEEEEECCCCCCCCC
DRNNLAYQAFVKLYEYINQTPPCVLVEIDLGVPLARGLGSSATAIVGGLLGANQLAGSPL
CCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHCCCCCHHHHHHHHHCCHHHCCCCC
SQTEVMNLAIAIEGHPDNVVPALLGGCRLTASTSKGWVVCDIPWHPDIVPVVAIPDFELS
CCCEEEEEEEEEECCCCCHHHHHHCCCEEEECCCCCEEEEECCCCCCEEEEEEECCCCCC
TTEARRVIPTEYIRSDAIFNCAHLGILLRGLETGYGEWLQAGMQDKIHQPYRKSLIKGYE
CCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH
YVRSAALNAGAYEMVISGAGPTLLALTNSLTSSKVIAAMTGAWENQGVVTQVQALEINTR
HHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEEEEEECC
GAVFS
CCCCC
>Mature Secondary Structure 
TTLSSITVSVPATTANLGPGFDCLGAAISLYNRFKFSIADSAIEVKITVTGKEAPKVST
CCCCEEEEECCCEECCCCCCHHHHHHHHHHHHHHEEEEECCEEEEEEEEECCCCCCCCC
DRNNLAYQAFVKLYEYINQTPPCVLVEIDLGVPLARGLGSSATAIVGGLLGANQLAGSPL
CCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHCCCCCHHHHHHHHHCCHHHCCCCC
SQTEVMNLAIAIEGHPDNVVPALLGGCRLTASTSKGWVVCDIPWHPDIVPVVAIPDFELS
CCCEEEEEEEEEECCCCCHHHHHHCCCEEEECCCCCEEEEECCCCCCEEEEEEECCCCCC
TTEARRVIPTEYIRSDAIFNCAHLGILLRGLETGYGEWLQAGMQDKIHQPYRKSLIKGYE
CCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH
YVRSAALNAGAYEMVISGAGPTLLALTNSLTSSKVIAAMTGAWENQGVVTQVQALEINTR
HHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEEEEEECC
GAVFS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA