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The map label for this gene is mutM

Identifier: 113474804

GI number: 113474804

Start: 1583042

End: 1583944

Strand: Direct

Name: mutM

Synonym: Tery_1015

Alternate gene names: 113474804

Gene position: 1583042-1583944 (Clockwise)

Preceding gene: 113474803

Following gene: 113474805

Centisome position: 20.43

GC content: 36.43

Gene sequence:

>903_bases
GTGCCAGAACTGCCGGAAGTTGAAATAGTAAAACAAGGTTTAAATCAACTGACTCTCAATAAAAGAATATTGGGTGGGGA
AGTACTATTAGAACGTACGCTTGCTTACCCAATTTCTGTAGCTGATTTTTTGAGAGGGTTGGAAGGAAAAGCGATCGCCC
AATGGCATCGACAAGGTAAATATTTACTTGCCCAACTTTATAAATGGGGCAAAAAAAACTCAAAACTTCAAGAATACGAA
AATGAAGATGGTTGGTTAGGAGTACATCTACGAATGACAGGCCAACTCTTATGGGTAAACCCAGAAGAGAGTCTGCACAA
ACACACACGAGTAAGATTATTTTTTGGTCATAACTCTTCAGGAGATAAAGATAGCTCTAATTATGAATTGAGATTTGTAG
ATCAACGCACTTTTGGCAAGATGTGGGGAGTACCACCAGGAAAAGAAATATCTAAAGTTATAACTGGTTTGCAACAACTG
GGTCTTGAACCATTTTCTCCAGAATTTTCTCCAAAATACCTTAATAAAAAACTTTACAAAAGACATCGACCAATTAAAAC
AGCTCTTTTAGACCAGACAACCATTGCCGGGTTAGGTAATATTTATGCTGATGAAGCTCTATTTCTCAGTGGTATTAGAC
CAACAACTATATGTAAAGATTTGACAGAAAAACAAATAGAACAATTACACCTAGCCATACTTAAAGTTTTACAAACTGCT
ATAAATGCAGGTGGTACAACTTTCAGCAACTTTCTTAATGTAAAGGGAGTTAATGGTAATTATGGAGGTGTAGCTTGGGT
TTATAGTCGTGCTGGTCAACCATGTCGAATTTGTAATACACCTTTAGAAAAAATTAAACTAGCGGGACGGTCTACTCATT
TTTGTCCTCAATGTCAAAAATAA

Upstream 100 bases:

>100_bases
TACAGAAATAGAAAATTTGGCCATTGAAGAAGAGGCTCAGTTGGTGCCTTCAGATGGGGTGTCTATATAATAATAAATAC
TGTGAGAAATATTTAGTACT

Downstream 100 bases:

>100_bases
TAGGGAGTGAGGAAGATGAGAAGATGGGGATATTAAGACTAAACGACCAGTCCTAAACAAAAAATTGATGCACTAGGCTA
GGGTCAGACTAGGGTCAAGT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MPELPEVEIVKQGLNQLTLNKRILGGEVLLERTLAYPISVADFLRGLEGKAIAQWHRQGKYLLAQLYKWGKKNSKLQEYE
NEDGWLGVHLRMTGQLLWVNPEESLHKHTRVRLFFGHNSSGDKDSSNYELRFVDQRTFGKMWGVPPGKEISKVITGLQQL
GLEPFSPEFSPKYLNKKLYKRHRPIKTALLDQTTIAGLGNIYADEALFLSGIRPTTICKDLTEKQIEQLHLAILKVLQTA
INAGGTTFSNFLNVKGVNGNYGGVAWVYSRAGQPCRICNTPLEKIKLAGRSTHFCPQCQK

Sequences:

>Translated_300_residues
MPELPEVEIVKQGLNQLTLNKRILGGEVLLERTLAYPISVADFLRGLEGKAIAQWHRQGKYLLAQLYKWGKKNSKLQEYE
NEDGWLGVHLRMTGQLLWVNPEESLHKHTRVRLFFGHNSSGDKDSSNYELRFVDQRTFGKMWGVPPGKEISKVITGLQQL
GLEPFSPEFSPKYLNKKLYKRHRPIKTALLDQTTIAGLGNIYADEALFLSGIRPTTICKDLTEKQIEQLHLAILKVLQTA
INAGGTTFSNFLNVKGVNGNYGGVAWVYSRAGQPCRICNTPLEKIKLAGRSTHFCPQCQK
>Mature_299_residues
PELPEVEIVKQGLNQLTLNKRILGGEVLLERTLAYPISVADFLRGLEGKAIAQWHRQGKYLLAQLYKWGKKNSKLQEYEN
EDGWLGVHLRMTGQLLWVNPEESLHKHTRVRLFFGHNSSGDKDSSNYELRFVDQRTFGKMWGVPPGKEISKVITGLQQLG
LEPFSPEFSPKYLNKKLYKRHRPIKTALLDQTTIAGLGNIYADEALFLSGIRPTTICKDLTEKQIEQLHLAILKVLQTAI
NAGGTTFSNFLNVKGVNGNYGGVAWVYSRAGQPCRICNTPLEKIKLAGRSTHFCPQCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=304, Percent_Identity=34.8684210526316, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786932, Length=148, Percent_Identity=29.7297297297297, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_TRIEI (Q117D2)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720865.1
- ProteinModelPortal:   Q117D2
- SMR:   Q117D2
- STRING:   Q117D2
- GeneID:   4243094
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1015
- NMPDR:   fig|203124.1.peg.6169
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q117D2
- ProtClustDB:   PRK13945
- BioCyc:   TERY203124:TERY_1015-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 33876; Mature: 33744

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 290-290 BINDING 108-108 BINDING 136-136 BINDING 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEIVKQGLNQLTLNKRILGGEVLLERTLAYPISVADFLRGLEGKAIAQWHRQGK
CCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHCCH
YLLAQLYKWGKKNSKLQEYENEDGWLGVHLRMTGQLLWVNPEESLHKHTRVRLFFGHNSS
HHHHHHHHHCCCCCHHHHHCCCCCEEEEEEEEECEEEEECCHHHHHHCEEEEEEECCCCC
GDKDSSNYELRFVDQRTFGKMWGVPPGKEISKVITGLQQLGLEPFSPEFSPKYLNKKLYK
CCCCCCCCEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
RHRPIKTALLDQTTIAGLGNIYADEALFLSGIRPTTICKDLTEKQIEQLHLAILKVLQTA
HCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAGGTTFSNFLNVKGVNGNYGGVAWVYSRAGQPCRICNTPLEKIKLAGRSTHFCPQCQK
HHCCCCCHHHHEEEECCCCCCCCEEEEECCCCCCCHHHCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEIVKQGLNQLTLNKRILGGEVLLERTLAYPISVADFLRGLEGKAIAQWHRQGK
CCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHCCH
YLLAQLYKWGKKNSKLQEYENEDGWLGVHLRMTGQLLWVNPEESLHKHTRVRLFFGHNSS
HHHHHHHHHCCCCCHHHHHCCCCCEEEEEEEEECEEEEECCHHHHHHCEEEEEEECCCCC
GDKDSSNYELRFVDQRTFGKMWGVPPGKEISKVITGLQQLGLEPFSPEFSPKYLNKKLYK
CCCCCCCCEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
RHRPIKTALLDQTTIAGLGNIYADEALFLSGIRPTTICKDLTEKQIEQLHLAILKVLQTA
HCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAGGTTFSNFLNVKGVNGNYGGVAWVYSRAGQPCRICNTPLEKIKLAGRSTHFCPQCQK
HHCCCCCHHHHEEEECCCCCCCCEEEEECCCCCCCHHHCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA